Chih-Chi Andrew Hu, PhD

The research interests of the Hu lab include the analysis of the mechanisms of B cell development and B cell cancer formation. We investigate endoplasmic reticulum-associated stress signaling molecules, which play important roles in the quality control of secretory and integral membrane proteins. We are especially interested in knowing how B cell cancers employ these signaling molecules to work in favor of their survival, spreading and chemoresistance in response to therapies. These signaling molecules may also play a role in tumor development in other organs, and are being evaluated in melanoma and other tumor types. We take biochemical, cell biological, and immunological approaches to study these questions in mouse tumor models and human cancer cell

• Ranatunga S, Tang CH, Hu CC, Del Valle JR. Total synthesis and structural revision of lucentamycin a. J Org Chem. 2012 Nov;77(21):9859-9864. Pubmedid: 23039096.
• Kim YB, Balasis ME, Doi K, Berndt N, DuBoulay C, Hu CC, Guida W, Wang HG, Sebti SM, Del Valle JR. Synthesis and evaluation of substituted hexahydronaphthalenes as novel inhibitors of the Mcl-1/BimBH3 interaction. Bioorg Med Chem Lett. 2012 Sep;22(18):5961-5965. Pubmedid: 22901384. Pmcid: PMC3432503.
• Dougan SK, Ogata S, Hu CC, Grotenbreg GM, Guillen E, Jaenisch R, Ploegh HL. IgG1+ ovalbumin-specific B-cell transnuclear mice show class switch recombination in rare allelically included B cells. Proc Natl Acad Sci U S A. 2012 Aug;109(34):13739-13744. Pubmedid: 22869725. Pmcid: PMC3427072.
• Kriss CL, Pinilla-Ibarz JA, Mailloux AW, Powers JJ, Tang CH, Kang CW, Zanesi N, Epling-Burnette PK, Sotomayor EM, Croce CM, Del Valle JR, Hu CC. Overexpression of TCL1 activates the endoplasmic reticulum stress response: a novel mechanism of leukemic progression in mice. Blood. 2012 Aug;120(5):1027-1038. Pubmedid: 22692508.
• Dougan SK, Hu CC, Paquet ME, Greenblatt MB, Kim J, Lilley BN, Watson N, Ploegh HL. Derlin-2-deficient mice reveal an essential role for protein dislocation in chondrocytes. Mol Cell Biol. 2011 Mar;31(6):1145-1159. Pubmedid: 21220515. Pmcid: PMC3067910.
• Hu CC, Dougan SK, Winter SV, Paton AW, Paton JC, Ploegh HL. Subtilase cytotoxin cleaves newly synthesized BiP and blocks antibody secretion in B lymphocytes. J Exp Med. 2009 Oct;206(11):2429-2440. Pubmedid: 19808260. Pmcid: PMC2768844.
• McGehee AM, Dougan SK, Klemm EJ, Shui G, Park B, Kim YM, Watson N, Wenk MR, Ploegh HL, Hu CC. XBP-1-deficient plasmablasts show normal protein folding but altered glycosylation and lipid synthesis. J Immunol. 2009 Sep;183(6):3690-3699. Pubmedid: 19710472.
• Hu CC, Dougan SK, McGehee AM, Love JC, Ploegh HL. XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells. EMBO J. 2009 Jun;28(11):1624-1636. Pubmedid: 19407814. Pmcid: PMC2684024.
• Story CM, Papa E, Hu CC, Ronan JL, Herlihy K, Ploegh HL, Love JC. Profiling antibody responses by multiparametric analysis of primary B cells. Proc Natl Acad Sci U S A. 2008 Nov;105(46):17902-17907. Pubmedid: 19004776. Pmcid: PMC2584674.
• Hu CC, Bachmann T, Zhou G, Liang FX, Ghiso J, Kreibich G, Sun TT. Assembly of a membrane receptor complex: roles of the uroplakin II prosequence in regulating uroplakin bacterial receptor oligomerization. Biochem J. 2008 Sep;414(2):195-203. Pubmedid: 18481938.
• Hu CC, Liang FX, Zhou G, Tu L, Tang CH, Zhou J, Kreibich G, Sun TT. Assembly of urothelial plaques: tetraspanin function in membrane protein trafficking. Mol Biol Cell. 2005 Sep;16(9):3937-3950. Pubmedid: 15958488. Pmcid: PMC1196309.
• Jenkins D, Bitner-Glindzicz M, Malcolm S, Hu CC, Allison J, Winyard PJ, Gullett AM, Thomas DF, Belk RA, Feather SA, Sun TT, Woolf AS. De novo Uroplakin IIIa heterozygous mutations cause human renal adysplasia leading to severe kidney failure. J Am Soc Nephrol. 2005 Jul;16(7):2141-2149. Pubmedid: 15888565.
• Tang CH, Hu CC, Wei CW, Wang JJ. Synergism of Rana catesbeiana ribonuclease and IFN-gamma triggers distinct death machineries in different human cancer cells. FEBS Lett. 2005 Jan;579(1):265-270. Pubmedid: 15620724.
• Chiou CT, Hu CC, Chen PH, Liao CL, Lin YL, Wang JJ. Association of Japanese encephalitis virus NS3 protein with microtubules and tumour susceptibility gene 101 (TSG101) protein. J Gen Virol. 2003 Oct;84(Pt 10):2795-2805. Pubmedid: 13679614.
• Deng FM, Liang FX, Tu L, Resing KA, Hu P, Supino M, Hu CC, Zhou G, Ding M, Kreibich G, Sun TT. Uroplakin IIIb, a urothelial differentiation marker, dimerizes with uroplakin Ib as an early step of urothelial plaque assembly. J Cell Biol. 2002 Nov;159(4):685-694. Pubmedid: 12446744. Pmcid: PMC2173100.
• Wei CW, Hu CC, Tang CH, Lee MC, Wang JJ. Induction of differentiation rescues HL-60 cells from Rana catesbeiana ribonuclease-induced cell death. FEBS Lett. 2002 Nov;531(3):421-426. Pubmedid: 12435586.
• Liu RT, Huang CC, You HL, Chou FF, Hu CC, Chao FP, Chen CM, Cheng JT. Overexpression of tumor susceptibility gene TSG101 in human papillary thyroid carcinomas. Oncogene. 2002 Jul;21(31):4830-4837. Pubmedid: 12101421.
• Hu CC, Tang CH, Wang JJ. Caspase activation in response to cytotoxic Rana catesbeiana ribonuclease in MCF-7 cells. FEBS Lett. 2001 Aug;503(1):65-68. Pubmedid: 11513856.
• Hu CC, Lee YH, Tang CH, Cheng JT, Wang JJ. Synergistic cytotoxicity of Rana catesbeiana ribonuclease and IFN-gamma on hepatoma cells. Biochem Biophys Res Commun. 2001 Feb;280(5):1229-1236. Pubmedid: 11162659.
• Liu TZ, Hu CC, Chen YH, Stern A, Cheng JT. Differentiation status modulates transcription factor NF-kappaB activity in unstimulated human hepatocellular carcinoma cell lines. Cancer Lett. 2000 Apr;151(1):49-56. Pubmedid: 10766422.