H. Lee Moffitt Cancer Center & Research Institute

Physician, Faculty, and Staff

G. Douglas Letson, MD

G. Douglas Letson, MD

Faculty Rank:

Senior Member

Titles:

  • Chair, Sarcoma Department
  • Education Director
  • Director of Rehabilitation

Department/Program Affiliations:

  • Sarcoma  
  • Experimental Therapeutics  

Primary Address:

H. Lee Moffitt Cancer Center &
Research Institute
12902 Magnolia Drive
Tampa, FL 33612

Office:

(813) 745-3976

USF Affiliations/College Department:

  • Medicine / Oncologic Sciences
  • Medicine / Radiology
  • Medicine / Surgery
  • Medicine / Orthopaedics & Sports Medicine

University Academic Rank:

Professor

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G. Douglas Letson, MD

Education & Training:

  • M.D., Louisiana State University, 1988
  • Internship, Charity Hospital of Louisiana, 1988
  • Residency, Louisiana State Medical School Affiliated Hospitals, 1993 - Orthopaedics
  • Fellowship, Harvard Medical School, 1992 - Musculoskeletal Oncology

General Board Certification / SubSpecialty:

  • Orthopaedic Surgery

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G. Douglas Letson, MD

Research Interests:

Matrix metalloproteinases.


Clinical Interests:

Dr. Letson's clinical practice employs an interdisciplinary approach to treating musculoskeletal tumors for patients ranging from pediatrics to advance age. He has extensive clinical experience in the areas of pediatric and adult limb salvage in both bone and soft tissue tumors. His clinical interests have a strong scientific focus in the development of segmental prosthesis, new hinge designs and soft tissue attachment to metallic prosthesis.


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G. Douglas Letson, MD

Publications:

  1. Biermann JS, Adkins DR, Benjamin RS, Brigman B, Chow W, Conrad EU, Frassica DA, Frassica FJ, George S, Hande KR, Hornicek FJ, Letson GD, Mayerson J, McGarry SV, McGrath B, Morris CD, O'Donnell RJ, Randall RL, Santana VM, Satcher RL, Siegel HJ, Somaiah N, Yasko AW. Bone cancer. J Natl Compr Canc Netw. 2010 Jun;8(6):688-712. Pubmedid: 20581300.   Pubmed ID: 20581300

  2. Demetri GD, Antonia S, Benjamin RS, Bui MM, Casper ES, Conrad EU, Delaney TF, Ganjoo KN, Heslin MJ, Hutchinson RJ, Kane JM, Letson GD, McGarry SV, O'Donnell RJ, Paz IB, Pfeifer JD, Pollock RE, Randall RL, Riedel RF, Schupak KD, Schwartz HS, Thornton K, von Mehren M, Wayne J. Soft tissue sarcoma. J Natl Compr Canc Netw. 2010 Jun;8(6):630-674. Pubmedid: 20581298.   Pubmed ID: 20581298

  3. Farma JM, Ammori JB, Zager JS, Marzban SS, Bui MM, Bichakjian CK, Johnson TM, Lowe L, Sabel MS, Wong SL, Letson GD, Messina JL, Cimmino VM, Sondak VK. Dermatofibrosarcoma protuberans: how wide should we resect?. Ann Surg Oncol. 2010 Aug;17(8):2112-2118. Pubmedid: 20354798.   Pubmed ID: 20354798

  4. Henderson ER, Jennings JM, Marulanda GA, Groundland JS, Cheong D, Letson GD. Enhancing Soft Tissue Ingrowth in Proximal Femoral Arthroplasty With Aortograft Sleeve A Novel Technique and Early Results. J Arthroplasty. 2010 Aug. Pubmedid: 20801613.   Pubmed ID: 20801613

  5. Henderson ER, Jennings JM, Marulanda GA, Palumbo BT, Cheong D, Letson GD. Purse-string capsule repair to reduce proximal femoral arthroplasty dislocation for tumor--a novel technique with results. J Arthroplasty. 2010 Jun;25(4):654-657. Pubmedid: 20097040.   Pubmed ID: 20097040

  6. Henderson ER, Pepper AM, Marulanda GA, Millard JD, Letson GD. What is the Emotional Acceptance After Limb Salvage with an Expandable Prosthesis?. Clin Orthop Relat Res. 2010 Jul. Pubmedid: 20632139.   Pubmed ID: 20632139

  7. Kraybill WG, Harris J, Spiro IJ, Ettinger DS, Delaney TF, Blum RH, Lucas DR, Harmon DC, Letson GD, Eisenberg B. Long-term results of a phase 2 study of neoadjuvant chemotherapy and radiotherapy in the management of high-risk, high-grade, soft tissue sarcomas of the extremities and body wall: radiation Therapy Oncology Group Trial 9514. Cancer. 2010 Jun;. Pubmedid: 20572040.   Pubmed ID: 20572040

  8. Marulanda GA, Henderson E, Cheong D, Letson GD. Proximal and Total Humerus Reconstruction With the Use of an Aortograft Mesh. Clin Orthop Relat Res. 2010 Jun;. Pubmedid: 20568029.   Pubmed ID: 20568029

  9. Alexander GE, Henderson ER, Rodriguez AR, Bui MM, Cheong D, Letson GD. Extraskeletal myxoid chondrosarcoma: rare presentation in the knee joint space. Orthopedics. 2009 Dec;32(12):919-922. Pubmedid: 19968226.   Pubmed ID: 19968226

  10. Potter BK, Chow VE, Adams SC, Letson GD, Temple HT. Endoprosthetic proximal femur replacement: metastatic versus primary tumors. Surg Oncol. 2009 Dec;18(4):343-349. Pubmedid: 18835153.   Pubmed ID: 18835153

  11. Bui M, Smith P, Agresta S, Cheong D, Letson G. Practical issues of intraoperative frozen section diagnosis of bone and soft tissue lesions. Cancer Control. 2008 Jan;15(1):7-12. Pubmedid: 18094656.   Pubmed ID: 18094656

  12. Marulanda G, Henderson E, Johnson D, Letson G, Cheong D. Orthopedic surgery options for the treatment of primary osteosarcoma. Cancer Control. 2008 Jan;15(1):13-20. Pubmedid: 18094657.   Pubmed ID: 18094657

  13. Marulanda G, Henderson E, Palumbo B, Alexander G, Cheong D, Letson G. Use of extendable prostheses: a limb-salvaging alternative for patients with malignant bone tumors. Expert Rev Med Devices. 2008 Jul;5(4):467-474. Pubmedid: 18573046.   Pubmed ID: 18573046

  14. Marulanda G, Mont M, Lucci A, Letson G, Khakpour N. Orthopedic surgery implications of breast cancer. Expert Rev Anticancer Ther. 2008 Jun;8(6):949-956. Pubmedid: 18533804.   Pubmed ID: 18533804

  15. Biermann J, Adkins D, Benjamin R, Brigman B, Chow W, Conrad EU 3rd, Frassica D, Frassica F, George S, Healey J, Heck R J, Letson G, Mayerson J, McGarry S, O'donnell R, Patt J, Randall R, Santana V, Satcher R, Schmidt R, Siegel H, Wong M, Yasko A. Bone cancer. J Natl Compr Canc Netw. 2007 Apr;5(4):420-437. Pubmedid: 17442233.   Pubmed ID: 17442233

  16. Demetri G, Baker L, Benjamin R, Casper E, Conrad EU 3rd, D'Amato G, Delaney T, Ettinger D, Heck R J, Heslin M, Hutchinson R, Jacobs C, Kiel K, Kraybill W, Letson G, O'donnell R, Paz I, Pfeifer J, Pollock R, Randall R, Sasson A, Schupak K, Tyler D, Mehren M, Wayne J. Soft tissue sarcoma. J Natl Compr Canc Netw. 2007 Apr;5(4):364-399. Pubmedid: 17442230.   Pubmed ID: 17442230

  17. Shor AC, Keschman EA, Lee FY, Muro-Cacho C, Letson GD, Trent JC, Pledger WJ, Jove R. Dasatinib inhibits migration and invasion in diverse human sarcoma cell lines and induces apoptosis in bone sarcoma cells dependent on SRC kinase for survival. Cancer Res. 2007 Mar;67(6):2800-2808. Pubmedid: 17363602.   Pubmed ID: 17363602

  18. Kraybill W, Harris J, Spiro I, Ettinger D, DeLaney T, Blum R, Lucas DR, Harmon D, Letson G, Eisenberg B. Phase II study of neoadjuvant chemotherapy and radiation therapy in the management of high-risk, high-grade, soft tissue sarcomas of the extremities and body wall: Radiation Therapy Oncology Group Trial 9514. J Clin Oncol. 2006 Feb;24(4):619-625. Pubmedid: 16446334.   Pubmed ID: 16446334

  19. Knapp E, Kransdorf M, Letson G. Diagnostic imaging update: soft tissue sarcomas. Cancer Control. 2005 Jan;12(1):22-26. Pubmedid: 15668649.   Pubmed ID: 15668649

  20. Letson G. Soft tissue sarcoma: status in 2005. Cancer Control. 2005 Jan;12(1):2-2. Pubmedid: 15668647.   Pubmed ID: 15668647

  21. Saba HI, Morelli GA, Azam RR, Klein CJ, Letson GD. Efficacy of NovoSeven during surgery on a haemophiliac with previous history of inhibitors. Haemophilia. 2003 Jan;9(1):131-136. Pubmedid: 12558792.   Pubmed ID: 12558792

  22. Kim C, Puleo C, Letson G, Reintgen D. Hyperthermic isolated limb perfusion for extremity sarcoma. Cancer Control. 2001;8(3):269-273. Pubmedid: 11378653.   Pubmed ID: 11378653

  23. Letson G, Muro-Cacho C. Genetic and molecular abnormalities in tumors of the bone and soft tissues. Cancer Control. 2001;8(3):239-251. Pubmedid: 11378650.   Pubmed ID: 11378650

  24. Neel M, Letson G. Modular endoprostheses for children with malignant bone tumors. Cancer Control. 2001;8(4):344-348. Pubmedid: 11483888.   Pubmed ID: 11483888

  25. Strickland L, Letson GD, Muro-Cacho C. Gastrointestinal stromal tumors. Cancer Control. 2001;8(3):252-261. Pubmedid: 11378651.   Pubmed ID: 11378651

  26. Letson G, Ward W. Appropriate follow-up of orthopaedic oncology patients. Instr Course Lect. 1999;48:603-606. Pubmedid: 10098088.   Pubmed ID: 10098088

  27. Garcia E, Sandin R, Greene J, Baekey P, Walling A, Letson G, Choy J, Nicosia S, Moscinski L. Infections of the leg which mimic malignancy. Infect Med. 1998;15(8):557-567. Pubmedid: noPMID.  

  28. Letson G, Greenfield G, Heinrich S. Evaluation of the child with a bone or soft-tissue neoplasm. Orthop Clin North Am. 1996;27(3):431-451. Pubmedid: 8649727.   Pubmed ID: 8649727

G. Douglas Letson, MD

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