H. Lee Moffitt Cancer Center & Research Institute

Faculty Rank:

Senior Member

USF Affiliations/College Department:

• Medicine / Oncologic Sciences

General Board Certification / SubSpecialty:

• Internal Medicine / Medical Oncology
• Internal Medicine / Hematology
• Internal Medicine / Geriatric Medicine

Research Interests:

The scientific scope of the Senior Adult Oncology Program, under the direction of Dr. Balducci, has been patient assessment and prediction of treatment-related toxicity. This has been the focus of this group's research for several years, and this work has resulted in numerous scientific presentations and publications. The most important scientific findings of the group's research have included the following:

• Independence of comorbidity and functional status


• Ability of comprehensive geriatric assessment to unearth unsuspected conditions that interfere with antineoplastic treatment


• Prediction of benefits and risk of adjuvant chemotherapy for breast cancer in women aged 70 years and older based on functional status and comorbidity


• Formulation of the MAX-2 index for prediction of chemotherapy-related toxicityAssessment of quality of life in older cancer patients


• Treatment-related preferences in older patients based on risk-taking profile


• Treatment-related preferences in older patients based on national origin

This main research focus has been interwoven with other research areas, in particular decision analysis, health care delivery, and clinical pharmacology. Ongoing studies include cost-effectiveness of cancer prevention and cancer treatment, enrollment of older individuals in phase II trials, pharmacokinetics of docetaxel in patients aged 70 years and older, and cognitive effects of chemotherapy in older patients.

Dr. Balducci is protocol chairman of the Geriatric Oncology Consortium, which conducts nationwide clinical trials in older individuals, and is chairman of the committee on guidelines for the management of older individuals of the National Comprehensive Cancer Network. He also is involved in cooperative research related to anemia of aging through the National Anemia Action Council.

Clinical Interests:

cancer in the elderly; treatment related toxicity; comprehensive geratric assessment tool; independence of comorbidity and functional status; risks and benefits of adjuvant chemotherapy in older patients

Publications:

1. Droz JP, Balducci L, Bolla M, Emberton M, Fitzpatrick JM, Joniau S, Kattan MW, Monfardini S, Moul JW, Naeim A, van Poppel H, Saad F, Sternberg CN. Background for the proposal of SIOG guidelines for the management of prostate cancer in senior adults. Crit Rev Oncol Hematol. 2010 Jan;73(1):68-91. Pubmedid: 19836968.   Pubmed ID: 19836968

2. Balducci L, Colloca G, Cesari M, Gambassi G. Assessment and treatment of elderly patients with cancer. Surg Oncol. 2009 Dec;. Pubmedid: 20006489.   Pubmed ID: 20006489

3. Balducci L. Pharmacology of antineoplastic medications in older cancer patients. Oncology (Williston Park). 2009 Jan;23(1):78-85. Pubmedid: 19283925.   Pubmed ID: 19283925

4. Balducci L. Supportive care in elderly cancer patients. Curr Opin Oncol. 2009 Jul;21(4):310-317. Pubmedid: 19412099.   Pubmed ID: 19412099

5. Balducci L. Treating elderly patients with hormone sensitive breast cancer: What do the data show. Cancer Treat Rev. 2009 Feb;35(1):47-56. Pubmedid: 18840391.   Pubmed ID: 18840391

6. Bennett JM, Hall WJ, Sahasrabudhe D, Balducci L. Enhancing geriatric oncology training to care for elders: A clinical initiative with long-term follow-up. Crit Rev Oncol Hematol. 2009 Aug;. Pubmedid: 19665902.   Pubmed ID: 19665902

7. Brunello A, Loaldi E, Balducci L. Dose adjustment and supportive care before and during treatment. Cancer Treat Rev. 2009 Oct;35(6):493-498. Pubmedid: 19493625.   Pubmed ID: 19493625

8. Silbermann M, Dweib Khleif A, Balducci L. Healing by Cancer. J Clin Oncol. 2009 Nov;. Pubmedid: 19917857.   Pubmed ID: 19917857

9. Balducci L, Tam-McDevitt J, Hauser R, Simon J. Long overdue - phase II studies in older cancer patients: where does the FDAstand. J Clin Oncol. 2008 Mar;26(8):1387-1388. Pubmedid: 18323564.   Pubmed ID: 18323564

10. Balducci L, Tam-McDevitt J, Hauser R, Simon J. Re: Cost of care for the elderly cancer patients in the United States. J Natl Cancer Inst. 2008 Oct;100(19):1413-1414. Pubmedid: 18812555.   Pubmed ID: 18812555

11. Balducci L. Journal of Clinical Oncology: the next 25 years. J Clin Oncol. 2008 Apr;26(10):e4-e4. Pubmedid: 18375885.   Pubmed ID: 18375885

12. Ferrucci L, Balducci L. Anemia of aging: the role of chronic inflammation and cancer. Semin Hematol. 2008 Oct;45(4):242-249. Pubmedid: 18809094. Pmcid: PMC2645640.   Pubmed ID: 18809094

13. Balducci L, Al-Halawani H, Charu V, Tam J, Shahin S, Dreiling L, Ershler W. Elderly cancer patients receiving chemotherapy benefit from first-cycle pegfilgrastim. Oncologist. 2007 Dec;12(12):1416-1424. Pubmedid: 18165618.   Pubmed ID: 18165618

14. Balducci L. Aging, frailty, and chemotherapy. Cancer Control. 2007 Jan;14(1):7-12. Pubmedid: 17242666.   Pubmed ID: 17242666

15. Balducci L. An overlooked problem: anemia in the elderly patient with cancer. J Support Oncol. 2007 Mar;5(3):115-116. Pubmedid: 17410808.   Pubmed ID: 17410808

16. Balducci L. Molecular insight in cancer treatment and prevention. Int J Biochem Cell Biol. 2007;39(7-8):1329-1336. Pubmedid: 17531523.   Pubmed ID: 17531523

17. Boccia R, Lillie T, Tomita D, Balducci L. The effectiveness of darbepoetin alfa administered every 3 weeks on hematologic outcomes and quality of life in older patients with chemotherapy-induced anemia. Oncologist. 2007 May;12(5):584-593. Pubmedid: 17522247.   Pubmed ID: 17522247

18. Crawford J, Althaus B, Armitage J, Balducci L, Bennett C, Blayney D, Cataland S, Dale D, Demetri G, Erba H, Foran J, Freifeld A, Heaney M, HtoyS, Kloth D, Lyman G, Messersmith W, Michaud L, Miyata S, Robbins A, TallmanMS, Vadhan-Raj S, Westervelt P, Wong M. Myeloid growth factors guidelines. J Natl Compr Canc Netw. 2007 Feb;5(2):188-202. Pubmedid: 17335688.   Pubmed ID: 17335688

19. Kumar A, Soares H, Balducci L, Djulbegovic B. Treatment tolerance and efficacy in geriatric oncology: a systematic review of phase III randomized trials conducted by five National Cancer Institute-sponsored cooperative groups. J Clin Oncol. 2007 Apr;25(10):1272-1276. Pubmedid: 17401017.   Pubmed ID: 17401017

20. Lichtman SM, Balducci L, Aapro M. Geriatric oncology: a field coming of age. J Clin Oncol. 2007 May;25(14):1821-1823. Pubmedid: 17488979.   Pubmed ID: 17488979

21. Perkins EA, Small BJ, Balducci L, Extermann M, Robb C, Haley WE. Individual differences in well-being in older breast cancer survivors. Crit Rev Oncol Hematol. 2007 Apr;62(1):74-83. Pubmedid: 17240157.   Pubmed ID: 17240157

22. Robb C, Haley W, Balducci L, Extermann M, Perkins E, Small B, Mortimer J. Impact of breast cancer survivorship on quality of life in older women. Crit Rev Oncol Hematol. 2007 Apr;62(1): 84-91. Pubmedid: 17188505.   Pubmed ID: 17188505

23. Tam-McDevitt J, Balducci L, Hauser R, Gura D, Paraghamian A, Thomas H, Lichtman S. Has demand for clinical trial participants outpaced supply?. J Natl Cancer Inst. 2007 Jan;99(1):86-87. Pubmedid: 17202120.   Pubmed ID: 17202120

24. Balducci L, Ershler W, Krantz S. Anemia in the elderly-Clinical findings and impact on health. Crit Rev Oncol Hematol. 2006 May;58(2):156-165. Pubmedid: 16387511.   Pubmed ID: 16387511

25. Balducci L. Management of cancer in the elderly. Oncology (Williston Park). 2006 Feb;20(2):135-143. Pubmedid: 16562648.   Pubmed ID: 16562648

26. Balducci L. Management of chemotherapy-induced neutropenia in the older cancer patient. Oncology (Williston Park). 2006 Dec;20(14):26-31.  

27. Balducci L. Transfusion independence in patients with myelodysplastic syndromes: impact on outcomes and quality of life. Cancer. 2006 May;106(10):2087-2094. Pubmedid: 16607649.   Pubmed ID: 16607649

28. Smith T, Khatcheressian J, Lyman G, Ozer H, Armitage J, Balducci L, Bennett C, Cantor S, Crawford J, Cross S, Demetri G, Desch C, Pizzo P, Schiffer C, Schwartzberg L, Somerfield M, Somlo G, Wade J, Wade J, Winn R, Wozniak A, Wolff A. 2006 update of recommendations for the use of white blood cell growth factors: an evidence-based clinical practice guideline. J Clin Oncol. 2006 Jul;24(19):3187-3205. Pubmedid: 16682719.   Pubmed ID: 16682719

29. Balducci L, Aapro M. Epidemiology of cancer and aging. Cancer Treat Res. 2005;124:1-15. Pubmedid: 15839188.   Pubmed ID: 15839188

30. Balducci L, Cohen H, Engstrom P, Ettinger D, Halter J, Gordon L, Kiel K, Kneier A, Lim D, Petersdorf S, Rosenthal R, Silliman R, Vose J, Walker M, Zachariah B. Senior adult oncology clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2005 Jul;3(4):572-590. Pubmedid: 16038647.   Pubmed ID: 16038647

31. Balducci L, Ershler W. Cancer and ageing: a nexus at several levels. Nat Rev Cancer. 2005 Aug;5(8):655-662. Pubmedid: 16056261.   Pubmed ID: 16056261

32. Balducci L, Hardy C, Lyman G. Hemopoiesis and aging. Cancer Treat Res. 2005;124:109-134. Pubmedid: 15839193.   Pubmed ID: 15839193

33. Balducci L. Cancer chemotherapy in elderly cancer patients. J Oncol Manag. 2005 Apr;14(2):35-38. Pubmedid: 16018197.   Pubmed ID: 16018197

34. Balducci L. Epidemiology of cancer and aging. J Oncol Manag. 2005 Apr;14(2):47-50. Pubmedid: 16018199.   Pubmed ID: 16018199

35. Balducci L. Guidelines for the management of the older cancer patient. Cancer Treat Res. 2005;124:233-256. Pubmedid: 15839199.   Pubmed ID: 15839199

36. Balducci L. Prevention of cancer in the older person. Cancer J. 2005 Nov;11(6):442-448. Pubmedid: 16393478.   Pubmed ID: 16393478

37. Balducci L. Squaring the circle: adjuvant chemotherapy for older women with breast cancer. J Gerontol A Biol Sci Med Sci. 2005 Oct;60(9):1135-1136. Pubmedid: 16183951.   Pubmed ID: 16183951

38. Balducci L. Supportive care of elderly patients with cancer. Support Cancer Ther. 2005 Jul;2(4):225-228. Pubmedid: 18628177.   Pubmed ID: 18628177

39. Beghe C, Balducci L. Biological basis of cancer in the older person. Cancer Treat Res. 2005;124:189-221. Pubmedid: 15839197.   Pubmed ID: 15839197

40. Carreca I, Balducci L, Extermann M. Cancer in the older person. Cancer Treat Rev. 2005 Aug;31(5):380-402. Pubmedid: 15967582.   Pubmed ID: 15967582

41. Extermann M, Chen H, Booth-Jones M, Meyer J, Balducci L, Jacobsen P. Pilot testing of the computerized cognitive test Microcog in chemotherapy-treated older cancer patients. Crit Rev Oncol Hematol. 2005 May;54(2):137-143. Pubmedid: 15843096.   Pubmed ID: 15843096

42. Gridelli C, Aapro M, Ardizzoni A, Balducci L, De Marinis F, Kelly K, LeChevalier T, Manegold C, Perrone F, Rosell R, Shepherd F, De Petris L, Di MaioM, Langer C. Treatment of advanced non-small-cell lung cancer in the elderly: results of an international expert panel. J Clin Oncol. 2005 May;23(13):3125-3137. Pubmedid: 15860872.   Pubmed ID: 15860872

43. Mandelblatt JS, Schechter CB, Yabroff KR, Lawrence W, Dignam J, Extermann M, Fox S, Orosz G, Silliman R, Cullen J, Balducci L. Toward optimal screening strategies for older women. Costs, benefits, and harms of breast cancer screening by age, biology, and health status. J Gen Intern Med. 2005 Jun;20(6):487-496. Pubmedid: 15987322.   Pubmed ID: 15987322

44. Balducci L, Repetto L. Increased risk of myelotoxicity in elderly patients with non-Hodgkin lymphoma. Cancer. 2004;100(1):6-11. Pubmedid: 14692018.   Pubmed ID: 14692018

45. Balducci L. Believing is seeing: a new parameter to study cancer prevention and cancer treatment in older individuals. Cancer. 2004;100(5):881-882. Pubmedid: 14983480.   Pubmed ID: 14983480

46. Balducci L. Cost of cancer clinical trials in elderly patients. Expert Opin Pharmacother. 2004;5(3):505-511. Pubmedid: 15013919.   Pubmed ID: 15013919

47. Balducci L. Profile of Prof. Paul Calabresi. Oncologist. 2004;9(1):110-110. Pubmedid: 14755021.   Pubmed ID: 14755021

48. Biganzoli L, Aapro M, Balducci L, Crivellari D, Minisini A, Piccart M. Adjuvant therapy in elderly patients with breast cancer. Clin Breast Cancer. 2004;5(3):188-195. Pubmedid: 15335450.   Pubmed ID: 15335450

49. Donovan KA, Jacobsen PB, Andrykowski MA, Winters EM, Balducci L, Malik U, Kenady D, McGrath P. Course of fatigue in women receiving chemotherapy and/or radiotherapy for early stage breast cancer. J Pain Symptom Manage. 2004 Oct;28(4):373-380. Pubmedid: 15471655.   Pubmed ID: 15471655

50. Extermann M, Meyer J, McGinnis M, Crocker T, Corcoran M, Yoder J, Haley W, Chen H, Boulware D, Balducci L. A comprehensive geriatric intervention detects multiple problems in older breast cancer patients. Crit Rev Oncol Hematol. 2004;49(1):69-75. Pubmedid: 14734156.   Pubmed ID: 14734156

51. Knight K, Wade S, Balducci L. Prevalence and outcomes of anemia in cancer: a systematic review of the literature. Am J Med. 2004;116:11S-26S. Pubmedid: 15050883.   Pubmed ID: 15050883

52. Kumar N, Allen K, Riccardi D, Bercu B, Cantor A, Minton S, Balducci L, Jacobsen P. Fatigue, weight gain, lethargy and amenorrhea in breast cancer patients on chemotherapy: is subclinical hypothyroidism the culprit. Breast Cancer Res Treat. 2004;83(2):149-159. Pubmedid: 14997046.   Pubmed ID: 14997046

53. Luciani A, Balducci L. Multiple primary malignancies. Semin Oncol. 2004;31(2):264-273. Pubmedid: 15112155.   Pubmed ID: 15112155

54. Martoni A, Cucinotta D, Balducci L. Meeting report: Breast cancer in the older woman. Tumori. 2004;90(4):437-445. Pubmedid: 15510992.   Pubmed ID: 15510992

55. Balducci L, Carreca I. Supportive care of the older cancer patient. Crit Rev Oncol Hematol. 2003;48:S65-S70. Pubmedid: 14563523.   Pubmed ID: 14563523

56. Balducci L. Anemia, cancer, and aging. Cancer Control. 2003;10(6):478-486. Pubmedid: 14652524.   Pubmed ID: 14652524

57. Balducci L. Epidemiology of anemia in the elderly: information on diagnostic evaluation. J Am Geriatr Soc. 2003;51:2-9. Pubmedid: 12588565.   Pubmed ID: 12588565

58. Balducci L. Geriatric oncology. Crit Rev Oncol Hematol. 2003;46(3):211-220. Pubmedid: 12791420.   Pubmed ID: 12791420

59. Balducci L. Lung cancer in the elderly: so many patients, so little time. Ca Cancer J Clin. 2003;53:322-324. Pubmedid: 15224972.   Pubmed ID: 15224972

60. Balducci L. Management of cancer pain in geriatric patients. J Support Oncol. 2003;1(3):175-191. Pubmedid: 15334874.   Pubmed ID: 15334874

61. Balducci L. Myelosuppression and its consequences in elderly patients with cancer. Oncology (Williston Park). 2003;17:27-32. Pubmedid: 14682116.   Pubmed ID: 14682116

62. Balducci L. New paradigms for treating elderly patients with cancer: the comprehensive geriatric assessment and guidelines for supportive care. J Support Oncol. 2003;1(4):30-37. Pubmedid: 15346998.   Pubmed ID: 15346998

63. Balducci L. The elderly patient with cancer: new approaches for improved outcomes. J Support Oncol. 2003;1(4):3-4. Pubmedid: 15346993.   Pubmed ID: 15346993

64. Chen H, Cantor A, Meyer J, Corcoran M, Grendys E, Cavanaugh D, AntonekS, Camarata A, Haley W, Balducci L, Extermann M. Can older cancer patients tolerate chemotherapy? A prospective pilot study. Cancer. 2003;97(4):1107-1114. Pubmedid: 12569613.   Pubmed ID: 12569613

65. Extermann M, Balducci L. Optimizing cancer care in the elderly: progress in geriatric oncology. Cancer Control. 2003;10(6):440-441. Pubmedid: 14652519.   Pubmed ID: 14652519

66. Lyman G, Kuderer N, Agboola O, Balducci L. Evidence-based use of colony-stimulating factors in elderly cancer patients. Cancer Control. 2003;10(6):487-499. Pubmedid: 14652525.   Pubmed ID: 14652525

67. Repetto L, Carreca I, Maraninchi D, Aapro M, Calabresi P, Balducci L. Use of growth factors in the elderly patient with cancer: a report from the Second International Society for Geriatric Oncology (SIOG) 2001 meeting. Crit Rev Oncol Hematol. 2003;45(2):123-128. Pubmedid: 12604125.   Pubmed ID: 12604125

68. Respini D, Jacobsen P, Thors C, Tralongo P, Balducci L. The prevalence and correlates of fatigue in older cancer patients. Crit Rev Oncol Hematol. 2003;47(3):273-279. Pubmedid: 12962901.   Pubmed ID: 12962901

69. Balducci L, Beghe C. Prevention of cancer in the older person. Clin Geriatr Med. 2002;18(3):505-528. Pubmedid: 12424870.   Pubmed ID: 12424870

70. Balducci L, Carreca I. The role of myelopoietic growth factors in managing cancer in the elderly. Drugs. 2002;62:47-63. Pubmedid: 12479594.   Pubmed ID: 12479594

71. Balducci L. The clinical impact of cancer in the old-aged person. Tumori. 2002;88(1):S47-S48. Pubmedid: 11989923.   Pubmed ID: 11989923

72. Extermann M, Chen H, Cantor A, Corcoran M, Meyer J, Grendys E, CavanaughD, Antonek S, Camarata A, Haley W, Balducci L. Predictors of tolerance to chemotherapy in older cancer patients: a prospective pilot study. Eur J Cancer. 2002;38(11):1466-1473. Pubmedid: 12110492.   Pubmed ID: 12110492

73. Lyman G, Kuderer N, Balducci L. Cost-benefit analysis of granulocyte colony-stimulating factor in the management of elderly cancer patients. Curr Opin Hematol. 2002;9(3):207-214. Pubmedid: 11953666.   Pubmed ID: 11953666

74. Patterson S, Balducci L, Meyer R. The Book of Job: a 2,500-year-old current guide to the practice of oncology: the nexus of medicine and spirituality. J Cancer Educ. 2002;17(4):237-240. Pubmedid: 12556063.   Pubmed ID: 12556063

75. Patterson S, Balducci L, Pow-Sang J. Controversies surrounding androgen deprivation for prostate cancer. Cancer Control. 2002;9(4):315-325. Pubmedid: 12228757.   Pubmed ID: 12228757

76. Repetto L, Balducci L. A case for geriatric oncology. Lancet Oncol. 2002;3(5):289-297. Pubmedid: 12067806.   Pubmed ID: 12067806

77. Balducci L, Beghe C. Cancer and age in the USA. Crit Rev Oncol Hematol. 2001;37(2):137-145. Pubmedid: 11166587.   Pubmed ID: 11166587

78. Balducci L, Extermann M, Carreca I. Management of breast cancer in the older woman. Cancer Control. 2001;8(5):431-441. Pubmedid: 11579340.   Pubmed ID: 11579340

79. Balducci L, Extermann M. A practical approach to the older patient with cancer: a review. Curr Probl Cancer. 2001;25(1):6-76. Pubmedid: 11261937.   Pubmed ID: 11261937

80. Balducci L, Hardy C, Lyman G. Hematopoietic growth factors in the older cancer patient. Curr Opin Hematol. 2001;8(3):170-187. Pubmedid: 11303151.   Pubmed ID: 11303151

81. Balducci L, Lyman G. Patients aged > or = 70 are at high risk for neutropenic infection and should receive hemopoietic growth factors when treated with moderately toxic chemotherapy. J Clin Oncol. 2001;19(5):1583-1585. Pubmedid: 11230505.   Pubmed ID: 11230505

82. Balducci L, Meyer R. Spirituality and medicine: a proposal. Cancer Control. 2001;8(4):368-376. Pubmedid: 11483891.   Pubmed ID: 11483891

83. Balducci L. Cancer: an experiment education. Cancer Control. 2001;8(2):192-196. Pubmedid: 11326176.   Pubmed ID: 11326176

84. Balducci L. The geriatric cancer patient: equal benefit from equal treatment. Cancer Control. 2001;8(2):1-25. Pubmedid: 11326165.   Pubmed ID: 11326165

85. Overcash J, Extermann M, Parr J, Perry J, Balducci L. Validity and reliability of the FACT-G scale for use in the older person with cancer. Am J Clin Oncol. 2001;24(6):591-596. Pubmedid: 11801761.   Pubmed ID: 11801761

86. Balducci L, Beghe C. The application of the principles of geriatrics to the management of the older person with cancer. Crit Rev Oncol Hematol. 2000;35(3):147-154. Pubmedid: 10960797.   Pubmed ID: 10960797

87. Balducci L, Corcoran M. Antineoplastic chemotherapy of the older cancer patient. Hematol Oncol Clin North Am. 2000;14(1):193-212. Pubmedid: 10680078.   Pubmed ID: 10680078

88. Balducci L, Extermann M. Cancer and aging. An evolving panorama. Hematol Oncol Clin North Am. 2000;14(1):1-16. Pubmedid: 10680068.   Pubmed ID: 10680068

89. Balducci L, Extermann M. Management of cancer in the older person: a practical approach. Oncologist. 2000;5(3):224-237. Pubmedid: 10884501.   Pubmed ID: 10884501

90. Balducci L, Extermann M. Management of the frail person with advanced cancer. Crit Rev Oncol Hematol. 2000;33(2):143-148. Pubmedid: 10737376.   Pubmed ID: 10737376

91. Balducci L, Hardy C, Lyman G. Hemopoietic reserve in the older cancer patient: clinical and economic considerations. Cancer Control. 2000;7(6):539-547. Pubmedid: 11088062.   Pubmed ID: 11088062

92. Balducci L, Stanta G. Cancer in the frail patient. A coming epidemic. Hematol Oncol Clin North Am. 2000;14(1):235-50,xi. Pubmedid: 10680080.   Pubmed ID: 10680080

93. Balducci L, Yates J. General guidelines for the management of older patients with cancer. Oncology (Williston Park). 2000;14(11A):221-227. Pubmedid: 11195414.   Pubmed ID: 11195414

94. Balducci L. Cancer in the elderly: tailoring treatment. Hosp Pract (Off Ed). 2000;35(3):73-80. Pubmedid: 10737241.   Pubmed ID: 10737241

95. Balducci L. Evidence-based management of cancer in the elderly. Cancer Control. 2000;7(4):368-376. Pubmedid: 10895132.   Pubmed ID: 10895132

96. Balducci L. Geriatric oncology: challenges for the new century. Eur J Cancer. 2000;36(14):1741-1754. Pubmedid: 10974621.   Pubmed ID: 10974621

97. Balducci L. Inspiration from a forum arranged by students. J Cancer Educ. 2000;15(4):245-245. Pubmedid: 11199245.   Pubmed ID: 11199245

98. Broeckel J, Jacobsen P, Balducci L, Horton J, Lyman G. Quality of life after adjuvant chemotherapy for breast cancer. Breast Cancer Res Treat. 2000;62(2):141-150. Pubmedid: 11016752.   Pubmed ID: 11016752

99. Extermann M, Balducci L, Lyman G. What threshold for adjuvant therapy in older breast cancer patients?. J Clin Oncol. 2000;18(8):1709-1717. Pubmedid: 10764431.   Pubmed ID: 10764431

100. Kimmick G, Balducci L. Breast cancer and aging. Clinical interactions. Hematol Oncol Clin North Am. 2000;14(1):213-234. Pubmedid: 10680079.   Pubmed ID: 10680079

101. Mandelblatt J, Orosz G, Yabroff K, Extermann M, Lawrence W, Yi B, Satariano W, Bloom H, Fox S, Silliman R, Fahs M, Schecther C, Muenning P, Balducci L. Screening mammography in elderly women. Research on Breast Cancer in Older Women Consortium. Jama. 2000;283(24):3202-3203. Pubmedid: 10866863.   Pubmed ID: 10866863

102. Remick S, Sedransk N, Haase R, Craffey M, Subramanian N, Dowlati A, Nazeer T, Ramnes C, Blanchard C, Martrianni D, Balducci L, Horton J, Ruckdeschel J. Oral combination chemotherapy in the management of AIDS-related lymphoproliferative malignancies. Drugs. 2000;58(3):99-107. Pubmedid: 10711848.   Pubmed ID: 10711848

103. Zachariah B, Balducci L. Radiation therapy of the older patient. Hematol Oncol Clin North Am. 2000;14(1):131-167. Pubmedid: 10680076.   Pubmed ID: 10680076

104. Balducci L, Beghe C. Pharmacology of chemotherapy in the older cancer patient. Cancer Control. 1999;6(5):466-470. Pubmedid: 10758578.   Pubmed ID: 10758578

105. Balducci L, Extermann M. Cancer in the elderly. Clin Geriatr Med. 1999;6(13):51-58. Pubmedid: noPMID.  

106. Balducci L, Hardy C. Aging, stress and anemia. Matur Med Canada. 1999;82-85. Pubmedid: noPMID.  

107. Balducci L. Mangement of cancer in the older person. Clin Geriatr Med. 1999;7(5):89-97. Pubmedid: noPMID.  

108. Jacobsen PB, Hann DM, Azzarello LM, Horton J, Balducci L, Lyman GH. Fatigue in women receiving adjuvant chemotherapy for breast cancer: characteristics, course, and correlates. J Pain Symptom Manage. 1999 Oct;18(4):233-242. Pubmedid: 10534963.   Pubmed ID: 10534963

109. Lyman G, Balducci L. Update on the economic analyses of the use of the colony-stimulating factors. Curr Opin Hematol. 1999;6(3):145-151. Pubmedid: 10226734.   Pubmed ID: 10226734

110. Balducci L, Extermann M. Difficulties in treating older patients with cancer. Oncology Pract. 1998;15-18. Pubmedid: noPMID.  

111. Balducci L, Hardy C. Anemia of aging: a model of erythropoiesis in cancer patients. Cancer Control. 1998;5(2):17-21. Pubmedid: 10762462.   Pubmed ID: 10762462

112. Balducci L, Phillips D. Breast cancer in older women Am Fam Physician. Am Fam Phys. 1998;58(5):1163-1172. Pubmedid: 9787281.   Pubmed ID: 9787281

113. Benson K, Agosti S, Lyman G, Pow-Sang J, Saba H, Balducci L. Estimated blood loss in group O as compared to non-group O radical prostatectomy. Hematology. 1998;3:257-261. Pubmedid: noPMID.  

114. Broeckel J, Jacobsen P, Horton J, Balducci L, Lyman G. Characteristics and correlates of fatigue after adjuvant therapy for breast cancer. J Clin Oncol. 1998;16(5):1689-1696. Pubmedid: 9586880.   Pubmed ID: 9586880

115. Extermann M, Overcash J, Lyman G, Parr J, Balducci L. Comorbidity and functional status are independent in older cancer patients. J Clin Oncol. 1998;16(4):1582-1587. Pubmedid: 9552069.   Pubmed ID: 9552069

116. Lyman G, Kuderer N, Balducci L. Cancer care in the elderly: cost and quality of life considerations. Cancer Control. 1998;5:347-354. Pubmedid: 10761085.   Pubmed ID: 10761085

117. Lyman G, Kuderer N, Balducci L. Economic impact of granulopoiesis stimulating agents on the management of febrile neutropenia. Curr Opin Oncol. 1998;10:291-298. Pubmedid: 9702395.   Pubmed ID: 9702395

118. Lyman G, Kuderer N, Greene J, Balducci L. The economics of febrile neutropenia: implications for the use of colony-stimulating factors. Eur J Cancer. 1998;34(12):1857-1864. Pubmedid: 10023306.   Pubmed ID: 10023306

119. Lyman G, Lyman S, Kuderer N, Balducci L, Reintgen D, Cox C. Menopausal status and breast cancer survival following recurrence. Matur Med Canada. 1998;1:29-31.  

120. Balducci L, Extermann M, Fentiman I, Monfardini S, Perrone F. Should adjuvant chemotherapy be used to treat breast cancer in elderly patients (> or = 70 years of age)?. Eur J Cancer. 1997;33:1720-1724. Pubmedid: 9470824.   Pubmed ID: 9470824

121. Balducci L, Extermann M. Advances in cancer therapy for the older patient. Intern Med. 1997;18:79-92. Pubmedid: noPIMID.  

122. Balducci L, Extermann M. Cancer chemotherapy in the older person: what the medical oncologists needs to know. Cancer. 1997;80:1317-1322. Pubmedid: 9317185.   Pubmed ID: 9317185

123. Balducci L, Lyman G. Cancer in the elderly: epidemiologic and clinical implications. Clin Geriatr Med. 1997;13:1-14. Pubmedid: 8995097.   Pubmed ID: 8995097

124. Balducci L, Trotti, III A. Organ preservation: an effective and safe form of cancer treatment. Clin Geriatr Med. 1997;13(1):185-201. Pubmedid: 8995107.   Pubmed ID: 8995107

125. Balducci L. Highlights of the third international conference in geriatric oncology held in Tampa, Florida, 13-15 November, 1996. Eur J Cancer. 1997;33(6):836-837. Pubmedid: noPMID.  

126. Balducci L. Issues in the management of haematologic malignancies. From the 26th Congress of the International Society of Haematology (ISH), Signapore, 25-29 August 1996. Oncology Forum. 1997;1(1):12-12. Pubmedid: noPMID.  

127. Kimmick G, Fleming R, Muss H, Balducci L. Cancer chemotherapy in older adults: a tolerability perspective. Drugs Aging. 1997;10(1):34-49. Pubmedid: 9111706.   Pubmed ID: 9111706

128. Lyman G, Kuderer N, Lyman S, Debus M, Minton S, Balducci L, Horton J, Reintgen D, Cox C. Menopausal status and the impact of early recurrence on breast cancer survival. Cancer Control. 1997;4(4):335-341. Pubmedid: 10763039.   Pubmed ID: 10763039

129. Reintgen D, Joseph E, Lyman G, Yeatman T, Balducci L, Ku N, Berman C, Shons A, Wells K, Horton J, Greenberg H, Nicosia S, Clark R, Shivers S, Li W, Wang X, Cantor A, Cox C. The role of selective lymphadenectomy in breast cancer. Cancer Control. 1997;4(3):211-219. Pubmedid: 10763020.   Pubmed ID: 10763020

130. Wells N, Balducci L. Geriatric Oncology Medical and Psychosocial Perspectives. Cancer Practice. 1997;5(2):87-91. Pubmedid: 9110644.   Pubmed ID: 9110644

131. Zachariah B, Balducci L, Venkattaramanabalaji G, Casey L, Greenberg H, DelRegato J. Radiotherpay for cancer patients aged 80 and older: a study of effectiveness and side effects. Int J Radiat Oncol Biol Phys. 1997;39(5):1125-1129. Pubmedid: 9392554.   Pubmed ID: 9392554

132. Albertini J, Lyman G, Cox C, Yeatman T, Balducci L, Ku N, Shivers S, Berman C, Wells K, Rapaport D, Shons A, Horton J, Greenberg H, Nicosia S, Clark R, Cantor A, Reintgen D. Lymphatic mapping and sentinel node biopsy in the patient with breast cancer. Jama. 1996;276(22):1818-1822. Pubmedid: 8946902.   Pubmed ID: 8946902

133. Balducci L, Lyman G, Fabri P. Management of cancer in the aged. Compr Ther. 1996;22(2):88-93. Pubmedid: 8689868.   Pubmed ID: 8689868

134. Benson K, Balducci L, Milo K, Heckel L, Lyman G. Patient's attitudes regarding out-of-hospital blood transfusion. Transfusion. 1996;36:140-143. Pubmedid: 8614964.   Pubmed ID: 8614964

135. Extermann M, Balducci L, Lyman G. Optimal duration of adjuvant tamoxifen treatment in elderly breast cancer patients: influence of age, cormorbidites, and various effectiveness hypothesis on life-expectancy. Breast Dis. 1996;9:327-339.  

136. Lyman G, Kuderer N, Balducci L, Horton J. Thresholds for the use of recombinant human colony-stimulating factors (CSFs) based on revised cost estimates incorporating indirect medical, non-medical and intangible cost considerations. Blood. 1996;88:346a-346a.  

137. Lyman G, Kuderer N, Balducci L. The decision to use colony stimulating factors in patients receiving cancer chemotherapy: quality of life adjustment. Proc Am Soc Clin Oncol. 1996;15:535-535.  

138. Lyman G, Lyman S, Balducci L, Kuderer N, Reintgen D, Harris J, Cox C, Baekey P, Greenberg H, Horton J. Age and the risk of recurrence in women with breast cancer. Cancer Control. 1996;3:421-427. Pubmedid: 10764500.   Pubmed ID: 10764500

139. Casey L, Zachariah B, Balducci L. Radiotherapy of the oldest old cancer patients: a study of effectiveness and toxicity. J Am Geriatr Soc. 1995;43:1-3. Pubmedid: noPMID.  

140. Lyman G, Balducci L. A cost analysis of hematopoietic colony-stimulating factors. Oncology. 1995;9:85-91. Pubmedid: 8608061.   Pubmed ID: 8608061

141. Robinson B, Balducci L. Breast lump in an 85-year-old woman with dementia: a decision analysis. Am Geriatr Soc. 1995;155:171-175. Pubmedid: 7884120.   Pubmed ID: 7884120

142. Zachariah B, Casey L, Balducci L. Radiotherapy of the oldest old cancer patients: a study of effectiveness and toxicity. J Am Geriatr Soc. 1995;43:793-795. Pubmedid: 7602034.   Pubmed ID: 7602034

143. Zachariah B, Zachariah S, Varghese R, Balducci L. Review: carcinomatous meningitis: clinical manifestations and management. Int J Clin Pharmacol Ther Toxicol. 1995;33(1):7-12. Pubmedid: 7711996.   Pubmed ID: 7711996

144. Balducci L, Barry P. A practical approach to the screening of asymptomatic older persons with cancer. Cancer Control. 1994;1(2):126-131.  

145. Balducci L, Cox C, Greenberg H, Lyman G, Miguel R, Karl R, Fabri P. Management of cancer in the older aged person. Cancer Control. 1994;1(2):132-137.  

146. Balducci L, Greenberg H. Breast cancer in the older woman: therapeutic controversies. Cancer Control. 1994;1(4):350-355.  

147. Balducci L, Lyman G, Schapira D. Trends in prevention and treatment of breast cancer in the older woman. Facts Res Gerontol. 1994;179-192.  

148. Balducci L, Lyman G. Cost-effectiveness of hematopoietic growth factors in cancer management. Adv Oncol. 1994;10(1):11-11.  

149. Balducci L. Cancer and age: issues and perspectives. Facts Res Gerontol. 1994;173-178.  

150. Balducci L. Do we need geriatric oncology?. Cancer Control. 1994;1(2):91-93.  

151. Balducci L. Perspectives on quality of life of older persons with cancer. Drugs Aging. 1994;4(4):313-324.  

152. Beghe C, Balducci L, Cohen H. Secondary prevention of breast cancer in the older woman: issues related to screening. Cancer Control. 1994;1(4):320-326.  

153. Lyman G, Balducci L. The effect of changing disease risk on clinical reasoning. J Gen Intern Med. 1994;09:488-495.  

154. Lyman GH, Balducci L. The effect of changing disease risk on clinical reasoning. J Gen Intern Med. 1994 Sep;9(9):488-495. Pubmedid: 7996291.   Pubmed ID: 7996291

155. Wyckoff J, Greenberg H, Sanderson R, Wallach P, Balducci L. Breast irradiation in the older woman: a toxicity study. J Am Geriatr Soc. 1994;42:150-152.  

156. Balducci L, Benson K, Lyman G, Sanderson R, Fields K, Ballester O, Elfenbein G. Cost-effectiveness of leukocyte depletion filters in adult acute myelogenous leukemia. Transfusion. 1993;33(8):665-670.  

157. Ballester O, Moscinski L, Spiers A, Balducci L. Non-Hodgkin's lymphoma in the older person: a review. J Am Geriatr Soc. 1993;41:1245-1254.  

158. Iacobini M, Torre A, Palumbo G, DelPrincipe D, Digilio G, Balducci L. Study of chronic granulomatous disease by a nitroblue tetrazolium densitometric kinetic test: a new research method. Clin Chim Acta. 1993;221:197-202.  

159. Lyman G, Balducci L. Overestimation of test effects in clinical judgment. J Cancer Educ. 1993;8(4):297-308.  

160. Lyman G, Lyman C, Sanderson R, Balducci L. Decision analysis of hematopoietic growth factor use in patients receiving cancer chemotherapy. J Natl Cancer Inst. 1993;85(6):488-493.  

161. Silliman R, Balducci L, Goodwin J, Holmes F, Leventhal E. Breast cancer care in old age: what we know, don't know, and do. J Natl Cancer Inst. 1993;85(3):190-199.  

162. Virgilio J, Moscinski L, Ballester O, Corrado C, Guida C, Balducci L, Saba H. Acute lymphoblastic leukemia (ALL) in elderly patients. Hematol Oncol. 1993;11(3):121-126.  

163. Balducci L, Mowrey K. Pharmacology and organ toxicity of cancer chemotherapy in older patients. Oncology. 1992;6:62-68.  

164. Ballester O, Moscinski L, Morris D, Balducci L. Acute myelogenous leukemia in the elderly. J Am Geriatr Soc. 1992;40:277-284.  

165. Ballester O, Wang T, Saba H, Morelli G, Tantranond O, Balducci L. Classic hemophilia in elderly patients. J Am Geriatr Soc. 1992;40(8):824-826.  

166. Heal A, Tyson I, Greenberg H, Balducci L, Ketch R, Tenorio L, Berman C, Silbiger M. Evaluation of multiple infusions (IP) of 131-I-HMFG1 MoAb in ovarian and colorectal carcinoma patients and a nude mouse xenograft with and without IV use of unlabeled MoAb. Antibody Immunoconjugates Radiopharm. 1992;5:86-86.  

167. Saba H, Ballester O, Balducci L. Hemopoietic growth factors in myelodysplasia. Hematol Rev. 1992;5:207-221.  

168. Shank W, Balducci L. Hemopoietic growth factors and aging: review. Hematol Rev. 1992;5:229-236.  

169. Shank W, Balducci L. Recombinant hemopoietic growth factors: comparative hemopoietic response in younger vs older aged subjects. J Am Geriatr Soc. 1992;40:151-154.  

170. Tantranond P, Karam F, Wang T, Parker M, Hescock H, Cherryholmes D, Balducci L. Management of cutaneous squamous cell carcinoma in an elderly man. Report of a case and review of the literature. J Am Geriatr Soc. 1992;40:510-512.  

171. Zachariah S, Zachariah B, Wang T, Balducci L. Primary brain tumors in the older patient: an annotated review. J Am Geriatr Soc. 1992;40:1265-1271.  

172. Balducci L, Cox C, Greenberg H, Lyman G, Miguel R, Karl R, Fabri P. Management of cancer in the older person. In: Balducci L, Lyman G, Erschler W, et al, eds. Comprehensive Geriatric Oncology. 2 ed. London. Harwood Academic Publishers; 1998;363-368.  

173. Balducci L, Cox C, Greenberg H, Lyman G, Miguel R, Karl R, Fabri P. Management of cancer in the older person. In: Complete geriatric oncology. London. Harwood Academic Publishers; 1999;363-368.  

174. Balducci L, Extermann M. Cancer and age. In: Haskell C, ed. Cancer treatment. Philadelphia, PA: W.B. Saunders; 2000;435-451.  

175. Balducci L, Extermann M. Cancer, carcinogenesis and aging. In: Rosenthal R, Zenilman M, Katlic M, et al, eds. Principles and practice of geriatric surgery. New York, NY: Springer Publishing Co Verlag; 2000;38-45.  

176. Balducci L, Extermann M. Issues in the care of the older cancer patient: delayed diagnosis, inadequate treatment, and information gaps. In: The older cancer patient. New York, NY: Springer Publishing Company Inc; 2003;24-44.  

177. Balducci L, Extermann M. The cost of cancer prevention and treatment in the older person. In: The older cancer patient. New York, NY: Springer Publishing Company Inc; 2003;284-296.  

178. Balducci L, Lyman G, Erschler W. Management of cancer in the older person. In: Balducci L, Lyman G, Erschler W, et al, eds. Comprehensive Geriatric Oncology. London. Harwood Academic Publishers; 1998;363-368.  

179. Balducci L, Pow-Sang J, Friedland J, Diaz J. Cancer in the elderly part II: prostate cancer. In: Balducci L, ed. Clinics in geriatric medicine. Philadelphia, PA: Saunders; 1997;283-306.  

180. Balducci L, Silliman R, Baekey P. Breast cancer: a geriatric perspective-part I. In: Balducci L, Lyman G, Ershler, et al, eds. Comprehensive geriatric oncology. London. Harwood Academic Publishers; 1998;629-660.  

181. Carreca I, Balducci L. Cancer chemotherapy in the older cancer patient. Urol Oncol. 27(6):633-642. Pubmedid: 19879474.   Pubmed ID: 19879474

182. Cova D, Beretta G, Balducci L. Cancer chemotherapy in the older patient. In: Balducci L, Lyman G, Ershler W, et al, eds. Comprehensive geriatric oncology. Amsterdam. Harwood Academic Publishers; 1998;429-442.  

183. Extermann M, Balducci L. Practical proposals for clinical protocols in elderly patients with cancer. In: Balducci L, Lyman G, Ershler W, et al, eds. Comprehensive Geriatric Oncology. Amsterdam. Harwood Academic Publishers; 1998;263-269.  

184. Saba H, Nawab U, Nadeem S, Cosgrove D, Moscinski L, Spiers A, Balducci L, Lyman G, Zuckerman K. 1994;624a.  

185. Silliman R, Balducci L. Breast cancer: a geriatric perspective-part II. In: Balducci L, Lyman G, Ershler W, et al, eds. Comprehensive geriatric oncology. Amsterdam. Harwood Academic Publishers; 1998;661-671.