Matthew B. Schabath, PhD

Dr. Schabath is a lung cancer epidemiologist interested in translational epidemiology research to identify genetic markers that influence treatment-response and lung cancer survival.   The overarching goal of this research is to use somatic and germline genetic information to predict which treatment options will be the most efficacious and increase lung cancer survival.   Since joining Moffitt Cancer Center in 2008, Dr. Schabath has expanded his research interests to include assessing the natural history of human papillomavirus (HPV) in men and assessing the role of HPV in lung cancer.  Presently he has several on-going studies including: (1) defining the molecular heterogeneity of KRAS mutant lung cancer using microarray gene signatures; (2) assessing the role of germline genetic variations on treatment response in lung cancer patients; (3) assessing the prevalence, integration, and molecular profile of HPV in lung cancer; (4) assessing the influence of smoking and diet on the natural history of HPV in men; and (5) establishing a large, prospectively recruited cohort of lung cancer patients to assess the impact of risk factors and clinical covariates on lung cancer outcomes.

• Schabath MB, McIntyre J, Pratt C, Gonzalez LE, Munoz-Antonia T, Haura EB, Quinn GP. Healthcare providers' knowledge and attitudes about rapid tissue donation (RTD): phase one of establishing a rapid tissue donation programme in thoracic oncology. J Med Ethics. 2013 Apr. Pubmedid: 23557908.
• Quinn GP, Murphy D, Pratt C, Muñoz-Antonia T, Guerra L, Schabath MB, Leon ME, Haura E. Altruism in terminal cancer patients and rapid tissue donation program: does the theory apply?. Med Health Care Philos. 2013 Mar. Pubmedid: 23539332.
• Kumar V, Gu Y, Basu S, Berglund A, Eschrich SA, Schabath MB, Forster K, Aerts HJ, Dekker A, Fenstermacher D, Goldgof DB, Hall LO, Lambin P, Balagurunathan Y, Gatenby RA, Gillies RJ. Radiomics: the process and the challenges. Magn Reson Imaging. 2012 Nov;30(9):1234-1248. Pubmedid: 22898692. Pmcid: PMC3563280.
• Akogbe GO, Ajidahun A, Sirak B, Anic GM, Papenfuss MR, Fulp WJ, Lin HY, Abrahamsen M, Villa LL, Lazcano-Ponce E, Quiterio M, Smith D, Schabath MB, Salmeron J, Giuliano AR. Race and prevalence of human papillomavirus infection among men residing in Brazil, Mexico and the United States. Int J Cancer. 2012 Aug;131(3):E282-E291. Pubmedid: 22161806. Pmcid: PMC3458422.
• McHugh MK, Schabath MB, Ho CH, Liu M, D'Amelio AM, Greisinger AJ, Delclos GL, Spitz MR, Etzel CJ. Self-Reported Prior Lung Diseases as Risk Factors for Non-small Cell Lung Cancer in Mexican Americans. J Immigr Minor Health. 2012 Jul. Pubmedid: 22847640.
• Wood DE, Eapen GA, Ettinger DS, Hou L, Jackman D, Kazerooni E, Klippenstein D, Lackner RP, Leard L, Leung AN, Massion PP, Meyers BF, Munden RF, Otterson GA, Peairs K, Pipavath S, Pratt-Pozo C, Reddy C, Reid ME, Rotter AJ, Schabath MB, Sequist LV, Tong BC, Travis WD, Unger M, Yang SC. Lung cancer screening. J Natl Compr Canc Netw. 2012 Feb;10(2):240-265. Pubmedid: 22308518.
• Schabath MB, Villa LL, Lazcano-Ponce E, Salmerón J, Quiterio M, Giuliano AR. Smoking and human papillomavirus (HPV) infection in the HPV in Men (HIM) study. Cancer Epidemiol Biomarkers Prev. 2012 Jan;21(1):102-110. Pubmedid: 22016473. Pmcid: PMC3253903.
• Hesselbacher SE, Ross R, Schabath MB, Smith EO, Perusich S, Barrow N, Smithwick P, Mammen MJ, Coxson H, Krowchuk N, Corry DB, Kheradmand F. Cross-sectional analysis of the utility of pulmonary function tests in predicting emphysema in ever-smokers. Int J Environ Res Public Health. 2011 May;8(5):1324-1340. Pubmedid: 21655122. Pmcid: PMC3108112.
• Hancock DB, Eijgelsheim M, Wilk JB, Gharib SA, Loehr LR, Marciante KD, Franceschini N, van Durme YM, Chen TH, Barr RG, Schabath MB, Couper DJ, Brusselle GG, Psaty BM, van Duijn CM, Rotter JI, Uitterlinden AG, Hofman A, Punjabi NM, Rivadeneira F, Morrison AC, Enright PL, North KE, Heckbert SR, Lumley T, Stricker BH, O'Connor GT, London SJ. Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nat Genet. 2010 Jan;42(1):45-52. Pubmedid: 20010835. Pmcid: PMC2832852.
• Barahmani N, Schabath MB, Duvic M. History of atopy or autoimmunity increases risk of alopecia areata. J Am Acad Dermatol. 2009 Oct;61(4):581-591. Pubmedid: 19608295.
• Nettleton JA, Follis JL, Schabath MB. Coffee intake, smoking, and pulmonary function in the Atherosclerosis Risk in Communities Study. Am J Epidemiol. 2009 Jun;169(12):1445-1453. Pubmedid: 19372215. Pmcid: PMC2727200.
• Chamberlain AM, Schabath MB, Folsom AR. Associations of chronic obstructive pulmonary disease with all-cause mortality in Blacks and Whites: the atherosclerosis risk in communities (ARIC) study. Ethn Dis. 2009;19(3):308-314. Pubmedid: 19769014. Pmcid: PMC2826210.
• Wilkinson A, Schabath M, Prokhorov A, Spitz M. Age-related differences in factors associated with smoking initiation. Cancer Causes Control. 2007 Aug;18(6):635-44. Epub 2. Pubmedid: 17473909.
• Spitz M, Hong W, Amos C, Wu X, Schabath M, Dong Q, Shete S, Etzel C. A risk model for prediction of lung cancer. J Natl Cancer Inst. 2007 May;99(9):715-726. Pubmedid: 17470739.
• Kader A, Shao L, Dinney C, Schabath M, Wang Y, Liu J, Gu J, Grossman H, WuX. Matrix metalloproteinase polymorphisms and bladder cancer risk. Cancer Res. 2006 Dec;66(24):11644-11648. Pubmedid: 17178858.
• El-Zein R, Schabath M, Etzel C, Lopez M, Franklin J, Spitz M. Cytokinesis-blocked micronucleus assay as a novel biomarker for lung cancer risk. Cancer Res. 2006 Jun;66(12):6449-6456. Pubmedid: 16778224.
• Gorlova O, Zhang Y, Schabath M, Lei L, Zhang Q, Amos C, Spitz M. Never smokers and lung cancer risk: a case-control study of epidemiological factors. Int J Cancer. 2006 Apr;118(7):1798-1804. Pubmedid: 16217766.
• Schabath M, Wu X, Wei Q, Li G, Gu J, Spitz M. Combined effects of the p53 and p73 polymorphisms on lung cancer risk. Cancer Epidemiol Biomarkers Prev. 2006 Jan;15(1):158-161. Pubmedid: 16434604.
• Schabath M, Hernandez L, Wu X, Pillow P, Spitz M. Dietary phytoestrogens and lung cancer risk.JAMA. 2005 Sep 28;294(12):1493-504. Jama. 2005 Sep;294(12):1493-1504. Pubmedid: 16189362.
• Schabath MB, Delclos GL, Grossman HB, Wang Y, Lerner SP, Chamberlain RM, Spitz MR, Wu X. Polymorphisms in XPD exons 10 and 23 and bladder cancer risk. Cancer Epidemiol Biomarkers Prev. 2005 Apr;14(4):878-884. Pubmedid: 15824159.
• Schabath M, Delclos G, Martynowicz M, Greisinger A, Lu C, Wu X, Spitz M. Opposing effects of emphysema, hay fever, and select genetic variants on lung cancer risk. Am J Epidemiol. 2005 Mar;161(5):412-422. Pubmedid: 15718477.
• Schabath M, Spitz M, Lerner S, Pillow P, Hernandez L, Delclos G, Grossman H, Wu X. Case-control analysis of dietary folate and risk of bladder cancer. Nutr Cancer. 2005;53(2):144-151. Pubmedid: 16573375.
• Schabath M, Grossman H, Delclos G, Hernandez L, Day R, Davis B, LernerSP, Spitz M, Wu X. Dietary carotenoids and genetic instability modify bladder cancer risk. J Nutr. 2004 Dec;134(12):3362-3369. Pubmedid: 15570038.
• Lin J, Spitz M, Wang Y, Schabath M, Gorlov I, Hernandez L, Pillow P, Grossman H, Wu X. Polymorphisms of folate metabolic genes and susceptibility to bladder cancer: a case-control study. Carcinogenesis. 2004 Sep;25(9):1639-1647. Pubmedid: 15117811.
• Zhu Y, Spitz MR, Amos CI, Lin J, Schabath MB, Wu X. An evolutionary perspective on single-nucleotide polymorphism screening in molecular cancer epidemiology. Cancer Res. 2004 Mar;64(6):2251-2257. Pubmedid: 15026370.
• Schabath M, Wu X, Vassilopoulou-Sellin R, Vaporciyan A, Spitz M. Hormone replacement therapy and lung cancer risk: a case-control analysis. Clin Cancer Res. 2004 Jan;10(1 Pt 1):113-123. Pubmedid: 14734459.
• Zheng L, Wang Y, Schabath MB, Grossman HB, Wu X. Sulfotransferase 1A1 (SULT1A1) polymorphism and bladder cancer risk: a case-control study. Cancer Lett. 2003 Dec;202(1):61-69. Pubmedid: 14643027.
• Schabath M, Spitz M, Grossman H, Zhang K, Dinney C, Zheng P, Wu X. Genetic instability in bladder cancer assessed by the comet assay. J Natl Cancer Inst. 2003 Apr;95(7):540-547. Pubmedid: 12671022.
• Wang Y, Spitz M, Schabath M, Ali-Osman F, Mata H, Wu X. Association between glutathione S-transferase p1 polymorphisms and lung cancer risk in Caucasians: a case-control study. Lung Cancer. 2003 Apr;40(1):25-32. Pubmedid: 12660004.
• Wu X, Schabath MB, Spitz MR. Myeloperoxidase promoter region polymorphism and lung cancer risk. Methods Mol Med. 2003;75:121-133. Pubmedid: 12407737.
• Schabath M, Spitz M, Delclos G, Gunn G, Whitehead L, Wu X. Association between asbestos exposure, cigarette smoking, myeloperoxidase (MPO) genotypes, and lung cancer risk. Am J Ind Med. 2002 Jul;42(1):29-37. Pubmedid: 12111688.
• Schabath MB, Spitz MR, Hong WK, Delclos GL, Reynolds WF, Gunn GB, Whitehead LW, Wu X. A myeloperoxidase polymorphism associated with reduced risk of lung cancer. Lung Cancer. 2002 Jul;37(1):35-40. Pubmedid: 12057865.
• Zhang H, Spitz M, Tomlinson G, Schabath M, Minna J, Wu X. Modification of lung cancer susceptibility by green tea extract as measured by the comet assay. Cancer Detect Prev. 2002;26(6):411-418. Pubmedid: 12507225.
• Schabath M, Spitz M, Zhang X, Delclos G, Wu X. Genetic variants of myeloperoxidase and lung cancer risk. Carcinogenesis. 2000 Jun;21(6):1163-1166. Pubmedid: 10837005.