Our laboratory interests include antibody targeting of the T-cell receptor and CD28 to prevent GVHD in mouse models and human transplants. Clinical interests include clinical blood and bone marrow transplantation; immunogenetics and donor selection; prevention and treatment of GVHD. Dr. Anasetti has initiated outstanding novel clinical trials to upregulate T regulatory cells and suppress allogeneic T cells via manipulation of specific signal pathways utilized by these different T cell types.