H. Lee Moffitt Cancer Center & Research Institute

Faculty Rank:

Associate Member

USF Affiliations/College Department:

• Medicine / Oncologic Sciences
• Public Health / Epidemiology And Biostatistics
• Arts & Sciences / Mathematics & Statistics

Research Interests:

Dr. Lee's primary research interest is in developing methods for repeated measurement data such as that collected in biomedical studies in which subjects are monitored and data are collected over time. Specifically, Dr. Lee and her collaborators are developing tools for testing goodness-of-fit of models for correlated binary data. Dr. Lee also works on change-point models using a generalized estimating equations (GEE) method. Applications of interest to her in this area include the use of prostate specific antigen to monitor recurrence of prostate cancer after surgery or radiotherapy treatment and the use of dementia measurements before and after diagnosis of Alzheimer's disease and in normal ageing. Dr. Lee spends a significant amount of her time working in collaboration with oncologists. Some of the new and interesting directions in which these collaborations take her include group randomized trials with multiple endpoints. Her website can be accessed at: http://personal.health.usf.edu/jlee2/

Publications:

1. Lu B, Hagensee ME, Lee JH, Wu Y, Stockwell HG, Nielson CM, Abrahamsen M, Papenfuss M, Harris RB, Giuliano AR. Epidemiologic Factors Associated with Seropositivity to Human Papillomavirus Type 16 and 18 Virus-Like Particles and Risk of Subsequent Infection in Men. Cancer Epidemiol Biomarkers Prev. 2010 Jan;. Pubmedid: 20086109.   Pubmed ID: 20086109

2. Eschrich S, Zhang H, Zhao H, Boulware D, Lee JH, Bloom G, Torres-Roca JF. Systems biology modeling of the radiation sensitivity network: a biomarker discovery platform. Int J Radiat Oncol Biol Phys. 2009 Oct;75(2):497-505. Pubmedid: 19735874.   Pubmed ID: 19735874

3. Eschrich SA, Pramana J, Zhang H, Zhao H, Boulware D, Lee JH, Bloom G, Rocha-Lima C, Kelley S, Calvin DP, Yeatman TJ, Begg AC, Torres-Roca JF. A gene expression model of intrinsic tumor radiosensitivity: prediction of response and prognosis after chemoradiation. Int J Radiat Oncol Biol Phys. 2009 Oct;75(2):489-496. Pubmedid: 19735873.   Pubmed ID: 19735873

4. Giuliano A, Lazcano E, Villa L, Flores R, Salmeron J, Lee J, Papenfuss M, Abrahamsen M, Baggio M, Silva R, Quiterio M. Circumcision and sexual behavior: Factors independently associated with human papillomavirus detection among men in the HIM study. Int J Cancer. 2009 Mar;124(6):1251-1257. Pubmedid: 19089913.   Pubmed ID: 19089913

5. Gwede CK, Menard JM, Martinez-Tyson DD, Lee JH, Vadaparampil ST, Padhya TA, Meade CD. Strategies for Assessing Community Challenges and Strengths for Cancer Disparities Participatory Research and Outreach. Health Promot Pract. 2009 Jun;. Pubmedid: 19515858.   Pubmed ID: 19515858

6. Hunter S, Wells KJ, Jacobsen PB, Lee JH, Boulware D, Love-Jackson K, Abdulla R, Roetzheim RG. Assessment of Elementary School Students' Sun Protection Behaviors. Pediatr Dermatol. 2009 Jul;. Pubmedid: 19686304.   Pubmed ID: 19686304

7. Jacobsen PB, Shibata D, Siegel EM, Lee JH, Alemany CA, Brown R, Cartwright TH, Levine RM, Smith JC, Abesada-Terk G, Malafa MP. Initial evaluation of quality indicators for psychosocial care of adults with cancer. Cancer Control. 2009 Oct;16(4):328-334. Pubmedid: 19910919.   Pubmed ID: 19910919

8. Lee JH, Schell MJ, Roetzheim R. Analysis of group randomized trials with multiple binary endpoints and small number of groups. PLoS One. 2009;4(10):e7265-. Pubmedid: 19844579.   Pubmed ID: 19844579

9. Lee JY, Miladinovic B, Schell MJ. Statistical tutorial notes: analysis of two group comparisons, a practical guide. Med Probl Perform Art. 2009 Dec;(166):169-.  

10. Malafa MP, Corman MM, Shibata D, Siegel EM, Lee JH, Jacobsen PB. The Florida Initiative for Quality Cancer Care: a regional project to measure and improve cancer care. Cancer Control. 2009 Oct;16(4):318-327. Pubmedid: 19910918.   Pubmed ID: 19910918

11. Permuth-Wey J, Boulware D, Valkov N, Livingston S, Nicosia S, Lee JH, Sutphen R, Schildkraut J, Narod S, Parker A, Coppola D, Sellers T, Pal T. Sampling strategies for tissue microarrays to evaluate biomarkers in ovarian cancer. Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):28-34. Pubmedid: 19124477.   Pubmed ID: 19124477

12. Quinn GP, Vadaparampil ST, Lee JH, Jacobsen PB, Bepler G, Lancaster J, Keefe DL, Albrecht TL. Physician referral for fertility preservation in oncology patients: a national study of practice behaviors. J Clin Oncol. 2009 Dec;27(35):5952-5957. Pubmedid: 19826115.   Pubmed ID: 19826115

13. Rollison DE, Helzlsouer KJ, Lee JH, Fulp W, Clipp S, Hoffman-Bolton JA, Giuliano AR, Platz EA, Viscidi RP. Prospective study of JC virus seroreactivity and the development of colorectal cancers and adenomas. Cancer Epidemiol Biomarkers Prev. 2009 May;18(5):1515-1523. Pubmedid: 19383887.   Pubmed ID: 19383887

14. Cangiano J, Centeno BA, Garrett CR, Caceres W, de Jesus A, Lee JH, Pavia O, Jove R, Baez L, Sullivan DM, Muro-Cacho CA, Munoz-Antonia T. Signal transduction proteins in tumors from Puerto Rican and Caucasian gastric adenocarcinoma patients: expression differences with potential for specific targeted therapies. Dig Dis Sci. 2008 Aug;53(8):2090-2100. Pubmedid: 18224443.   Pubmed ID: 18224443

15. Clayton H, Quinn G, Lee J, King L, Miree C, Nieder M, Vadaparampil S. Trends in clinical practice and nurses' attitudes about fertility preservation for pediatric patients with cancer. Oncol Nurs Forum. 2008 Mar;35(2):249-255. Pubmedid: 18321837.   Pubmed ID: 18321837

16. Daud A, Mirza N, Lenox B, Andrews S, Urbas P, Gao G, Lee J, Sondak V, Riker A, Deconti R, Gabrilovich D. Phenotypic and functional analysis of dendritic cells and clinical outcome in patients with high-risk melanoma treated with adjuvant granulocyte macrophage colony-stimulating factor. J Clin Oncol. 2008 Jul;26(19):3235-3241. Pubmedid: 18591558.   Pubmed ID: 18591558

17. Fishman M, Hunter T, Soliman H, Thompson P, Dunn M, Smilee R, Farmelo M, Noyes D, Mahany J, Lee J, Cantor A, Messina J, Seigne J, Pow-Sang J, JanssenW, Antonia S. Phase II Trial of B7-1 (CD-86) Transduced, Cultured Autologous Tumor Cell Vaccine Plus Subcutaneous Interleukin-2 for Treatment of Stage IV Renal Cell Carcinoma. J Immunother (1997). 2008 Jan;31(1):72-80. Pubmedid: 18157014.   Pubmed ID: 18157014

18. Flores R, Beibei L, Nielson C, Abrahamsen M, Wolf K, Lee J, Harris R, Giuliano A. Correlates of human papillomavirus viral load with infection site in asymptomatic men. Cancer Epidemiol Biomarkers Prev. 2008 Dec;17(12):3573-3576. Pubmedid: 19064573.   Pubmed ID: 19064573

19. Giuliano A, Lazcano-Ponce E, Villa L, Flores R, Salmeron J, Lee J, Papenfuss M, Abrahamsen M, Jolles E, Nielson C, Baggio M, Silva R, Quiterio M. The human papillomavirus infection in men study: human papillomavirus prevalence and type distribution among men residing in Brazil, Mexico, and the United States. Cancer Epidemiol Biomarkers Prev. 2008 Aug;17(8):2036-2043. Pubmedid: 18708396.   Pubmed ID: 18708396

20. Giuliano A, Lu B, Nielson C, Flores R, Papenfuss M, Lee J, Abrahamsen M, Harris R. Age-Specific Prevalence, Incidence, and Duration of Human Papillomavirus Infections in a Cohort of 290 US Men. J Infect Dis. 2008 Sep;198(6):827-835. Pubmedid: 18657037.   Pubmed ID: 18657037

21. Fricke I, Mirza N, Dupont J, Lockhart C, Jackson A, Lee JH, Sosman JA, Gabrilovich DI. Vascular endothelial growth factor-trap overcomes defects in dendritic cell differentiation but does not improve antigen-specific immune responses. Clin Cancer Res. 2007 Aug;13(16):4840-4848. Pubmedid: 17699863.   Pubmed ID: 17699863

22. Jacobsen P, Shibata D, Siegel E, Mihaela D, Lee J, Marshburn J, Davenport J, Cruse H, Richard L, Gondi A, Brown R, Malafa M. Measuring quality of care in the treatment of colorectal cancer: The Moffitt Quality Pracice Initiative. J Oncol Manag. 2007;3:60-65.  

23. Lee J, Eschrich S, Beam C. An exact test for detecting inconsistency in readers interpretation over time in screening mammograms. Biom J. 2007 Aug;49(5):672-681. Pubmedid: 17638286.   Pubmed ID: 17638286

24. Lee J, Herzog T, Meade C, Webb M, Brandon T. The use of GEE for analyzing longitudinal binomial data: A primer using data from a tobacco intervention. Addict Behav. 2007 Jan;32(1):187-193. Pubmedid: 16650625.   Pubmed ID: 16650625

25. Munster P, Marchion D, Bicaku E, Schmitt M, Lee JH, DeConti R, Simon G, Fishman M, Minton S, Garrett C, Chiappori A, Lush R, Sullivan D, Daud A. Phase I trial of histone deacetylase inhibition by valproic acid followed by the topoisomerase II inhibitor epirubicin in advanced solid tumors: a clinical and translational study. J Clin Oncol. 2007 May;25(15):1979-1985. Pubmedid: 17513804.   Pubmed ID: 17513804

26. Antonia S, Mirza N, Fricke I, Chiappori A, Thompson P, Williams N, Bepler G, Simon G, Janssen W, Lee J, Menander K, Chada S, Gabrilovich D. Combination of p53 cancer vaccine with chemotherapy in patients with extensive stage small cell lung cancer. Clin Cancer Res. 2006 Feb;12(3 Pt1):878-887. Pubmedid: 16467102.   Pubmed ID: 16467102

27. Chen L, Ambrosone CB, Lee J, Sellers TA, Pow-Sang J, Park JY. Association between polymorphisms in the DNA repair genes XRCC1 and APE1, and the risk of prostate cancer in white and black Americans. J Urol. 2006 Jan;175(1):108-112. Pubmedid: 16406883.   Pubmed ID: 16406883

28. Diaz N, Minton S, Cox C, Bowman T, Gritsko T, Garcia R, Eweis I, Wloch M, Livingston S, Seijo E, Cantor A, Lee JH, Beam CA, Sullivan D, Jove R, Muro-Cacho CA. Activation of stat3 in primary tumors from high-risk breast cancer patients is associated with elevated levels of activated SRC and survivin expression. Clin Cancer Res. 2006 Jan;12(1):20-28. Pubmedid: 16397019.   Pubmed ID: 16397019

29. Fay M, Lee J. Measuring agreement between two statistics with applications to age-standardization. J Royal Stat Soc Series A. 2006;160:1-16. Pubmedid: NOPMID.  

30. Gritsko T, Williams A, Turkson J, Kaneko S, Bowman T, Huang M, Nam S, Eweis I, Diaz N, Sullivan D, Yoder S, Enkemann S, Eschrich S, Lee J, Beam C, ChengJ, Minton S, Muro-Cacho C, Jove R. Persistent activation of stat3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells. Clin Cancer Res. 2006 Jan;12(1):11-19. Pubmedid: 16397018.   Pubmed ID: 16397018

31. Lee J, Qaqish B. A latent change point model using a generalized estimating equations approach. Comm In Stat. 2006;34:1233-1242. Pubmedid: NOPMID.  

32. Park J, Chen L, Ratnashinge L, Sellers T, Tanner J, Lee J, Dossett N, Lang N, Kadlubar F, Ambrosone C, Zachariah B, Heysek R, Patterson S, Pow-SangJ. Deletion polymorphism of UDP-glucuronosyltransferase 2B17 and risk of prostate cancer in African American and Caucasian men. Cancer Epidemiol Biomarkers Prev. 2006 Aug;15(8):1473-1478. Pubmedid: 16896035.   Pubmed ID: 16896035

33. Hensing T, Schell M, Lee J, Socinski M. Factors associated with the likelihood of receiving second line therapy for advanced non-small cell lung cancer. Lung Cancer. 2005 Feb;47(2):253-259. Pubmedid: 15639724.   Pubmed ID: 15639724

34. Nam S, Kim D, Cheng JQ, Zhang S, Lee JH, Buettner R, Mirosevich J, Lee FY, Jove R. Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells. Cancer Res. 2005 Oct;65(20):9185-9189. Pubmedid: 16230377.   Pubmed ID: 16230377

35. Park J, Chen L, Lee J, Sellers T, Tockman M. Polymorphisms in the promoter region of neutrophil elastase gene and lung cancer risk. Lung Cancer. 2005 Jun;48(3):315-321. Pubmedid: 15892999.   Pubmed ID: 15892999

36. Lee J, Qaqiah B. Modified GEE and Goodness-of-Marginal-Fit (GOMF) tests with correlated binary responses for contingency tables. Biomet J. 2004;46:675-686. Pubmedid: NOPMID.  

37. Hensing T, Peterman A, Schell M, Lee J, Socinski M. The impact of age on toxicity, response rate, quality of life, and survival in patients with advanced, Stage IIIB or IV nonsmall cell lung carcinoma treated with carboplatin and paclitaxel. Cancer. 2003;98(4):779-788. Pubmedid: 12910523.   Pubmed ID: 12910523

38. Olivier K, Weber D, Lee J, Handler A, Tudor G, Molina P, Tomashefski J, Knowles M. Nontuberculous mycobacteria. II: nested-cohort study of impact on cystic fibrosis lung disease. Am J Respir Crit Care Med. 2003;167(6):835-840. Pubmedid: 12433669.   Pubmed ID: 12433669

39. Olivier KN, Weber DJ, Wallace RJ, Faiz AR, Lee JH, Zhang Y, Brown-Elliot BA, Handler A, Wilson RW, Schechter MS, Edwards LJ, Chakraborti S, Knowles MR. Nontuberculous mycobacteria. I: multicenter prevalence study in cystic fibrosis. Am J Respir Crit Care Med. 2003 Mar;167(6):828-834. Pubmedid: 12433668.   Pubmed ID: 12433668

40. Socinski MA, Neubauer MA, Olivares J, Ketchel S, Tynan M, Moore M, Lee JH, Davis K, Schell M, Garfield D. Phase II trial of paclitaxel, ifosfamide, and carboplatin in extensive-stage small cell lung cancer. Lung Cancer. 2003 Apr;40(1):91-97. Pubmedid: 12660013.   Pubmed ID: 12660013

41. Socikski M, Schell M, Peterman A, Bakri K, Yates S, Gitten R, Unger P, Lee J, Lee J, et al.. Phase III trial comparing a defined duration of therapy versus continuous therapy followed by second-line therapy in advanced-stage IIIB/IV non-small-cell lung cancer. J Clin Oncol. 2002;20(5):1335-1343. Pubmedid: 11870177.   Pubmed ID: 11870177

42. Socinski M, Schell M, Bakri K, Peterman A, Lee J, et al.. Second-line, low-dose, weekly paclitaxel in patients with stage IIIB/IV nonsmall cell lung carcinoma who fail first-line chemotherapy with carboplatin plus paclitaxel. Cancer. 2002;95(6):1265-1273. Pubmedid: 12216094.   Pubmed ID: 12216094

43. Daley EM, Buhi ER, Baldwin J, Lee JH, Vadaparampil S, Abrahamsen M, Vamos CA, Kolar S, Chandler R, Anstey EH, Giuliano A. Men's responses to HPV test results: development of a theory-based survey. Am J Health Behav. 33(6):728-744. Pubmedid: 19320621.   Pubmed ID: 19320621