Jesus Gonzalez Bosquet, MD, PhD

BOARD CERTIFICATION:
          •  Gynecologic Oncology

FELLOWSHIP:
          •  Mayo Clinic Rochester - Gynecologic Oncology

RESIDENCY:
          •  Mayo Clinic Rochester - Obstetrics and Gynecology
          •  Autonomous University of Barcelona - Obstetrics and Gynecology

MEDICAL SCHOOL:
          •  Medical School of the University of Barcelona - MD

• Marchion DC, Bicaku E, Xiong Y, Zgheib NB, Al Sawah E, Stickles XB, Judson PL, Lopez AS, Cubitt CL, Gonzalez-Bosquet J, Wenham RM, Apte SM, Berglund A, Lancaster JM. A novel c-Met inhibitor, MK8033, synergizes with carboplatin plus paclitaxel to inhibit ovarian cancer cell growth. Oncol Rep. 2013 May;29(5):2011-2018. Pubmedid: 23467907.


• Teefey P, Zgheib NB, Apte SM, Gonzalez-Bosquet J, Judson PL, Roberts WS, Lancaster JM, Wenham RM. Factors associated with improved toxicity and tolerability of intraperitoneal chemotherapy in advanced-stage epithelial ovarian cancers. Am J Obstet Gynecol. 2013 Mar;208(6):501.e1-501.e7. Pubmedid: 23507546.


• Bansal N, Marchion DC, Bicaku E, Xiong Y, Chen N, Stickles XB, Sawah EA, Wenham RM, Apte SM, Gonzalez-Bosquet J, Judson PL, Hakam A, Lancaster JM. BCL2 antagonist of cell death kinases, phosphatases, and ovarian cancer sensitivity to cisplatin. J Gynecol Oncol. 2012 Aug;23(1):35-42. Pubmedid: 22355465. Pmcid: PMC3280065.


• Zgheib NB, Xiong Y, Marchion DC, Bicaku E, Chon HS, Stickles XB, Sawah EA, Judson PL, Hakam A, Gonzalez-Bosquet J, Wenham RM, Apte SM, Cubitt CL, Chen DT, Lancaster JM. The O-glycan pathway is associated with in vitro sensitivity to gemcitabine and overall survival from ovarian cancer. Int J Oncol. 2012 Aug;41(1):179-188. Pubmedid: 22552627.


• Bicaku E, Xiong Y, Marchion DC, Chon HS, Stickles XB, Chen N, Judson PL, Hakam A, Gonzalez-Bosquet J, Wenham RM, Apte SM, Fulp W, Cubitt CL, Chen DT, Lancaster JM. In vitro analysis of ovarian cancer response to cisplatin, carboplatin, and paclitaxel identifies common pathways that are also associated with overall patient survival. Br J Cancer. 2012 Aug;106(12):1967-1975. Pubmedid: 22596241. Pmcid: PMC3388569.


• Judson PL, Al Sawah E, Marchion DC, Xiong Y, Bicaku E, Zgheib NB, Chon HS, Stickles XB, Hakam A, Wenham RM, Apte SM, Gonzalez-Bosquet J, Chen DT, Lancaster JM. Characterizing the efficacy of fermented wheat germ extract against ovarian cancer and defining the genomic basis of its activity. Int J Gynecol Cancer. 2012 Jul;22(6):960-967. Pubmedid: 22740002.


• Lee P, Fu YP, Figueroa JD, Prokunina-Olsson L, Gonzalez-Bosquet J, Kraft P, Wang Z, Jacobs KB, Yeager M, Horner MJ, Hankinson SE, Hutchinson A, Chatterjee N, Garcia-Closas M, Ziegler RG, Berg CD, Buys SS, McCarty CA, Feigelson HS, Thun MJ, Diver R, Prentice R, Jackson R, Kooperberg C, Chlebowski R, Lissowska J, Peplonska B, Brinton LA, Tucker M, Fraumeni JF, Hoover RN, Thomas G, Hunter DJ, Chanock SJ. Fine mapping of 14q24.1 breast cancer susceptibility locus. Hum Genet. 2012 Mar;131(3):479-490. Pubmedid: 21959381.


• Permuth-Wey J, Chen Z, Tsai YY, Lin HY, Chen YA, Barnholtz-Sloan J, Birrer MJ, Chanock SJ, Cramer DW, Cunningham JM, Fenstermacher D, Fridley BL, Garcia-Closas M, Gayther SA, Gentry-Maharaj A, Gonzalez-Bosquet J, Iversen E, Jim H, McLaughlin J, Menon U, Narod SA, Phelan CM, Ramus SJ, Risch H, Song H, Sutphen R, Terry KL, Tyrer J, Vierkant RA, Wentzensen N, Lancaster JM, Cheng JQ, Berchuck A, Pharoah PD, Schildkraut JM, Goode EL, Sellers TA. MicroRNA processing and binding site polymorphisms are not replicated in the Ovarian Cancer Association Consortium. Cancer Epidemiol Biomarkers Prev. 2012 Feb;20(8):1793-1797. Pubmedid: 21636674. Pmcid: PMC3153581.


• Chon HS, Marchion DC, Xiong Y, Chen N, Bicaku E, Stickles XB, Zgheib NB, Judson PL, Hakam A, Gonzalez-Bosquet J, Wenham RM, Apte SM, Lancaster JM. The BCL2 antagonist of cell death pathway influences endometrial cancer cell sensitivity to cisplatin. Gynecol Oncol. 2012 Jan;124(1):119-124. Pubmedid: 22032837.


• Marchion DC, Cottrill HM, Xiong Y, Chen N, Bicaku E, Fulp WJ, Bansal N, Chon HS, Stickles XB, Kamath SG, Hakam A, Li L, Su D, Moreno C, Judson PL, Berchuck A, Wenham RM, Apte SM, Gonzalez-Bosquet J, Bloom GC, Eschrich SA, Sebti S, Chen DT, Lancaster JM. BAD phosphorylation determines ovarian cancer chemosensitivity and patient survival. Clin Cancer Res. 2011 Oct;17(19):6356-6366. Pubmedid: 21849418. Pmcid: PMC3186862.


• Permuth-Wey J, Kim D, Tsai YY, Lin HY, Chen YA, Barnholtz-Sloan J, Birrer MJ, Bloom G, Chanock SJ, Chen Z, Cramer DW, Cunningham JM, Dagne G, Ebbert-Syfrett J, Fenstermacher D, Fridley BL, Garcia-Closas M, Gayther SA, Ge W, Gentry-Maharaj A, Gonzalez-Bosquet J, Goode EL, Iversen E, Jim H, Kong W, McLaughlin J, Menon U, Monteiro AN, Narod SA, Pharoah PD, Phelan CM, Qu X, Ramus SJ, Risch H, Schildkraut JM, Song H, Stockwell H, Sutphen R, Terry KL, Tyrer J, Vierkant RA, Wentzensen N, Lancaster JM, Cheng JQ, Sellers TA. LIN28B polymorphisms influence susceptibility to epithelial ovarian cancer. Cancer Res. 2011 Sep;71(11):3896-3903. Pubmedid: 21482675. Pmcid: PMC3107389.


• Chung CC, Ciampa J, Yeager M, Jacobs KB, Berndt SI, Hayes RB, Gonzalez-Bosquet J, Kraft P, Wacholder S, Orr N, Yu K, Hutchinson A, Boland J, Chen Q, Feigelson HS, Thun MJ, Diver WR, Albanes D, Virtamo J, Weinstein S, Schumacher FR, Cancel-Tassin G, Cussenot O, Valeri A, Andriole GL, Crawford ED, Haiman CA, Henderson BE, Kolonel L, Le Marchand L, Siddiq A, Riboli E, Key TJ, Kaaks R, Isaacs WB, Isaacs SD, Gr?nberg H, Wiklund F, Xu J, Vatten LJ, Hveem K, Njolstad I, Gerhard DS, Tucker M, Hoover RN, Fraumeni JF, Hunter DJ, Thomas G, Chatterjee N, Chanock SJ. Fine mapping of a region of chromosome 11q13 reveals multiple independent loci associated with risk of prostate cancer. Hum Mol Genet. 2011 Jul;20(14):2869-2878. Pubmedid: 21531787. Pmcid: PMC3118760.


• Gonzalez Bosquet J, Peedicayil A, Maguire J, Chien J, Rodriguez GC, Whitaker R, Petitte JN, Anderson KE, Barnes HJ, Shridhar V, Cliby WA. Comparison of gene expression patterns between avian and human ovarian cancers. Gynecol Oncol. 2011 Feb;120(2):256-264. Pubmedid: 21093898.


• Gonzalez-Bosquet J, Calcei J, Wei JS, Garcia-Closas M, Sherman ME, Hewitt S, Vockley J, Lissowska J, Yang HP, Khan J, Chanock S. Detection of Somatic Mutations by High-Resolution DNA Melting (HRM) Analysis in Multiple Cancers. PLoS One. 2011;6(1):e14522. Pubmedid: 21264207.


• Yang HP, Gonzalez Bosquet J, Li Q, Platz EA, Brinton LA, Sherman ME, Lacey JV, Gaudet MM, Burdette LA, Figueroa JD, Ciampa JG, Lissowska J, Peplonska B, Chanock SJ, Garcia-Closas M. Common genetic variation in the sex hormone metabolic pathway and endometrial cancer risk: pathway-based evaluation of candidate genes. Carcinogenesis. 2010 May;31(5):827-833. Pubmedid: 20053928. Pmcid: PMC2864407.


• Gonzalez Bosquet J, Terstriep SA, Cliby WA, Brown-Jones M, Kaur JS, Podratz KC, Keeney GL. The impact of multi-modal therapy on survival for uterine carcinosarcomas. Gynecol Oncol. 2010 Mar;116(3):419-423. Pubmedid: 19896181.


• Chung CC, Magalhaes WC, Gonzalez-Bosquet J, Chanock SJ. Genome-wide association studies in cancer--current and future directions. Carcinogenesis. 2010 Jan;31(1):111-120. Pubmedid: 19906782. Pmcid: PMC2860704.


• Yeager M, Deng Z, Boland J, Matthews C, Bacior J, Lonsberry V, Hutchinson A, Burdett LA, Qi L, Jacobs KB, Gonzalez-Bosquet J, Berndt SI, Hayes RB, Hoover RN, Thomas G, Hunter DJ, Dean M, Chanock SJ. Comprehensive resequence analysis of a 97 kb region of chromosome 10q11.2 containing the MSMB gene associated with prostate cancer. Hum Genet. 2009 Dec;126(6):743-750. Pubmedid: 19644707. Pmcid: PMC2778717.


• Yeager M, Chatterjee N, Ciampa J, Jacobs KB, Gonzalez-Bosquet J, Hayes RB, Kraft P, Wacholder S, Orr N, Berndt S, Yu K, Hutchinson A, Wang Z, Amundadottir L, Feigelson HS, Thun MJ, Diver WR, Albanes D, Virtamo J, Weinstein S, Schumacher FR, Cancel-Tassin G, Cussenot O, Valeri A, Andriole GL, Crawford ED, Haiman CA, Henderson B, Kolonel L, Le Marchand L, Siddiq A, Riboli E, Key TJ, Kaaks R, Isaacs W, Isaacs S, Wiley KE, Gronberg H, Wiklund F, Stattin P, Xu J, Zheng SL, Sun J, Vatten LJ, Hveem K, Kumle M, Tucker M, Gerhard DS, Hoover RN, Fraumeni JF, Hunter DJ, Thomas G, Chanock SJ. Identification of a new prostate cancer susceptibility locus on chromosome 8q24. Nat Genet. 2009 Oct;41(10):1055-1057. Pubmedid: 19767755. Pmcid: PMC3430510.


• Chien J, Fan JB, Bell DA, April C, Klotzle B, Ota T, Lingle WL, Gonzalez Bosquet J, Shridhar V, Hartmann LC. Analysis of gene expression in stage I serous tumors identifies critical pathways altered in ovarian cancer. Gynecol Oncol. 2009 Jul;114(1):3-11. Pubmedid: 19410283.


• Thomas G, Jacobs KB, Kraft P, Yeager M, Wacholder S, Cox DG, Hankinson SE, Hutchinson A, Wang Z, Yu K, Chatterjee N, Garcia-Closas M, Gonzalez-Bosquet J, Prokunina-Olsson L, Orr N, Willett WC, Colditz GA, Ziegler RG, Berg CD, Buys SS, McCarty CA, Feigelson HS, Calle EE, Thun MJ, Diver R, Prentice R, Jackson R, Kooperberg C, Chlebowski R, Lissowska J, Peplonska B, Brinton LA, Sigurdson A, Doody M, Bhatti P, Alexander BH, Buring J, Lee IM, Vatten LJ, Hveem K, Kumle M, Hayes RB, Tucker M, Gerhard DS, Fraumeni JF, Hoover RN, Chanock SJ, Hunter DJ. A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1). Nat Genet. 2009 Jun;41(5):579-584. Pubmedid: 19330030. Pmcid: PMC2928646.


• Lou H, Yeager M, Li H, Bosquet JG, Hayes RB, Orr N, Yu K, Hutchinson A, Jacobs KB, Kraft P, Wacholder S, Chatterjee N, Feigelson HS, Thun MJ, Diver WR, Albanes D, Virtamo J, Weinstein S, Ma J, Gaziano JM, Stampfer M, Schumacher FR, Giovannucci E, Cancel-Tassin G, Cussenot O, Valeri A, Andriole GL, Crawford ED, Anderson SK, Tucker M, Hoover RN, Fraumeni JF, Thomas G, Hunter DJ, Dean M, Chanock SJ. Fine mapping and functional analysis of a common variant in MSMB on chromosome 10q11.2 associated with prostate cancer susceptibility. Proc Natl Acad Sci U S A. 2009 May;106(19):7933-7938. Pubmedid: 19383797. Pmcid: PMC2671324.


• Thomas G, Jacobs KB, Yeager M, Kraft P, Wacholder S, Orr N, Yu K, Chatterjee N, Welch R, Hutchinson A, Crenshaw A, Cancel-Tassin G, Staats BJ, Wang Z, Gonzalez-Bosquet J, Fang J, Deng X, Berndt SI, Calle EE, Feigelson HS, Thun MJ, Rodriguez C, Albanes D, Virtamo J, Weinstein S, Schumacher FR, Giovannucci E, Willett WC, Cussenot O, Valeri A, Andriole GL, Crawford ED, Tucker M, Gerhard DS, Fraumeni JF, Hoover R, Hayes RB, Hunter DJ, Chanock SJ. Multiple loci identified in a genome-wide association study of prostate cancer. Nat Genet. 2008 Mar;40(3):310-315. Pubmedid: 18264096.


• Gonzalez Bosquet J, Magrina JF, Magtibay PM, Gaffey TA, Cha SS, Jones MB, Podratz KC, Cliby WA. Patterns of inguinal groin metastases in squamous cell carcinoma of the vulva. Gynecol Oncol. 2007 Jun;105(3):742-746. Pubmedid: 17379281.


• Xiong Y, Dowdy SC, Gonzalez Bosquet J, Zhao Y, Eberhardt NL, Podratz KC, Jiang SW. Epigenetic-mediated upregulation of progesterone receptor B gene in endometrial cancer cell lines. Gynecol Oncol. 2005 Oct;99(1):135-141. Pubmedid: 16024066.


• Gonzalez Bosquet J, Magrina JF, Gaffey TA, Hernandez JL, Webb MJ, Cliby WA, Podratz KC. Long-term survival and disease recurrence in patients with primary squamous cell carcinoma of the vulva. Gynecol Oncol. 2005 Jun;97(3):828-833. Pubmedid: 15896831.


• Gonzalez Bosquet J, Keeney GL, Mariani A, Webb MJ, Cliby WA. Cytokeratin staining of resected lymph nodes may improve the sensitivity of surgical staging for endometrial cancer. Gynecol Oncol. 2003 Dec;91(3):518-525. Pubmedid: 14675670.


• Gonzalez Bosquet J, Kinney WK, Russell AH, Gaffey TA, Magrina JF, Podratz KC. Risk of occult inguinofemoral lymph node metastasis from squamous carcinoma of the vulva. Int J Radiat Oncol Biol Phys. 2003 Oct;57(2):419-424. Pubmedid: 12957253.


• Carley ME, Gonzalez Bosquet J, Stanhope CR. Small bowel obstruction associated with post-hysterectomy vaginal vault prolapse. Obstet Gynecol. 2003 Sep;102(3):524-526. Pubmedid: 12962936.


• Magrina JF, Gonzalez-Bosquet J, Weaver AL, Gaffey TA, Leslie KO, Webb MJ, Podratz KC. Squamous cell carcinoma of the vulva stage IA: long-term results. Gynecol Oncol. 2000 Jan;76(1):24-27. Pubmedid: 10620436.


• Magrina JF, Gonzalez-Bosquet J, Weaver AL, Gaffey TA, Webb MJ, Podratz KC, Cornella JL. Primary squamous cell cancer of the vulva: radical versus modified radical vulvar surgery. Gynecol Oncol. 1998 Oct;71(1):116-121. Pubmedid: 9784331.


• Gonz?lez-Bosquet E, Gonz?lez-Bosquet J, Garc?a Jim?nez A, Gil A, Xercavins J. Carcinoid tumor of the uterine corpus. A case report. J Reprod Med. 1998 Sep;43(9):844-846. Pubmedid: 9777628.


• Gil-Moreno A, Garcia-Jim?nez A, Gonz?lez-Bosquet J, Esteller M, Castellv?-Vives J, Mart?nez Palones JM, Xercavins J. Merkel cell carcinoma of the vulva. Gynecol Oncol. 1997 Mar;64(3):526-532. Pubmedid: 9062165.


• Castellv? Vives J, Garc?a Jim?nez A, Centeno Mediavilla C, Gil Moreno A, Hern?ndez de la Calle I, Gonz?lez-Bosquet J. Ectopic vaginal decidualization. An unusual finding that presents problems of differential diagnosis with carcinoma. Eur J Gynaecol Oncol. 1997;18(3):183-184. Pubmedid: 9174831.


• Gonz?lez-Bosquet E, Mart?nez-Palones JM, Gonz?lez-Bosquet J, Garc?a Jim?nez A, Xercavins J. Uterine sarcoma: a clinicopathological study of 93 cases. Eur J Gynaecol Oncol. 1997;18(3):192-195. Pubmedid: 9174834.


• Permuth-Wey J, Lawrenson K, Shen HC, Velkova A, Tyrer JP, Chen Z, Lin HY, Ann Chen Y, Tsai YY, Qu X, Ramus SJ, Karevan R, Lee J, Lee N, Larson MC, Aben KK, Anton-Culver H, Antonenkova N, Antoniou AC, Armasu SM, Bacot F, Baglietto L, Bandera EV, Barnholtz-Sloan J, Beckmann MW, Birrer MJ, Bloom G, Bogdanova N, Brinton LA, Brooks-Wilson A, Brown R, Butzow R, Cai Q, Campbell I, Chang-Claude J, Chanock S, Chenevix-Trench G, Cheng JQ, Cicek MS, Coetzee GA, Cook LS, Couch FJ, Cramer DW, Cunningham JM, Dansonka-Mieszkowska A, Despierre E, Doherty JA, D?rk T, du Bois A, D?rst M, Easton DF, Eccles D, Edwards R, Ekici AB, Fasching PA, Fenstermacher DA, Flanagan JM, Garcia-Closas M, Gentry-Maharaj A, Giles GG, Glasspool RM, Gonzalez-Bosquet J, Goodman MT, Gore M, G?rski B, Gronwald J, Hall P, Halle MK, Harter P, Heitz F, Hillemanns P, Hoatlin M, H?gdall CK, H?gdall E, Hosono S, Jakubowska A, Jensen A, Jim H, Kalli KR, Karlan BY, Kaye SB, Kelemen LE, Kiemeney LA, Kikkawa F, Konecny GE, Krakstad C, Kr?ger Kjaer S, Kupryjanczyk J, Lambrechts D, Lambrechts S, Lancaster JM, Le ND, Leminen A, Levine DA, Liang D, Kiong Lim B, Lin J, Lissowska J, Lu KH, Lubi?ski J, Lurie G, Massuger LF, Matsuo K, McGuire V, McLaughlin JR, Menon U, Modugno F, Moysich KB, Nakanishi T, Narod SA, Nedergaard L, Ness RB, Nevanlinna H, Nickels S, Noushmehr H, Odunsi K, Olson SH, Orlow I, Paul J, Pearce CL, Pejovic T, Pelttari LM, Pike MC, Poole EM, Raska P, Renner SP, Risch HA, Rodriguez-Rodriguez L, Anne Rossing ...

Dr. Gonzalez is a gynecologic oncologist in The Center for Women’s Oncology at the Moffitt Cancer Center. Dr. Gonzalez is interested in the genetics of cancer and was the first physician to receive a scholarship from the Gynecologic Cancer Foundation and National Cancer Institute to pursue this field of study at the National Institutes of Health.

Dr. Gonzales believes that the future of cancer treatment lies in prevention. Discoveries in genetics research will pave the way for preventive measures that help reduce or eliminate gyn cancers in women.

A native of Spain, Dr. Gonzalez received his medical degree from one of the oldest medical schools in Europe, which was founded in 1450. Following his residency and a Ph.D., he came to the Mayo Clinic to complete a gynecologic surgery fellowship and conduct research into vulvar cancer.

Dr. Gonzalez was then in private practice as a gynecologist oncologist in Spain for five years before returning to the U.S. He completed a second residency and fellowship at the Mayo Clinic, as well as completing a master’s degree in biomedical sciences.

Dr. Gonzalez encourages his patients to be proactive about all aspects of their treatment, from quality of care issues to asking about clinical trials that might be beneficial.

Dr. Gonzalez is fluent in Spanish and Catalan.

In addition to seeing patients at Moffitt Cancer Center in the USF area, he sees patients at the Moffitt Medical Group office on MacDill Avenue in West Tampa and operates at Moffitt Cancer Center, St. Joseph's Women's Hospital and Florida Hospital Tampa.