Jonathan S. Zager, MD

BOARD CERTIFICATION:
          •  Surgery

FELLOWSHIP:
          •  University of Texas, M.D. Anderson Cancer Center - Administrative Fellow
          •  University of Texas, M.D. Anderson Cancer Center - Surgical Oncology
          •  Memorial-Sloan Kettering Cancer Center - Hepatobiliary Oncology Laboratory

RESIDENCY:
          •  Montefiore Medical Center - Albert Einstein College of Medicine - Department of Surgery

MEDICAL SCHOOL:
          •  Sackler School of Medicine - New York State American Program - MD

• Deneve JL, Turaga KK, Marzban SS, Puleo CA, Sarnaik AA, Gonzalez RJ, Sondak VK, Zager JS. Single-institution Outcome Experience Using AlloDerm? as Temporary Coverage or Definitive Reconstruction for Cutaneous and Soft Tissue Malignancy Defects. Am Surg. 2013 May;79(5):476-482. Pubmedid: 23635582.


• Wong J, Chen YA, Fisher KJ, Zager JS. Isolated limb infusion in a series of over 100 infusions: a single-center experience. Ann Surg Oncol. 2013 Apr;20(4):1121-1127. Pubmedid: 23456376.


• Gibney GT, Zager JS. Clinical development of dabrafenib in BRAF mutant melanoma and other malignancies. Expert Opin Drug Metab Toxicol. 2013 Apr. Pubmedid: 23621583.


• Farma JM, Zager JS, Barnica-Elvir V, Puleo CA, Marzban SS, Rollison DE, Messina JL, Sondak VK. A collision of diseases: chronic lymphocytic leukemia discovered during lymph node biopsy for melanoma. Ann Surg Oncol. 2013 Apr;20(4):1360-1364. Pubmedid: 23179994.


• Anic GM, Sondak VK, Messina JL, Fenske NA, Zager JS, Cherpelis BS, Lee JH, Fulp WJ, Epling-Burnette PK, Park JY, Rollison DE. Telomere length and risk of melanoma, squamous cell carcinoma, and basal cell carcinoma. Cancer Epidemiol. 2013 Mar. Pubmedid: 23523330.


• Sondak VK, King DW, Zager JS, Schneebaum S, Kim J, Leong SP, Faries MB, Averbook BJ, Martinez SR, Puleo CA, Messina JL, Christman L, Wallace AM. Combined Analysis of Phase III Trials Evaluating [(99m)Tc]Tilmanocept and Vital Blue Dye for Identification of Sentinel Lymph Nodes in Clinically Node-Negative Cutaneous Melanoma. Ann Surg Oncol. 2013 Feb;20(2):680-688. Pubmedid: 23054107.


• Han D, Zager JS, Yu D, Zhao X, Walls B, Marzban SS, Rao NG, Sondak VK, Messina JL. Desmoplastic Melanoma: Is There a Role for Sentinel Lymph Node Biopsy?. Ann Surg Oncol. 2013 Feb. Pubmedid: 23389470.


• Vohra NA, Turaga KK, Gonzalez RJ, Conley A, Reed D, Bui MM, Cheong D, Letson DG, Zager JS. The use of isolated limb infusion in limb threatening extremity sarcomas. Int J Hyperthermia. 2013;29(1):1-7. Pubmedid: 23205633.


• Deneve JL, Choi J, Gonzalez RJ, Conley AP, Stewart S, Han D, Werner P, Chaudhry TA, Zager JS. Chemosaturation with percutaneous hepatic perfusion for unresectable isolated hepatic metastases from sarcoma. Cardiovasc Intervent Radiol. 2012 Dec;35(6):1480-1487. Pubmedid: 22699779.


• de la Fuente SG, Deneve JL, Parsons CM, Zager JS, Conley AP, Gonzalez RJ. A comparison between patients with gastrointestinal stromal tumours diagnosed with isolated liver metastases and liver metastases plus sarcomatosis. HPB (Oxford). 2012 Dec. Pubmedid: 23458233.


• Beasley GM, Sharma K, Wong J, Miller M, Turley RS, Lidsky M, Masoud M, Dewhirst MW, Mosca PJ, Zager JS, Tyler DS. A multi-institution experience comparing the clinical and physiologic differences between upper extremity and lower extremity melphalan-based isolated limb infusion. Cancer. 2012 Dec;118(24):6136-6143. Pubmedid: 22674423.


• Han D, Zager JS, Han G, Marzban SS, Puleo CA, Sarnaik AA, Reed D, Messina JL, Sondak VK. The unique clinical characteristics of melanoma diagnosed in children. Ann Surg Oncol. 2012 Nov;19(12):3888-3895. Pubmedid: 22864798.


• Leong SP, Mihm MC, Murphy GF, Hoon DS, Kashani-Sabet M, Agarwala SS, Zager JS, Hauschild A, Sondak VK, Guild V, Kirkwood JM. Progression of cutaneous melanoma: implications for treatment. Clin Exp Metastasis. 2012 Oct;29(7):775-796. Pubmedid: 22892755.


• Leong SP, Mihm MC, Murphy GF, Hoon DS, Kashani-Sabet M, Agarwala SS, Zager JS, Hauschild A, Sondak VK, Guild V, Kirkwood JM. Erratum to: Progression of cutaneous melanoma: implications for treatment. Clin Exp Metastasis. 2012 Oct;29(7):797-799. Pubmedid: 23053741.


• Pilon-Thomas S, Kuhn L, Ellwanger S, Janssen W, Royster E, Marzban S, Kudchadkar R, Zager J, Gibney G, Sondak VK, Weber J, Mul? JJ, Sarnaik AA. Efficacy of Adoptive Cell Transfer of Tumor-infiltrating Lymphocytes After Lymphopenia Induction for Metastatic Melanoma. J Immunother. 2012 Oct;35(8):615-620. Pubmedid: 22996367.


• Sondak VK, Zager JS, Messina JL. Primary tumor thickness as a prognostic factor in merkel cell carcinoma: the next big thing?. Ann Surg Oncol. 2012 Oct;19(11):3307-3309. Pubmedid: 22825775.


• Han D, Yu D, Zhao X, Marzban SS, Messina JL, Gonzalez RJ, Wayne Cruse C, Sarnaik AA, Puleo C, Sondak VK, Zager JS. Sentinel Node Biopsy is Indicated for Thin Melanomas??0.76?mm. Ann Surg Oncol. 2012 Oct;19(11):3335-3342. Pubmedid: 22766986.


• Beasley GM, Parsons C, Broadwater G, Selim MA, Marzban S, Abernethy AP, Salama AK, Eikman EA, Wong T, Zager JS, Tyler DS. A multicenter prospective evaluation of the clinical utility of F-18 FDG-PET/CT in patients with AJCC stage IIIB or IIIC extremity melanoma. Ann Surg. 2012 Aug;256(2):350-356. Pubmedid: 22691370.


• Deneve JL, Messina JL, Marzban SS, Gonzalez RJ, Walls BM, Fisher KJ, Ann Chen Y , Wayne Cruse C, Sondak VK, Zager JS. Merkel cell carcinoma of unknown primary origin. Ann Surg Oncol. 2012 Jul;19(7):2360-2366. Pubmedid: 22271206.


• Chai CY, Deneve JL, Beasley GM, Marzban SS, Chen YA, Rawal B, Grobmyer SR, Hochwald SN, Tyler DS, Zager JS. A Multi-institutional Experience of Repeat Regional Chemotherapy for Recurrent Melanoma of Extremities. Ann Surg Oncol. 2012 May;19(5):1637-1643. Pubmedid: 22143576.


• Chai CY, Zager JS, Szabunio MM, Marzban SS, Chau A, Rossi RM, Sondak VK. Preoperative Ultrasound is Not Useful for Identifying Nodal Metastasis in Melanoma Patients Undergoing Sentinel Node Biopsy: Preoperative Ultrasound in Clinically Node-Negative Melanoma. Ann Surg Oncol. 2012 Apr;19(4):1100-1106. Pubmedid: 22193886.


• Deneve JL, Zager JS. Isolated regional therapy for advanced extremity soft tissue sarcomas. Surg Oncol Clin N Am. 2012 Apr;21(2):287-299. Pubmedid: 22365520.


• Mills OL, Marzban S, Zager JS, Sondak VK, Messina JL. Sentinel node biopsy in atypical melanocytic neoplasms in childhood: a single institution experience in 24 patients. J Cutan Pathol. 2012 Mar;39(3):331-336. Pubmedid: 22335592.


• Parsons CM, Pimiento JM, Cheong D, Marzban SS, Gonzalez RJ, Johnson D, Letson GD, Zager JS. The role of radical amputations for extremity tumors: a single institution experience and review of the literature. J Surg Oncol. 2012 Feb;105(2):149-155. Pubmedid: 21837679.


• Finkelstein SE, Iclozan C, Bui MM, Cotter MJ, Ramakrishnan R, Ahmed J, Noyes DR, Cheong D, Gonzalez RJ, Heysek RV, Berman C, Lenox BC, Janssen W, Zager JS, Sondak VK, Letson GD, Antonia SJ, Gabrilovich DI. Combination of external beam radiotherapy (EBRT) with intratumoral injection of dendritic cells as neo-adjuvant treatment of high-risk soft tissue sarcoma patients. Int J Radiat Oncol Biol Phys. 2012 Feb;82(2):924-932. Pubmedid: 21398051.


• Ettinger DS, Agulnik M, Cates JM, Cristea M, Denlinger CS, Eaton KD, Fidias PM, Gierada D, Gockerman JP, Handorf CR, Iyer R, Lenzi R, Phay J, Rashid A, Saltz L, Shulman LN, Smerage JB, Varadhachary GR, Zager JS, Zhen WK. Occult primary. J Natl Compr Canc Netw. 2011 Dec;9(12):1358-1395. Pubmedid: 22157556.


• Zager JS, Puleo CA, Sondak VK. Erratum to: What is the Significance of the In Transit or Interval Sentinel Node in Melanoma?. Ann Surg Oncol. 2011 Dec;18 Suppl 3:317-318. Pubmedid: 22048634.


• Zager JS, Puleo CA, Sondak VK. What is the Significance of the In Transit or Interval Sentinel Node in Melanoma?. Ann Surg Oncol. 2011 Nov;18(12):3232-3234. Pubmedid: 21837524.


• Han D, Beasley GM, Tyler DS, Zager JS. Minimally invasive intra-arterial regional therapy for metastatic melanoma: isolated limb infusion and percutaneous hepatic perfusion. Expert Opin Drug Metab Toxicol. 2011 Nov;7(11):1383-1394. Pubmedid: 21978383.


• Marcum CB, Zager JS, B?longie IP, Messina JL, Fenske NA. Profound proliferating angiolymphoid hyperplasia with eosinophilia of pregnancy mimicking angiosarcoma. Cutis. 2011 Sep;88(3):122-128. Pubmedid: 22017064.


• Mullinax JE, Zager JS, Gonzalez RJ. Current diagnosis and management of retroperitoneal sarcoma. Cancer Control. 2011 Jul;18(3):177-187. Pubmedid: 21666580.


• Turaga KK, Beasley GM, Kane JM, Delman KA, Grobmyer SR, Gonzalez RJ, Letson GD, Cheong D, Tyler DS, Zager JS. Limb preservation with isolated limb infusion for locally advanced nonmelanoma cutaneous and soft-tissue malignant neoplasms. Arch Surg. 2011 Jul;146(7):870-875. Pubmedid: 21768436.


• Cheong D, Gonzalez RJ, Zager JS. Strategies for solutions in sarcoma management. Cancer Control. 2011 Jul;18(3):148-149. Pubmedid: 21666576.


• Zager JS, Rollison DE, Messina J. Prognostication in Merkel cell carcinoma. Expert Rev Anticancer Ther. 2011 May;11(5):665-667. Pubmedid: 21554038.


• Zager JS, Hochwald SN, Marzban SS, Francois R, Law KM, Davis AH, Messina JL, Vincek V, Mitchell C, Church A, Copeland EM, Sondak VK, Grobmyer SR. Shave biopsy is a safe and accurate method for the initial evaluation of melanoma. J Am Coll Surg. 2011 Apr;212(4):454-460. Pubmedid: 21463767.


• Beasley GM, Riboh JC, Augustine CK, Zager JS, Hochwald SN, Grobmyer SR, Peterson B, Royal R, Ross MI, Tyler DS. Prospective multicenter phase II trial of systemic ADH-1 in combination with melphalan via isolated limb infusion in patients with advanced extremity melanoma. J Clin Oncol. 2011 Mar;29(9):1210-1215. Pubmedid: 21343562.


• Santillan AA, Zager JS. Isolated limb infusion for melanoma: a less morbid alternative to hyperthermic isolated limb perfusion in the US. Expert Opin Drug Metab Toxicol. 2010 Sep;6(9):1033-1037. Pubmedid: 20078252.


• Chu CK, Zager JS, Marzban SS, Gimbel MI, Murray DR, Hestley AC, Messina JL, Sondak VK, Carlson GW, Delman KA. Routine biopsy of Cloquet's node is of limited value in sentinel node positive melanoma patients. J Surg Oncol. 2010 Sep;102(4):315-320. Pubmedid: 20740592.


• Farma JM, Ammori JB, Zager JS, Marzban SS, Bui MM, Bichakjian CK, Johnson TM, Lowe L, Sabel MS, Wong SL, Letson GD, Messina JL, Cimmino VM, Sondak VK. Dermatofibrosarcoma protuberans: how wide should we resect?. Ann Surg Oncol. 2010 Aug;17(8):2112-2118. Pubmedid: 20354798.


• Feeney K, Maguire HC, McClay EF, Sato T, Sondak VK, Toporcer M, Zager JS. Surgically unresectable regional melanoma metastases in a patient with renal failure and peripheral vascular disease: are there safe and potentially effective treatments?. Semin Oncol. 2010 Aug;37(4):303-313. Pubmedid: 20816500.


• Sondak VK, Zager JS. Who is to blame for false-negative sentinel node biopsies in melanoma?. Ann Surg Oncol. 2010 Mar;17(3):670-673. Pubmedid: 19953329. Pmcid: PMC2820671.


• Zager JS, Delman KA. Commentary on pharmacotherapy of regional melanoma therapy. Expert Opin Pharmacother. 2010 Jan;11(1):1-3. Pubmedid: 20001424.


• Zager JS, Brodsky S, Berman CG. Imaging of Merkel cell carcinoma. Curr Probl Cancer. 2010 Jan;34(1):65-76. Pubmedid: 20371075.


• Gonzalez RJ, Padhya TA, Cherpelis BS, Prince MD, Aya-Ay ML, Sondak VK, Cruse CW, Zager JS. The surgical management of primary and metastatic Merkel cell carcinoma. Curr Probl Cancer. 2010 Jan-Feb;34(1):77-96. Pubmedid: 20371076.


• Sarnaik AA, Zager JS, Cox LE, Ochoa TM, Messina JL, Sondak VK. Routine Omission of Sentinel Lymph Node Biopsy for Merkel Cell Carcinoma <= 1 cm Is Not Justified. J Clin Oncol. 2010 Jan;28(1):e7-e7. Pubmedid: 19933899.


• Santillan AA, Messina JL, Marzban SS, Crespo G, Sondak VK, Zager JS. Pathology review of thin melanoma and melanoma in situ in a multidisciplinary melanoma clinic: impact on treatment decisions. J Clin Oncol. 2010 Jan;28(3):481-486. Pubmedid: 20008627.


• McCardle TW, Sondak VK, Zager J, Messina JL. Merkel cell carcinoma: pathologic findings and prognostic factors. Curr Probl Cancer. 2010 Jan-Feb;34(1):47-64. Pubmedid: 20371074.


• Santillan AA, Delman KA, Beasley GM, Mosca PJ, Hochwald SN, Grobmyer SR, Andtbacka RH, Noyes RD, Kane JM, Ross MI, Tyler DS, Zager JS. Predictive Factors of Regional Toxicity and Serum Creatine Phosphokinase Levels After Isolated Limb Infusion for Melanoma: A Multi-Institutional Analysis. Ann Surg Oncol. 2009 Sep;16(9):2570-2578. Pubmedid: 19543771.


• Phan GQ, Messina JL, Sondak VK, Zager JS. Sentinel lymph node biopsy for melanoma: indications and rationale. Cancer Control. 2009 Jul;16(3):234-239. Pubmedid: 19556963.


• Sarnaik AA, Puleo CA, Zager JS, Sondak VK. Limiting the morbidity of inguinal lymphadenectomy for metastatic melanoma. Cancer Control. 2009 Jul;16(3):240-247. Pubmedid: 19556964.


• Zager JS, Weber JS. Melanoma: promising new discoveries and treatment modalities for difficult clinical scenarios - part II. Cancer Control. 2009 Jul;16(3):196-197. Pubmedid: 19556959.


• M?ller MG, Pappas-Politis E, Zager JS, Santiago LA, Yu D, Prakash A, Kinal A, Clark GS, Zhu W, Puleo CA, Glass LF, Messina JL, Sondak VK, Cruse CW. Surgical management of melanoma-in-situ using a staged marginal and central excision technique. Ann Surg Oncol. 2009 Jun;16(6):1526-1536. Pubmedid: 19050971.


• Beasley GM, Caudle A, Petersen RP, McMahon NS, Padussis J, Mosca PJ, Zager JS, Hochwald SN, Grobmyer SR, Delman KA, Andtbacka RH, Noyes RD, Kane JM, Seigler H, Pruitt SK, Ross MI, Tyler DS. A multi-institutional experience of isolated limb infusion: defining response and toxicity in the US. J Am Coll Surg. 2009 May;208(5):706-715. Pubmedid: 19476821.


• Melis M, Zager J, Sondak V. Multimodality management of desmoid tumors: how important is a negative surgical margin. J Surg Oncol. 2008 Dec;98(8):594-602. Pubmedid: 19072851.


• Ettinger DS, Agulnik M, Cristea M, Eaton K, Fidias PM, Gockerman JP, Hameed O, Handorf C, Harris EI, Jacobs CD, Javle M, Khushalani NI, Kvols L, Lenzi R, Lewis NL, Rashid A, Saltz L, Shulman LN, Zager JS, Zhen W. Occult primary. J Natl Compr Canc Netw. 2008 Nov;6(10):1026-1060. Pubmedid: 19176200.


• Zager J, Bui M, Farma J, Messina J, Sondak V. Proper margins of excision in dermatofibrosarcoma protuberans: wide or narrow?. Ann Surg Oncol. 2008 Sep;15(9):2614-2616. Pubmedid: 18452044.


• Gimbel M, Delman K, Zager J. Therapy for unresectable recurrent and in-transit extremity melanoma. Cancer Control. 2008 Jul;15(3):225-232. Pubmedid: 18596674.


• Zager J, Daud A. Melanoma: promising new discoveries and treatment modalities for difficult clinical scenarios. Cancer Control. 2008 Jul;15(3):192-194. Pubmedid: 18596670.


• McLoughlin J, Zager J, Sondak V, Berk L. Treatment options for limited or symptomatic metastatic melanoma. Cancer Control. 2008 Jul;15(3):239-247. Pubmedid: 18596676.


• Moller M, Lewis J, Dessureault S, Zager J. Toxicities associated with hyperthermic isolated limb perfusion and isolated limb infusion in the treatment of melanoma and sarcoma. Int J Hyperthermia. 2008 May;24(3):275-289. Pubmedid: 18393005.


• Sarnaik AA, Zager JS, Sondak VK. Multidisciplinary management of special melanoma situations: oligometastatic disease and bulky nodal sites. Curr Oncol Rep. 2007 Sep;9(5):417-427. Pubmedid: 17706171.


• McLoughlin J, Zager J, Sondak V. Cytoreductive surgery for melanoma. Surg Oncol Clin N Am. 2007 Jul;16(3):683-693. Pubmedid: 17606201.


• Gannon C, Zager J, Chang G, Feig B, Wood C, Skibber J, Rodriguez-BigasMA. Pelvic exenteration affords safe and durable treatment for locally advanced rectal carcinoma. Ann Surg Oncol. 2007 Jun;14(6):1870-1877. Pubmedid: 17406945.


• Sondak V, Zager J, Messina J, Thomas J. Sentinel lymph node biopsy as the standard of care for cutaneous melanoma. Clin Adv Hematol Oncol. 2007 Jun;5(6):483-490. Pubmedid: 17679922.


• Malhotra S, Kim T, Zager J, Bennett J, Ebright M, D'Angelica M, Fong Y. Use of an oncolytic virus secreting GM-CSF as combined oncolytic and immunotherapy for treatment of colorectal and hepatic adenocarcinomas. Surgery. 2007 Apr;141(4):520-529. Pubmedid: 17383529.


• Lin Y, Deavers M, Sasan F, Zager J, Ramondetta L. Clinical challenges presented by three simultaneous solid tumors. Gynecol Oncol. 2006 Dec;103(3):1159-1163. Pubmedid: 17055558.


• Khakpour N, Zager J, Yen T, Stephens T, Kuerer H, Singletary E, Ross M, Hunt K, Babiera G. The role of ultrasound in the surgical management of patients diagnosed with ductal carcinoma in situ of the breast. Breast J. 2006 May;12(3):212-215. Pubmedid: 16684318.


• Jarnagin W, Zager J, Hezel M, Stanziale S, Adusumilli P, Gonen M, EbrightMI, Culliford A, Gusani N, Fong Y. Treatment of cholangiocarcinoma with oncolytic herpes simplex virus combined with external beam radiation therapy. Cancer Gene Ther. 2006 Mar;13(3):326-334. Pubmedid: 16138120.


• Kaleya R, Heckman J, Most M, Zager J. Lymphatic mapping and sentinel node biopsy: a surgical perspective. Semin Nucl Med. 2005 Apr;35(2):129-134. Pubmedid: 15765375.


• Delman K, Zager J, Bhargava A, Petrowsky H, Malhotra S, Ebright M, BennettJJ, Gusani N, Kooby D, Roberts G, Fong Y. Effect of murine liver cell proliferation on herpes viral behavior: implications for oncolytic viral therapy. Hepatology. 2004 Jun;39(6):1525-1532. Pubmedid: 15185293.


• Bocker J, Vasile J, Zager J, Goodman E. Intussusception: an uncommon cause of postoperative small bowel obstruction after gastric bypass. Obes Surg. 2004 Jan;14(1):116-119. Pubmedid: 14980045.


• Zager J, Ohki T, Simon J, Gruber B, Zoe H, Teperman S, Stone ME J, VeithFJ, Simon R. Endovascular repair of a traumatic pseudoaneurysm of the thoracic aorta in a patient with concomitant intracranial and intra-abdominal injuries. J Trauma. 2003 Oct;55(4):778-781. Pubmedid: 14566138.


• Zager J, Delman K, Ebright M, Malhotra S, Larson S, Fong Y. Use of radiolabelled iododeoxyuridine as adjuvant treatment for experimental tumours of the liver. Br J Surg. 2003 Oct;90(10):1225-1231. Pubmedid: 14515291.


• Jarnagin W, Zager J, Klimstra D, Delman K, Malhotra S, Ebright M, LittleS, DeRubertis B, Stanziale S, Hezel M, Federoff H, Fong Y. Neoadjuvant treatment of hepatic malignancy: an oncolytic herpes simplex virus expressing IL-12 effectively treats the parent tumor and protects againstrecurrence-after resection. Cancer Gene Ther. 2003 Mar;10(3):215-223. Pubmedid: 12637943.


• Bennett JJ, Delman KA, Burt BM, Mariotti A, Malhotra S, Zager J, Petrowsky H, Mastorides S, Federoff H, Fong Y. Comparison of safety, delivery, and efficacy of two oncolytic herpes viruses (G207 and NV1020) for peritoneal cancer. Cancer Gene Ther. 2002 Nov;9(11):935-945. Pubmedid: 12386832.


• Delman KA, Zager JS, Bennett JJ, Malhotra S, Ebright MI, McAuliffe PF, Halterman MW, Federoff HJ, Fong Y. Efficacy of multiagent herpes simplex virus amplicon-mediated immunotherapy as adjuvant treatment for experimental hepatic cancer. Ann Surg. 2002 Sep;236(3):337-342. Pubmedid: 12192320. Pmcid: PMC1422587.


• Stanziale SF, Petrowsky H, Joe JK, Roberts GD, Zager JS, Gusani NJ, Ben-Porat L, Gonen M, Fong Y. Ionizing radiation potentiates the antitumor efficacy of oncolytic herpes simplex virus G207 by upregulating ribonucleotide reductase. Surgery. 2002 Aug;132(2):353-359. Pubmedid: 12219034.


• Ebright M, Zager J, Malhotra S, Delman K, Weigel T, Rusch V, Fong Y. Replication-competent herpes virus NV1020 as direct treatment of pleural cancer in a rat model. J Thorac Cardiovasc Surg. 2002 Jul;124(1):123-129. Pubmedid: 12091817.


• Zager J, Gusani N, Derubertis B, Shaw J, Kaufman J, DeNoto G. Laparoscopic appendectomy for Crohn's disease of the appendix presenting as acute appendicitis. J Laparoendosc Adv Surg Tech A. 2001 Aug;11(4):255-258. Pubmedid: 11569518.


• Zager J, Shaw J, Kaufman J, DeNoto G. Three cases of small bowel intussusception in relation to a rare lesion :inflammatory fibrous polyps. Dig Surg. 2001 Aug;18(2):142-146. Pubmedid: 11351161.


• Zager JS, Delman KA, Malhotra S, Ebright MI, Bennett JJ, Kates T, Halterman M, Federoff H, Fong Y. Combination vascular delivery of herpes simplex oncolytic viruses and amplicon mediated cytokine gene transfer is effective therapy for experimental liver cancer. Mol Med. 2001 Aug;7(8):561-568. Pubmedid: 11591892. Pmcid: PMC1950059.


• Bennett J, Malhotra S, Wong R, Delman K, Zager J, St-Louis M, Johnson P, Fong Y. Interleukin 12 secretion enhances antitumor efficacy of oncolytic herpes simplex viral therapy for colorectal cancer. Ann Surg. 2001 Jun;233(6):819-826. Pubmedid: 11371740.


• Paris F, Grassme H, Cremesti A, Zager J, Fong Y, Haimovitz-Friedman A, Fuks Z, Gulbins E, Kolesnick R. Natural ceramide reverses Fas resistance of acid sphingomyelinase(-/-) hepatocytes. J Biol Chem. 2001 Mar;276(11):8297-8305. Pubmedid: 11096096.


• Delman KA, Bennett JJ, Zager JS, Burt BM, McAuliffe PF, Petrowsky H, Kooby DA, Hawkins WG, Horsburgh BC, Johnson P, Fong Y. Effects of preexisting immunity on the response to herpes simplex-based oncolytic viral therapy. Hum Gene Ther. 2000 Dec;11(18):2465-2472. Pubmedid: 11119418.


• Cohen M, Greenwald M, Garbus J, Zager J. Granular cell tumor--a unique neoplasm of the internal anal sphincter: report of a case. Dis Colon Rectum. 2000 Oct;43(10):1444-1446. Pubmedid: 11052524.


• Zager J, Garbus J, Shaw J, Cohen M, Garber S. Jejunal diverticulosis: a rare entity with multiple presentations, a series of cases. Dig Surg. 2000 Jul;17(6):643-645. Pubmedid: 11155015.


• Jarnagin W, Delman K, Kooby D, Mastorides S, Zager J, Brennan M, BlumgartLH, Federoff H, Fong Y. Neoadjuvant interleukin-12 immunogene therapy protects against cancer recurrence after liver resection in an animal model. Ann Surg. 2000 May;231(5):762-771. Pubmedid: 10767798.


• Lewis J, Zager J, Yu D, Pelaez D, Riker A, Dessureault S, Cruse C, Reintgen D, Puleo C, Sondak V. Full-Thickness Grafts Procured from Skin Overlying the Sentinel Lymph Node Basin; Reconstruction of Primary Cutaneous Malignancy Excision Defects. Ann Surg Oncol. 2008 Jun;15(6):1733-1740. Pubmedid: 18379848.

Dr. Jonathan Zager is a surgical oncologist in the Departments of Cutaneous Oncology and Sarcoma at Moffitt Cancer Center and director of outcomes research at Moffitt’s Donald A. Adam Comprehensive Melanoma Research Center.  He is an assistant professor of surgery and surgical oncology at the University of South Florida College of Medicine.

Dr. Zager’s research and clinical interests include cutaneous melanoma and non-melanoma skin cancers, soft tissue sarcomas, isolated limb infusions in transit or recurrent melanoma and intraoperative PET probe-directed surgery for metastatic lesions.

Dr. Zager graduated magna cum laude from University Sackler School of Medicine’s New York State/American Program.  He served a junior residency at North Shore University Hospital-New York University School of Medicine and was a research fellow at Memorial-Sloan Kettering Cancer Center before pursuing a residency in surgery at Montefiore Medical Center-Albert Einstein College of Medicine.  He was chief resident his last year.  Dr. Zager completed fellowship training in surgical oncology at the University of Texas-M.D. Anderson Cancer Center.

Dr. Zager has received numerous awards, including Best Doctors in America, America’s Top Oncologists and Patients Choice Physician Award.  He is a member of numerous editorial and advisory boards and professional organizations, including the Sentinel Node Oncology Foundation executive committee.