Erin M. Siegel, PhD, MPH

Dr. Siegel is an Assistant Member in the Department of Cancer Epidemiology at the H. Lee Moffitt Cancer Center and Research Institute.  Her research has focused on discovering novel cancer biomarkers of early detection and progression.  She has a primary interest in HPV related disease and has investigated epigenetic biomarkers of cancer risk and HPV infection and factors associated with HPV persistence and clearance.  As an epidemiologist, she has experience conducting molecular epidemiological studies focused on HPV, cervical dysplasia and cancer risk.  In addition, she directs a Molecular Epidemiology laboratory and has over ten years of molecular biology laboratory expertise.  She has established and maintained the Bisulfite Genomic Sequencing technique, quantitative Methylation Specific PCR (QMSP), and pyrosequencing in her laboratory. She is NCI-funded to evaluate DNA methylation patterns in cervical cancers utilizing archived formalin fixed paraffin embedded specimens.  Since 2004, she has collaborated in colorectal, esophageal and anal cancer outcomes research and has co-authored manuscripts in this area.  She is a co-investigator evaluating the quality of care in the treatment of colorectal, breast and lung cancers throughout the state of Florida (PI Jacobsen).  Moreover, she was awarded funding to establish the ColoCare Moffitt Site.  This pilot grant provides funding to complement TCC by collecting detailed exposure and health behaviors on 150 TCC colon cancer patients, including anthropometrics and quality of life.  This feasibility study is providing the foundation for several additional proposed studies.  Additionally, Dr. Siegel has collaborated in colorectal, esophageal and anal cancer outcomes research. She leads, as PI, a small cohort study examining the association between IGF/insulin and anthropometrics and colon cancer outcomes.

• Clark W, Siegel EM, Chen YA, Zhao X, Parsons CM, Hernandez JM, Weber J, Thareja S, Choi J, Shibata D. Quantitative Measures of Visceral Adiposity and Body Mass Index in Predicting Rectal Cancer Outcomes after Neoadjuvant Chemoradiation. J Am Coll Surg. 2013 Jun;216(6):1070-1081. Pubmedid: 23523147.
• Siegel EM, Nabors LB, Thompson RC, Olson JJ, Browning JE, Madden MH, Han G, Egan KM. Prediagnostic body weight and survival in high grade glioma. J Neurooncol. 2013 May. Pubmedid: 23666204.
• Siegel EM, Patel N, Lu B, Lee JH, Nyitray AG, Craft NE, Frenkel K, Villa LL, Franco EL, Giuliano AR. Biomarkers of oxidant load and type-specific clearance of prevalent oncogenic human papillomavirus infection: markers of immune response?. Int J Cancer. 2012 Jul;131(1):219-228. Pubmedid: 21858808. Pmcid: PMC3319468.
• Siegel EM, Jacobsen PB, Malafa M, Fulp W, Fletcher M, Lee JH, Smith JC, Brown R, Levine R, Cartwright T, Abesada-Terk G, Kim G, Alemany C, Faig D, Sharp P, Markham MJ, Shibata D. Evaluating the Quality of Colorectal Cancer Care in the State of Florida: Results From the Florida Initiative for Quality Cancer Care. J Oncol Pract. 2012 Jul;8(4):239-245. Pubmedid: 23180990. Pmcid: PMC3396822.
• Siegel EM, Patel N, Lu B, Lee JH, Nyitray AG, Huang X, Villa LL, Franco EL, Giuliano AR. Circulating biomarkers of iron storage and clearance of incident human papillomavirus infection. Cancer Epidemiol Biomarkers Prev. 2012 May;21(5):859-865. Pubmedid: 22426142.
• Hernandez JM, Siegel EM, Riggs B, Eschrich S, Elahi A, Qu X, Ajidahun A, Berglund A, Coppola D, Grady WM, Giuliano AR, Shibata D. DNA Methylation Profiling across the Spectrum of HPV-Associated Anal Squamous Neoplasia. PLoS One. 2012;7(11):e50533. Pubmedid: 23226306.
• Jacobsen PB, Shibata D, Siegel EM, Lee JH, Fulp WJ, Alemany C, Abesada-Terk G, Brown R, Cartwright T, Faig D, Kim G, Levine R, Markham MJ, Schreiber F, Sharp P, Malafa M. Evaluating the quality of psychosocial care in outpatient medical oncology settings using performance indicators. Psychooncology. 2011 Nov;20(11):1221-1227. Pubmedid: 20878724.
• Tanvetyanon T, Corman M, Lee JH, Fulp WJ, Schreiber F, Brown RH, Levine RM, Cartwright TH, Abesada-Terk G, Kim GP, Alemany C, Faig D, Sharp PV, Markham MJ, Bepler G, Siegel E, Shibata D, Malafa M, Jacobsen PB. Quality of Care in Non-Small-Cell Lung Cancer: Findings From 11 Oncology Practices in Florida. J Oncol Pract. 2011 Nov;7(6):e25-e31. Pubmedid: 22379428.
• Delmas AL, Riggs BM, Pardo CE, Dyer LM, Darst RP, Izumchenko EG, Monroe M, Hakam A, Kladde MP, Siegel EM, Brown KD. WIF1 is a frequent target for epigenetic silencing in squamous cell carcinoma of the cervix. Carcinogenesis. 2011 Nov;32(11):1625-1633. Pubmedid: 21873353. Pmcid: PMC3204350.
• Hernandez JM, Farma JM, Coppola D, Hakam A, Fulp WJ, Chen DT, Siegel EM, Yeatman TJ, Shibata D. Expression of the antiapoptotic protein survivin in colon cancer. Clin Colorectal Cancer. 2011 Sep;10(3):188-193. Pubmedid: 21855041.
• Gray JE, Laronga C, Siegel EM, Lee JH, Fulp WJ, Fletcher M, Schreiber F, Brown R, Levine R, Cartwright T, Abesada-Terk G, Kim G, Alemany C, Faig D, Sharp P, Markham MJ, Shibata D, Malafa M, Jacobsen PB. Degree of Variability in Performance on Breast Cancer Quality Indicators: Findings From the Florida Initiative for Quality Cancer Care. J Oncol Pract. 2011 Jul;7(4):247-251. Pubmedid: 22043190.
• Hernandez J, Elahi A, Siegel E, Coppola D, Riggs B, Shibata D. HPV L1 capsid protein detection and progression of anal squamous neoplasia. Am J Clin Pathol. 2011 Mar;135(3):436-441. Pubmedid: 21350099.
• Melis M, Weber JM, McLoughlin JM, Siegel EM, Hoffe S, Shridhar R, Turaga KK, Dittrick G, Dean EM, Karl RC, Meredith KL. An elevated body mass index does not reduce survival after esophagectomy for cancer. Ann Surg Oncol. 2011 Mar;18(3):824-831. Pubmedid: 20865331.
• Siegel EM, Salemi JL, Villa LL, Ferenczy A, Franco EL, Giuliano AR. Dietary consumption of antioxidant nutrients and risk of incident cervical intraepithelial neoplasia. Gynecol Oncol. 2010 Sep;118(3):289-294. Pubmedid: 20691333.
• Siegel EM, Salemi JL, Craft NE, Villa LL, Ferenczy AS, Franco EL, Giuliano AR. No association between endogenous retinoic acid and human papillomavirus clearance or incident cervical lesions in Brazilian women. Cancer Prev Res (Phila). 2010 Aug;3(8):1007-1014. Pubmedid: 20606041. Pmcid: PMC2917513.
• Melis M, Hernandez J, Siegel EM, McLoughlin JM, Ly QP, Nair RM, Lewis JM, Jensen EH, Alvarado MD, Coppola D, Eschrich S, Bloom GC, Yeatman TJ, Shibata D. Gene expression profiling of colorectal mucinous adenocarcinomas. Dis Colon Rectum. 2010 Jun;53(6):936-943. Pubmedid: 20485009.
• Meredith KL, Weber JM, Turaga KK, Siegel EM, McLoughlin J, Hoffe S, Marcovalerio M, Shah N, Kelley S, Karl R. Pathologic response after neoadjuvant therapy is the major determinant of survival in patients with esophageal cancer. Ann Surg Oncol. 2010 Apr;17(4):1159-1167. Pubmedid: 20140529.
• Siegel EM, Ulrich CM, Poole EM, Holmes RS, Jacobsen PB, Shibata D. The effects of obesity and obesity-related conditions on colorectal cancer prognosis. Cancer Control. 2010 Jan;17(1):52-57. Pubmedid: 20010519.
• Jacobsen PB, Shibata D, Siegel EM, Lee JH, Alemany CA, Brown R, Cartwright TH, Levine RM, Smith JC, Abesada-Terk G, Malafa MP. Initial evaluation of quality indicators for psychosocial care of adults with cancer. Cancer Control. 2009 Oct;16(4):328-334. Pubmedid: 19910919.
• Malafa MP, Corman MM, Shibata D, Siegel EM, Lee JH, Jacobsen PB. The Florida Initiative for Quality Cancer Care: a regional project to measure and improve cancer care. Cancer Control. 2009 Oct;16(4):318-327. Pubmedid: 19910918.
• Melis M, McLoughlin JM, Dean EM, Siegel EM, Weber JM, Shah N, Kelley ST, Karl RC. Correlations between neoadjuvant treatment, anemia, and perioperative complications in patients undergoing esophagectomy for cancer. J Surg Res. 2009 May;153(1):114-120. Pubmedid: 19201421.
• Whiteside MA, Siegel EM, Unger ER. Human papillomavirus and molecular considerations for cancer risk. Cancer. 2008 Nov;113(10 Suppl):2981-2994. Pubmedid: 18980282.
• Nair R, Siegel E, Chen D, Fulp W, Yeatman T, Malafa M, Marcet J, Shibata D. Long-Term Results of Transanal Excision After Neoadjuvant Chemoradiation for T2 and T3 Adenocarcinomas of the Rectum. J Gastrointest Surg. 2008 Oct;12(10):1797-1805. Pubmedid: 18709419.
• McLoughlin J, Melis M, Siegel E, Dean E, Weber J, Chern J, Elliott M, Kelley S, Karl R. Are patients with esophageal cancer who become PET negative after neoadjuvantchemoradiation free of cancer. J Am Coll Surg. 2008 May;206(5):879-886. Pubmedid: 18471715.
• Jacobsen PB, Shibata D, Siegel EM, Druta M, Lee JH, Marshburn J, Davenport L, Cruse H, Levine R, Gondi A, Brown R, Malafa M. Measuring quality of care in the treatment of colorectal cancer: the moffitt quality practice initiative. J Oncol Pract. 2007 Mar;3(2):60-65. Pubmedid: 20859375.
• Siegel EM, Craft NE, Duarte-Franco E, Villa LL, Franco EL, Giuliano AR. Associations between serum carotenoids and tocopherols and type-specific HPV persistence: the Ludwig-McGill cohort study. Int J Cancer. 2007 Feb;120(3):672-680. Pubmedid: 17096322. Pmcid: PMC3458424.
• Jacobsen P, Shibata D, Siegel E, Mihaela D, Lee J, Marshburn J, Davenport J, Cruse H, Richard L, Gondi A, Brown R, Malafa M. Measuring quality of care in the treatment of colorectal cancer: The Moffitt Quality Pracice Initiative. J Oncol Manag. 2007;3:60-65.
• Kellner EM, Orsborn KI, Siegel EM, Mandel MA, Orbach MJ, Galgiani JN, Henning RJ, Cuevas J. Cocaine activates calcium/calmodulin kinase II and causes cardiomyocyte hypertrophy. J Cardiovasc Pharmacol. 2006;48(1):802-813.
• Griffith KA, Sherrill DL, Siegel EM, Manolio TA, Bonekart HW, Enright PL, Bugos JD, Henning RJ, Ondrovic L, Sanberg P, Balis J, Morgan MB. Human umbilical cord blood progenitor cells are attracted to infracted myocardium and significantly reduce myocardial infarction size. Cell Transplant. 2006;15:647-658.
• Griffith KA, Sherrill Dl, Siegel EM, Manolio TA, Bonekart HW, Enright PL, Bugos JD, Henning RJ, Ondrovic L, Sanberg P, Balis J, Morgan MB. Human umbilical cord blood progenitor cells are attracted to infracted myocardium and significantly reduce myocardial infarction size. Cell Transplant. 2006;15:647-658.
• Kellner EM, Orsborn KI, Siegel EM, Mandel MA, Orbach MJ, Galgiani JN, Cuevas J, Henning RJ. Cocaine activates calcium/calmodulin kinase II and causes cardiomyocyte hypertrophy. J Cardiovasc Pharmacol. 2006;48(1):802-813.
• Kellner EM, Orsborn KI, Siegel EM, Mandel MA, Orbach MJ, Galgiani JN. Coccidioides posadasii contains a single 1,3-beta-glucan synthase gene that appears to be essential for growth. Eukaryot Cell. 2005 Jan;4(1):111-120. Pubmedid: 15643067. Pmcid: PMC544152.
• Kellner EM, Orsborn KI, Siegel EM, Mandel MA, Orbach MJ, Galgiani JN. Coccidioides posadasii contains a single 1,3-B-glucan synthase gene that appears essential for growth. 2005;4(1):111-120.
• Flores-Munguia R, Siegel E, Klimecki WT, Giuliano AR. Performance assessment of eight high-throughput PCR assays for viral load quantitation of oncogenic HPV types. J Mol Diagn. 2004 May;6(2):115-124. Pubmedid: 15096567.
• Siegel E, Craft N, Roe D, Duarte-Franco E, Villa L, Franco E, Giuliano AR. Temporal variation and identification of factors associated with endogenous retinoic acid isomers in serum from Brazilian women. Cancer Epidemiol Biomarkers Prev. 2004;13(11Pt1):1693-1703. Pubmedid: 15533895.
• Sawyer D, Guikema A, Siegel E. Evaluation of a new oscillometric blood pressure monitor in isoflurane-anesthetized dogs. Vet Anaesth Analg. 2004;31(1):27-39. Pubmedid: 14756751.
• Giuliano AR, Siegel EM, Roe DJ, Ferreira S, Baggio ML, Galan L, Duarte Franco E, Villa LL, Rohan TE, Franco EL, Marshall JR. Dietary intake and risk of persistent human papillomavirus (HPV) infection: the Ludwig-McGill HPV Natural History Study. J Infect Dis. 2003 Nov;188(10):1508-1516. Pubmedid: 14624376.
• Burgess J, Kovalchick D, Siegel E, Hysong T, McCurdy S. Medical surveillance of clandestine drug laboratory investigators. J Occup Environ Med. 2002;44(2):184-189. Pubmedid: 11851220.
• Keim SM, Anderson KA, Siegel E, Spaite DW, Valenzuela TD. Factors Associated with CPR Certification within an Elderly Community. 2001;51(3):267-272.
• Griffith KA, Sherrill DL, Siegel EM, Manolio TA, Bonekart HW, Enright PL. Predictors of loss of lung function in the elderly: the cardiovascular health study. 2001;163:61-68.
• Hadeli KO, Siegel EM, Sherrill DL, Beck KC, Enright PL. Predictors of oxygen desaturation during submaximal exercise in 8000 patients. Chest. 2001;120(1):88-92.
• Abuodeh RO, Shubitz LF, Siegel E, Snyder S, Peng T, Orsborn KI, Stevens DA, Galgiani JN. Resistance to Coccidioides immitis in mice after immunization with recombinant protein or a DNA vaccine of a proline-rich antigen. Infect Immun. 1999;67(6):2935-2940.