H. Lee Moffitt Cancer Center & Research Institute

Faculty Rank:

Assistant Member

USF Affiliations/College Department:

• Medicine / Oncologic Sciences

Research Interests:

My research focuses on the development of statistical methods and computational tools for large-scale genomics and proteomics data. I am particularly interested in 1) developing statistical methods to incorporate multiple data sources, select biologically relevant markers, and predict clinical outcomes in an integrated manner, and 2) devising novel statistics to quantify multi-scale and nonlinear correlation, which cannot be detected using traditional linear methods.

Publications:

1. Chen X, Bai F, Sokol L, Zhou J, Ren A, Painter JS, Liu J, Sallman DA, Chen YA, Yoder JA, Djeu JY, Loughran TP J, Epling-Burnette PK, Wei S. A critical role for DAP10 and DAP12 in CD8+ T cell-mediated tissue damage in large granular lymphocyte leukemia. Blood. 2009 Apr;113(4):3226-3234. Pubmedid: 19075187.   Pubmed ID: 19075187

2. Hosako H, Martin GS, Barrier M, Chen YA, Ivanov IV, Mirkes PE. Gene and microRNA expression in p53-deficient day 8.5 mouse embryos. Birth Defects Res A Clin Mol Teratol. 2009 Feb;. Pubmedid: 19229884.   Pubmed ID: 19229884

3. Jenny M, Chapman R, Mancia A, Chen Y, Warr G, et al. A cDNA microarray for Crassostrea virginica and C. gigas. Marine Biotechnology. 2007;1:15-15.  

4. Mancia A, Lundqvist M, Romano T, Peden-Adams M, Fair P, Kindy M, EllisBC, Gattoni-Celli S, McKillen D, Trent H, Chen Y, Almeida J, Gross P, Chapman R, Warr G. A dolphin peripheral blood leukocyte cDNA microarray for studies of immune function and stress reactions. Dev Comp Immunol. 2007;31(5):520-529. Pubmedid: 17084893.   Pubmed ID: 17084893

5. Robalino J, Almeida J, McKillen D, Colglazier J, Trent HF 3rd, Chen Y, PeckME, Browdy C, Chapman R, Warr G, Gross P. Insights into the immune transcriptome of the shrimp Litopenaeus vannamei: tissue-specific expression profiles and transcriptomic responses to immune challenge. Physiol Genomics. 2007 Mar;29(1):44-56. Pubmedid: 17148689.   Pubmed ID: 17148689

6. Chen Y, Chou C, Lu X, Slate E, Peck K, Xu W, Voit E, Almeida J. A multivariate prediction model for microarray cross-hybridization. Bmc Bioinformatics. 2006 Mar;7:101-101. Pubmedid: 16509965.   Pubmed ID: 16509965

7. Almeida J, McKillen D, Chen Y, Gross P, Chapman R, Warr G. Design and calibration of microarrays as universal transcriptomic environmentalbiosensors. Comp Funct Genomics. 2005;6(3):132-137. Pubmedid: 18629225.   Pubmed ID: 18629225

8. McKillen D, Chen Y, Chen C, Jenny M, Trent HF 3rd, Robalino J, McLean DCJr, Gross P, Chapman R, Warr G, Almeida J. Marine genomics: a clearing-house for genomic and transcriptomic data of marineorganisms. Bmc Genomics. 2005 Mar;6(1):34-34. Pubmedid: 15760464.   Pubmed ID: 15760464

9. Chen Y, McKillen D, Wu S, Jenny M, Chapman R, Gross P, Warr G, AlmeidaJS. Optimal cDNA microarray design using expressed sequence tags for organisms with limited genomic information. Bmc Bioinformatics. 2004 Dec;5(1):191-191. Pubmedid: 15585062.   Pubmed ID: 15585062

10. Wenner E, Sanger D, Arendt M, Holland F, Chen Y. Variability in dissolved oxygen and other water quality variables within the National Estuarine Research Reserve System. Journal Of Coastal Research. 2004;45:17-38. Pubmedid: noPMID.