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Erin  George

Erin George, MD

Program: Gynecologic Oncology

Research Program: Molecular Medicine Program

  • Overview


    • Drug Discovery
    • Gynecologic Oncology
    • Molecular Medicine Program

    Education & Training


    • Hospital of the University of Pennsylvania - Gynecologic Oncology


    • New York Presbyterian Hospital – Columbia University - Obstetrics and Gynecology

    Medical School:

    • Columbia University College of Physicians and Surgeons - MD
  • Publications

    • Gitto SB, George E, Medvedev S, Simpkins F, Powell DJ. Humanized Patient-Derived Xenograft Models of Ovarian Cancer. Methods Mol Biol. 2022 Jan.2424:255-274. Pubmedid: 34918300.
    • Xu H, George E, Kinose Y, Kim H, Shah JB, Peake JD, Ferman B, Medvedev S, Murtha T, Barger CJ, Devins KM, D'Andrea K, Wubbenhorst B, Schwartz LE, Hwang WT, Mills GB, Nathanson KL, Karpf AR, Drapkin R, Brown EJ, Simpkins F. CCNE1 copy number is a biomarker for response to combination WEE1-ATR inhibition in ovarian and endometrial cancer models. Cell Rep Med. 2021 Sep.2(9):100394. Pubmedid: 34622231. Pmcid: PMC8484689.
    • Kóder G, Olasz J, Tanyi JL, George E, Tóth L, Antal-Szalmás P, Nagy B, Bubán T, András C, Urbancsek H, Laczik M, Csuka O, Damjanovich L, Tanyi M. Identification of Novel Pathogenic Sequence Variants of the Mismatch Repair Genes During Screening for Lynch Syndrome in a Single Centre of Eastern Hungary. J Gastrointest Cancer. 2020 Sep.51(3):1007-1015. Pubmedid: 31939059. Pmcid: PMC7399673.
    • Kim H, Xu H, George E, Hallberg D, Kumar S, Jagannathan V, Medvedev S, Kinose Y, Devins K, Verma P, Ly K, Wang Y, Greenberg RA, Schwartz L, Johnson N, Scharpf RB, Mills GB, Zhang R, Velculescu VE, Brown EJ, Simpkins F. Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models. Nat Commun. 2020 Jul.11(1):3726. Pubmedid: 32709856. Pmcid: PMC7381609.
    • Tanyi JL, George E. Personalized vaccination against ovarian cancer: what are the possibilities?. Expert Rev Vaccines. 2018 Nov.17(11):955-958. Pubmedid: 30362844. Pmcid: PMC6592278.
    • Kim H, George E, Ragland R, Rafail S, Zhang R, Krepler C, Morgan M, Herlyn M, Brown E, Simpkins F. Targeting the ATR/CHK1 Axis with PARP Inhibition Results in Tumor Regression in BRCA-Mutant Ovarian Cancer Models. Clin Cancer Res. 2017 Jun.23(12):3097-3108. Pubmedid: 27993965. Pmcid: PMC5474193.
    • George E, Kim H, Krepler C, Wenz B, Makvandi M, Tanyi JL, Brown E, Zhang R, Brafford P, Jean S, Mach RH, Lu Y, Mills GB, Herlyn M, Morgan M, Zhang X, Soslow R, Drapkin R, Johnson N, Zheng Y, Cotsarelis G, Nathanson KL, Simpkins F. A patient-derived-xenograft platform to study BRCA-deficient ovarian cancers. JCI Insight. 2017 Jan.2(1):e89760. Pubmedid: 28097235. Pmcid: PMC5214535.
    • George EM, Burke WM, Hou JY, Tergas AI, Chen L, Neugut AI, Ananth CV, Hershman DL, Wright JD. Measurement and validation of frailty as a predictor of outcomes in women undergoing major gynaecological surgery. BJOG. 2016 Feb.123(3):455-461. Pubmedid: 26301606. Pmcid: PMC4548816.
    • Wang Y, Krais JJ, Bernhardy AJ, Nicolas E, Cai KQ, Harrell MI, Kim HH, George E, Swisher EM, Simpkins F, Johnson N. RING domain-deficient BRCA1 promotes PARP inhibitor and platinum resistance. J Clin Invest. 2016 Aug.126(8):3145-3157. Pubmedid: 27454289. Pmcid: PMC4966309.
    • George EM, Tergas AI, Ananth CV, Burke WM, Lewin SN, Prendergast E, Neugut AI, Hershman DL, Wright JD. Safety and tolerance of radical hysterectomy for cervical cancer in the elderly. Gynecol Oncol. 2014 Jul.134(1):36-41. Pubmedid: 24768851. Pmcid: PMC4158005.
    • George EM, Herzog TJ, Neugut AI, Lu YS, Burke WM, Lewin SN, Hershman DL, Wright JD. Carcinosarcoma of the ovary: natural history, patterns of treatment, and outcome. Gynecol Oncol. 2013 Oct.131(1):42-45. Pubmedid: 23838036. Pmcid: PMC4230696.
    • Horvath S, George E, Herzog TJ. Unintended consequences: surgical complications in gynecologic cancer. Womens Health (Lond Engl). 2013 Nov.9(6):595-604. Pubmedid: 24161311.
    • Baxi LV, George EM. Three-way tie: the umbilical cord insertion site was different for each member of a set of triplets. Am J Obstet Gynecol. 2013 Dec.209(6):590.e1. Pubmedid: 23665250.
    • George EM, Cabreriza SE, Quinn TA, Rusanov A, Gerrah R, Broyles JM, Weinberg AD, Spotnitz HM. Validation of automated monitoring of cardiac output for biventricular pacing optimization. Asaio J. 2010 May.56(3):265-269. Pubmedid: 20335801. Pmcid: PMC5719881.

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