Total cancer care moffit cancer center
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Domenico Coppola, MD

Where You Are:
Domenico Coppola, MD

Senior Member

"My primary research focus is on the study of markers of tumor progression with special emphasis on insulin-like growth factor 1-receptor and AKT."

Office  (813) 745-3275

Education And Training
  • Fellow, University of Pittsburgh, 1995
  • Fellow, Thomas Jefferson University, Philadelphia, 1994 - Molecular Biology; Surgical Pathology
  • Resident, Temple University, Philadelphia, 1992
  • Resident, Monmouth Medical Center, NJ, 1988 - General Surgery
  • MD, University of Naples, 1983


Dr. Coppola's area of research focuses on the study of markers of tumor progression with special emphasis on insulin-like growth factor 1-receptor and AKT. He is investigating the effect of Ascorbyl stearate on proliferation and apoptosis of a variety of cancers (ovarian, colon, pancreas, etc.)

  • Martinez GV, Navath S, Sewda K, Rao V, Foroutan P, Alleti R, Moberg VE, Ahad AM, Coppola D, Lloyd MC, Gillies RJ, Morse DL, Mash EA. Demonstration of a sucrose-derived contrast agent for magnetic resonance imaging of the GI tract. Bioorg Med Chem Lett. 2013 Apr;23(7):2061-2064. Pubmedid: 23481651.
  • Almhanna K, Meredith KL, Hoffe SE, Shridhar R, Coppola D. Targeting the human epidermal growth factor receptor 2 in esophageal cancer. Cancer Control. 2013 Apr;20(2):111-116. Pubmedid: 23571701.
  • Strosberg JR, Weber JM, Feldman M, Coppola D, Meredith K, Kvols LK. Prognostic validity of the American Joint Committee on Cancer staging classification for midgut neuroendocrine tumors. J Clin Oncol. 2013 Feb;31(4):420-425. Pubmedid: 23248248.
  • Kong W, He L, Richards EJ, Challa S, Xu CX, Permuth-Wey J, Lancaster JM, Coppola D, Sellers TA, Djeu JY, Cheng JQ. Upregulation of miRNA-155 promotes tumour angiogenesis by targeting VHL and is associated with poor prognosis and triple-negative breast cancer. Oncogene. 2013 Jan. Pubmedid: 23353819.
  • Mayhall K, Ghayouri M, Henry K, Margin V, Copolla D, Shackelford R. Thirty-five-year-old woman with signet ring cell gastric carcinoma secondary to the chernobyl nuclear accident: a case report. Case Rep Oncol. 2013 Jan;6(1):158-162. Pubmedid: 23626554. Pmcid: PMC3636966.
  • Hodul PJ, Dong Y, Husain K, Pimiento JM, Chen J, Zhang A, Francois R, Pledger WJ, Coppola D, Sebti SM, Chen DT, Malafa MP. Vitamin E δ-Tocotrienol Induces p27(Kip1)-Dependent Cell-Cycle Arrest in Pancreatic Cancer Cells via an E2F-1-Dependent Mechanism. PLoS One. 2013;8(2):e52526. Pubmedid: 23393547.
  • Coppola D, Nicosia SV, Doty A, Sellers TA, Lee JH, Fulp J, Thompson Z, Galeb S, McLaughlin J, Narod SA, Schildkraut J, Pal T. Uncertainty in the utility of immunohistochemistry in mismatch repair protein expression in epithelial ovarian cancer. Anticancer Res. 2012 Nov;32(11):4963-4969. Pubmedid: 23155266.
  • Pal T, Akbari MR, Sun P, Lee JH, Fulp J, Thompson Z, Coppola D, Nicosia S, Sellers TA, McLaughlin J, Risch HA, Rosen B, Shaw P, Schildkraut J, Narod SA. Frequency of mutations in mismatch repair genes in a population-based study of women with ovarian cancer. Br J Cancer. 2012 Nov;107(10):1783-1790. Pubmedid: 23047549. Pmcid: PMC3493867.
  • Helm J, Coppola D, Ganapathy V, Lloyd M, Centeno BA, Chen DT, Malafa MP, Park JY. SLC5A8 Nuclear Translocation and Loss of Expression are Associated With Poor Outcome in Pancreatic Ductal Adenocarcinoma. Pancreas. 2012 Aug;41(6):904-909. Pubmedid: 22450368.
  • Panjehpour M, Overholt BF, Vo-Dinh T, Coppola D. The effect of reactive atypia/inflammation on the laser-induced fluorescence diagnosis of non-dysplastic Barrett's esophagus. Lasers Surg Med. 2012 Jul;44(5):390-396. Pubmedid: 22535652. Pmcid: PMC3371107.
  • Mahajan K, Coppola D, Chen YA, Zhu W, Lawrence HR, Lawrence NJ, Mahajan NP. Ack1 tyrosine kinase activation correlates with pancreatic cancer progression. Am J Pathol. 2012 Jul;180(4):1386-1393. Pubmedid: 22322295. Pmcid: PMC3349895.
  • Shackelford RE, Whitling NA, McNab P, Japa S, Coppola D. KRAS Testing: A Tool for the Implementation of Personalized Medicine. Genes Cancer. 2012 Jul;3(7-8):459-466. Pubmedid: 23264846. Pmcid: PMC3527988.
  • Mahajan K, Coppola D, Rawal B, Chen YA, Lawrence HR, Engelman RW, Lawrence NJ, Mahajan NP. Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer. J Biol Chem. 2012 Jun;287(26):22112-22122. Pubmedid: 22566699. Pmcid: PMC3381169.
  • Strosberg JR, Yeatman T, Weber J, Coppola D, Schell MJ, Han G, Almhanna K, Kim R, Valone T, Jump H, Sullivan D. A phase II study of RO4929097 in metastatic colorectal cancer. Eur J Cancer. 2012 May;48(7):997-1003. Pubmedid: 22445247.
  • Chen DT, Hernandez JM, Shibata D, McCarthy SM, Humphries LA, Clark W, Elahi A, Gruidl M, Coppola D, Yeatman T. Complementary Strand MicroRNAs Mediate Acquisition of Metastatic Potential in Colonic Adenocarcinoma. J Gastrointest Surg. 2012 May;16(5):905-913. Pubmedid: 22362069.
  • Seifert RP, McNab P, Sexton WJ, Sawczyn KK, Smith P, Coppola D, Bui MM. Rhabdomyomatous differentiation in wilms tumor pulmonary metastases: a case report and literature review. Ann Clin Lab Sci. 2012;42(4):409-416. Pubmedid: 23090738.
  • Singh S, Trevino J, Bora-Singhal N, Coppola D, Haura E, Altiok S, Chellappan SP. EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancer. Mol Cancer. 2012;11:73. Pubmedid: 23009336. Pmcid: PMC3497614.
  • Hernandez JM, Siegel EM, Riggs B, Eschrich S, Elahi A, Qu X, Ajidahun A, Berglund A, Coppola D, Grady WM, Giuliano AR, Shibata D. DNA Methylation Profiling across the Spectrum of HPV-Associated Anal Squamous Neoplasia. PLoS One. 2012;7(11):e50533. Pubmedid: 23226306.
  • Garrett CR, Coppola D, Wenham RM, Cubitt CL, Neuger AM, Frost TJ, Lush RM, Sullivan DM, Cheng JQ, Sebti SM. Phase I pharmacokinetic and pharmacodynamic study of triciribine phosphate monohydrate, a small-molecule inhibitor of AKT phosphorylation, in adult subjects with solid tumors containing activated AKT. Invest New Drugs. 2011 Dec;29(6):1381-1389. Pubmedid: 20644979.
  • Chen DT, Hsu YL, Fulp WJ, Coppola D, Haura EB, Yeatman TJ, Cress WD. Prognostic and predictive value of a malignancy-risk gene signature in early-stage non-small cell lung cancer. J Natl Cancer Inst. 2011 Dec;103(24):1859-1870. Pubmedid: 22157961. Pmcid: PMC3243673.
  • Pagán B, Isidro AA, Cruz ML, Ren Y, Coppola D, Wu J, Appleyard CB. Erlotinib inhibits progression to dysplasia in a colitis-associated colon cancer model. World J Gastroenterol. 2011 Nov;17(44):4858-4866. Pubmedid: 22171126. Pmcid: PMC3235628.
  • Guo JP, Coppola D, Cheng JQ. IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation. J Biol Chem. 2011 Oct;286(43):37389-37398. Pubmedid: 21908616. Pmcid: PMC3199486.
  • Lin HY, Park HY, Radlein S, Mahajan NP, Sellers TA, Zachariah B, Pow-Sang J, Coppola D, Ganapathy V, Park JY. Protein expressions and genetic variations of SLC5A8 in prostate cancer risk and aggressiveness. Urology. 2011 Oct;78(4):971.e1-971.e9. Pubmedid: 21802122. Pmcid: PMC3190039.
  • Henderson-Jackson EB, Helm J, Strosberg J, Nasir NA, Yeatman TJ, Kvols LK, Coppola D, Nasir A. Palladin is a marker of liver metastasis in primary pancreatic endocrine carcinomas. Anticancer Res. 2011 Sep;31(9):2957-2962. Pubmedid: 21868544.
  • Hernandez JM, Farma JM, Coppola D, Hakam A, Fulp WJ, Chen DT, Siegel EM, Yeatman TJ, Shibata D. Expression of the antiapoptotic protein survivin in colon cancer. Clin Colorectal Cancer. 2011 Sep;10(3):188-193. Pubmedid: 21855041.
  • Strosberg JR, Cheema A, Weber J, Han G, Coppola D, Kvols LK. Prognostic validity of a novel American Joint Committee on Cancer Staging Classification for pancreatic neuroendocrine tumors. J Clin Oncol. 2011 Aug;29(22):3044-3049. Pubmedid: 21709192.
  • Coppola D, Nebozhyn M, Khalil F, Dai H, Yeatman T, Loboda A, Mulé JJ. Unique ectopic lymph node-like structures present in human primary colorectal carcinoma are identified by immune gene array profiling. Am J Pathol. 2011 Jul;179(1):37-45. Pubmedid: 21703392. Pmcid: PMC3123872.
  • Pillai S, Rizwani W, Li X, Rawal B, Nair S, Schell MJ, Bepler G, Haura E, Coppola D, Chellappan S. ID1 facilitates the growth and metastasis of non-small cell lung cancer in response to nicotinic acetylcholine receptor and epidermal growth factor receptor signaling. Mol Cell Biol. 2011 Jul;31(14):3052-3067. Pubmedid: 21606196. Pmcid: PMC3133413.
  • Cheng A, Guo J, Henderson-Jackson E, Kim D, Malafa M, Coppola D. IκB Kinase ε expression in pancreatic ductal adenocarcinoma. Am J Clin Pathol. 2011 Jul;136(1):60-66. Pubmedid: 21685032.
  • Nishihori T, Fernandez HF, Coppola D, Ochoa-Bayona JL, Lancet JE, Komrokji RS, Kharfan-Dabaja MA. Hepatobiliary manifestations of acute myeloid leukemia. Leuk Res. 2011 Jun;35(6):e81-e83. Pubmedid: 21232795.
  • Nasir A, Helm J, Turner L, Chen DT, Strosberg J, Hafez N, Henderson-Jackson EB, Hodul P, Bui MM, Nasir NA, Hakam A, Malafa MP, Yeatman TJ, Coppola D, Kvols LK. RUNX1T1: a novel predictor of liver metastasis in primary pancreatic endocrine neoplasms. Pancreas. 2011 May;40(4):627-633. Pubmedid: 21499216.
  • Balasis ME, Forinash KD, Chen YA, Fulp WJ, Coppola D, Hamilton AD, Cheng JQ, Sebti SM. Combination of farnesyltransferase and Akt inhibitors is synergistic in breast cancer cells and causes significant breast tumor regression in ErbB2 transgenic mice. Clin Cancer Res. 2011 May;17(9):2852-2862. Pubmedid: 21536547. Pmcid: PMC3156694.
  • Coppola D, Helm J, Ghayouri M, Malafa MP, Wang HG. Down-regulation of Bax-interacting factor 1 in human pancreatic ductal adenocarcinoma. Pancreas. 2011 Apr;40(3):433-437. Pubmedid: 21283040. Pmcid: PMC3063470.
  • Donate A, Coppola D, Cruz Y, Heller R. Evaluation of a novel non-penetrating electrode for use in DNA vaccination. PLoS One. 2011 Apr;6(4):e19181. Pubmedid: 21559474.
  • Hernandez J, Elahi A, Siegel E, Coppola D, Riggs B, Shibata D. HPV L1 capsid protein detection and progression of anal squamous neoplasia. Am J Clin Pathol. 2011 Mar;135(3):436-441. Pubmedid: 21350099.
  • Dasgupta P, Rizwani W, Pillai S, Davis R, Banerjee S, Hug K, Lloyd M, Coppola D, Haura E, Chellappan SP. ARRB1-mediated regulation of E2F target genes in nicotine-induced growth of lung tumors. J Natl Cancer Inst. 2011 Feb;103(4):317-333. Pubmedid: 21212384. Pmcid: PMC3039728.
  • Park JY, Helm J, Coppola D, Kim D, Malafa M, Kim SJ. MicroRNAs in pancreatic ductal adenocarcinoma. World J Gastroenterol. 2011 Feb;17(7):817-827. Pubmedid: 21412491. Pmcid: PMC3051132.
  • Strosberg JR, Fine RL, Choi J, Nasir A, Coppola D, Chen DT, Helm J, Kvols L. First-line chemotherapy with capecitabine and temozolomide in patients with metastatic pancreatic endocrine carcinomas. Cancer. 2011 Jan;117(2):268-275. Pubmedid: 20824724.
  • Wang X, Raulji P, Mohapatra SS, Patel R, Hellermann G, Kong X, Vera PL, Meyer-Siegler KL, Coppola D, Mohapatra S. Natriuretic peptide receptor a as a novel target for prostate cancer. Mol Cancer. 2011;10:56. Pubmedid: 21586128. Pmcid: PMC3121714.
  • Ghayouri M, Boulware D, Nasir A, Strosberg J, Kvols L, Coppola D. Activation of the serine/theronine protein kinase Akt in enteropancreatic neuroendocrine tumors. Anticancer Res. 2010 Dec;30(12):5063-5067. Pubmedid: 21187491.
  • Henderson-Jackson EB, Helm J, Ghayouri M, Hakam A, Nasir A, Leon M, Bui M, Yeatman T, Coppola D. Correlation between Mcl-1 and pAKT protein expression in colorectal cancer. Int J Clin Exp Pathol. 2010 Oct;3(8):768-774. Pubmedid: 21151390. Pmcid: PMC2993227.
  • Shu SK, Liu Q, Coppola D, Cheng JQ. Phosphorylation and activation of androgen receptor by Aurora-A. J Biol Chem. 2010 Oct;285(43):33045-33053. Pubmedid: 20713353. Pmcid: PMC2963369.
  • Mahajan K, Challa S, Coppola D, Lawrence H, Luo Y, Gevariya H, Zhu W, Chen YA, Lawrence NJ, Mahajan NP. Effect of Ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activity. Prostate. 2010 Sep;70(12):1274-1285. Pubmedid: 20623637.
  • Morse DL, Balagurunathan Y, Hostetter G, Trissal M, Tafreshi NK, Burke N, Lloyd M, Enkemann S, Coppola D, Hruby VJ, Gillies RJ, Han H. Identification of novel pancreatic adenocarcinoma cell-surface targets by gene expression profiling and tissue microarray. Biochem Pharmacol. 2010 Sep;80(5):748-754. Pubmedid: 20510208. Pmcid: PMC2914681.
  • Pagán B, Isidro AA, Coppola D, Chen Z, Ren Y, Wu J, Appleyard CB. Effect of a neurokinin-1 receptor antagonist in a rat model of colitis-associated colon cancer. Anticancer Res. 2010 Sep;30(9):3345-3353. Pubmedid: 20944107.
  • Strosberg JR, Coppola D, Klimstra DS, Phan AT, Kulke MH, Wiseman GA, Kvols LK. The NANETS consensus guidelines for the diagnosis and management of poorly differentiated (high-grade) extrapulmonary neuroendocrine carcinomas. Pancreas. 2010 Aug;39(6):799-800. Pubmedid: 20664477. Pmcid: PMC3100733.
  • Vinik AI, Woltering EA, Warner RR, Caplin M, O'Dorisio TM, Wiseman GA, Coppola D, Go VL. NANETS Consensus Guidelines for the Diagnosis of Neuroendocrine Tumor. Pancreas. 2010 Aug;39(6):713-734. Pubmedid: 20664471.
  • Lauriola M, Ugolini G, Rosati G, Zanotti S, Montroni I, Manaresi A, Zattoni D, Rivetti S, Mattei G, Coppola D, Strippoli P, Taffurelli M, Solmi R. Identification by a Digital Gene Expression Displayer (DGED) and test by RT-PCR analysis of new mRNA candidate markers for colorectal cancer in peripheral blood. Int J Oncol. 2010 Aug;37(2):519-525. Pubmedid: 20596680.
  • Klimstra DS, Modlin IR, Coppola D, Lloyd RV, Suster S. The pathologic classification of neuroendocrine tumors: a review of nomenclature, grading, and staging systems. Pancreas. 2010 Aug;39(6):707-712. Pubmedid: 20664470.
  • Bui MM, Draper NL, Dessureault S, Nasir NA, Cooper H, Nasir A, Coppola D. Colonic angiolymphoid hyperplasia with eosinophilia masquerading as malignancy: a case report and review of the literature. Clin Colorectal Cancer. 2010 Jul;9(3):179-182. Pubmedid: 20643624.
  • Melis M, Hernandez J, Siegel EM, McLoughlin JM, Ly QP, Nair RM, Lewis JM, Jensen EH, Alvarado MD, Coppola D, Eschrich S, Bloom GC, Yeatman TJ, Shibata D. Gene expression profiling of colorectal mucinous adenocarcinomas. Dis Colon Rectum. 2010 Jun;53(6):936-943. Pubmedid: 20485009.
  • Kong W, He L, Coppola M, Guo J, Esposito NN, Coppola D, Cheng JQ. MicroRNA-155 regulates cell survival, growth, and chemosensitivity by targeting FOXO3a in breast cancer. J Biol Chem. 2010 Jun;285(23):17869-17879. Pubmedid: 20371610. Pmcid: PMC2878550.
  • Yuan Z, Villagra A, Peng L, Coppola D, Glozak M, Sotomayor EM, Chen J, Lane WS, Seto E. The ATDC (TRIM29) protein binds p53 and antagonizes p53-mediated functions. Mol Cell Biol. 2010 Jun;30(12):3004-3015. Pubmedid: 20368352. Pmcid: PMC2876676.
  • Betsou F, Lehmann S, Ashton G, Barnes M, Benson EE, Coppola D, DeSouza Y, Eliason J, Glazer B, Guadagni F, Harding K, Horsfall DJ, Kleeberger C, Nanni U, Prasad A, Shea K, Skubitz A, Somiari S, Gunter E. Standard preanalytical coding for biospecimens: defining the sample PREanalytical code. Cancer Epidemiol Biomarkers Prev. 2010 Apr;19(4):1004-1011. Pubmedid: 20332280.
  • Efferson CL, Winkelmann CT, Ware C, Sullivan T, Giampaoli S, Tammam J, Patel S, Mesiti G, Reilly JF, Gibson RE, Buser C, Yeatman T, Coppola D, Winter C, Clark EA, Draetta GF, Strack PR, Majumder PK. Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model. Cancer Res. 2010 Mar;70(6):2476-2484. Pubmedid: 20197467.
  • Kim D, Shu S, Coppola MD, Kaneko S, Yuan ZQ, Cheng JQ. Regulation of proapoptotic mammalian ste20-like kinase MST2 by the IGF1-Akt pathway. PLoS One. 2010 Mar;5(3):e9616. Pubmedid: 20231902. Pmcid: PMC2834758.
  • Yuan Z, Kim D, Shu S, Wu J, Guo J, Xiao L, Kaneko S, Coppola D, Cheng JQ. Phosphoinositide 3-kinase/Akt inhibits MST1-mediated pro-apoptotic signaling through phosphorylation of threonine 120. J Biol Chem. 2010 Feb;285(6):3815-3824. Pubmedid: 19940129. Pmcid: PMC2823523.
  • Guo JP, Shu SK, Esposito NN, Coppola D, Koomen JM, Cheng JQ. IKKepsilon phosphorylation of estrogen receptor alpha Ser-167 and contribution to tamoxifen resistance in breast cancer. J Biol Chem. 2010 Feb;285(6):3676-3684. Pubmedid: 19940156. Pmcid: PMC2823508.
  • Mahajan K, Coppola D, Challa S, Fang B, Chen YA, Zhu W, Lopez AS, Koomen J, Engelman RW, Rivera C, Muraoka-Cook RS, Cheng JQ, Schönbrunn E, Sebti SM, Earp HS, Mahajan NP. Ack1 mediated AKT/PKB tyrosine 176 phosphorylation regulates its activation. PLoS One. 2010;5(3):e9646. Pubmedid: 20333297. Pmcid: PMC2841635.
  • Lloyd MC, Allam-Nandyala P, Purohit CN, Burke N, Coppola D, Bui MM. Using image analysis as a tool for assessment of prognostic and predictive biomarkers for breast cancer: How reliable is it?. J Pathol Inform. 2010;1:29. Pubmedid: 21221174. Pmcid: PMC3017682.
  • Shackelford RE, Bui MM, Coppola D, Hakam A. Over-expression of nicotinamide phosphoribosyltransferase in ovarian cancers. Int J Clin Exp Pathol. 2010;3(5):522-527. Pubmedid: 20606733. Pmcid: PMC2897104.
  • Henderson-Jackson E, Nasir NA, Hakam A, Nasir A, Coppola D. Primary mixed lymphoepithelioma-like carcinoma and intra-hepatic cholangiocarcinoma: a case report and review of literature. Int J Clin Exp Pathol. 2010;3(7):736-741. Pubmedid: 20830246. Pmcid: PMC2933395.
  • Coppola D, Parikh V, Boulware D, Blanck G. Substantially reduced expression of PIAS1 is associated with colon cancer development. J Cancer Res Clin Oncol. 2009 Sep;135(9):1287-1291. Pubmedid: 19288270.
  • Helm J, Centeno BA, Coppola D, Melis M, Lloyd M, Park JY, Chen DT, Malafa MP. Histologic characteristics enhance predictive value of American Joint Committee on Cancer staging in resectable pancreas cancer. Cancer. 2009 Sep;115(18):4080-4089. Pubmedid: 19626671.
  • Strosberg J, Nasir A, Coppola D, Wick M, Kvols L. Correlation between grade and prognosis in metastatic gastroenteropancreatic neuroendocrine tumors. Hum Pathol. 2009 Sep;40(9):1262-1268. Pubmedid: 19368957.
  • Guo JP, Shu SK, He L, Lee YC, Kruk PA, Grenman S, Nicosia SV, Mor G, Schell MJ, Coppola D, Cheng JQ. Deregulation of IKBKE is associated with tumor progression, poor prognosis, and cisplatin resistance in ovarian cancer. Am J Pathol. 2009 Jul;175(1):324-333. Pubmedid: 19497997. Pmcid: PMC2708818.
  • Kabra N, Li Z, Chen L, Li B, Zhang X, Wang C, Yeatman T, Coppola D, Chen J. SirT1 is an inhibitor of proliferation and tumor formation in colon cancer. J Biol Chem. 2009 Jul;284(27):18210-18217. Pubmedid: 19433578. Pmcid: PMC2709385.
  • Ferraro B, Cruz YL, Coppola D, Heller R. Intradermal delivery of plasmid VEGF(165) by electroporation promotes wound healing. Mol Ther. 2009 Apr;17(4):651-657. Pubmedid: 19240696. Pmcid: PMC2835103.
  • Sparano JA, Moulder S, Kazi A, Coppola D, Negassa A, Vahdat L, Li T, Pellegrino C, Fineberg S, Munster P, Malafa M, Lee D, Hoschander S, Hopkins U, Hershman D, Wright JJ, Kleer C, Merajver S, Sebti SM. Phase II trial of tipifarnib plus neoadjuvant doxorubicin-cyclophosphamide in patients with clinical stage IIB-IIIC breast cancer. Clin Cancer Res. 2009 Apr;15(8):2942-2948. Pubmedid: 19351752. Pmcid: PMC2785076.
  • Betsou F, Barnes R, Burke T, Coppola D, Desouza Y, Eliason J, Glazer B, Horsfall D, Kleeberger C, Lehmann S, Prasad A, Skubitz A, Somiari S, Gunter E. Human biospecimen research: experimental protocol and quality control tools. Cancer Epidemiol Biomarkers Prev. 2009 Apr;18(4):1017-1025. Pubmedid: 19336543.
  • Moran CA, Suster S, Coppola D, Wick MR. Neuroendocrine carcinomas of the lung: a critical analysis. Am J Clin Pathol. 2009 Feb;131(2):206-221. Pubmedid: 19141381.
  • Dasgupta P, Rizwani W, Pillai S, Kinkade R, Kovacs M, Rastogi S, Banerjee S, Carless M, Kim E, Coppola D, Haura E, Chellappan S. Nicotine induces cell proliferation, invasion and epithelial-mesenchymal transition in a variety of human cancer cell lines. Int J Cancer. 2009 Jan;124(1):36-45. Pubmedid: 18844224. Pmcid: PMC2826200.
  • Kazemfar K, Chen R, Nicholson K, Coppola D, Zhou JM, Chen X, Wei S, Blanck G. Combined IL-8 and TGF-beta blockade efficiently prevents neutrophil infiltrates into an A549-cell tumor. Immunol Lett. 2009 Jan;122(1):25-29. Pubmedid: 19056425.
  • Permuth-Wey J, Boulware D, Valkov N, Livingston S, Nicosia S, Lee JH, Sutphen R, Schildkraut J, Narod S, Parker A, Coppola D, Sellers T, Pal T. Sampling strategies for tissue microarrays to evaluate biomarkers in ovarian cancer. Cancer Epidemiol Biomarkers Prev. 2009 Jan;18(1):28-34. Pubmedid: 19124477. Pmcid: PMC2664171.
  • Husain K, Francois RA, Hutchinson SZ, Neuger AM, Lush R, Coppola D, Sebti S, Malafa MP. Vitamin E delta-tocotrienol levels in tumor and pancreatic tissue of mice after oral administration. Pharmacology. 2009;83(3):157-163. Pubmedid: 19142032. Pmcid: PMC2834260.
  • Davis R, Rizwani W, Banerjee S, Kovacs M, Haura E, Coppola D, Chellappan S. Nicotine promotes tumor growth and metastasis in mouse models of lung cancer. PLoS One. 2009;4(10):e7524. Pubmedid: 19841737. Pmcid: PMC2759510.
  • McNab PM, DeMers NM, Schlauder S, Morgan M, Nasir A, Coppola D, Bui MM. Potential utility of CD5 immunohistochemical staining in the diagnosis of muscle tumors. Ann Clin Lab Sci. 2009;39(2):108-113. Pubmedid: 19429795.
  • Coppola D, Ouban A, Gilbert-Barness E. Expression of the insulin-like growth factor receptor 1 during human embryogenesis. Fetal Pediatr Pathol. 2009;28(2):47-54. Pubmedid: 19241236.
  • Draper N, Bui M, Boulware DC, Lloyd M, Chiappori AA, Pledger WJ, Coppola D. Increased cyclin D3 expression significantly correlates with p27 nuclear positivity in gastrointestinal stromal tumors. Hum Pathol. 2008 Dec;39(12):1784-1791. Pubmedid: 18701138.
  • Kong W, Yang H, He L, Zhao JJ, Coppola D, Dalton WS, Cheng JQ. MicroRNA-155 Is regulated by transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA. Mol Cell Biol. 2008 Nov;28(22):6773-6784. Pubmedid: 18794355.
  • Coppola D, Khalil F, Eschrich SA, Boulware D, Yeatman T, Wang HG. Down-regulation of Bax-interacting factor-1 in colorectal adenocarcinoma. Cancer. 2008 Nov;113(10):2665-2670. Pubmedid: 18833585. Pmcid: PMC2614910.
  • Zhao JJ, Lin J, Yang H, Kong W, He L, Ma X, Coppola D, Cheng JQ. MicroRNA-221/222 negatively regulates estrogen receptor alpha and is associated with tamoxifen resistance in breast cancer. J Biol Chem. 2008 Nov;283(45):31079-31086. Pubmedid: 18790736. Pmcid: PMC2576549.
  • Helm J, Centeno B, Coppola D, Druta M, Park J, Chen D, Hodul P, Kvols LK, Yeatman T, Carey L, Karl R, Malafa M. Outcomes following resection of pancreatic adenocarcinoma: 20-year experience at a single institution. Cancer Control. 2008 Oct;15(4):288-294. Pubmedid: 18813196.
  • Coppola D, Mule J. Ectopic lymph nodes within human solid tumors. J Clin Oncol. 2008 Sep;26(27):4369-4370. Pubmedid: 18802146.
  • Lopez D, Sekharam M, Coppola D, Carter W. Purified human chorionic gonadotropin induces apoptosis in breast cancer. Mol Cancer Ther. 2008 Sep;7(9):2837-2844. Pubmedid: 18790764.
  • Coppola D, Oliveri C, Sayegh Z, Boulware D, Takahashi Y, Pow-Sang J, Djeu JY, Wang HG. Bax-interacting factor-1 expression in prostate cancer. Clin Genitourin Cancer. 2008 Sep;6(2):117-121. Pubmedid: 18824435. Pmcid: PMC2626142.
  • Cheng GZ, Zhang WZ, Sun M, Wang Q, Coppola D, Mansour M, Xu LM, Costanzo C, Cheng JQ, Wang LH. Twist is transcriptionally induced by activation of STAT3 and mediates STAT3 oncogenic function. J Biol Chem. 2008 May;283(21):14665-14673. Pubmedid: 18353781.
  • Nasir A, Gardner N, Strosberg J, Ahmad N, Choi J, Malafa M, Coppola D, Kwekkeboom D, Teunissen J, Kvols L. Multimodality management of a polyfunctional pancreatic endocrine carcinoma with markedly elevated serum vasoactive intestinal polypeptide and calcitonin levels. Pancreas. 2008 Apr;36(3):309-313. Pubmedid: 18362846.
  • Gilkes DM, Pan Y, Coppola D, Yeatman T, Reuther GW, Chen J. Regulation of MDMX expression by mitogenic signaling. Mol Cell Biol. 2008 Mar;28(6):1999-2010. Pubmedid: 18172009.
  • Panjehpour M, Coppola D, Overholt B, Vo-Dinh T, Overholt S. Photodynamic therapy of Barrett's esophagus: ablation of Barrett's mucosa and reduction in p53 protein expression after treatment. Anticancer Res. 2008 Jan;28(1B):485-489. Pubmedid: 18383889.
  • Yang H, Kong W, He L, Zhao JJ, O'Donnell JD, Wang J, Wenham RM, Coppola D, Kruk PA, Nicosia SV, Cheng JQ. MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN. Cancer Res. 2008 Jan;68(2):425-433. Pubmedid: 18199536.
  • Solmi R, Lauriola M, Francesconi M, Martini D, Voltattorni M, Ceccarelli C, Ugolini G, Rosati G, Zanotti S, Montroni I, Mattei G, Taffurelli M, Santini D, Pezzetti F, Ruggeri A, Castellani G, Guidotti L, Coppola D, Strippoli P. Displayed correlation between gene expression profiles and submicroscopic alterations in response to cetuximab, gefitinib and EGF in human colon cancer cell lines. BMC Cancer. 2008;8:227-. Pubmedid: 18691415. Pmcid: PMC2528013.
  • Heller LC, Jaroszeski MJ, Coppola D, Heller R. Comparison of electrically mediated and liposome-complexed plasmid DNA delivery to the skin. Genet Vaccines Ther. 2008;6:16. Pubmedid: 19055808. Pmcid: PMC2631522.
  • Naidu K, Fang Q, Naidu K, Cheng J, Nicosia S, Coppola D. P53 enhances ascorbyl stearate-induced G2/M arrest of human ovarian cancer cells. Anticancer Res. 2007 Nov;27(6B):3927-3934. Pubmedid: 18225552.
  • Takahashi Y, Coppola D, Matsushita N, Cualing HD, Sun M, Sato Y, Liang C, Jung JU, Cheng JQ, Mule JJ, Pledger WJ, Wang HG. Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis. Nat Cell Biol. 2007 Oct;9(10):1142-1151. Pubmedid: 17891140. Pmcid: PMC2254521.
  • Sagatys E, Garrett CR, Boulware D, Kelley S, Malafa M, Cheng JQ, Sebti S, Coppola D. Activation of the serine/threonine protein kinase Akt during the progression of Barrett neoplasia. Hum Pathol. 2007 Oct;38(10):1526-1531. Pubmedid: 17640711.
  • Saglam O, Garrett CR, Boulware D, Sayegh Z, Shibata D, Malafa M, Yeatman T, Cheng JQ, Sebti S, Coppola D. Activation of the serine/threonine protein kinase AKT during the progression of colorectal neoplasia. Clin Colorectal Cancer. 2007 Sep;6(9):652-656. Pubmedid: 17945038.
  • Bui MM, Bagui TK, Boulware DC, Letson DG, Nasir A, Kaiser HE, Pledger WJ, Coppola D. Altered expression of cell cycle regulatory proteins in benign and malignant bone and soft tissue neoplasms. In Vivo. 2007 Sep;21(5):729-737. Pubmedid: 18019405.
  • Holden Ja, Willmore-Payne C, Coppola D, Garrett CR, Layfield LJ. High-resolution melting amplicon analysis as a method to detect c-kit and platelet-derived growth factor receptor alpha activating mutations in gastrointestinal stromal tumors. Am J Clin Pathol. 2007 Aug;128(2):230-238. Pubmedid: 17638656.
  • Engelman R, Jackson R, Coppola D, Wharton W, Cantor A, Pledger W. Loss of nuclear p21(Cip1/WAF1) during neoplastic progression to metastasis in gamma-irradiated p21 hemizygous mice. Exp Mol Pathol. 2007 Jun;82(3):234-244. Pubmedid: 17207793.
  • Vitale L, Frabetti F, Huntsman SA, Canaider S, Casadei R, Lenzi L, FacchinF, Carinci P, Zannotti M, Coppola D, Strippoli P. Sequence, "subtle" alternative splicing and expression of the CYYR1 (cysteine/tyrosine-rich 1) mRNA in human neuroendocrine tumors. BMC Cancer. 2007 Apr; 7(1): 66- . Pubmedid: 17442112.
  • Lee H, Kim D, Dan HC, Wu EL, Gritsko TM, Cao C, Nicosia SV, Golemis EA, Liu W, Coppola D, Brem SS, Testa JR, Cheng JQ. Identification and characterization of putative tumor suppressor NGB, a GTP-binding protein that interacts with the neurofibromatosis 2 protein. Mol Cell Biol. 2007 Mar;27(6):2103-2119. Pubmedid: 17210637. Pmcid: PMC1820506.
  • Bloom GC, Eschrich S, Zhou J, Coppola D, Yeatman TJ. Elucidation of a protein signature discriminating six common types of adenocarcinoma. Int J Cancer. 2007 Feb;120(4):769-775. Pubmedid: 17131332.
  • Mohapatra S, Coppola D, Riker A, Pledger W. Roscovitine inhibits differentiation and invasion in a three-dimensional skin reconstruction model of metastatic melanoma. Mol Cancer Res. 2007 Feb;5(2):145-151. Pubmedid: 17314272.
  • Heller LC, Jaroszeski M, Coppola D, McCray A, Hickey J, Heller R. Optimization of cutaneous electrically mediated plasmid DNA delivery using novel electrode. Gene Ther. 2007 Feb;14(3):275-280. Pubmedid: 16988718.
  • Nasir A, Boulware D, Kaiser H, Lancaster J, Coppola D, Smith P, Hakam A, Siegel S, Bodey B. Cyclooxygenase-2 (COX-2) expression in human endometrial carcinoma and precursor lesions and its possible use in cancer chemoprevention and therapy. In Vivo. 2007 Jan;21(1):35-43. Pubmedid: 17354612.
  • Rezania D, Ouban A, Marcet J, Kelley S, Coppola D. CMV colitis mimicking recurrent inflammatory bowel disease: report of three cases. Am Surg. 2007 Jan;73(1):58-61. Pubmedid: 17249458.
  • Kumar N, Shibata D, Helm J, Coppola D, Malafa M. Green tea polyphenols in the prevention of colon cancer. Front Biosci. 2007;12:2309-2315. Pubmedid: 17127241.
  • Solmi R, Ugolini G, Rosati G, Zanotti S, Lauriola M, Montroni I, del Governatore M, Caira A, Taffurelli M, Santini D, Coppola D, Guidotti L, CarinciP, Strippoli P. Microarray-based identification and RT-PCR test screening for epithelial-specific mRNAs in peripheral blood of patients with colon cancer. BMC Cancer. 2006 Oct;6:250-250. Pubmedid: 17054783.
  • Ugen K, Kutzler M, Marrero B, Westover J, Coppola D, Weiner D, Heller R. Regression of subcutaneous B16 melanoma tumors after intratumoral delivery ofan IL-15-expressing plasmid followed by in vivo electroporation. Cancer Gene Ther. 2006 Oct;13(10):969-974. Pubmedid: 16763607.
  • Vitale L, Lenzi L, Huntsman SA, Canaider S, Frabetti F, Casadei R, FacchinF, Carinci P, Zannotti M, Coppola D, Strippoli P. Differential expression of alternatively spliced mRNA forms of the insulin-like growth factor 1 receptor in human neuroendocrine tumors. Oncol Rep. 2006 May;15(5):1249-1256. Pubmedid: 16596194.
  • Heller L, Merkler K, Westover J, Cruz Y, Coppola D, Benson K, Daud A, Heller R. Evaluation of toxicity following electrically mediated interleukin-12 gene delivery in a B16 mouse melanoma model. Clin Cancer Res. 2006 May;12(10):3177-3183. Pubmedid: 16707618.
  • Fang Q, Naidu KA, Naidu KA, Zhao H, Sun M, Dan HC, Nasir A, Kaiser HE, Cheng JQ, Nicosia SV, Coppola D. Ascorbyl stearate inhibits cell proliferation and tumor growth in human ovarian carcinoma cells by targeting the PI3K/AKT pathway. Anticancer Res. 2006 Jan;26(1A):203-209. Pubmedid: 16475700.
  • Nasir A, Stridsberg M, Strosberg J, Su P, Livingston S, Malik H, Kelley ST, Centeno B, Coppola D, Malafa M, Yeatman T, Kvols L. Somatostatin receptor profiling in hepatic metastases from small intestinal and pancreatic neuroendocrine neoplasms: immunohistochemical approach with potential clinical utility. Cancer Control. 2006 Jan;13(1):52-60. Pubmedid: 16508627.
  • Haura E, Livingston S, Coppola D. Autocrine interleukin-6/interleukin-6 receptor stimulation in non-small-cell lung cancer. Clin Lung Cancer. 2006 Jan;7(4):273-275. Pubmedid: 16512982.
  • Reed J, Hakam A, Nicosia S, Coppola D. Significance of Fas receptor protein expression in epithelial ovarian cancer. Hum Pathol. 2005 Oct;36(9):971-976. Pubmedid: 16153459.
  • Kwong K, Bloom G, Yang I, Boulware D, Coppola D, Haseman J, Chen E, McGrath A, Makusky A, Taylor J, Steiner S, Zhou J, Yeatman T, Quackenbush J. Synchronous global assessment of gene and protein expression in colorectal cancer progression. Genomics. 2005 Aug;86(2):142-158. Pubmedid: 15951154.
  • Kelley S, Coppola D, Yeatman T, Marcet J. Tumor response to neoadjuvant chemoradiation therapy for rectal adenocarcinoma is mediated by p53-dependent and caspase 8-dependent apoptotic pathways. Clin Colorectal Cancer. 2005 Jul;5(2):114-118. Pubmedid: 16098252.
  • Sun J, Wang DA, Jain RK, Carie A, Paquette S, Ennis E, Blaskovich MA, Baldini L, Coppola D, Hamilton AD, Sebti SM. Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors. Oncogene. 2005 Jul;24(29):4701-4709. Pubmedid: 15897913.
  • Eschrich S, Yang I, Bloom G, Kwong K, Boulware D, Cantor A, Coppola D, Kruhoffer M, Aaltonen L, Orntoft T, Quackenbush J, Yeatman T. Molecular staging for survival prediction of colorectal cancer patients. J Clin Oncol. 2005 May;23(15):3526-3535. Pubmedid: 15908663.
  • Sun J, Blaskovich MA, Jove R, Livingston SK, Coppola D, Sebti SM. Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity. Oncogene. 2005 May;24(20):3236-3245. Pubmedid: 15735720.
  • Helm J, Enkemann S, Coppola D, Barthel J, Kelley S, Yeatman T. Dedifferentiation precedes invasion in the progression from Barrett's metaplasia to esophageal adenocarcinoma. Clin Cancer Res. 2005 Apr;11(7):2478-2485. Pubmedid: 15814623.
  • Centeno B, Enkemann S, Coppola D, Huntsman S, Bloom G, Yeatman T. Classification of human tumors using gene expression profiles obtained after microarray analysis of fine-needle aspiration biopsy samples. Cancer. 2005 Apr;105(2):101-109. Pubmedid: 15643601.
  • Song L, Coppola D, Livingston S, Cress D, Haura EB. Mcl-1 regulates survival and sensitivity to diverse apoptotic stimuli in human non-small cell lung cancer cells. Cancer Biol Ther. 2005 Mar;4(3):267-276. Pubmedid: 15753661.
  • Sun J, Blaskovich MA, Jain RK, Delarue F, Paris D, Brem S, Wotoczek-Obadia M, Lin Q, Coppola D, Choi K, Mullan M, Hamilton AD, Sebti SM. Blocking angiogenesis and tumorigenesis with GFA-116, a synthetic molecule that inhibits binding of vascular endothelial growth factor to its receptor. Cancer Res. 2004 May;64(10):3586-3592. Pubmedid: 15150116.
  • Dan HC, Jiang K, Coppola D, Hamilton A, Nicosia SV, Sebti SM, Cheng JQ. Phosphatidylinositol-3-OH kinase/AKT and survivin pathways as critical targets for geranylgeranyltransferase I inhibitor-induced apoptosis. Oncogene. 2004 Jan;23(3):706-715. Pubmedid: 14737105.
  • Bloom G, Yang IV, Boulware D, Kwong KY, Coppola D, Eschrich S, Quackenbush J, Yeatman TJ. Multi-platform, multi-site, microarray-based human tumor classification. Am J Pathol. 2004 Jan;164(1):9-16. Pubmedid: 14695313.
  • Nasir A, Kaiser H, Boulware D, Hakam A, Zhao H, Yeatman T, Barthel J, Coppola D. Cyclooxygenase-2 expression in right- and left-sided colon cancer: a rationale for optimization of cyclooxygenase-2 inhibitor therapy. Clin Colorectal Cancer. 2004;3(4):243-247. Pubmedid: 15025797.
  • Nicosia S, Wilbanks G, Saunders B, Mayer J, Cardosi R, Kruk P, Cheng J, Bai W, Coppola D, Fiorica J. Cytology of human ovarian surface epithelial brushings. Cancer Cytopathol. 2004;102(1):1-10. Pubmedid: 14968412.
  • Kelley S, Coppola D, Karl R. Neoadjuvant chemoradiotherapy is not associated with a higher complication rate vs. surgery alone in patients undergoing esophagectomy. J Gastrointest Surg. 2004;8(3):227-231. Pubmedid: 15019913.
  • Bodey V, Body V, Siegel S, Nasir A, Coppola D, Hakam A, Kaiser H. Immunocytochemical detection of members of the caspase cascade of apoptosis in high-grade astrocytomas. In Vivo. 2004;18(5):593-602. Pubmedid: 15523899.
  • Solmi R, Sanctis P, Zucchini C, Ugolini G, Rosati G, Del Governatore M, Coppola D, Yeatman T, Lenzi L, Caira A, Zanotti S, Taffurelli M, Carinci P, Valvassori L, Strippoli P. Search for epithelial-specific mRNAs in peripheral blood of patients with colon cancer by RT-PCR. Int J Oncology. 2004;25(4):1049-1056. Pubmedid: 15375555.
  • Nasir A, Boulware D, Kaiser H, Bodey B, Siegel S, Crawley S, Yeatman T, Marcet J, Coppola D. Flat and polypoid adenocarcinomas of the colorectum: A comparative histomorphologic analysis of 47 cases. Hum Pathol. 2004;35(5):604-611. Pubmedid: 15138936.
  • Nasir A, Catalano E, Calafati S, Cantor A, Kaiser H, Coppola D. Role of p53, CD44V6 and CD57 in differentiating between benign and malignant follicular neoplasms of the thyroid. In Vivo. 2004;18(2):189-195. Pubmedid: 15113046.
  • Wang T, Niu G, Kortylewski M, Burdelya L, Shain K, Zhang S, Bhattacharya R, Gabrilovich D, Heller R, Coppola D, Dalton W, Jove R, Pardoll D, Yu H. Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells. Nat Med. 2004;10(1):48-54. Pubmedid: 14702634.
  • Coppola D, Szabo M, Boulware D, Muraca P, Alsarraj M, Chambers A, Yeatman TJ. Correlation of osteopontin protein expression and pathological stage across a wide variety of tumor histologies. Clin Cancer Res. 2004;10(1):184-190. Pubmedid: 14734468.
  • Ahmad N, Keehn C, Coppola D. The expression of insulin-like growth factor-I receptor correlates with Fuhrman grading of renal cell carcinomas. Hum Pathol. 2004;35(9):1132-1136. Pubmedid: 15343516.
  • Paris D, Townsend K, Quadros A, Humphrey J, Sun J, Brem S, Wotoczek-Obadia M, DelleDonne A, Patel N, Obregon DF, Crescentini R, Abdullah L, Coppola D, Rojiani A,, Crawford F, Sebti SM, Mullan M. Inhibition of angiogenesis by Abeta peptides. Angiogenesis. 2004;7(1):75-85. Pubmedid: 15302999.
  • Sekharam M, Zhao H, Sun M, Fang Q, Zhang Q, Yuan Z, Dan HC, Boulware D, Cheng JQ, Coppola D. Insulin-like growth factor 1 receptor enhances invasion and induces resistance to apoptosis of colon cancer cells through the Akt/Bcl-x(L) pathway. Cancer Res. 2003 Nov;63(22):7708-7716. Pubmedid: 14633695.
  • Iravani S, Zhang HQ, Yuan ZQ, Cheng JQ, Karl RC, Jove R, Coppola D. Modification of insulin-like growth factor 1 receptor, c-Src, and Bcl-XL protein expression during the progression of Barrett's neoplasia. Hum Pathol. 2003 Oct;34(10):975-982. Pubmedid: 14608530.
  • Hakam A, Fang Q, Karl R, Coppola D. Coexpression of IGF-1R and c-Src proteins in human pancreatic ductal adenocarcinoma. Dig Dis Sci. 2003 Oct;48(10):1972-1978. Pubmedid: 14627343.
  • Yuan ZQ, Feldman RI, Sussman GE, Coppola D, Nicosia SV, Cheng JQ. AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: implication of AKT2 in chemoresistance. J Biol Chem. 2003 Jun;278(26):23432-23440. Pubmedid: 12697749.
  • Gritsko TM, Coppola D, Paciga JE, Yang L, Sun M, Shelley SA, Fiorica JV, Nicosia SV, Cheng JQ. Activation and overexpression of centrosome kinase BTAK/Aurora-A in human ovarian cancer. Clin Cancer Res. 2003 Apr;9(4):1420-1426. Pubmedid: 12684414.
  • Allen E, Brinker D, Coppola D, Diaz J, Epstein J. Multilocular prostatic cystadenoma with high-grade prostatic intraepithelial neoplasia. Urology. 2003;61(3):644-644. Pubmedid: 12639673.
  • Naidu K, Nasir A, Pinkas H, Kaiser H, Brady P, Coppola D. Glutathione-S-transferase pi expression and activity is increased in colonic neoplasia. In Vivo. 2003;17(5):479-482. Pubmedid: 14598612.
  • Ouban A, Muraca P, Yeatman T, Coppola D. Expression and distribution of insulin-like growth factor-1 receptor in human carcinomas. Hum Pathol. 2003;34(8):803-808. Pubmedid: 14506643.
  • Jackson R, Engelman R, Coppola D, Cantor A, Wharton W, Pledger W. p21Cip1 nullizygosity increases tumor metastasis in irradiated mice. Cancer Res. 2003;63(12):3021-3025. Pubmedid: 12810620.
  • Agrawal D, Chen T, Irby R, Quackenbush J, Chambers A, Szabo M, Cantor A, Coppola D, Yeatman T. Osteopontin identified as colon cancer tumor progression marker. C R Biol. 2003;326(10-11):1041-1043. Pubmedid: 14744111.
  • Sekharam M, Nasir A, Kaiser HE, Coppola D. Insulin-like growth factor 1 receptor activates c-SRC and modifies transformation and motility of colon cancer in vitro. Anticancer Res. 2003;23(2B):1517-1524. Pubmedid: 12820418.
  • Sun J, Ohkanda J, Coppola D, Yin H, Kothare M, Busciglio B, Hamilton A, Sebti S. Geranylgeranyltransferase I inhibitor GGTI-2154 induces breast carcinoma apoptosis and tumor regression in H-Ras transgenic mice. Cancer Res. 2003;63(24):8922-8929. Pubmedid: 14695209.
  • Tsibris J, Segars J, Enkemann S, Coppola D, Wilbanks G, O'Brien W, Spellacy W. New and old regulators of uterine leiomyoma growth from screening with DNA arrays. Fertil Steril. 2003;80(2):279-281. Pubmedid: 12909486.
  • Nicosia S, Bai W, Cheng J, Coppola D, Kruk P. Oncogenic pathways implicated in ovarian epithelial cancer. Hematol Oncol Clin North Am. 2003;17(4):927-943. Pubmedid: 12959183.
  • Eason D, LeBron C, Coppola D, Moscinski L, Livingston S, Sutton E, Blanck G. Development of CD30+ lymphoproliferative disease in mice lacking interferon regulatory factor-1. Oncogene. 2003;22(40):6166-6176. Pubmedid: 13679855.
  • Naidu K, Karl R, Naidu K, Coppola D. Antiproliferative and proapoptotic effect of ascorbyl stearate in human pancreatic cancer cells: association with decreased expression of insulin-like growth factor 1 receptor. Dig Dis Sci. 2003;48(1):230-237. Pubmedid: 12645815.
  • Chen T, Yang I, Irby R, Shain K, Wang H, Quackenbush J, Coppola D, Cheng JQ, Yeatman T. Regulation of caspase expression and apoptosis by adenomatous polyposis coli. Cancer Res. 2003;63(15):4368-4374. Pubmedid: 12907606.
  • Yuan ZQ, Feldman RI, Sun M, Olashaw NE, Coppola D, Sussman GE, Shelley SA, Nicosia SV, Cheng JQ. Inhibition of JNK by cellular stress- and tumor necrosis factor alpha-induced AKT2 through activation of the NF kappa B pathway in human epithelial Cells. J Biol Chem. 2002 Aug;277(33):29973-29982. Pubmedid: 12048203.
  • Reed J, Ouban A, Schickor FK, Muraca P, Yeatman T, Coppola D. Immunohistochemical staining for c-Kit (CD117) is a rare event in human colorectal carcinoma. Clin Colorectal Cancer. 2002 Aug;2(2):119-122. Pubmedid: 12453327.
  • Lucas ML, Heller L, Coppola D, Heller R. IL-12 plasmid delivery by in vivo electroporation for the successful treatment of established subcutaneous B16.F10 melanoma. Mol Ther. 2002 Jun;5(6):668-675. Pubmedid: 12027550.
  • Davenport CM, McAdams HA, Kou J, Mascioli K, Eichman C, Healy L, Peterson J, Murphy S, Coppola D, Truneh A. Inhibition of pro-inflammatory cytokine generation by CTLA4-Ig in the skin and colon of mice adoptively transplanted with CD45RBhi CD4+ T cells correlates with suppression of psoriasis and colitis. Int Immunopharmacol. 2002 Apr;2(5):653-672. Pubmedid: 12013505.
  • Niu G, Wright KL, Huang M, Song L, Haura E, Turkson J, Zhang S, Wang T, Sinibaldi D, Coppola D, Heller R, Ellis LM, Karras J, Bromberg J, Pardoll D, Jove R, Yu H. Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. Oncogene. 2002 Mar;21(13):2000-2008. Pubmedid: 11960372.
  • Jantzen PT, Connor KE, DiCarlo G, Wenk GL, Wallace JL, Rojiani AM, Coppola D, Morgan D, Gordon MN. Microglial activation and beta -amyloid deposit reduction caused by a nitric oxide-releasing nonsteroidal anti-inflammatory drug in amyloid precursor protein plus presenilin-1 transgenic mice. J Neurosci. 2002 Mar;22(6):2246-2254. Pubmedid: 11896164.
  • Tsibris J, Segars J, Coppola D, Mane S, Wilbanks G, O'Brien W, Spellacy WN. Insights from gene arrays on the development and growth regulation of uterine leiomyomata. Fertil Steril. 2002;78(1):114-121. Pubmedid: 12095500.
  • Burdelya L, Catlett-Falcone R, Levitzki A, Cheng F, Mora L, Sotomayor E, Coppola D, Sun J, Sebti S, Dalton W, Jove R, Yu H. Combination therapy with AG-490 and interleukin 12 achieves greater antitumor effects than either agent alone. Mol Cancer Ther. 2002;1(11):893-899. Pubmedid: 12481410.
  • Ouban A, Nawab R, Coppola D. Diagnostic and pathogenetic implications of colorectal carcinomas with multidirectional differentiation: a report of 4 cases. Clin Colorectal Cancer. 2002;1(4):243-248. Pubmedid: 12450423.
  • Heller L, Coppola D. Electrically mediated delivery of vector plasmid DNA elicits an antitumor effect. Gene Ther. 2002;9(19):1321-1325. Pubmedid: 12224015.
  • Jaroszeski M, Coppola D, Pottinger C, Gilbert R. Electrochemotherapy for the treatment of human sarcoma in athymic rats. Technol Cancer Res Treat. 2002;1(5):393-399. Pubmedid: 12625765.
  • Dessureault S, Coppola D, Weitzner M, Powers P, Karl R. Barrett's esophagus and squamous cell carcinoma in a patient with psychogenic vomiting. Int J Gastrointest Cancer. 2002;32(1):57-61. Pubmedid: 12630772.
  • Wu J, Catalano E, Coppola D. Retroperitoneal fibrosis (Ormond's disease): clinical pathologic study of eight cases. Cancer Control. 2002;9(5):432-437. Pubmedid: 12410182.
  • Agrawal D, Chen T, Irby R, Quackenbush J, Chambers A, Szabo M, Cantor A, Coppola D, Yeatman T. Osteopontin identified as lead marker of colon cancer progression, using pooled sample expression profiling. J Natl Cancer Inst. 2002;94(7):513-521. Pubmedid: 11929952.
  • Heller R, Coppola D, Pottinger C, Gilbert R, Jaroszeski M. Effect of electrochemotherapy on muscle and skin. Technol Cancer Res Treat. 2002;1(5):385-392. Pubmedid: 12625764.
  • Nackley J 2nd, Barthel J, Coppola D. Upper gastrointestinal bleeding from leukemic gastric implants. Endoscopy. 2002;34(4):354-354. Pubmedid: 11932803.
  • Jackson R, Adnane J, Coppola D, Cantor A, Sebti S, Pledger W. Loss of the cell cycle inhibitors p21(Cip1) and p27(Kip1) enhances tumorigenesis in knockout mouse models. Oncogene. 2002;21(55):8486-8497. Pubmedid: 12466968.
  • Sun M, Paciga JE, Feldman RI, Yuan Z, Coppola D, Lu YY, Shelley SA, Nicosia SV, Cheng JQ. Phosphatidylinositol-3-OH Kinase (PI3K)/AKT2, activated in breast cancer, regulates and is induced by estrogen receptor alpha (ERalpha) via interaction between ERalpha and PI3K. Cancer Res. 2001 Aug;61(16):5985-5991. Pubmedid: 11507039.
  • Eason D, Coppola D, Livingstone S, Blanck G, Shepherd A. Loss of MHC class II inducibility in hyperplastic tissue in Rb-defective mice. Cancer Lett. 2001;171(2):209-214. Pubmedid: 11520605.
  • Naidu K, Tang J, Naidu K, Prockop L, Nicosia S, Coppola D. Antiproliferative and apoptotic effect of ascorbyl stearate in human glioblastoma multiforme cells: modulation of insulin-like growth factor-I receptor (IGF-IR) expression. J Neurooncol. 2001;54(1):15-22. Pubmedid: 11763418.
  • Jaroszeski M, Coppola D, Nesmith G, Pottinger C, Hyacinthe M, Benson K, Dang V, Gilbert R, Heller R. Effects of electrochemotherapy with bleomycin on normal liver tissue in a rat model. Eur J Cancer. 2001;37(3):414-421. Pubmedid: 11239765.
  • Kim C, Yeatman T, Coppola D, Trotti A, Williams B, Barthel J, Dinwoodie W, Karl R, Marcet J. Local excision of T2 and T3 rectal cancers after downstaging chemoradiation. Ann Surg. 2001;234(3):352-358. Pubmedid: 11524588.
  • Zhang X, Wharton W, Donovan M, Coppola D, Croxton R, Cress WD, Pledger WJ. Density-dependent growth inhibition of fibroblasts ectopically expressing p27(kip1). Mol Biol Cell. 2000 Jun;11(6):2117-2130. Pubmedid: 10848633.
  • Yuan ZQ, Sun M, Feldman RI, Wang G, Ma X, Jiang C, Coppola D, Nicosia SV, Cheng JQ. Frequent activation of AKT2 and induction of apoptosis by inhibition of phosphoinositide-3-OH kinase/Akt pathway in human ovarian cancer. Oncogene. 2000 May;19(19):2324-2330. Pubmedid: 10822383.
  • Jiang K, Coppola D, Crespo NC, Nicosia SV, Hamilton AD, Sebti SM, Cheng JQ. The phosphoinositide 3-OH kinase/AKT2 pathway as a critical target for farnesyltransferase inhibitor-induced apoptosis. Mol Cell Biol. 2000 Jan;20(1):139-148. Pubmedid: 10594016. Pmcid: PMC85069.
  • Jaroszeski M, Coppola D, Pottinger C, Benson K, Gilbert R, Heller R. Treatment of hepatocellular carcinoma in a rat model using electrochemotherapy. Eur J Cancer. 2000;37(3):422-430. Pubmedid: 11239766.
  • Kounelis S, Kapranos N, Kouri E, Coppola D, Papadaki H, Jones M. Immunohistochemical profile of endometrial adenocarcinoma: a study of 61 cases and review of the literature. Mod Pathol. 2000;13(4):379-388. Pubmedid: 10786803.
  • Kocab M, Coppola D, Hiotis S, Karl R, Barthel J. Captopril-associated cholestasis complicating the management of pancreatic cancer. Surg Endosc. 2000;14(7):681-681. Pubmedid: 11265073.
  • Karl R, Schreiber R, Boulware D, Baker S, Coppola D. Factors affecting morbidity, mortality, and survival in patients undergoing Ivor Lewis esophagogastrectomy. Ann Surg. 2000;231(5):635-643. Pubmedid: 10767784.
  • Blaskovich M, Lin Q, Delarue F, Sun J, Park H, Coppola D, Hamilton A, Sebti S. Design of GFB-111, a platelet-derived growth factor binding molecule with antiangiogenic and anticancer activity against human tumors in mice. Nat Biotechnol. 2000;18(10):1065-1070. Pubmedid: 11017044.
  • Sun J, Nam S, Lee C, Li B, Coppola D, Hamilton A, Dou Q, Sebti S. CEP1612, a dipeptidyl proteasome inhibitor, induces p21WAF1 and p27KIP1 expression and apoptosis and inhibits the growth of the human lung adenocarcinoma A-549 in nude mice. Cancer Res. 2000;61(4):1280-1284. Pubmedid: 11245420.
  • Nakshabendi I, Maldonado M, Coppola D, Mamel J. Esophageal cast: a manifestation of graft-versus-host disease. Dig Dis. 2000;18(2):103-105. Pubmedid: 11060473.
  • Heller L, Jaroszeski M, Coppola D, Pottinger C, Gilbert R, Heller R. Electrically mediated plasmid DNA delivery to hepatocellular carcinomas in vivo. Gene Ther. 2000;7(10):826-829. Pubmedid: 10845719.
  • Coppola D. Molecular markers of pancreatic neoplasia. Cancer Control. 2000;7(5):421-427. Pubmedid: 11000611.
  • Coppola D, Lu L, Boyce HW J. Chronic esophagitis dissecans presenting with esophageal strictures: a case report. Hum Pathol. 2000;31(10):1313-1317. Pubmedid: 11070124.
  • Zhang H, Wei S, Sun J, Coppola D, Zhong B, Wu G, Goodwin B, Sebti S, Djeu JY, Blanck G. Retinoblastoma protein activation of interleukin 8 expression inhibits tumor cell survival in nude mice. Cell Growth Differ. 2000;11(12):635-639. Pubmedid: 11149598.
  • Niu G, Heller R, Catlett-Falcone R, Coppola D, Jaroszeski M, Dalton W, Jove R, Yu H. Gene therapy with dominant-negative stat3 suppresses growth of the murine melanoma beta16 tumor in vivo. Cancer Res. 1999;59(20):5059-5063. Pubmedid: 10537273.
  • Coppola D, Karl R. Barrett's esophagus and Barrett's associated neoplasia: etiology and pathologic features. Cancer Control. 1999;6(1):21-27. Pubmedid: 10758531.
  • Coppola D, Catalano E, Nicosia S. Significance of p53 and Bcl-2 protein expression in human breast ductal carcinoma. Cancer Control. 1999;6(2):181-187. Pubmedid: 10758547.
  • Irby R, Mao W, Coppola D, Kang J, Trudeau W, Loubeau J, Karl R, Fujita D, Jove R, Yeatman T. Identification of an activating c-Src mutation with transforming and metastatic properties in human colon cancer. Nat Genet. 1999;21(2):187-190. Pubmedid: 9988270.
  • Coppola D, Saunders B, Fu L, Mao W, Nicosia S. The insulin-like growth factor 1 receptor induces transformation and tumorigenicity of ovarian mesothelial cells and down-regulates their Fas-receptor expression. Cancer Res. 1999;59(13):3264-3270. Pubmedid: 10397275.
  • Hyacinthe M, Jaroszeski M, Dang V, Coppola D, Karl R, Gilbert R, Heller R. Electrically enhanced drug delivery for the treatment of soft tissue sarcoma. Cancer. 1999;85:409-417. Pubmedid: 10023709.
  • Coppola D. Tumor markers of radiation sensitivity. Cancer Control. 1999;6(4):385-392. Pubmedid: 10758571.
  • Hakam A, Yeatman T, Lu L, Mora L, Marcet J, Nicosia S, Karl R, Coppola D. Expression of insulin-like growth factor-1 receptor in human colorectal cancer. Hum Pathol. 1999;30(10):1128-1133. Pubmedid: 10534157.
  • Coppola D, Schreiber R, Mora L, Dalton W, Karl R. Significance of FAS and RB protein expression during the progression of Barrett's metaplasia to adenocarcinoma. Ann Surg. 1999;6(3):298-304. Pubmedid: 10340890.
  • Iravani S, Mao W, Fu L, Karl R, Yeatman T, Jove R, Coppola D. Elevated c-Src protein expression is an early event in colonic neoplasia. Lab Invest. 1998 Mar;78(3):365-371. Pubmedid: 9520949 .
  • Coppola D, Lu L, Fruehauf J, Kyshtoobayeva A, Karl R, Nocosia S, Yeatman T. Analysis of p53, p21WAF1 and TFG-beta1 in human ductal adenocarcinoma of the pancreas: TFG-beta1 protein. Am J Clin Pathol. 1998;110(1):16-23. Pubmedid: 9661918.
  • Choudhry U, Boyce, Jr. H, Coppola D. Proton pump inhibitor associated gastric polyps: retrospective analyis of their frequency, endoscopic and histological characteristics, and their clinical significance. Am J Clin Pathol. 1998;5:615-621. Pubmedid: 9802346.
  • Thomas J, Sundman D, Greene J, Coppola D, Robinson L, Sandin R. A lung nodule: malignancy or the dog heartworm. Infect Med. 1998;15(2):105-106. Pubmedid: noPMID.
  • Coppola D, Fu L, Nicosia S, Kounelis S, Jones M. Prognostic significance of p53, Bcl-2, Vimentin and S100 protein-positive Langerhans cells in endometrial carcinoma. Hum Pathol. 1998;29:455-462. Pubmedid: 9596268.
  • Cowper S, Fiorica J, Nicosia S, Coppola D. Benign breast disorders: first rule out cancer. Cancer Control. 1998;31(7):140-154.
  • Coppola D, Hyacinthe M, Fu L, Cantor A, Karl R, Marcet J, Cooper D, Nicosia S, Cooper H. CD44V6 expression in human colorectal carcinoma. Hum Pathol. 1998;29(6):627-635. Pubmedid: 9635685.
  • Cowper S, Fiorica J, Nicosia S, Coppola D. Papillary squamous cell carcinoma of the vagina. Cancer Control. 1998;5(2):179-183. Pubmedid: 10761029.
  • Iravani S, Mao W, Fu I, Jove R, Yeatman T, Karl R, Coppola D. Elevated c-Src protein expression is an early event in colonic neoplasia. Lab Invest. 1998;78(3):365-371. Pubmedid: 9520949.
  • Hyacinthe M, Karl R, Coppola D, Goodgene T, Redwood W, Goldenfarb P, Ohiri N, Marcet J. Squamous-cell carcinoma of the pelvis in a giant candyloma accumination: use of neoadjuvant chemoradiation and surgical resection. Dis Colon Rectum. 1998;41:1450-1453. Pubmedid: 9823814.
  • Irby R, Mao W, Coppola D, Jove R, Gamero A, Cuthbertson D, Fujita D, Yeatman T. Overexpression of normal c-Src in poorly-metastatic human colon cancer cells enhances primary tumor growth but not metastatic potential. Cell Growth Differ. 1997;8:1287-1295. Pubmedid: 9419417.
  • Mao W, Irby R, Coppola D, Fu L, Wloch M, Turner J, Yu H, Garcia R, Jove R, Yeatman T. Activation of c-Src by receptor tyrosine kinases in human colon cancer cells with high metastatic potential. Oncogene. 1997;15:3083-3090. Pubmedid: 9444956.
  • Coppola D, Karl R. Brunner's Gland Hamartoma: Is It Just a Morphologic Curiosity. Cancer Control. 1997;4(4):359-363. Pubmedid: 10763043.
  • Coppola D, Karl R. Pathology of early colonic neoplasia: clinical and pathologic features of precursor lesions and minimal carcinomas. Cancer Control. 1997;4(2):60-66. Pubmedid: 10763014.
  • Murthy S, Murthy N, Coppola D, Wood D. The efficacy of BAY y1015 in dextran sulfate model of mouse colitis. Inflam Res. 1997;46:224-233. Pubmedid: 9243306.
  • Coppola D, Catalano E, Nicosia S. Transforming growth factor-alpha and c-erbB-2 oncogene products in ovarian epithelial tumors. Int J Surgical Pathol. 1997;4(3):129-136. Pubmedid: noPMID.
  • Coppola D, Clark M, Landreneau R, Weyant R, Cooper D, Yousem A. Bcl-2, P53, CD44 and CD44V6 isoforms expression in neuroendocrine tumors of the lung. Mod Pathol. 1996;9:484-490. Pubmedid: 8733762.
  • Coppola D, Catalano E, Nicosia R, Barnes L. Expression of TGF-(alpha) and c-fos in conventional and basaloid squamous cell carcinoma of floor of mouth. Int J Surgical Pathol. 1996;3:169-174.
  • Resnicoff M, Cui S, Coppola D, Hoek J, Rubin R. Ethanol-induced inhibition of cell proliferation is modulated by insulin-like growth factor-I receptor levels. Alcohol Clin Exp Res. 1996;20(5):961-966. Pubmedid: 8865975.
  • Ohori N, Coppola D, Landreneau R. CD44V6 expression in stage I bronchioloalveolar carcinoma and conventional pulmonary adenocarcinoma. Mod Pathol. 1996;9:507-512. Pubmedid: 8733765.
  • Coppola D, Catalano E, Clark M, Cantor A, Nicosia S. P53 protein expression in human ductal breast carcinoma and medullary variant. Int J Surgical Pathol. 1996;3:169-174.
  • Coppola D, Putong P, Finkelstein S, Cooper H. Defective synthesis of beta-human chorionic gonadotropin (beta)-HCG in placenta percreta. Int J Surgical Pathol. 1996;4(1):23-28.
  • Resnicoff M, Coppola D, Sell C, Rubini R, Ferrone S, Baserga R. Growth inhibition of human melanoma cells in nude mice by antisense strategies to the tyupe 1 insulin-like growth factor receptor. Cancer Res. 1994;54:4848-4850.
  • Ambrose D, Resnicoff M, Coppola D, Sell C, Miura C, Jameson S, Baserga R, Rubin R. Growth regulation of human glioblastoma T98G cells by insulin-like growth factor-1 and its receptor. J Cell Physiol. 1994;159:92-100.
  • Resnidoff M, Sell C, Rubini M, Coppola D, Ambrose D, Baserga R, Rubin R. Rat glioblastoma cells expressing an antisense RNA to insulin-like growth factor-1 (IGF-1) receptor are non-tumorigenic and induce regression of wild type tumors. Cancer Res. 1994;54:2218-2222.
  • Sell C, Dumenil G, Debeaud C, Miura M, Coppola D, DeAngelis T, Efstratiadis A, Baserga R. Effect of a null mutation of the type 1 IGF receptor gene on growth and transformation of mouse embryo fibroblast. Mol Cell Biol. 1994;14:3604-3612.
  • Coppola D, Ferber A, Miura M, Sell C, D'Ambrosio C, Rubin R, Baserga R. A functional IGF-I receptor is required for the mitogenic and transforming activities of the epidermal growth factor receptor. Mol Cell Biol. 1994;14:4588-4595.
  • De Chadarevian J, Coppola D, Billmire D. Bednar tumor pattern in recurring giant cell fibroblastoma. Am J Clin Pathol. 1993;100:164-166.
  • Coppola D, Catalano E, Tang C, Elfenbein I, Harwick R, Mohr R. Basaloid Squamous cell carcinoma of floor of mouth. Cancer. 1993;72:2299-2305.
  • Resnicoff M, Ambrose D, Coppola D, Rubin R. Insulin-like growth factor-1 and its receptor mediate the autocrine proliferation of human ovarian carcinoma cell lines. Lab Invest. 1993;69:756-760.
  • Coppola D, Brozena S, McClurken J, Goldman B. Aortic dissection in cardiac allograft recipients: a report of two cases. Arch Pathol Lab Med. 1993;117:1170-1173.
  • Holkova B, Perkins EB, Ramakrishnan V, Tombes MB, Shrader E, Talreja N, Wellons MD, Hogan KT, Roodman GD, Coppola D, Kang L, Dawson J, Stuart RK, Peer C, Figg WD, Kolla S, Doyle A, Wright J, Sullivan DM, Roberts JD, Grant S. Phase I trial of bortezomib (PS-341; NSC 681239) and alvocidib (flavopiridol; NSC 649890) in patients with recurrent or refractory B-cell neoplasms. Clin Cancer Res. 2011 May;17(10):3388-3397. Pubmedid: 21447728. Pmcid: PMC3096752.

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