H. Lee Moffitt Cancer Center & Research Institute

Physician, Faculty, and Staff

David Shibata, MD

David Shibata, MD

Faculty Rank:

Associate Member

Titles:

  • Section Head, Colorectal Oncology

Department/Program Affiliations:

  • Experimental Therapeutics  
  • Gastrointestinal Tumor  

Primary Address:

H. Lee Moffitt Cancer Center &
Research Institute
12902 Magnolia Drive
Tampa, FL 33612

Consultation/Referral Phone:

(813) 745-6898

USF Affiliations/College Department:

  • Medicine / Oncologic Sciences
  • Medicine / Surgery

University Academic Rank:

Associate Professor

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David Shibata, MD

Education & Training:

  • M.D., McGill University, Quebec, Canada, 1991 - Medicine
  • Research Fellowship, Harvard Medical School, 1996 - Cancer Biology
  • Residency, Beth Israel Deaconess Medical Center, Boston, MA, 1998 - General Surgery
  • Fellowship, Memorial Sloan-Kettering Cancer Center, New York, NY, 2000 - Surgical Oncology

General Board Certification / SubSpecialty:

  • Surgery

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David Shibata, MD

Research Interests:

Dr. Shibata's laboratory research centers on the study of specific molecular mechanisms such as DNA methylation that contribute to the development of colorectal and other gastrointestinal malignancies.


Clinical Interests:

Dr. Shibata is an expert in the surgical and multidisciplinary management of primary and metastatic tumors of the colon and rectum; Primary Colon Cancer: Laparoscopic/Minimally Invasive Colorectal Surgery; Primary Rectal Cancer: Transanal Surgery, Total Mesorectal Excision, Colonic J-pouch Reconstruction and Sphincter-Preserving Surgery for Rectal Cancer; Recurrent/Locally Advanced Colorectal Cancer; Metastatic Colorectal Cancer: Liver Resection, Radiofrequency Ablation (RFA); Hereditary and High-Risk Colorectal Cancer: Familial Adenomatous Polyposis (FAP) and Inflammatory Bowel Disease-associated colorectal cancer (Ileal Pouch procedures). Hereditary Non-Polyposis Colon Cancer (HNPCC), Young patients with colorectal cancer; Rare Tumors: Sarcomas, GI Stromal Tumors, Carcinoids

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David Shibata, MD

Publications:

  1. Chen Y, Gruidl M, Remily-Wood ER, Liu RZ, Eschrich S, Lloyd M, Nasir A, Bui MM, Huang E, Yeatman TJ, Koomen JM, Shibata D, . Quantification of beta-Catenin Signaling Components in Colon Cancer Cell Lines, Tissue Sections, and Microdissected Tumor Cells using Reaction Monitoring Mass Spectrometry. J Proteome Res. 2010 Aug;9(8):4215-4227. Pubmedid: 20590165.   Pubmed ID: 20590165

  2. Engstrom PF, Arnoletti JP, Benson AB, Berlin JD, Berry JM, Chen YJ, Choti MA, Cooper HS, Dilawari RA, Early DS, Enzinger PC, Fakih MG, Fleshman J, Fuchs C, Grem JL, Knol JA, Leong LA, Lin E, Mulcahy MF, Rohren E, Ryan DP, Saltz L, Shibata D, Skibber JM, Small W, Sofocleous C, Thomas J, Venook AP, Willett C. NCCN clinical practice guidelines in oncology. Anal carcinoma. J Natl Compr Canc Netw. 2010 Jan;8(1):106-120. Pubmedid: 20064293.   Pubmed ID: 20064293

  3. Faul LA, Shibata D, Townsend I, Jacobsen PB. Improving survivorship care for patients with colorectal cancer. Cancer Control. 2010 Jan;17(1):35-43. Pubmedid: 20010517.   Pubmed ID: 20010517

  4. Melis M, Hernandez J, Siegel EM, McLoughlin JM, Ly QP, Nair RM, Lewis JM, Jensen EH, Alvarado MD, Coppola D, Eschrich S, Bloom GC, Yeatman TJ, Shibata D. Gene expression profiling of colorectal mucinous adenocarcinomas. Dis Colon Rectum. 2010 Jun;53(6):936-943. Pubmedid: 20485009.   Pubmed ID: 20485009

  5. Shibata D. Colorectal cancer: perspectives on treatment, survivorship, and outcomes. Cancer Control. 2010 Jan;17(1):4-5. Pubmedid: 20010513.   Pubmed ID: 20010513

  6. Siegel EM, Ulrich CM, Poole EM, Holmes RS, Jacobsen PB, Shibata D. The effects of obesity and obesity-related conditions on colorectal cancer prognosis. Cancer Control. 2010 Jan;17(1):52-57. Pubmedid: 20010519.   Pubmed ID: 20010519

  7. Turaga K, Shibata D. K-Ras and MSI: potential markers of both patient prognosis and treatment efficacy. Ann Surg Oncol. 2010 Feb;17(2):354-355. Pubmedid: 19936842. Pmcid: PMC2816800.   Pubmed ID: 19936842

  8. Vadaparampil ST, Quinn G, Malo TL, Alvarez A, Miree CA, Shibata D. Knowledge About Hereditary Colorectal Cancer Among Colorectal Cancer Survivors. Genet Test Mol Biomarkers. 2010 Aug. Pubmedid: 20722496.   Pubmed ID: 20722496

  9. Wolkenhauer O, Auffray C, Baltrusch S, Bl?thgen N, Byrne H, Cascante M, Ciliberto A, Dale T, Drasdo D, Fell D, Ferrell JE, Gallahan D, Gatenby R, G?nther U, Harms BD, Herzel H, Junghanss C, Kunz M, van Leeuwen I, Lenormand P, Levi F, Linnebacher M, Lowengrub J, Maini PK, Malik A, Rateitschak K, Sansom O, Sch?fer R, Sch?rrle K, Sers C, Schnell S, Shibata D, Tyson J, Vera J, White M, Zhivotovsky B, Jaster R. Systems biologists seek fuller integration of systems biology approaches in new cancer research programs. Cancer Res. 2010 Jan;70(1):12-13. Pubmedid: 20028868. Pmcid: PMC2802734.   Pubmed ID: 20028868

  10. Engstrom PF, Arnoletti JP, Benson AB, Chen YJ, Choti MA, Cooper HS, Covey A, Dilawari RA, Early DS, Enzinger PC, Fakih MG, Fleshman J, Fuchs C, Grem JL, Kiel K, Knol JA, Leong LA, Lin E, Mulcahy MF, Rao S, Ryan DP, Saltz L, Shibata D, Skibber JM, Sofocleous C, Thomas J, Venook AP, Willett C. NCCN Clinical Practice Guidelines in Oncology: colon cancer. J Natl Compr Canc Netw. 2009 Sep;7(8):778-831. Pubmedid: 19755046.   Pubmed ID: 19755046

  11. Engstrom PF, Arnoletti JP, Benson AB, Chen YJ, Choti MA, Cooper HS, Covey A, Dilawari RA, Early DS, Enzinger PC, Fakih MG, Fleshman J, Fuchs C, Grem JL, Kiel K, Knol JA, Leong LA, Lin E, Mulcahy MF, Rao S, Ryan DP, Saltz L, Shibata D, Skibber JM, Sofocleous C, Thomas J, Venook AP, Willett C. NCCN Clinical Practice Guidelines in Oncology: rectal cancer. J Natl Compr Canc Netw. 2009 Sep;7(8):838-881. Pubmedid: 19755047.   Pubmed ID: 19755047

  12. Hernandez J, Shibata D. Paraneoplastic hypercalcemia caused by an invasive squamous cell carcinoma arising from a giant anal condyloma acuminatum. Int J Colorectal Dis. 2009 Mar;24(3):359-360. Pubmedid: 18688619.   Pubmed ID: 18688619

  13. Jacobsen PB, Shibata D, Siegel EM, Lee JH, Alemany CA, Brown R, Cartwright TH, Levine RM, Smith JC, Abesada-Terk G, Malafa MP. Initial evaluation of quality indicators for psychosocial care of adults with cancer. Cancer Control. 2009 Oct;16(4):328-334. Pubmedid: 19910919.   Pubmed ID: 19910919

  14. Malafa MP, Corman MM, Shibata D, Siegel EM, Lee JH, Jacobsen PB. The Florida Initiative for Quality Cancer Care: a regional project to measure and improve cancer care. Cancer Control. 2009 Oct;16(4):318-327. Pubmedid: 19910918.   Pubmed ID: 19910918

  15. Melis M, Gruel R, Darwin P, Drachenberg C, Shibata D. Full thickness transanal re-excision following endoscopic removal of malignant rectal polyps. Int J Colorectal Dis. 2009 May;24(5):531-536. Pubmedid: 19159936.   Pubmed ID: 19159936

  16. Meredith KL, Hoffe SE, Shibata D. The multidisciplinary management of rectal cancer. Surg Clin North Am. 2009 Feb;89(1):177-215. Pubmedid: 19186236.   Pubmed ID: 19186236

  17. Elahi A, Zhang L, Yeatman T, Gery S, Sebti S, Shibata D. HPP1-mediated tumor suppression requires activation of STAT1 pathways. Int J Cancer. 2008 Apr;122(7):1567-1572. Pubmedid: 18059030.   Pubmed ID: 18059030

  18. Greenberg J, Shibata D, Herndon JE 2nd, Steele GD J, Mayer R, Bleday R. Local Excision of Distal Rectal Cancer: An Update of Cancer and Leukemia Group B8984. Dis Colon Rectum. 2008 Aug;51(8):1185-1191. Pubmedid: 18536973.   Pubmed ID: 18536973

  19. Nair R, Siegel E, Chen D, Fulp W, Yeatman T, Malafa M, Marcet J, Shibata D. Long-Term Results of Transanal Excision After Neoadjuvant Chemoradiation for T2 and T3 Adenocarcinomas of the Rectum. J Gastrointest Surg. 2008 Oct;12(10):1797-1805. Pubmedid: 18709419.   Pubmed ID: 18709419

  20. Engstrom P, Arnoletti J, Benson AB 3rd, Chen Y, Choti M, Cooper H, Dilawari R, Early D, Fakih M, Fuchs C, Grem J, Kiel K, Knol J, Leong L, Ludwig K, Martin EW J, Rao S, Saltz L, Shibata D, Skibber J, Venook A. Colon cancer. J Natl Compr Canc Netw. 2007 Oct;5(9):884-925. Pubmedid: 17977501.   Pubmed ID: 17977501

  21. Engstrom P, Arnoletti J, Benson AB 3rd, Chen Y, Choti M, Cooper H, Dilawari R, Early D, Fakih M, Fuchs C, Grem J, Kiel K, Knol J, Leong L, Ludwig K, Martin EW J, Rao S, Saltz L, Shibata D, Skibber J, Venook A. Rectal cancer. J Natl Compr Canc Netw. 2007 Oct;5(9):940-981. Pubmedid: 17977503.   Pubmed ID: 17977503

  22. Jacobsen P, Shibata D, Siegel E, Mihaela D, Lee J, Marshburn J, Davenport J, Cruse H, Richard L, Gondi A, Brown R, Malafa M. Measuring quality of care in the treatment of colorectal cancer: The Moffitt Quality Pracice Initiative. J Oncol Manag. 2007;3:60-65.  

  23. Jensen E, Kvols L, McLoughlin J, Lewis J, Alvarado M, Yeatman T, Malafa M, Shibata D. Biomarkers Predict Outcomes Following Cytoreductive Surgery for Hepatic Metastases from Functional Carcinoid Tumors. Ann Surg Oncol. 2007 Feb;14(2):780-785. Pubmedid: 17146740.   Pubmed ID: 17146740

  24. Kumar N, Shibata D, Helm J, Coppola D, Malafa M. Green tea polyphenols in the prevention of colon cancer. Front Biosci. 2007 Jan;12:2309-2315. Pubmedid: 17127241.   Pubmed ID: 17127241

  25. Saglam O, Garrett CR, Boulware D, Sayegh Z, Shibata D, Malafa M, Yeatman T, Cheng JQ, Sebti S, Coppola D. Activation of the serine/threonine protein kinase AKT during the progression of colorectal neoplasia. Clin Colorectal Cancer. 2007 Sep;6(9):652-656. Pubmedid: 17945038.   Pubmed ID: 17945038

  26. Strosberg JR, Shibata D, Kvols LK. Intermittent bowel obstruction due to a retained wireless capsule endoscope in a patient with a small bowel carcinoid tumour. Can J Gastroenterol. 2007 Feb;21(2):113-115. Pubmedid: 17299616.   Pubmed ID: 17299616

  27. Shibata D, Mori Y, Cai K, Zhang L, Yin J, Elahi A, Hamelin R, Wong Y, Lo WK, Chung T, Sato F, Karpeh MS J, Meltzer S. RAB32 hypermethylation and microsatellite instability in gastric and endometrial adenocarcinomas. Int J Cancer. 2006 Aug;119(4):801-6. Pubmedid: 16557577.   Pubmed ID: 16557577

  28. Sato F, Shimada Y, Selaru F, Shibata D, Maeda M, Watanabe G, Mori Y, StassSA, Imamura M, Meltzer S. Prediction of survival in patients with esophageal carcinoma using artificial neural networks. Cancer. 2005 Apr;103(8):1596-1605. Pubmedid: 15751017.   Pubmed ID: 15751017

  29. Selaru F, Yin J, Xu Y, Epstein S, Sato F, Mori Y, Olaru A, Deacu E, Wang S, Sterian A, Fulton A, Abraham J, Shibata D, Baquet C, Stass S. An unsupervised approach to identify molecular phenotypic components influencing breast cancer features. Cancer Res. 2004;64(5):1584-1588. Pubmedid: 14996713.   Pubmed ID: 14996713

  30. Cunningham S, Shibata D, Volpe C. Isolated abdominal wound metastasis from gastrointestinal stromal tumor. Int J Gastrointest Cancer. 2003;33(2-3):129-132. Pubmedid: 14716061.   Pubmed ID: 14716061

  31. Mori Y, Selaru F, Sato F, Yin J, Simms L, Xu Y, Olaru A, Deacu E, Wang S, Taylor J, Young J, Leggett B, Jass J, Abraham J, Shibata D, Meltzer S. The impact of microsatellite instability on the molecular phenotype of colorectal tumors. Cancer Res. 2003;63(15):4577-4582. Pubmedid: 12907634.   Pubmed ID: 12907634

  32. Olaru A, Mori Y, Yin J, Wang S, Kimos MC, Perry K, Xu Y, Sato F, Selaru FM, Deacu E, Sterian A, Shibata D, Abraham JM, Meltzer SJ. Loss of heterozygosity and mutational analyses of the ACTRII gene locus in human colorectal tumors. Lab Invest. 2003 Dec;83(12):1867-1871. Pubmedid: 14691305.   Pubmed ID: 14691305

  33. Wang S, Mori Y, Sato F, Yin J, Xu Y, Zou TT, Olaru A, Kimos M, Perry K, Selaru F, Deacu E, Sun M, Shi Y, Shibata D, Abraham J, Greenwald B, Meltzer S. An LOH and mutational investigation of the ST7 gene locus in human esophageal carcinoma. Oncogene. 2003;22(3):467-470. Pubmedid: 12545169.   Pubmed ID: 12545169

  34. Mori Y, Sato F, Selaru F, Olaru A, Perry K, Kimos M, Tamura G, MatsubaraN, Wang S, Xu Y, Yin J, Zou T, Leggett B, Young J, Nukiwa T, Stine O, AbrahamJM, Shibata D, Meltzer S. Instabilotyping reveals unique mutational spectra in microsatellite-unstable gastric cancers. Cancer Res. 2002;62(13):3641-3645. Pubmedid: 12097267.   Pubmed ID: 12097267

  35. Sato F, Harpaz N, Shibata D, Xu Y, Yin J, Mori Y, Zou T, Wang S, Desai K, Leytin A, Selaru F, Abraham J, Meltzer S. Hypermethylation of the p14(ARF) gene in ulcerative colitis-associated colorectal carcinogenesis. Cancer Res. 2002;62(4):1148-1151. Pubmedid: 11861396.   Pubmed ID: 11861396

  36. Sato F, Shibata D, Harpaz N, Xu Y, Yin J, Mori Y, Wang S, Olaru A, Deacu E, Selaru F, Kimos M, Hytiroglou P, Young J, Leggett B, Gazdar A, Toyooka S, Abraham J, Meltzer S. Aberrant methylation of the HPP1 gene in ulcerative colitis-associated colorectal carcinoma. Cancer Res. 2002;62(23):6820-6822. Pubmedid: 12460892.   Pubmed ID: 12460892

  37. Selaru F, Xu Y, Yin J, Zou T, Liu T, Mori Y, Abraham J, Sato F, Wang S, Twigg C, Olaru A, Shustova V, Leytin A, Hytiroglou P, Shibata D, Harpaz N, Meltzer S. Artificial neural networks distinguish among subtypes of neoplastic colorectal lesions. Gastroenterology. 2002;122(3):606-613. Pubmedid: 11874992.   Pubmed ID: 11874992

  38. Shibata D, Paty P, Guillem J, Wong W, Cohen A. Surgical management of isolated retroperitoneal recurrences of colorectal carcinoma. Dis Colon Rectum. 2002;45(6):795-801. Pubmedid: 12072633.   Pubmed ID: 12072633

  39. Shibata D, Sato F, Mori Y, Perry K, Yin J, Wang S, Xu Y, Olaru A, SelaruF, Spring K, Young J, Abraham J, Meltzer S. Hypermethylation of HPP1 is associated with hMLH1 hypermethylation in gastric adenocarcinomas. Cancer Res. 2002;62(20):5637-5640. Pubmedid: 12384516.   Pubmed ID: 12384516

  40. Xu Y, Selaru F, Yin J, Zou T, Shustova V, Mori Y, Sato F, Liu T, OlaruA, Wang S, Kimos M, Perry K, Desai K, Greenwald B, Krasna M, Shibata D, Abraham J, Meltzer S. Artificial neural networks and gene filtering distinguish between global gene expression profiles of Barrett's esophagus and esophageal cancer. Cancer Res. 2002;62(12):3493-3497. Pubmedid: 12067993.   Pubmed ID: 12067993

  41. Zou T, Selaru F, Xu Y, Shustova V, Yin J, Mori Y, Shibata D, Sato F, WangS, Olaru A, Deacu E, Liu T, Abraham J, Meltzer S. Application of cDNA microarrays to generate a molecular taxonomy capable of distinguishing between colon cancer and normal colon. Oncogene. 2002;21(31):4855-4862. Pubmedid: 12101425.   Pubmed ID: 12101425

  42. Tsao JL, Zhang J, Salovaara R, Li ZH, J?rvinen HJ, Mecklin JP, Aaltonen LA, Shibata D. Tracing cell fates in human colorectal tumors from somatic microsatellite mutations: evidence of adenomas with stem cell architecture. Am J Pathol. 1998 Oct;153(4):1189-1200. Pubmedid: 9777950. Pmcid: PMC1853055.   Pubmed ID: 9777950

David Shibata, MD

Below is a list of active grants where the faculty member is the Principal Investigator. Grants are sorted by sponsor and then sorted by start date, with the more recent grant shown first.

STAT1 Activation and Hpp 1 Tumor Supression

5 R01 CA131398-02
Sponsor: Nat Institutes of Health / NCI
Project Dates: July 1, 2009 to May 31, 2014
Annual Direct Cost: $207,500
Annual Total Cost: $346,525
Project Total: $1,732,625

Molecular Signatures for Colon Cancer

08BR-02
Sponsor: State of Florida / Dept of Health
Project Dates: July 1, 2008 to June 30, 2011
Annual Direct Cost: $270,455
Annual Total Cost: $297,500
Project Total: $970,000

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