H. Lee Moffitt Cancer Center & Research Institute

Physician, Faculty, and Staff

Mokenge P. Malafa, MD

Mokenge P. Malafa, MD

Faculty Rank:

Associate Member

Titles:

  • Chair, Department of Gastrointestinal Oncology
  • Section Head, Pancreatic Oncology
  • Program Leader, Gastrointestinal Tumor Program

Department/Program Affiliations:

  • Gastrointestinal Tumor  
  • Experimental Therapeutics  

Primary Address:

H. Lee Moffitt Cancer Center &
Research Institute
12902 Magnolia Drive
Tampa, FL 33612

Office:

(813) 745-1432

USF Affiliations/College Department:

  • Medicine / Oncologic Sciences
  • Medicine / Surgery

University Academic Rank:

Associate Professor

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Mokenge P. Malafa, MD

Education & Training:

  • B.S., University of Wisconsin, Green Bay, Wisconsin, 1982
  • M.D., University of Wisconsin, Madison, Wisconsin, 1986
  • Residency, Medical College of Ohio, Toledo, Ohio, 1986 - General Surgery
  • Fellowship, City of Hope Nationals Medical Center, 1994 - Surgical Oncology

General Board Certification / SubSpecialty:

  • Surgery

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Mokenge P. Malafa, MD

Research Interests:

Dr. Malafa has demonstrated the pre clinical potential of specific vitamin E compounds in the prevention and therapy of breast, melanoma, and colorectal cancers. He is pursuing the development of these compounds in both laboratory models and human intervention trials.


Clinical Interests:

Pancreas, Liver, Colon & Esophageal Tumors

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Mokenge P. Malafa, MD

Publications:

  1. Helm J, Centeno BA, Coppola D, Melis M, Lloyd M, Park JY, Chen DT, Malafa MP. Histologic characteristics enhance predictive value of American Joint Committee on Cancer staging in resectable pancreas cancer. Cancer. 2009 Sep;115(18):4080-4089. Pubmedid: 19626671.   Pubmed ID: 19626671

  2. Husain K, Francois RA, Hutchinson SZ, Neuger AM, Lush R, Coppola D, Sebti S, Malafa MP. Vitamin E delta-tocotrienol levels in tumor and pancreatic tissue of mice after oral administration. Pharmacology. 2009;83(3):157-163. Pubmedid: 19142032. Pmcid: PMC2834260.   Pubmed ID: 19142032

  3. Jacobsen PB, Shibata D, Siegel EM, Lee JH, Alemany CA, Brown R, Cartwright TH, Levine RM, Smith JC, Abesada-Terk G, Malafa MP. Initial evaluation of quality indicators for psychosocial care of adults with cancer. Cancer Control. 2009 Oct;16(4):328-334. Pubmedid: 19910919.   Pubmed ID: 19910919

  4. Malafa MP, Corman MM, Shibata D, Siegel EM, Lee JH, Jacobsen PB. The Florida Initiative for Quality Cancer Care: a regional project to measure and improve cancer care. Cancer Control. 2009 Oct;16(4):318-327. Pubmedid: 19910918.   Pubmed ID: 19910918

  5. Sparano JA, Moulder S, Kazi A, Coppola D, Negassa A, Vahdat L, Li T, Pellegrino C, Fineberg S, Munster P, Malafa M, Lee D, Hoschander S, Hopkins U, Hershman D, Wright JJ, Kleer C, Merajver S, Sebti SM. Phase II trial of tipifarnib plus neoadjuvant doxorubicin-cyclophosphamide in patients with clinical stage IIB-IIIC breast cancer. Clin Cancer Res. 2009 Apr;15(8):2942-2948. Pubmedid: 19351752. Pmcid: PMC2785076.   Pubmed ID: 19351752

  6. Farma J, Santillan A, Melis M, Walters J, Belinc D, Chen D, Eikman E, Malafa M. PET/CT Fusion Scan Enhances CT Staging in Patients with Pancreatic Neoplasms. Ann Surg Oncol. 2008 Sep;15(9):2465-2471. Pubmedid: 18551347.   Pubmed ID: 18551347

  7. Helm J, Centeno B, Coppola D, Druta M, Park J, Chen D, Hodul P, Kvols LK, Yeatman T, Carey L, Karl R, Malafa M. Outcomes following resection of pancreatic adenocarcinoma: 20-year experience at a single institution. Cancer Control. 2008 Oct;15(4):288-294. Pubmedid: 18813196.   Pubmed ID: 18813196

  8. Husain K, Vazquez M, Ansari R, Malafa M, Lalla J. Chronic alcohol-induced oxidative endothelial injury relates to angiotensin II levels in the rat. Mol Cell Biochem. 2008 Jan;307(1-2):51-58. Pubmedid: 17721810.   Pubmed ID: 17721810

  9. Klapman J, Malafa M. Early detection of pancreatic cancer: why, who, and how to screen. Cancer Control. 2008 Oct;15(4):280-287. Pubmedid: 18813195.   Pubmed ID: 18813195

  10. Malafa M. New insights and gains in pancreatic cancer. Cancer Control. 2008 Oct;15(4):276-277. Pubmedid: 18813194.   Pubmed ID: 18813194

  11. Nair R, Barthel J, Centeno B, Choi J, Klapman J, Malafa M. Interdisciplinary management of an intraductal papillary mucinous neoplasm of the pancreas. Cancer Control. 2008 Oct;15(4):322-333. Pubmedid: 18813200.   Pubmed ID: 18813200

  12. Nair R, Siegel E, Chen D, Fulp W, Yeatman T, Malafa M, Marcet J, Shibata D. Long-Term Results of Transanal Excision After Neoadjuvant Chemoradiation for T2 and T3 Adenocarcinomas of the Rectum. J Gastrointest Surg. 2008 Oct;12(10):1797-1805. Pubmedid: 18709419.   Pubmed ID: 18709419

  13. Nasir A, Gardner N, Strosberg J, Ahmad N, Choi J, Malafa M, Coppola D, Kwekkeboom D, Teunissen J, Kvols L. Multimodality management of a polyfunctional pancreatic endocrine carcinoma with markedly elevated serum vasoactive intestinal polypeptide and calcitonin levels. Pancreas. 2008 Apr;36(3):309-313. Pubmedid: 18362846.   Pubmed ID: 18362846

  14. Park J, Helm J, Zheng W, Ly Q, Hodul P, Centeno B, Malafa M. Silencing of the candidate tumor suppressor gene solute carrier family 5 member 8 (SLC5A8) in human pancreatic cancer. Pancreas. 2008 May;36(4):e32-e39. Pubmedid: 18437076.   Pubmed ID: 18437076

  15. Jacobsen P, Shibata D, Siegel E, Mihaela D, Lee J, Marshburn J, Davenport J, Cruse H, Richard L, Gondi A, Brown R, Malafa M. Measuring quality of care in the treatment of colorectal cancer: The Moffitt Quality Pracice Initiative. J Oncol Manag. 2007;3:60-65.  

  16. Jensen E, Kvols L, McLoughlin J, Lewis J, Alvarado M, Yeatman T, Malafa M, Shibata D. Biomarkers Predict Outcomes Following Cytoreductive Surgery for Hepatic Metastases from Functional Carcinoid Tumors. Ann Surg Oncol. 2007 Feb;14(2):780-785. Pubmedid: 17146740.   Pubmed ID: 17146740

  17. Kumar N, Shibata D, Helm J, Coppola D, Malafa M. Green tea polyphenols in the prevention of colon cancer. Front Biosci. 2007 Jan;12:2309-2315. Pubmedid: 17127241.   Pubmed ID: 17127241

  18. Sagatys E, Garrett CR, Boulware D, Kelley S, Malafa M, Cheng JQ, Sebti S, Coppola D. Activation of the serine/threonine protein kinase Akt during the progression of Barrett neoplasia. Hum Pathol. 2007 Oct;38(10):1526-1531. Pubmedid: 17640711.   Pubmed ID: 17640711

  19. Saglam O, Garrett CR, Boulware D, Sayegh Z, Shibata D, Malafa M, Yeatman T, Cheng JQ, Sebti S, Coppola D. Activation of the serine/threonine protein kinase AKT during the progression of colorectal neoplasia. Clin Colorectal Cancer. 2007 Sep;6(9):652-656. Pubmedid: 17945038.   Pubmed ID: 17945038

  20. Tempero M, Alasadi R, Arnoletti J, Behrman S, Ben-Josef E, Benson AB 3rd, Bhargava P, Cameron J, Casper E, Hoffman J, Kim P, Koh W, Kuvshinoff B, Malafa M, Muscarella P 2nd, Nakakura E, Sasson A, Shibata S, Shrieve D, Talamonti M, Tyler D, Wang H, Warren R, Willett C, Wolff R. Pancreatic adenocarcinoma. J Natl Compr Canc Netw. 2007 Nov;5(10):998-1033. Pubmedid: 18053426.   Pubmed ID: 18053426

  21. Donapaty S, Louis S, Horvath E, Kun J, Sebti S, Malafa M. RRR-{alpha}-Tocopherol succinate down-regulates oncogenic Ras signaling. Mol Cancer Ther. 2006 Feb;5(2):309-316. Pubmedid: 16505104.   Pubmed ID: 16505104

  22. Hodul P, Malafa M, Choi J, Kvols L. The role of cytoreductive hepatic surgery as an adjunct to the management of metastatic neuroendocrine carcinomas. Cancer Control. 2006 Jan;13(1):61-71. Pubmedid: 16508628.   Pubmed ID: 16508628

  23. Malafa M, Fokum F, Andoh J, Neitzel L, Bandyopadhyay S, Zhan R, IiizumiM, Furuta E, Horvath E, Watabe K. Vitamin E succinate suppresses prostate tumor growth by inducing apoptosis. Int J Cancer. 2006 May;118(10):2441-2447. Pubmedid: 16380976.   Pubmed ID: 16380976

  24. Malafa M. Liver metastases: enhancing outcomes in 2006. Cancer Control. 2006;13:4-4. Pubmedid: 16508620.   Pubmed ID: 16508620

  25. McLoughlin J, Jensen E, Malafa M. Resection of colorectal liver metastases: current perspectives. Cancer Control. 2006 Jan;13(1):32-41. Pubmedid: 16508624.   Pubmed ID: 16508624

  26. Nasir A, Stridsberg M, Strosberg J, Su P, Livingston S, Malik H, Kelley ST, Centeno B, Coppola D, Malafa M, Yeatman T, Kvols L. Somatostatin receptor profiling in hepatic metastases from small intestinal and pancreatic neuroendocrine neoplasms: immunohistochemical approach with potential clinical utility. Cancer Control. 2006 Jan;13(1):52-60. Pubmedid: 16508627.   Pubmed ID: 16508627

  27. Osborne D, Zervos E, Strosberg J, Boe B, Malafa M, Rosemurgy A, Yeatman TJ, Carey L, Duhaine L, Kvols L. Improved outcome with cytoreduction versus embolization for symptomatic hepatic metastases of carcinoid and neuroendocrine tumors. Ann Surg Oncol. 2006 Apr;13(4):572-581. Pubmedid: 16511671.   Pubmed ID: 16511671

  28. Sparano J, Moulder S, Kazi A, Vahdat L, Li T, Pellegrino C, Munster P, Malafa M, Lee D, Hoschander S, Hopkins U, Hershman D, Wright J, Sebti S. Targeted inhibition of farnesyltransferase in locally advanced breast cancer: a phase I and II trial of tipifarnib plus dose-dense doxorubicin and cyclophosphamide. J Clin Oncol. 2006 Jul;24(19):3013-3018. Pubmedid: 16769985.   Pubmed ID: 16769985

  29. Ellis R, Seifert P, Neal C, Pavolka K, Mann J, Malafa M, WichtermanKA, Ross D, Dunnington G. Periareolar injection for localization of sentinel nodes in breast cancer patients. Breast J. 2004;10(2):94-100. Pubmedid: 15009034.   Pubmed ID: 15009034

  30. Barnett K, Fokum F, Malafa M. Vitamin E succinate inhibits colon cancer liver metastases. J Surg Res. 2002;106(2):292-298. Pubmedid: 12175981.   Pubmed ID: 12175981

  31. Malafa M, Fokum F, Mowlavi A, Abusief M, King M. Vitamin E inhibits melanoma growth in mice. Surgery. 2002;131(1):85-91. Pubmedid: 11812968.   Pubmed ID: 11812968

  32. Malafa MP, Fokum FD, Smith L, Louis A. Inhibition of angiogenesis and promotion of melanoma dormancy by vitamin E succinate. Ann Surg Oncol. 2002 Dec;9(10):1023-1032. Pubmedid: 12464597.   Pubmed ID: 12464597

Mokenge P. Malafa, MD

Below is a list of active grants where the faculty member is the Principal Investigator. Grants are sorted by sponsor and then sorted by start date, with the more recent grant shown first.

Unrestriced Research Grant
Sponsor: Davos Life Science, Ltd
Project Dates: May 2, 2007 to May 1, 2012
Earned to Date: $100,000

Intervention of Pancreatic Oncogenic Pathways with Dietary Tocotrienol

5 R01 CA129227-03
Sponsor: Nat Institutes of Health / NCI
Project Dates: September 22, 2008 to July 31, 2013
Annual Direct Cost: $394,085
Annual Total Cost: $656,718
Project Total: $3,319,668

Molecular Signatures for Colon Cancer

08BR-02
Sponsor: State of Florida / Dept of Health
Project Dates: July 1, 2008 to June 30, 2011
Annual Direct Cost: $270,455
Annual Total Cost: $297,500
Project Total: $970,000

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