Dung-Tsa Chen, PhD

Dr. Chen has been on numerous NCI grants as a co-investigator involving in the design, conduct, and analysis of research projects in cancer and has over 40 peer-reviewed publications. His key areas of expertise include microarray data analysis, mixed models, survival data analysis, biomarker analysis and clinical trials.His work involves the identification of novel biomarker strategies using genomics and other emerging technologies to guide clinical decision making. He has developed a statistical outlier approach to derive a malignancy-risk gene signature in breast cancer. This statistical outlier method has potential unique applications in cancer research, such as improved prediction of cancer risk, thereby providing better individualized therapy. Statistical outlier methods could be useful tools to help identify subgroups of individuals who may have high risk of cancer development and need special chemopreventive treatments. For example, an outlier gene signature to identifying high-risk normal breast tissue could improve the potential for breast biopsy to identify at-risk patients and refine the current practice of intraoperative assessment of the margins of the resected breast tissues based on histology alone, and may prove useful in guiding treatment choices after lumpectomy.

• Hopewell EL, Zhao W, Fulp WJ, Bronk CC, Lopez AS, Massengill M, Antonia S, Celis E, Haura EB, Enkemann SA, Chen DT, Beg AA. Lung tumor NF-?B signaling promotes T cell-mediated immune surveillance. J Clin Invest. 2013 May;123(6):2509-2522. Pubmedid: 23635779.
• Iclozan C, Antonia S, Chiappori A, Chen DT, Gabrilovich D. Therapeutic regulation of myeloid-derived suppressor cells and immune response to cancer vaccine in patients with extensive stage small cell lung cancer. Cancer Immunol Immunother. 2013 May;62(5):909-918. Pubmedid: 23589106.
• Hodul PJ, Dong Y, Husain K, Pimiento JM, Chen J, Zhang A, Francois R, Pledger WJ, Coppola D, Sebti SM, Chen DT, Malafa MP. Vitamin E ?-Tocotrienol Induces p27(Kip1)-Dependent Cell-Cycle Arrest in Pancreatic Cancer Cells via an E2F-1-Dependent Mechanism. PLoS One. 2013;8(2):e52526. Pubmedid: 23393547.
• Lin HY, Amankwah EK, Tseng TS, Qu X, Chen DT, Park JY. SNP-SNP Interaction Network in Angiogenesis Genes Associated with Prostate Cancer Aggressiveness. PLoS One. 2013;8(4):e59688. Pubmedid: 23593148. Pmcid: PMC3618555.
• Chen L, Chen DT, Kurtyka C, Rawal B, Fulp WJ, Haura EB, Cress WD. Tripartite motif containing 28 (Trim28) can regulate cell proliferation by bridging HDAC1/E2F interactions. J Biol Chem. 2012 Nov;287(48):40106-40118. Pubmedid: 23060449. Pmcid: PMC3504725.
• Cheng GC, Chen DT, Chen JJ, Soong SJ, Lamartiniere C, Barnes S. A chain reaction approach to modelling gene pathways. Transl Cancer Res. 2012 Aug;1(2):61-73. Pubmedid: 22943042.
• Bicaku E, Xiong Y, Marchion DC, Chon HS, Stickles XB, Chen N, Judson PL, Hakam A, Gonzalez-Bosquet J, Wenham RM, Apte SM, Fulp W, Cubitt CL, Chen DT, Lancaster JM. In vitro analysis of ovarian cancer response to cisplatin, carboplatin, and paclitaxel identifies common pathways that are also associated with overall patient survival. Br J Cancer. 2012 Aug;106(12):1967-1975. Pubmedid: 22596241. Pmcid: PMC3388569.
• Zgheib NB, Xiong Y, Marchion DC, Bicaku E, Chon HS, Stickles XB, Sawah EA, Judson PL, Hakam A, Gonzalez-Bosquet J, Wenham RM, Apte SM, Cubitt CL, Chen DT, Lancaster JM. The O-glycan pathway is associated with in vitro sensitivity to gemcitabine and overall survival from ovarian cancer. Int J Oncol. 2012 Aug;41(1):179-188. Pubmedid: 22552627.
• Helm J, Coppola D, Ganapathy V, Lloyd M, Centeno BA, Chen DT, Malafa MP, Park JY. SLC5A8 Nuclear Translocation and Loss of Expression are Associated With Poor Outcome in Pancreatic Ductal Adenocarcinoma. Pancreas. 2012 Aug;41(6):904-909. Pubmedid: 22450368.
• Judson PL, Al Sawah E, Marchion DC, Xiong Y, Bicaku E, Zgheib NB, Chon HS, Stickles XB, Hakam A, Wenham RM, Apte SM, Gonzalez-Bosquet J, Chen DT, Lancaster JM. Characterizing the efficacy of fermented wheat germ extract against ovarian cancer and defining the genomic basis of its activity. Int J Gynecol Cancer. 2012 Jul;22(6):960-967. Pubmedid: 22740002.
• Nishihori T, Alekshun TJ, Shain K, Sullivan DM, Baz R, Perez L, Pidala J, Kharfan-Dabaja MA, Ochoa-Bayona JL, Fernandez HF, Yarde DN, Oliveira V, Fulp W, Han G, Kim J, Chen DT, Raychaudhuri J, Dalton W, Anasetti C, Alsina M. Bortezomib salvage followed by a Phase I/II study of bortezomib plus high-dose melphalan and tandem autologous transplantation for patients with primary resistant myeloma. Br J Haematol. 2012 Jun;157(5):553-563. Pubmedid: 22449149.
• McDaniel JM, Zou JX, Fulp W, Chen DT, List AF, Epling-Burnette PK. Reversal of T-cell tolerance in myelodysplastic syndrome through lenalidomide immune modulation. Leukemia. 2012 Jun;26(6):1425-1429. Pubmedid: 22193963. Pmcid: PMC3321111.
• Chen DT, Hernandez JM, Shibata D, McCarthy SM, Humphries LA, Clark W, Elahi A, Gruidl M, Coppola D, Yeatman T. Complementary Strand MicroRNAs Mediate Acquisition of Metastatic Potential in Colonic Adenocarcinoma. J Gastrointest Surg. 2012 May;16(5):905-913. Pubmedid: 22362069.
• Chen DT, Hsu YL, Fulp WJ, Coppola D, Haura EB, Yeatman TJ, Cress WD. Prognostic and predictive value of a malignancy-risk gene signature in early-stage non-small cell lung cancer. J Natl Cancer Inst. 2011 Dec;103(24):1859-1870. Pubmedid: 22157961. Pmcid: PMC3243673.
• Marchion DC, Cottrill HM, Xiong Y, Chen N, Bicaku E, Fulp WJ, Bansal N, Chon HS, Stickles XB, Kamath SG, Hakam A, Li L, Su D, Moreno C, Judson PL, Berchuck A, Wenham RM, Apte SM, Gonzalez-Bosquet J, Bloom GC, Eschrich SA, Sebti S, Chen DT, Lancaster JM. BAD phosphorylation determines ovarian cancer chemosensitivity and patient survival. Clin Cancer Res. 2011 Oct;17(19):6356-6366. Pubmedid: 21849418. Pmcid: PMC3186862.
• Hernandez JM, Farma JM, Coppola D, Hakam A, Fulp WJ, Chen DT, Siegel EM, Yeatman TJ, Shibata D. Expression of the antiapoptotic protein survivin in colon cancer. Clin Colorectal Cancer. 2011 Sep;10(3):188-193. Pubmedid: 21855041.
• Nasir A, Helm J, Turner L, Chen DT, Strosberg J, Hafez N, Henderson-Jackson EB, Hodul P, Bui MM, Nasir NA, Hakam A, Malafa MP, Yeatman TJ, Coppola D, Kvols LK. RUNX1T1: a novel predictor of liver metastasis in primary pancreatic endocrine neoplasms. Pancreas. 2011 May;40(4):627-633. Pubmedid: 21499216.
• Sokol L, Caceres G, Volinia S, Alder H, Nuovo GJ, Liu CG, McGraw K, Clark JA, Sigua CA, Chen DT, Moscinski L, Croce CM, List AF. Identification of a risk dependent microRNA expression signature in myelodysplastic syndromes. Br J Haematol. 2011 Apr;153(1):24-32. Pubmedid: 21332710.
• Strosberg JR, Fine RL, Choi J, Nasir A, Coppola D, Chen DT, Helm J, Kvols L. First-line chemotherapy with capecitabine and temozolomide in patients with metastatic pancreatic endocrine carcinomas. Cancer. 2011 Mar;117(2):268-275. Pubmedid: 20824724.
• Bepler G, Dilling TJ, Wagner H, Hazelton T, Williams C, Chen DT, Greenberg H, Walsh F, Simon G, Tanvetyanon T, Chiappori A, Haura E, Stevens C. Phase II trial of induction gemcitabine and carboplatin followed by conformal thoracic radiation to 74 Gy with weekly paclitaxel and carboplatin in unresectable stage III non-small cell lung cancer. J Thorac Oncol. 2011 Mar;6(3):553-558. Pubmedid: 21289520.
• Nasir A, Chen DT, Gruidl M, Henderson-Jackson EB, Venkataramu C, McCarthy SM, McBride HL, Harris E, Khakpour N, Yeatman TJ. Novel molecular markers of malignancy in histologically normal and benign breast. Patholog Res Int. 2011;2011:489064. Pubmedid: 21785684. Pmcid: PMC3140260.
• Wiener M, Acland KM, Shaw HM, Soong SJ, Lin HY, Chen DT, Scolyer RA, Winstanley JB, Thompson JF. Sentinel node positive melanoma patients: prediction and prognostic significance of nonsentinel node metastases and development of a survival tree model. Ann Surg Oncol. 2010 Aug;17(8):1995-2005. Pubmedid: 20490699.
• Centeno BA, Bloom G, Chen DT, Chen Z, Gruidl M, Nasir A, Yeatman TY. Hybrid model integrating immunohistochemistry and expression profiling for the classification of carcinomas of unknown primary site. J Mol Diagn. 2010 Jul;12(4):476-486. Pubmedid: 20558571. Pmcid: PMC2893632.
• Chen DT, Nasir A, Culhane A, Venkataramu C, Fulp W, Rubio R, Wang T, Agrawal D, McCarthy SM, Gruidl M, Bloom G, Anderson T, White J, Quackenbush J, Yeatman T. Proliferative genes dominate malignancy-risk gene signature in histologically-normal breast tissue. Breast Cancer Res Treat. 2010 Mar;119(2):335-346. Pubmedid: 19266279. Pmcid: PMC2796276.
• Chen DT, Nasir A, Venkataramu C, Fulp W, Gruidl M, Yeatman T. Evaluation of malignancy-risk gene signature in breast cancer patients. Breast Cancer Res Treat. 2010 Mar;120(1):25-34. Pubmedid: 19306088. Pmcid: PMC2808422.
• Yarde DN, Oliveira V, Mathews L, Wang X, Villagra A, Boulware D, Shain KH, Hazlehurst LA, Alsina M, Chen DT, Beg AA, Dalton WS. Targeting the Fanconi anemia/BRCA pathway circumvents drug resistance in multiple myeloma. Cancer Res. 2009 Dec;69(24):9367-9375. Pubmedid: 19934314.
• Rajecki M, af Hällström T, Hakkarainen T, Nokisalmi P, Hautaniemi S, Nieminen AI, Tenhunen M, Rantanen V, Desmond RA, Chen DT, Guse K, Stenman UH, Gargini R, Kapanen M, Klefström J, Kanerva A, Pesonen S, Ahtiainen L, Hemminki A. Mre11 inhibition by oncolytic adenovirus associates with autophagy and underlies synergy with ionizing radiation. Int J Cancer. 2009 Nov;125(10):2441-2449. Pubmedid: 19672857.
• Helm J, Centeno BA, Coppola D, Melis M, Lloyd M, Park JY, Chen DT, Malafa MP. Histologic characteristics enhance predictive value of American Joint Committee on Cancer staging in resectable pancreas cancer. Cancer. 2009 Sep;115(18):4080-4089. Pubmedid: 19626671.
• Zou JX, Rollison DE, Boulware D, Chen DT, Sloand EM, Pfannes LV, Goronzy JJ, Bai F, Painter JS, Wei S, Cosgrove D, List AF, Epling-Burnette PK. Altered naive and memory CD4+ T-cell homeostasis and immunosenescence characterize younger patients with myelodysplastic syndrome. Leukemia. 2009 Aug;23(7):1288-1296. Pubmedid: 19282834. Pmcid: PMC3252820.
• Boren T, Xiong Y, Hakam A, Wenham R, Apte S, Chan G, Kamath SG, Chen DT, Dressman H, Lancaster JM. MicroRNAs and their target messenger RNAs associated with ovarian cancer response to chemotherapy. Gynecol Oncol. 2009 Apr;113(2):249-255. Pubmedid: 19237188.
• Nair R, Siegel E, Chen D, Fulp W, Yeatman T, Malafa M, Marcet J, Shibata D. Long-Term Results of Transanal Excision After Neoadjuvant Chemoradiation for T2 and T3 Adenocarcinomas of the Rectum. J Gastrointest Surg. 2008 Oct;12(10):1797-1805. Pubmedid: 18709419.
• Farma J, Santillan A, Melis M, Walters J, Belinc D, Chen D, Eikman E, Malafa M. PET/CT Fusion Scan Enhances CT Staging in Patients with Pancreatic Neoplasms. Ann Surg Oncol. 2008 Sep;15(9):2465-2471. Pubmedid: 18551347.
• Chu K, Cheng CJ, Ye X, Lee YC, Zurita AJ, Chen DT, Yu-Lee LY, Zhang S, Yeh ET, Hu MC, Logothetis CJ, Lin SH. Cadherin-11 promotes the metastasis of prostate cancer cells to bone. Mol Cancer Res. 2008 Aug;6(8):1259-1267. Pubmedid: 18708358. Pmcid: PMC2643879.
• Lee H, Reddy M, Geurs N, Palcanis K, Lemons J, Rahemtulla F, Ho K, Chen DT, Davis C, Feldman D. Efficacy of Platelet-Rich Plasma on Wound Healing in Rabbits. J Periodontol. 2008 Apr;79(4):691-696. Pubmedid: 18380563.
• Raki M, S??rkioja M, Desmond R, Chen D, B??tzow R, Hemminki A, Kanerva A. Oncolytic adenovirus Ad5/3-delta24 and chemotherapy for treatment of orthotopic ovarian cancer. Gynecol Oncol. 2008 Jan;108(1):166-172. Pubmedid: 17950450.
• Chen DT, Schell MJ, Chen JJ, Fulp WJ, Eschrich S, Yeatman T. A predictive risk probability approach for microarray data with survival as an endpoint. J Biopharm Stat. 2008;18(5):841-852. Pubmedid: 18781520. Pmcid: PMC2717790.
• Tsai CA, Chen DT, Chen JJ, Balch CM, Thompson JF, Soong SJ. An integrated tree-based classification approach to prognostic grouping with application to localized melanoma patients. J Biopharm Stat. 2007;17(3):445-460. Pubmedid: 17479393.
• Crowley M, Frost A, Chen D, Baffi M, Nicola T, Serra R. Transforming growth factor-beta signaling helps specify tumor type in DMBA and hormone-induced mammary cancers. Differentiation. 2006 Feb;74(1):40-52. Pubmedid: 16466399.
• Raki M, Kanerva A, Ristimaki A, Desmond R, Chen D, Ranki T, Sarkioja M, Kangasniemi L, Hemminki A. Combination of gemcitabine and Ad5/3-Delta24, a tropism modified conditionally replicating adenovirus, for the treatment of ovarian cancer. Gene Ther. 2005 Aug;12(15):1198-1205. Pubmedid: 15800658.
• Chen D, Chen J, Soong S. Probe rank approaches for gene selection in oligonucleotide arrays with a small number of replicates. Bioinformatics. 2005 Jun;21(12):2861-2866. Pubmedid: 15814562.
• Tsai C, Wang S, Chen D, Chen J. Sample size for gene expression microarray experiments. Bioinformatics. 2005 Apr;21(8):1502-1508. Pubmedid: 15564298.
• Van Kampen K, Shi Z, Gao P, Zhang J, Foster K, Chen D, Marks D, ElmetsCA, Tang D. Safety and immunogenicity of adenovirus-vectored nasal and epicutaneous influenza vaccines in humans. Vaccine. 2005 Jan;23(8):1029-1036. Pubmedid: 15620476.
• Lin D, Liu H, Yin R, Chen D, Soong S, Liu R. Effectiveness of multiple internal standards: deuterated analogues of methylenedioxymethamphetamine, methylenedioxyamphetamine, methamphetamine, and amphetamine. J Anal Toxicol. 2004 Nov;28(8):650-654. Pubmedid: 15538959.
• Morgan S, Chen D, Carlee J, Baggott J. Effect of methotrexate therapy on bone mineral density and body composition in rat adjuvant arthritis. J Rheumatol. 2004 Sep;31(9):1693-1697. Pubmedid: 15338486.
• Chen D. A graphical approach for quality control of oligonucleotide array data. J Biopharm Stat. 2004 Aug;14(3):591-606. Pubmedid: 15468754.
• Chen D, Lin S, Soong S. Gene selection for oligonucleotide array: an approach using PM probe level data. Bioinformatics. 2004 Aug;20(6):854-862. Pubmedid: 14752002.
• Lin S, Lin Y, Chen D, Chu P, Hsu C, Halperin M. Laboratory tests to determine the cause of hypokalemia and paralysis. Arch Intern Med. 2004 Jul;164(14):1561-1566. Pubmedid: 15277290.
• Nicholas AP, O'Hearn E, Holmes SE, Chen DT, Margolis RL. Clinical signs and symptoms in a large hereditary spastic paraparesis pedigree with a novel spastin mutation. Mov Disord. 2004 Jun;19(6):641-648. Pubmedid: 15197701.
• Tu S, Millikan R, Pagliaro L, Daliani D, Papandreou C, Kim J, Chen D, Williams D, Logothetis C. Treatment of refractory urothelial carcinoma with alternating paclitaxel, methotrexate, cisplatin (TMP) and 5-fluorouracil, alpha-interferon, cisplatin (FAP). Urol Oncol. 2003 Sep;21(5):342-348. Pubmedid: 14670540.
• Plants B, Chen D, Fiveash J, Kim R. Bulb of penis as a marker for prostatic apex in external beam radiotherapy of prostate cancer. Int J Radiat Oncol Biol Phys. 2003 Jul;56(4):1079-1084. Pubmedid: 12829145.
• Wang-Johanning F, Frost A, Jian B, Azerou R, Lu D, Chen D, Johanning G. Detecting the expression of human endogenous retrovirus E envelope transcripts in human prostate adenocarcinoma. Cancer. 2003 Jul;98(1):187-197. Pubmedid: 12833471.
• Safavy A, Bonner JA, Waksal HW, Buchsbaum DJ, Gillespie GY, Khazaeli MB, Arani R, Chen DT, Carpenter M, Raisch KP. Synthesis and biological evaluation of paclitaxel-C225 conjugate as a model for targeted drug delivery. Bioconjug Chem. 2003 Mar;14(2):302-310. Pubmedid: 12643740.
• Kim J, Luo W, Chen D, Earley K, Tunstead J, Yu-Lee L, Lin S. Antitumor activity of the 16-kDa prolactin fragment in prostate cancer. Cancer Res. 2003 Jan;63(2):386-393. Pubmedid: 12543792.
• Phan D, Sui X, Chen D, Najjar S, Jenster G, Lin S. Androgen regulation of the cell-cell adhesion molecule-1 (Ceacam1) gene. Mol Cell Endocrinol. 2001 Nov;184(1-2):115-123. Pubmedid: 11694347.
• Estrera V, Chen D, Luo W, Hixson D, Lin S. Signal transduction by the CEACAM1 tumor suppressor. Phosphorylation of serine 503 is required for growth-inhibitory activity. J Biol Chem. 2001 May;276(18):15547-15553. Pubmedid: 11278391.
• Lee J, Chen D, Hung H, Chen J. Analysis of drug dissolution data. Stat Med. 1999 Apr;18(7):799-814. Pubmedid: 10327528.
• Husain K, Centeno BA, Chen DT, Fulp WJ, Perez M, Zhang Lee G, Luetteke N, Hingorani SR, Sebti SM, Malafa MP. Prolonged survival and delayed progression of pancreatic intraepithelial neoplasia in LSL-KrasG12D/+;Pdx-1-Cre mice by vitamin E ?-tocotrienol. Carcinogenesis. 2013 Jun;34(4):858-863. Pubmedid: 23302291. Pmcid: PMC3616675.