H. Lee Moffitt Cancer Center & Research Institute

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Kathleen M. Egan, ScD

Kathleen M. Egan, ScD

Faculty Rank:

Senior Member

Titles:

Department/Program Affiliations:

  • Risk Assessment,Detection & Intervention  
  • Comprehensive Melanoma Research Center  
  • Cutaneous Oncology  

Primary Address:

H. Lee Moffitt Cancer Center &
Research Institute
12902 Magnolia Drive
Tampa, FL 33612

Consultation/Referral Phone:

(813) 745-6803

USF Affiliations/College Department:

  • Medicine / Oncologic Sciences
  • Public Health / Epidemiology And Biostatistics

University Academic Rank:

Professor

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Kathleen M. Egan, ScD

Education & Training:

  • ScD, Harvard University, 1996
  • MPH, Boston University, 1984
  • BS, University of Connecticut, 1979

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Kathleen M. Egan, ScD

Research Interests:

My chief research focus is the molecular epidemiology and nutritional risk factors in melanoma, multiple myeloma and brain cancer etiology.


Clinical Interests:

I am not a clinician. However, I have had many years of experience in clinical epidemiology, with a focus on eye disease (primarily ocular melanoma) treatment and outcomes. Research in this area, in particular, gaining a better understanding of natural history of disease at the molecular level, and interactions of genetic factors with treatments on clinical outcomes I consider to be one of the more important and potentially fruitful lines of inquiry in the next few decades.


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Kathleen M. Egan, ScD

Publications:

  1. Anic GM, Titus-Ernstoff L, Newcomb PA, Trentham-Dietz A, Egan KM. Sleep duration and obesity in a population-based study. Sleep Med. 2010 May;11(5):447-451. Pubmedid: 20363668. Pmcid: PMC2854876.   Pubmed ID: 20363668

  2. Beasley JM, Newcomb PA, Trentham-Dietz A, Hampton JM, Ceballos RM, Titus-Ernstoff L, Egan KM, Holmes MD. Social networks and survival after breast cancer diagnosis. J Cancer Surviv. 2010 Jul. Pubmedid: 20652435.   Pubmed ID: 20652435

  3. Fair AM, Wujcik D, Lin JM, Zheng W, Egan KM, Grau AM, Champion VL, Wallston KA. Psychosocial determinants of mammography follow-up after receipt of abnormal mammography results in medically underserved women. J Health Care Poor Underserved. 2010 Feb;21(1 Suppl):71-94. Pubmedid: 20173286. Pmcid: PMC2927817.   Pubmed ID: 20173286

  4. Kim IK, Lane AM, Egan KM, Munzenrider J, Gragoudas ES. Natural history of radiation papillopathy after proton beam irradiation of parapapillary melanoma. Ophthalmology. 2010 Aug;117(8):1617-1622. Pubmedid: 20363507.   Pubmed ID: 20363507

  5. Lane AM, Egan KM, Kim IK, Gragoudas ES. Mortality after diagnosis of small melanocytic lesions of the choroid. Arch Ophthalmol. 2010 Aug;128(8):996-1000. Pubmedid: 20696999.   Pubmed ID: 20696999

  6. Lewis TJ, Dupont WD, Egan KM, Jones CD, Disher AC, Riddle WR, Fair AM. The "Got D'ViBE?" study: an inter-institutional project assessing vitamin D and mammographic breast density. J Health Care Poor Underserved. 2010 Feb;21(1 Suppl):17-25. Pubmedid: 20173282.   Pubmed ID: 20173282

  7. Peterson NB, Trentham-Dietz A, Garcia-Closas M, Newcomb PA, Titus-Ernstoff L, Huang Y, Chanock SJ, Haines JL, Egan KM. Association of COMT haplotypes and breast cancer risk in caucasian women. Anticancer Res. 2010 Jan;30(1):217-220. Pubmedid: 20150638.   Pubmed ID: 20150638

  8. Ahern TP, Lash TL, Egan KM, Baron JA. Lifetime tobacco smoke exposure and breast cancer incidence. Cancer Causes Control. 2009 Jun;. Pubmedid: 19533391.   Pubmed ID: 19533391

  9. Egan KM. Vitamin D and melanoma. Ann Epidemiol. 2009 Jul;19(7):455-461. Pubmedid: 19282200.   Pubmed ID: 19282200

  10. Fair AM, Wujcik D, Lin JM, Grau A, Wilson V, Champion V, Zheng W, Egan KM. Obesity, Gynecological Factors, and Abnormal Mammography Follow-Up in Minority and Medically Underserved Women. J Womens Health (Larchmt). 2009 Jul;18(7):1033-1039. Pubmedid: 19558307.   Pubmed ID: 19558307

  11. Gaudet MM, Milne RL, Cox A, Camp NJ, Goode EL, Humphreys MK, Dunning AM, Morrison J, Giles GG, Severi G, Baglietto L, English DR, Couch FJ, Olson JE, Wang X, Chang-Claude J, Flesch-Janys D, Abbas S, Salazar R, Mannermaa A, Kataja V, Kosma VM, Lindblom A, Margolin S, Heikkinen T, K?mpj?rvi K, Aaltonen K, Nevanlinna H, Bogdanova N, Coinac I, Sch?rmann P, D?rk T, Bartram CR, Schmutzler RK, Tchatchou S, Burwinkel B, Brauch H, Torres D, Hamann U, Justenhoven C, Ribas G, Arias JI, Benitez J, Bojesen SE, Nordestgaard BG, Flyger HL, Peto J, Fletcher O, Johnson N, Dos Santos Silva I, Fasching PA, Beckmann MW, Strick R, Ekici AB, Broeks A, Schmidt MK, van Leeuwen FE, Van't Veer LJ, Southey MC, Hopper JL, Apicella C, Haiman CA, Henderson BE, Le Marchand L, Kolonel LN, Kristensen V, Grenaker Alnaes G, Hunter DJ, Kraft P, Cox DG, Hankinson SE, Seynaeve C, Vreeswijk MP, Tollenaar RA, Devilee P, Chanock S, Lissowska J, Brinton L, Peplonska B, Czene K, Hall P, Li Y, Liu J, Balasubramanian S, Rafii S, Reed MW, Pooley KA, Conroy D, Baynes C, Kang D, Yoo KY, Noh DY, Ahn SH, Shen CY, Wang HC, Yu JC, Wu PE, Anton-Culver H, Ziogoas A, Egan K, Newcomb P, Titus-Ernstoff L, Trentham Dietz A, Sigurdson AJ, Alexander BH, Bhatti P, Allen-Brady K, Cannon-Albright LA, Wong J, Chenevix-Trench G, Spurdle AB, Beesley J, Pharoah PD, Easton DF, Garcia-Closas M. Five polymorphisms and breast cancer risk: results from the Breast Cancer Association Consortium. Cancer Epidemiol Biomarkers Prev. 2009 May;18(5) ...   Pubmed ID: 19423537

  12. Huang Y, Trentham-Dietz A, Garc?a-Closas M, Newcomb PA, Titus-Ernstoff L, Hampton JM, Chanock SJ, Haines JL, Egan KM. Association of CYP1B1 haplotypes and breast cancer risk in Caucasian women. Cancer Epidemiol Biomarkers Prev. 2009 Apr;18(4):1321-1323. Pubmedid: 19293312. Pmcid: PMC2692636.   Pubmed ID: 19293312

  13. Kumar N, Titus-Ernstoff L, Newcomb PA, Trentham-Dietz A, Anic G, Egan KM. Tea consumption and risk of breast cancer. Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):341-345. Pubmedid: 19124518.   Pubmed ID: 19124518

  14. Lane AM, Egan KM, Harmon D, Holbrook A, Munzenrider JE, Gragoudas ES. Adjuvant Interferon Therapy for Patients with Uveal Melanoma at High Risk of Metastasis. Ophthalmology. 2009 Nov;116(11):2206-2212. Pubmedid: 19744725.   Pubmed ID: 19744725

  15. Mignone L, Giovannucci E, Newcomb P, Titus-Ernstoff L, Trentham-Dietz A, Hampton J, Orav E, Willett W, Egan K. Meat consumption, heterocyclic amines, NAT2, and the risk of breast cancer. Nutr Cancer. 2009;61(1):36-46. Pubmedid: 19116874.   Pubmed ID: 19116874

  16. Mignone LI, Giovannucci E, Newcomb PA, Titus-Ernstoff L, Trentham-Dietz A, Hampton JM, Willett WC, Egan KM. Dietary carotenoids and the risk of invasive breast cancer. Int J Cancer. 2009 Jun;124(12):2929-2937. Pubmedid: 19330841.   Pubmed ID: 19330841

  17. Newcomb PA, Nichols HB, Beasley JM, Egan K, Titus-Ernstoff L, Hampton JM, Trentham-Dietz A. No difference between red wine or white wine consumption and breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2009 Mar;18(3):1007-1010. Pubmedid: 19273487. Pmcid: PMC2710299.   Pubmed ID: 19273487

  18. Nichols HB, Trentham-Dietz A, Egan KM, Titus-Ernstoff L, Holmes MD, Bersch AJ, Holick CN, Hampton JM, Stampfer MJ, Willett WC, Newcomb PA. Body mass index before and after breast cancer diagnosis: associations with all-cause, breast cancer, and cardiovascular disease mortality. Cancer Epidemiol Biomarkers Prev. 2009 May;18(5):1403-1409. Pubmedid: 19366908. Pmcid: PMC2715918.   Pubmed ID: 19366908

  19. Parl FF, Egan KM, Li C, Crooke PS. Estrogen exposure, metabolism, and enzyme variants in a model for breast cancer risk prediction. Cancer Inform. 2009 May;7:109-121. Pubmedid: 19718449.   Pubmed ID: 19718449

  20. Permuth-Wey J, Egan KM. Family history is a significant risk factor for pancreatic cancer: results from a systematic review and meta-analysis. Fam Cancer. 2009 Sep;8(2):109-117. Pubmedid: 18763055.   Pubmed ID: 18763055

  21. Wise LA, Titus-Ernstoff L, Newcomb PA, Trentham-Dietz A, Trichopoulos D, Hampton JM, Egan KM. Exposure to breast milk in infancy and risk of breast cancer. Cancer Causes Control. 2009 Sep;20(7):1083-1090. Pubmedid: 19330531.   Pubmed ID: 19330531

  22. Cai H, Shu XO, Egan KM, Cai Q, Long JR, Gao YT, Zheng W. Association of genetic polymorphisms in CYP19A1 and blood levels of sex hormones among postmenopausal Chinese women. Pharmacogenet Genomics. 2008 Aug;18(8):657-664. Pubmedid: 18622258.   Pubmed ID: 18622258

  23. Egan K, Signorello L, Munro H, Hargreaves M, Hollis B, Blot W. Vitamin D insufficiency among African-Americans in the southeastern UnitedStates: implications for cancer disparities (United States). Cancer Causes Control. 2008 Jun;19(5):527-535. Pubmedid: 18219582.   Pubmed ID: 18219582

  24. Fair AM, Wujcik D, Lin JM, Egan KM, Grau AM, Zheng W. Timing is everything: methodologic issues locating and recruiting medically underserved women for abnormal mammography follow-up research. Contemp Clin Trials. 2008 Jul;29(4):537-546. Pubmedid: 18289943.   Pubmed ID: 18289943

  25. Holick C, Newcomb P, Trentham-Dietz A, Titus-Ernstoff L, Bersch A, Stampfer M, Baron J, Egan K, Willett W. Physical activity and survival after diagnosis of invasive breast cancer. Cancer Epidemiol Biomarkers Prev. 2008 Feb;17(2):379-386. Pubmedid: 18250341.   Pubmed ID: 18250341

  26. Newcomb PA, Egan KM, Trentham-Dietz A, Titus-Ernstoff L, Baron JA, HamptonJM, Stampfer MJ, Willett WC. Prediagnostic use of hormone therapy and mortality after breast cancer. Cancer Epidemiol Biomarkers Prev. 2008 Apr;17(4):864-871. Pubmedid: 18381475.   Pubmed ID: 18381475

  27. Peterson NB, Huang Y, Newcomb PA, Titus-Ernstoff L, Trentham-Dietz A, Anic G, Egan KM. Childbearing recency and modifiers of premenopausal breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2008 Nov;17(11):3284-3287. Pubmedid: 18990773. Pmcid: PMC2674789.   Pubmed ID: 18990773

  28. Pocobelli G, Newcomb P, Trentham-Dietz A, Titus-Ernstoff L, Hampton J, Egan KM. Statin use and risk of breast cancer. Cancer. 2008 Jan;112(1):27-33. Pubmedid: 18008366.   Pubmed ID: 18008366

  29. Sprague BL, Trentham-Dietz A, Egan KM, Titus-Ernstoff L, Hampton JM, Newcomb PA. Proportion of invasive breast cancer attributable to risk factors modifiable after menopause. Am J Epidemiol. 2008 Aug;168(4):404-411. Pubmedid: 18552361.   Pubmed ID: 18552361

  30. Wernli KJ, Newcomb PA, Hampton JM, Trentham-Dietz A, Egan KM. Hormone therapy and ovarian cancer: incidence and survival. Cancer Causes Control. 2008 Aug;19(6):605-613. Pubmedid: 18264784.   Pubmed ID: 18264784

  31. Gaudet M, Egan K, Lissowska J, Newcomb P, Brinton L, Titus-Ernstoff L, Yeager M, Chanock S, Welch R, Peplonska B, Trentham-Dietz A, Garcia-Closas M. Genetic variation in tumor necrosis factor and lymphotoxin-alpha (TNF-LTA) and breast cancer risk. Hum Genet. 2007 May;121(3-4):483-490. Pubmedid: 17216494.   Pubmed ID: 17216494

  32. Liang X, Trentham-Dietz A, Titus-Ernstoff L, Newcomb P, Welch R, HutchinsonAA, Hampton J, Sutcliffe C, Haines J, Egan K. Whole-genome amplification of oral rinse self-collected DNA in a population-based case-control study of breast cancer. Cancer Epidemiol Biomarkers Prev. 2007 Aug;16(8):1610-1614. Pubmedid: 17684135.   Pubmed ID: 17684135

  33. McElroy J, Egan K, Titus-Ernstoff L, Anderson H, Trentham-Dietz A, Hampton J, Newcomb P. Occupational exposure to electromagnetic field and breast cancer risk in a large, population-based, case-control study in the United States. J Occup Environ Med. 2007 Mar;49(3):266-274. Pubmedid: 17351512.   Pubmed ID: 17351512

  34. Nichols H, Trentham-Dietz A, Egan K, Titus-Ernstoff L, Hampton J, NewcombPA. Oral Contraceptive Use and Risk of Breast Carcinoma In situ. Cancer Epidemiol Biomarkers Prev. 2007 Nov;16(11):2262-2268. Pubmedid: 18006914.   Pubmed ID: 18006914

  35. Sprague B, Trentham-Dietz A, Garcia-Closas M, Newcomb P, Titus-Ernstoff L, Hampton J, Chanock S, Haines J, Egan K. Genetic variation in TP53 and risk of breast cancer in a population-based case-control study. Carcinogenesis. 2007 Aug;28(8):1680-6. Pubmedid: 17449902.   Pubmed ID: 17449902

  36. Sprague B, Trentham-Dietz A, Newcomb P, Titus-Ernstoff L, Hampton J, Egan K. Lifetime recreational and occupational physical activity and risk of in situ and invasive breast cancer. Cancer Epidemiol Biomarkers Prev. 2007 Feb;16(2):236-243. Pubmedid: 17301255.   Pubmed ID: 17301255

  37. Trentham-Dietz A, Nichols H, Egan K, Titus-Ernstoff L, Hampton J, NewcombPA. Cigarette Smoking and Risk of Breast Carcinoma In Situ. Epidemiology. 2007 Sep;18(5):629-638. Pubmedid: 17700252.   Pubmed ID: 17700252

  38. Egan K. Commentary: sunlight, vitamin D, and the cancer connection revisited. Int J Epidemiol. 2006 Apr;35(2):227-30. Pubmedid: 16303801.   Pubmed ID: 16303801

  39. Garcia-Closas M, Egan K, Newcomb P, Brinton L, Titus-Ernstoff L, ChanockS, Welch R, Lissowska J, Peplonska B, Szeszenia-Dabrowska N, Zatonski W, Bardin-Mikolajczak A, Struewing J. Polymorphisms in DNA double-strand break repair genes and risk of breastcancer: two population-based studies in USA and Poland, and meta-analyses. Hum Genet. 2006 May;119(4):376-88. Epub 2. Pubmedid: 16485136.   Pubmed ID: 16485136

  40. Long J, Egan K, Dunning L, Shu X, Cai Q, Cai H, Dai Q, Holtzman J, GaoYT, Zheng W. Population-based case-control study of AhR (aryl hydrocarbon receptor) andCYP1A2 polymorphisms and breast cancer risk. Pharmacogenet Genomics. 2006 Apr;16(4):237-243. Pubmedid: 16538170.   Pubmed ID: 16538170

  41. Marucci L, Lane A, Li W, Egan K, Gragoudas E, Adams J, Collier J, Munzenrider J. Conservation treatment of the eye: Conformal proton reirradiation for recurrentuveal melanoma. Int J Radiat Oncol Biol Phys. 2006 Mar;64(4):1018-22. Epub 2. Pubmedid: 16376492.   Pubmed ID: 16376492

  42. Newcomb P, Egan K. Dairy food and ovarian cancer risk. Lancet. 2006 Mar;367(9513):797-799. Pubmedid: 16530561.   Pubmed ID: 16530561

  43. Nichols H, Trentham-Dietz A, Hampton J, Titus-Ernstoff L, Egan K, WillettWC, Newcomb P. From menarche to menopause: trends among US Women born from 1912 to 1969. Am J Epidemiol. 2006 Nov;164(10):1003-1011. Pubmedid: 16928728.   Pubmed ID: 16928728

  44. Peterson N, Trentham-Dietz A, Newcomb P, Chen Z, Gebretsadik T, HamptonJM, Stampfer M, Willett W, Egan K. Relation of anthropometric measurements to ovarian cancer risk in apopulation-based case-control study (United States). Cancer Causes Control. 2006 May;17(4):459-467. Pubmedid: 16596298.   Pubmed ID: 16596298

  45. Peterson N, Trentham-Dietz A, Newcomb P, Chen Z, Hampton J, Willett W, Egan K. Alcohol consumption and ovarian cancer risk in a population-based case-control study. Int J Cancer. 2006 Nov;119(10):2423-2427. Pubmedid: 16921486.   Pubmed ID: 16921486

  46. Yasui Y, Newcomb P, Trentham-Dietz A, Egan K. Familial relative risk estimates for use in epidemiologic analyses. Am J Epidemiol. 2006 Oct;164(7):697-705. Pubmedid: 16923773.   Pubmed ID: 16923773

  47. Zhang Y, Newcomb P, Egan K, Titus-Ernstoff L, Chanock S, Welch R, BrintonLA, Lissowska J, Bardin-Mikolajczak A, Peplonska B, Szeszenia-Dabrowska N, Zatonski W, Garcia-Closas M. Genetic polymorphisms in base-excision repair pathway genes and risk of breastcancer. Cancer Epidemiol Biomarkers Prev. 2006 Feb;15(2):353-358. Pubmedid: 16492928.   Pubmed ID: 16492928

  48. Roscoe L, Egan K, Schonwetter R. Creating an academic-community provider partnership in hospice, palliative care, and end-of-life studies. Cancer Control. 2004 Nov;11(6):397-403. Pubmedid: 15625527.   Pubmed ID: 15625527

  49. Gragoudas ES, Lane AM, Munzenrider J, Egan KM, Li W. Long-term risk of local failure after proton therapy for choroidal/ciliary body melanoma. Trans Am Ophthalmol Soc. 2002;100:43-48. Pubmedid: 12545676. Pmcid: PMC1358945.   Pubmed ID: 12545676

  50. Newcomb PA, Kim H, Trentham-Dietz A, Farin F, Hunter D, Egan KM. Vitamin D receptor polymorphism and breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2002 Nov;11(11):1503-1504. Pubmedid: 12433736.   Pubmed ID: 12433736

  51. Newcomb PA, Titus-Ernstoff L, Egan KM, Trentham-Dietz A, Baron JA, Storer BE, Willett WC, Stampfer MJ. Postmenopausal estrogen and progestin use in relation to breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2002 Jul;11(7):593-600. Pubmedid: 12101105.   Pubmed ID: 12101105

Kathleen M. Egan, ScD

Below is a list of active grants where the faculty member is the Principal Investigator. Grants are sorted by sponsor and then sorted by start date, with the more recent grant shown first.

Moffitt Postdoctoral Training Program in Molecular & Genetic Epidemiology

1 R25 CA147832-01
Sponsor: Nat Institutes of Health / NCI
Project Dates: June 1, 2010 to May 31, 2015
Annual Direct Cost: $284,166
Annual Total Cost: $306,899
Project Total: $2,283,270

Southeast Region Case-Control Study of Adult Glioma

5 R01 CA116174-04
Sponsor: Nat Institutes of Health / NCI
Project Dates: June 1, 2007 to May 31, 2012
Annual Direct Cost: $1,133,425
Annual Total Cost: $1,701,658
Project Total: $4,151,466

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