Prakash Chinnaiyan, MD

Dr. Chinnaiyan's laboratory is committed to the study of glioblastoma, with current projects focused on studying altered metabolism, radiation response and the role the unfolded protein response plays in the underlying biology of this malignancy. The overarching goal of his research is translational in nature, with a clear objective of bringing laboratory-based discoveries into the clinic.

• Chinnaiyan P, Kensicki E, Bloom G, Prabhu A, Sarcar B, Kahali S, Eschrich S, Qu X, Forsyth P, Gillies R. The metabolomic signature of malignant glioma reflects accelerated anabolic metabolism. Cancer Res. 2012 Nov;72(22):5878-5888. Pubmedid: 23026133.
• Krop I, Demuth T, Guthrie T, Wen PY, Mason WP, Chinnaiyan P, Butowski N, Groves MD, Kesari S, Freedman SJ, Blackman S, Watters J, Loboda A, Podtelezhnikov A, Lunceford J, Chen C, Giannotti M, Hing J, Beckman R, Lorusso P. Phase I pharmacologic and pharmacodynamic study of the gamma secretase (Notch) inhibitor MK-0752 in adult patients with advanced solid tumors. J Clin Oncol. 2012 Jul;30(19):2307-2313. Pubmedid: 22547604.
• Kahali S, Sarcar B, Prabhu A, Seto E, Chinnaiyan P. Class I histone deacetylases localize to the endoplasmic reticulum and modulate the unfolded protein response. FASEB J. 2012 Jun;26(6):2437-2445. Pubmedid: 22389438.
• Chinnaiyan P, Chowdhary S, Potthast L, Prabhu A, Tsai YY, Sarcar B, Kahali S, Brem S, Yu HM, Rojiani A, Murtagh R, Pan E. Phase I trial of vorinostat combined with bevacizumab and CPT-11 in recurrent glioblastoma. Neuro Oncol. 2012 Jan;14(1):93-100. Pubmedid: 22028388. Pmcid: PMC3246000.
• Prabhu A, Sarcar B, Kahali S, Shan Y, Chinnaiyan P. Targeting the Unfolded Protein Response in Glioblastoma Cells with the Fusion Protein EGF-SubA. PLoS One. 2012;7(12):e52265. Pubmedid: 23284962.
• Scott JG, Basanta D, Chinnaiyan P, Canoll P, Swanson KR, Anderson AR. Production of 2-hydroxyglutarate by isocitrate dehydrogenase 1-mutated gliomas: an evolutionary alternative to the Warburg shift?. Neuro Oncol. 2011 Dec;13(12):1262-1264. Pubmedid: 21784755. Pmcid: PMC3223086.
• Sarcar B, Kahali S, Prabhu AH, Shumway SD, Xu Y, Demuth T, Chinnaiyan P. Targeting Radiation-Induced G2 Checkpoint Activation with the Wee-1 Inhibitor MK-1775 in Glioblastoma Cell Lines. Mol Cancer Ther. 2011 Dec;10(12):2405-2414. Pubmedid: 21992793.
• Scott J, Tsai YY, Chinnaiyan P, Yu HH. Effectiveness of radiotherapy for elderly patients with glioblastoma. Int J Radiat Oncol Biol Phys. 2011 Sep;81(1):206-210. Pubmedid: 20675068.
• Kahali S, Sarcar B, Chinnaiyan P. The emerging role of histone deacetylases (HDACs) in UPR regulation. Methods Enzymol. 2011;490:159-174. Pubmedid: 21266250.
• Backer MV, Backer JM, Chinnaiyan P. Targeting the unfolded protein response in cancer therapy. Methods Enzymol. 2011;491:37-56. Pubmedid: 21329793.
• Sarcar B, Kahali S, Chinnaiyan P. Vorinostat enhances the cytotoxic effects of the topoisomerase I inhibitor SN38 in glioblastoma cell lines. J Neurooncol. 2010 Sep;99(2):201-207. Pubmedid: 20135194.
• Kahali S, Sarcar B, Fang B, Williams ES, Koomen JM, Tofilon PJ, Chinnaiyan P. Activation of the unfolded protein response contributes toward the antitumor activity of vorinostat. Neoplasia. 2010 Jan;12(1):80-86. Pubmedid: 20072656. Pmcid: PMC2805886.
• Feygelman V, Walker L, Chinnaiyan P, Forster K. Simulation of intrafraction motion and overall geometrical accuracy of a frameless intracranial radiosurgery process. J Appl Clin Med Phys. 2008 Oct;9(4):2828-2828. Pubmedid: 19020489.
• Chinnaiyan P, Cerna D, Burgan WE, Beam K, Williams ES, Camphausen K, Tofilon PJ. Postradiation sensitization of the histone deacetylase inhibitor valproic acid. Clin Cancer Res. 2008 Sep;14(17):5410-5415. Pubmedid: 18765532. Pmcid: PMC3393085.
• Chinnaiyan P, Wang M, Rojiani AM, Tofilon PJ, Chakravarti A, Ang KK, Zhang HZ, Hammond E, Curran W J, Mehta MP. The Prognostic value of nestin expression in newly diagnosed glioblastoma: report from the Radiation Therapy Oncology Group. Radiat Oncol. 2008 Sep;3(3):32-32. Pubmedid: 18817556.
• Kumaraswamy S, Chinnaiyan P, Shankavaram UT, Lu X, Camphausen K, Tofilon PJ. Radiation-induced gene translation profiles reveal tumor type and cancer-specific components. Cancer Res. 2008 May;68(10):3819-3826. Pubmedid: 18483266.
• Chinnaiyan P, Varambally S, Tomlins SA, Ray S, Huang S, Chinnaiyan AM, Harari PM. Enhancing the antitumor activity of ErbB blockade with histone deacetylase (HDAC) inhibition. Int J Cancer. 2006 Feb;118(4):1041-1050. Pubmedid: 16152586.
• Chinnaiyan P, Allen GW, Harari PM. Radiation and new molecular agents, part II: targeting HDAC, HSP90, IGF-1R, PI3K, and Ras. Semin Radiat Oncol. 2006 Jan;16(1):59-64. Pubmedid: 16378908.
• Chinnaiyan P, Harari PM. Clinical advancement of EGFR inhibitors in cancer therapy. Methods Mol Biol. 2006;327:189-202. Pubmedid: 16780222.
• Chinnaiyan P, Vallabhaneni G, Armstrong E, Huang SM, Harari PM. Modulation of radiation response by histone deacetylase inhibition. Int J Radiat Oncol Biol Phys. 2005 May;62(1):223-229. Pubmedid: 15850925.
• Chinnaiyan P, Tena L, Brenner M, Welsh J. Modern external beam radiation therapy for refractory dissecting cellulitis of the scalp. Br J Dermatol. 2005 Apr;152(4):777-779. Pubmedid: 15840113.
• Chinnaiyan P, Huang S, Vallabhaneni G, Armstrong E, Varambally S, Tomlins SA, Chinnaiyan AM, Harari PM. Mechanisms of enhanced radiation response following epidermal growth factor receptor signaling inhibition by erlotinib (Tarceva). Cancer Res. 2005 Apr;65(8):3328-3335. Pubmedid: 15833866.
• Hong T, Tome W, Chappell R, Chinnaiyan P, Mehta M, Harari P. The impact of daily setup variations on head-and-neck intensity-modulated radiation therapy. Int J Radiat Oncol Biol Phys. 2005 Mar;61(3):779-788. Pubmedid: 15708257.
• Huang S, Armstrong EA, Benavente S, Chinnaiyan P, Harari PM. Dual-agent molecular targeting of the epidermal growth factor receptor (EGFR): combining anti-EGFR antibody with tyrosine kinase inhibitor. Cancer Res. 2004 Aug;64(15):5355-5362. Pubmedid: 15289342.
• Manon R, Hui S, Chinnaiyan P, Suh J, Chang E, Timmerman R, Phan S, Das R, Mehta M. The impact of mid-treatment MRI on defining boost volumes in the radiation treatment of glioblastoma multiforme. Technol Cancer Res Treat. 2004 Jun;3(3):303-307. Pubmedid: 15161323.
• Chinnaiyan P, Tomee W, Patel R, Chappell R, Ritter M. 3D-ultrasound guided radiation therapy in the post-prostatectomy setting. Technol Cancer Res Treat. 2003 Oct;2(5):455-458. Pubmedid: 14529311.