H. Lee Moffitt Cancer Center & Research Institute

Physician, Faculty, and Staff

Geza Acs, MD, PhD

Geza Acs, MD, PhD

Faculty Rank:

Associate Member

Titles:

Department/Program Affiliations:

  • Experimental Therapeutics  
  • Gynecologic Oncology  
  • Anatomic Pathology  
  • Breast  

Primary Address:

H. Lee Moffitt Cancer Center &
Research Institute
12902 Magnolia Drive
Tampa, FL 33612

Consultation/Referral Phone:

(813) 745-3570

USF Affiliations/College Department:

  • Medicine / Pathology & Cell Biology
  • Medicine / Oncologic Sciences

University Academic Rank:

Associate Professor

For corrections, please e-mail a request

Printer friendly version
Printer friendly version (including publications)

Geza Acs, MD, PhD

Education & Training:

  • M.D., University Medical School of Debrecen, Debrecen, Hungary, 1991
  • Fellowship, National Cancer Institute, Bethesda, 1992
  • Ph.D., University Medical School of Debrecen, Debrecen, Hungary, 1996 - Cellular and Molecular Biology
  • Residency, University of Pennsylvania Medical Center, Philadelphia, PA, 1997 - Anatomic Pathology
  • Fellowship, University of Pennsylvania Medical Center, Philadelphia, PA, 2000 - Surgical Pathology

General Board Certification / SubSpecialty:

  • Anatomic Pathology

For corrections, please e-mail a request

Printer friendly version
Printer friendly version (including publications)

Geza Acs, MD, PhD

Research Interests:

In addition to clinicopathologic studies on malignant tumors of the breast and female genital tract, Dr Acs' main research interest focuses on the role of tumor hypoxia, in particular, hypoxia-induced erythropoietin signaling in the development, progression and treatment resistance of carcinomas of the breast and female genital tract. Dr Acs' lab has previously shown that biologically active autocrine/paracrine erythropoietin signaling is present in these tumors and can be activated by low oxygen concentrations. Another area of research interest in the lab is the role of altered tumor-stromal interactions in the metastasis and progression of breast cancer.


Clinical Interests:

Dr. Acs' clinical interests are in the diagnosis of benign and malignant diseases of the breast and female genital tract. His main areas of expertise are in the histopathological diagnosis of neoplasms of the breast and female genital tract and assessment of histologic, immunophenotypic and molecular prognostic and predictive factors.

For corrections, please e-mail a request

Printer friendly version
Printer friendly version (including publications)

Geza Acs, MD, PhD

Publications:

  1. Sarnaik AA, Meade T, King J, Acs G, Hoover S, Cox CE, Carter WB, Laronga C. Adenoid cystic carcinoma of the breast: a review of a single institution's experience. Breast J. 2010 Mar;16(2):208-210. Pubmedid: 20030648.   Pubmed ID: 20030648

  2. Turaga K, Acs G, Laronga C. Gene expression profiling in breast cancer. Cancer Control. 2010 Jul;17(3):177-182. Pubmedid: 20664515.   Pubmed ID: 20664515

  3. Acs G, Paragh G, Chuang S, Laronga C, Zhang P. The Presence of Micropapillary Features and Retraction Artifact in Core Needle Biopsy Material Predicts Lymph Node Metastasis in Breast Carcinoma. Am J Surg Pathol. 2009 Feb;33(2):202-210. Pubmedid: 18987549.   Pubmed ID: 18987549

  4. Paragh G, Kumar SM, Rakosy Z, Choi SC, Xu X, Acs G. RNA interference-mediated inhibition of erythropoietin receptor expression suppresses tumor growth and invasiveness in A2780 human ovarian carcinoma cells. Am J Pathol. 2009 Apr;174(4):1504-1514. Pubmedid: 19264915.   Pubmed ID: 19264915

  5. Wagoner M, Laronga C, Acs G. Extent and histologic pattern of atypical ductal hyperplasia present on core needle biopsy specimens of the breast can predict ductal carcinoma in situ in subsequent excision. Am J Clin Pathol. 2009 Jan;131(1):112-121. Pubmedid: 19095574.   Pubmed ID: 19095574

  6. Bing Z, Pasha T, Acs G, Zhang P. Cytoplasmic overexpression of WT-1 in gastrointestinal stromal tumor and other soft tissue tumors. Appl Immunohistochem Mol Morphol. 2008 Jul;16(4):316-321. Pubmedid: 18528287.   Pubmed ID: 18528287

  7. Xu X, Gimotty PA, Guerry D, Karakousis G, Van Belle P, Liang H, Montone K, Pasha T, Ming ME, Acs G, Feldman M, Barth S, Hammond R, Elenitsas R, Zhang PJ, Elder DE. Lymphatic invasion revealed by multispectral imaging is common in primary melanomas and associates with prognosis. Hum Pathol. 2008 Jun;39(6):901-909. Pubmedid: 18440591.   Pubmed ID: 18440591

  8. Acs G, Dumoff K, Solin L, Pasha T, Xu X, Zhang P. Extensive retraction artifact correlates with lymphatic invasion and nodal metastasis and predicts poor outcome in early stage breast carcinoma. Am J Surg Pathol. 2007 Jan;31(1):129-140. Pubmedid: 17197929.   Pubmed ID: 17197929

  9. Barroeta J, Pasha T, Acs G, Zhang P. Immunoprofile of endocervical and endometrial stromal cells and its potential application in localization of tumor involvement. Int J Gynecol Pathol. 2007 Jan;26(1):76-82. Pubmedid: 17197901.   Pubmed ID: 17197901

  10. Kiluk J, Acs G, Hoover S. High-risk benign breast lesions: current strategies in management. Cancer Control. 2007 Oct;14(4):321-329. Pubmedid: 17914332.   Pubmed ID: 17914332

  11. Kumar SM, Yu H, Edwards R, Chen L, Kazianis S, Brafford P, Acs G, Herlyn M, Xu X. Mutant V600E BRAF increases hypoxia inducible factor-1alpha expression in melanoma. Cancer Res. 2007 Apr;67(7):3177-3184. Pubmedid: 17409425.   Pubmed ID: 17409425

  12. Mohyeldin A, Dalgard C, Lu H, Mcfate T, Tait A, Patel V, Wong K, RushingE, Roy S, Acs G, Verma A. Survival and invasiveness of astrocytomas promoted by erythropoietin. J Neurosurg. 2007 Feb;106(2):338-350. Pubmedid: 17410721.   Pubmed ID: 17410721

  13. Yu H, Kumar SM, Fang D, Acs G, Xu X. Nuclear orphan receptor TR3/Nur77 mediates melanoma cell apoptosis. Cancer Biol Ther. 2007 Mar;6(3):405-412. Pubmedid: 17297306.   Pubmed ID: 17297306

  14. Dumoff KL, Chu CS, Harris EE, Holtz D, Xu X, Zhang PJ, Acs G. Low podoplanin expression in pretreatment biopsy material predicts poor prognosis in advanced-stage squamous cell carcinoma of the uterine cervix treated by primary radiation. Mod Pathol. 2006 May;19(5):708-716. Pubmedid: 16528371.   Pubmed ID: 16528371

  15. Jackson B, Kim S, Davidson R, Schuchter L, Acs G, Czerniecki B. Repeat operative sentinel lymph node biopsy. Clin Breast Cancer. 2006 Feb;6(6):530-532. Pubmedid: 16595037.   Pubmed ID: 16595037

  16. Kucher C, Zhang P, Acs G, Roberts S, Xu X. Can Melan-A replace S-100 and HMB-45 in the evaluation of sentinel lymph nodes from patients with malignant melanoma. Appl Immunohistochem Mol Morphol. 2006 Sep;14(3):324-327. Pubmedid: 16932024.   Pubmed ID: 16932024

  17. Kumar SM, Yu H, Fong D, Acs G, Xu X. Erythropoietin activates the phosphoinositide 3-kinase/Akt pathway in human melanoma cells. Melanoma Res. 2006 Aug;16(4):275-283. Pubmedid: 16845323.   Pubmed ID: 16845323

  18. Yu H, Fang D, Kumar SM, Li L, Nguyen TK, Acs G, Herlyn M, Xu X. Isolation of a novel population of multipotent adult stem cells from human hair follicles. Am J Pathol. 2006 Jun;168(6):1879-1888. Pubmedid: 16723703.   Pubmed ID: 16723703

  19. Z?borszky Z, Acs G, Papp T, Balatoni I, Fekete K. [Effect of the introduction of quality control on the working standards of specialist outpatient clinics]. Orv Hetil. 2006 Feb;147(5):229-231. Pubmedid: 16509224.   Pubmed ID: 16509224

  20. Argani P, Lae M, Hutchinson B, Reuter V, Collins M, Perentesis J, Tomaszewski J, Brooks J, Acs G, Bridge J, Vargas S, Davis I, Fisher D, Ladanyi M. Renal carcinomas with the t(6;11)(p21;q12): clinicopathologic features and demonstration of the specific alpha-TFEB gene fusion by immunohistochemistry, RT-PCR, and DNA PCR. Am J Surg Pathol. 2005 Feb;29(2):230-240. Pubmedid: 15644781.   Pubmed ID: 15644781

  21. Chu A, Litzky L, Pasha T, Acs G, Zhang P. Utility of D2-40, a novel mesothelial marker, in the diagnosis of malignant mesothelioma. Mod Pathol. 2005 Jan;18(1):105-110. Pubmedid: 15389250.   Pubmed ID: 15389250

  22. Gombos Z, Xu X, Chu C, Zhang P, Acs G. Peritumoral lymphatic vessel density and vascular endothelial growth factor C expression in early-stage squamous cell carcinoma of the uterine cervix. Clin Cancer Res. 2005 Dec;11(23):8364-8371. Pubmedid: 16322297.   Pubmed ID: 16322297

  23. Kumar SM, Acs G, Fang D, Herlyn M, Elder DE, Xu X. Functional erythropoietin autocrine loop in melanoma. Am J Pathol. 2005 Mar;166(3):823-830. Pubmedid: 15743794.   Pubmed ID: 15743794

  24. McBroom J, Acs G, Rose G, Krivak T, Mohyeldin A, Verma A. Erythropoietin receptor function and expression in epithelial ovarian carcinoma. Gynecol Oncol. 2005 Dec;99(3):571-7. Epub 20. Pubmedid: 16051335.   Pubmed ID: 16051335

  25. Mohyeldin A, Lu H, Dalgard C, Lai S, Cohen N, Acs G, Verma A. Erythropoietin signaling promotes invasiveness of human head and neck squamous cell carcinoma. Neoplasia. 2005 May;7(5):537-543. Pubmedid: 15967106.   Pubmed ID: 15967106

  26. Acs G, Chen M, Xu X, Acs P, Verma A, Koch C. Autocrine erythropoietin signaling inhibits hypoxia-induced apoptosis in human breast carcinoma cells. Cancer Lett. 2004 Oct;214(2):243-251. Pubmedid: 15363551.   Pubmed ID: 15363551

  27. Acs G, Pasha T, Zhang P. WT1 is differentially expressed in serous, endometrioid, clear cell, and mucinous carcinomas of the peritoneum, fallopian tube, ovary, and endometrium. Int J Gynecol Pathol. 2004 Apr;23(2):110-118. Pubmedid: 15084838.   Pubmed ID: 15084838

  28. Acs G, Xu X, Chu C, Acs P, Verma A. Prognostic significance of erythropoietin expression in human endometrial carcinoma. Cancer. 2004 Jun;100(11):2376-2386. Pubmedid: 15160341.   Pubmed ID: 15160341

  29. Giorgadze T, Zhang P, Pasha T, Coogan P, Acs G, Elder D, Xu X. Lymphatic vessel density is significantly increased in melanoma. J Cutan Pathol. 2004 Nov;31(10):672-677. Pubmedid: 15491327.   Pubmed ID: 15491327

  30. Lee J, Kim SY, Kang JH, Acs G, Acs P, Blumberg PM, Marquez VE. Conformationally constrained diacylglycerol (DAG) analogs: 4-C-hydroxyethyl-5-O-acyl-2,3-dideoxy-D-glyceropentono-1,4-lactone analogs as protein kinase C (PKC) ligands. Eur J Med Chem. 2004 Jan;39(1):69-77. Pubmedid: 14987835.   Pubmed ID: 14987835

  31. Purev E, Cai D, Miller E, Swoboda R, Mayer T, Klein-Szanto A, Marincola F, Mick R, Otvos L, Wunner W, Birebent B, Somasundaram R, Wikstrand CJ, Bigner D, DeMichele A, Acs G, Berlin JA, Herlyn D. Immune responses of breast cancer patients to mutated epidermal growth factor receptor (EGF-RvIII, Delta EGF-R, and de2-7 EGF-R). J Immunol. 2004 Nov;173(10):6472-6480. Pubmedid: 15528389.   Pubmed ID: 15528389

  32. Rathmell W, Acs G, Simon M, Vaughn D. HIF transcription factor expression and induction of hypoxic response genes in a retroperitoneal angiosarcoma. Anticancer Res. 2004 Jan;24(1):167-169. Pubmedid: 15015593.   Pubmed ID: 15015593

  33. Weinstein S, Conant E, Mies C, Acs G, Lee S, Sehgal C. Posterior acoustic shadowing in benign breast lesions: sonographic-pathologic correlation. J Ultrasound Med. 2004 Jan;23(1):73-83. Pubmedid: 14756356.   Pubmed ID: 14756356

  34. Acs G, Simpson J, Bleiweiss I, Hugh J, Reynolds C, Olson S, Page D. Microglandular adenosis with transition into adenoid cystic carcinoma of the breast. Am J Surg Pathol. 2003 Aug;27(8):1052-1060. Pubmedid: 12883237.   Pubmed ID: 12883237

  35. Acs G, Wang L, Raghunath P, Salscheider M, Zhang P. Role of different immunostaining patterns in HercepTest interpretation and criteria for gene amplification as determined by fluorescence in situ hybridization. Appl Immunohistochem Mol Morphol. 2003 Sep;11(3):222-229. Pubmedid: 12966348.   Pubmed ID: 12966348

  36. Acs G, Zhang PJ, McGrath CM, Acs P, McBroom J, Mohyeldin A, Liu S, Lu H, Verma A. Hypoxia-inducible erythropoietin signaling in squamous dysplasia and squamous cell carcinoma of the uterine cervix and its potential role in cervical carcinogenesis and tumor progression. Am J Pathol. 2003 Jun;162(6):1789-1806. Pubmedid: 12759237.   Pubmed ID: 12759237

  37. Scobie JV, Acs G, Bandera CA, Blank SV, Wheeler JE, Pasha TL, Salscheider M, Zhang PJ. C-kit immunoreactivity in endometrial adenocarcinomas and its clinicopathologic significance. Int J Gynecol Pathol. 2003 Apr;22(2):149-155. Pubmedid: 12649669.   Pubmed ID: 12649669

  38. Weinstein S, Conant E, Acs G. Case 59: Angiolipoma of the breast. Radiology. 2003 Jun;227(3):773-775. Pubmedid: 12773682.   Pubmed ID: 12773682

  39. Acs G, Zhang P, Rebbeck T, Acs P, Verma A. Immunohistochemical expression of erythropoietin and erythropoietin receptor in breast carcinoma. Cancer. 2002 Sep;95(5):969-981. Pubmedid: 12209679.   Pubmed ID: 12209679

  40. Acs G, Acs P, Beckwith S, Pitts R, Clements E, Wong K, Verma A. Erythropoietin and erythropoietin receptor expression in human cancer. Cancer Res. 2001 May;61(9):3561-3565. Pubmedid: 11325818.   Pubmed ID: 11325818

  41. Acs G, Lawton T, Rebbeck T, LiVolsi V, Zhang P. Differential expression of E-cadherin in lobular and ductal neoplasms of the breast and its biologic and diagnostic implications. Am J Clin Pathol. 2001 Jan;115(1):85-98. Pubmedid: 11190811.   Pubmed ID: 11190811

  42. Acs G, LiVolsi V. Loss of membrane expression of E-cadherin in leukemic erythroblasts. Arch Pathol Lab Med. 2001 Feb;125(2):198-201. Pubmedid: 11175634.   Pubmed ID: 11175634

  43. Weinstein S, Conant E, Orel S, Lawton T, Acs G. Diabetic mastopathy in men: imaging findings in two patients. Radiology. 2001 Jun;219(3):797-799. Pubmedid: 11376272.   Pubmed ID: 11376272

  44. Acs G, Gupta P, Baloch Z. Cytomorphology of high-grade neuroendocrine carcinoma of the urinary tract. Diagn Cytopathol. 2000 Aug;23(2):92-96. Pubmedid: 10888752.   Pubmed ID: 10888752

  45. Acs G, Gupta P, Baloch Z. Glandular and squamous atypia and intraepithelial lesions in atrophic cervicovaginal smears. One institution's experience. Acta Cytol. 2000;44(4):611-617. Pubmedid: 10934955.   Pubmed ID: 10934955

  46. Acs G, McGrath C, Gupta P. Duodenal carcinoid tumor: report of a case diagnosed by endoscopic ultrasound-guided fine-needle aspiration biopsy with immunocytochemical correlation. Diagn Cytopathol. 2000 Sep;23(3):183-186. Pubmedid: 10945906.   Pubmed ID: 10945906

  47. Xu X, Acs G, Yu G, Guttenberg M, Vautour R. Aspiration cytology of metanephric adenoma of the kidney. Diagn Cytopathol. 2000 May;22(5):330-331. Pubmedid: 10790243.   Pubmed ID: 10790243

  48. Biro T, Maurer M, Modarres S, Lewin N, Brodie C, Acs G, Acs P, Paus R, Blumberg P. Characterization of functional vanilloid receptors expressed by mast cells. Blood. 1998 Feb;91(4):1332-1340. Pubmedid: 9454764 .   Pubmed ID: 9454764

  49. Acs G, Biro T, Acs P, Modarres S, Blumberg P. Differential activation and desensitization of sensory neurons by resiniferatoxin. J Neurosci. 1997 Jul;17(14):5622-5628. Pubmedid: 9204943 .   Pubmed ID: 9204943

  50. Acs G, Lee J, Marquez V, Blumberg P. Distinct structure-activity relations for stimulation of 45Ca uptake and for high affinity binding in cultured rat dorsal root ganglion neurons and dorsal root ganglion membranes. Brain Res Mol Brain Res. 1996 Jan;35(1-2):173-182. Pubmedid: 8717353 .   Pubmed ID: 8717353

  51. Acs G, Palkovits M, Blumberg P. Specific binding of [3H]resiniferatoxin by human and rat preoptic area, locus ceruleus, medial hypothalamus, reticular formation and ventral thalamus membrane preparations. Life Sci. 1996;59(22):1899-1908. Pubmedid: 8950287 .   Pubmed ID: 8950287

  52. Szallasi A, Acs G, Cravotto G, Blumberg P, Lundberg J, Appendino G. A novel agonist, phorbol 12-phenylacetate 13-acetate 20-homovanillate, abolishes positive cooperativity of binding by the vanilloid receptor. Eur J Pharmacol. 1996 Mar;299(1-3):221-228. Pubmedid: 8901026 .   Pubmed ID: 8901026

  53. Szallasi A, Jonassohn M, Acs G, B?-r?? T, Acs P, Blumberg P, Sterner O. The stimulation of capsaicin-sensitive neurones in a vanilloid receptor-mediated fashion by pungent terpenoids possessing an unsaturated 1,4-dialdehyde moiety. Br J Pharmacol. 1996 Sep;119(2):283-290. Pubmedid: 8886410 .   Pubmed ID: 8886410

  54. Acs G, Lee J, Marquez V, Wang S, Milne G, Du L, Lewin N, Blumberg P. Resiniferatoxin-amide and analogues as ligands for protein kinase C and vanilloid receptors and determination of their biological activities as vanilloids. J Neurochem. 1995 Jul;65(1):301-318. Pubmedid: 7790875 .   Pubmed ID: 7790875

  55. Acs G, Palkovits M, Blumberg P. Trifluoperazine modulates [3H]resiniferatoxin binding by human and rat vanilloid (capsaicin) receptors and affects 45Ca uptake by adult rat dorsal root ganglion neurones. J Pharmacol Exp Ther. 1995 Sep;274(3):1090-1098. Pubmedid: 7562474 .   Pubmed ID: 7562474

  56. Acs G, Blumberg P. [3H]resiniferatoxin binding to pig dorsal horn membranes displays positive cooperativity. Life Sci. 1994;55(5):337-346. Pubmedid: 8035647 .   Pubmed ID: 8035647

  57. Acs G, Blumberg P. Comparison of [3H]resiniferatoxin binding to spinal cord and dorsal root ganglia of newborn and adult rats. Life Sci. 1994;54(24):1875-1882. Pubmedid: 8196505 .   Pubmed ID: 8196505

  58. Acs G, Palkovits M, Blumberg P. [3H]resiniferatoxin binding by the human vanilloid (capsaicin) receptor. Brain Res Mol Brain Res. 1994 May;23(3):185-190. Pubmedid: 8057776 .   Pubmed ID: 8057776

  59. Acs G, Palkovits M, Blumberg P. Comparison of [3H]resiniferatoxin binding by the vanilloid (capsaicin) receptor in dorsal root ganglia, spinal cord, dorsal vagal complex, sciatic and vagal nerve and urinary bladder of the rat. Life Sci. 1994;55(13):1017-1026. Pubmedid: 8084206 .   Pubmed ID: 8084206

  60. Hasler C, Acs G, Blumberg P. Specific binding to protein kinase C by ingenol and its induction of biological responses. Cancer Res. 1992 Jan;52(1):202-208. Pubmedid: 1727380 .   Pubmed ID: 1727380

Geza Acs, MD, PhD

Below is a list of active grants where the faculty member is the Principal Investigator. Grants are sorted by sponsor and then sorted by start date, with the more recent grant shown first.

Constitutively Active Erythropoietin Receptor Variants As Novel Therapeutic Targets In Breast Cancer

KG080717
Sponsor: Komen (Susan G) Fdtn
Project Dates: July 7, 2008 to July 6, 2011
Annual Direct Cost: $159,927
Annual Total Cost: $199,909
Project Total: $595,811

Physician/Faculty  Contact Form

© Copyright 1996 - 2010 H. Lee Moffitt Cancer Center & Research Institute