H. Lee Moffitt Cancer Center & Research Institute

Faculty Rank:

Senior Member

USF Affiliations/College Department:

• Medicine / Oncologic Sciences
• Medicine / Radiology
• Medicine / Surgery
• Medicine / Orthopedic Surgery

General Board Certification / SubSpecialty:

• Orthopaedic Surgery

Research Interests:

Matrix metalloproteinases.

Clinical Interests:

Dr. Letson's clinical practice employs an interdisciplinary approach to treating musculoskeletal tumors for patients ranging from pediatrics to advance age. He has extensive clinical experience in the areas of pediatric and adult limb salvage in both bone and soft tissue tumors. His clinical interests have a strong scientific focus in the development of segmental prosthesis, new hinge designs and soft tissue attachment to metallic prosthesis.

Publications:

1. Henderson ER, Jennings JM, Marulanda GA, Palumbo BT, Cheong D, Letson GD. Purse-String Capsule Repair to Reduce Proximal Femoral Arthroplasty Dislocation for Tumor-A Novel Technique With Results. J Arthroplasty. 2010 Jan;. Pubmedid: 20097040.   Pubmed ID: 20097040

2. Alexander GE, Henderson ER, Rodriguez AR, Bui MM, Cheong D, Letson GD. Extraskeletal myxoid chondrosarcoma: rare presentation in the knee joint space. Orthopedics. 2009 Dec;32(12):919-922. Pubmedid: 19968226.   Pubmed ID: 19968226

3. Potter BK, Chow VE, Adams SC, Letson GD, Temple HT. Endoprosthetic proximal femur replacement: metastatic versus primary tumors. Surg Oncol. 2009 Dec;18(4):343-349. Pubmedid: 18835153.   Pubmed ID: 18835153

4. Bui M, Smith P, Agresta S, Cheong D, Letson G. Practical issues of intraoperative frozen section diagnosis of bone and soft tissue lesions. Cancer Control. 2008 Jan;15(1):7-12. Pubmedid: 18094656.   Pubmed ID: 18094656

5. Marulanda G, Henderson E, Johnson D, Letson G, Cheong D. Orthopedic surgery options for the treatment of primary osteosarcoma. Cancer Control. 2008 Jan;15(1):13-20. Pubmedid: 18094657.   Pubmed ID: 18094657

6. Marulanda G, Henderson E, Palumbo B, Alexander G, Cheong D, Letson G. Use of extendable prostheses: a limb-salvaging alternative for patients with malignant bone tumors. Expert Rev Med Devices. 2008 Jul;5(4):467-474. Pubmedid: 18573046.   Pubmed ID: 18573046

7. Marulanda G, Mont M, Lucci A, Letson G, Khakpour N. Orthopedic surgery implications of breast cancer. Expert Rev Anticancer Ther. 2008 Jun;8(6):949-956. Pubmedid: 18533804.   Pubmed ID: 18533804

8. Biermann J, Adkins D, Benjamin R, Brigman B, Chow W, Conrad EU 3rd, Frassica D, Frassica F, George S, Healey J, Heck R J, Letson G, Mayerson J, McGarry S, O'donnell R, Patt J, Randall R, Santana V, Satcher R, Schmidt R, Siegel H, Wong M, Yasko A. Bone cancer. J Natl Compr Canc Netw. 2007 Apr;5(4):420-437. Pubmedid: 17442233.   Pubmed ID: 17442233

9. Demetri G, Baker L, Benjamin R, Casper E, Conrad EU 3rd, D'Amato G, Delaney T, Ettinger D, Heck R J, Heslin M, Hutchinson R, Jacobs C, Kiel K, Kraybill W, Letson G, O'donnell R, Paz I, Pfeifer J, Pollock R, Randall R, Sasson A, Schupak K, Tyler D, Mehren M, Wayne J. Soft tissue sarcoma. J Natl Compr Canc Netw. 2007 Apr;5(4):364-399. Pubmedid: 17442230.   Pubmed ID: 17442230

10. Shor AC, Keschman EA, Lee FY, Muro-Cacho C, Letson GD, Trent JC, Pledger WJ, Jove R. Dasatinib inhibits migration and invasion in diverse human sarcoma cell lines and induces apoptosis in bone sarcoma cells dependent on SRC kinase for survival. Cancer Res. 2007 Mar;67(6):2800-2808. Pubmedid: 17363602.   Pubmed ID: 17363602

11. Kraybill W, Harris J, Spiro I, Ettinger D, DeLaney T, Blum R, Lucas DR, Harmon D, Letson G, Eisenberg B. Phase II study of neoadjuvant chemotherapy and radiation therapy in the management of high-risk, high-grade, soft tissue sarcomas of the extremities and body wall: Radiation Therapy Oncology Group Trial 9514. J Clin Oncol. 2006 Feb;24(4):619-625. Pubmedid: 16446334.   Pubmed ID: 16446334

12. Knapp E, Kransdorf M, Letson G. Diagnostic imaging update: soft tissue sarcomas. Cancer Control. 2005 Jan;12(1):22-26. Pubmedid: 15668649.   Pubmed ID: 15668649

13. Letson G. Soft tissue sarcoma: status in 2005. Cancer Control. 2005 Jan;12(1):2-2. Pubmedid: 15668647.   Pubmed ID: 15668647

14. Saba HI, Morelli GA, Azam RR, Klein CJ, Letson GD. Efficacy of NovoSeven during surgery on a haemophiliac with previous history of inhibitors. Haemophilia. 2003 Jan;9(1):131-136. Pubmedid: 12558792.   Pubmed ID: 12558792

15. Kim C, Puleo C, Letson G, Reintgen D. Hyperthermic isolated limb perfusion for extremity sarcoma. Cancer Control. 2001;8(3):269-273. Pubmedid: 11378653.   Pubmed ID: 11378653

16. Letson G, Muro-Cacho C. Genetic and molecular abnormalities in tumors of the bone and soft tissues. Cancer Control. 2001;8(3):239-251. Pubmedid: 11378650.   Pubmed ID: 11378650

17. Neel M, Letson G. Modular endoprostheses for children with malignant bone tumors. Cancer Control. 2001;8(4):344-348. Pubmedid: 11483888.   Pubmed ID: 11483888

18. Strickland L, Letson GD, Muro-Cacho C. Gastrointestinal stromal tumors. Cancer Control. 2001;8(3):252-261. Pubmedid: 11378651.   Pubmed ID: 11378651

19. Letson G, Ward W. Appropriate follow-up of orthopaedic oncology patients. Instr Course Lect. 1999;48:603-606. Pubmedid: 10098088.   Pubmed ID: 10098088

20. Garcia E, Sandin R, Greene J, Baekey P, Walling A, Letson G, Choy J, Nicosia S, Moscinski L. Infections of the leg which mimic malignancy. Infect Med. 1998;15(8):557-567. Pubmedid: noPMID.  

21. Letson G, Greenfield G, Heinrich S. Evaluation of the child with a bone or soft-tissue neoplasm. Orthop Clin North Am. 1996;27(3):431-451. Pubmedid: 8649727.   Pubmed ID: 8649727