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Lianchun Wang, MD

Research Program: Molecular Medicine Program

  • Overview


    • Molecular Medicine Program
  • Publications

    • Yang H, Wang L. Heparan sulfate proteoglycans in cancer: Pathogenesis and therapeutic potential. Adv Cancer Res. 2023 Feb.157:251-291. Pubmedid: 36725112.
    • Zhu Y, Gandy L, Zhang F, Liu J, Wang C, Blair LJ, Linhardt RJ, Wang L. Heparan Sulfate Proteoglycans in Tauopathy. Biomolecules. 2022 Nov.12(12). Pubmedid: 36551220. Pmcid: PMC9776397.
    • Xiao W, Pinilla-Baquero A, Faulkner J, Song X, Prabhakar P, Qiu H, Moremen KW, Ludwig A, Dempsey PJ, Azadi P, Wang L. Robo4 is constitutively shed by ADAMs from endothelial cells and the shed Robo4 functions to inhibit Slit3-induced angiogenesis. Sci Rep. 2022 Mar.12(1):4352. Pubmedid: 35288626. Pmcid: PMC8921330.
    • Joladarashi D, Zhu Y, Willman M, Nash K, Cimini M, Thandavarayan RA, Youker KA, Song X, Ren D, Li J, Kishore R, Krishnamurthy P, Wang L. STK35 Gene Therapy Attenuates Endothelial Dysfunction and Improves Cardiac Function in Diabetes. Front Cardiovasc Med. 2022 Jan.8:798091. Pubmedid: 35097018. Pmcid: PMC8792894.
    • Yang H, Cao J, Lin X, Yue J, Zieneldien T, Kim J, Wang L, Fang J, Huang RP, Bai Y, Sneed K, Cao C. Developing an Effective Peptide-Based Vaccine for COVID-19: Preliminary Studies in Mice Models. Viruses. 2022 Feb.14(3). Pubmedid: 35336856. Pmcid: PMC8954996.
    • Wang Y, Li T, Li N, Huang C, Xiong X, Xie X, Wu M, Wang L, Jiang J. 6-O-desulfated heparin attenuates myocardial ischemia/reperfusion injury in mice through the regulation of miR-199a-5p/klotho axis. Glycoconj J. 2022 Dec.39(6):747-758. Pubmedid: 36107266.
    • Faulkner J, Song X, Wang L. Application of a Mutant Cell Library to Determine the Structure-Function Relationship of Heparan Sulfate in Facilitating FGF2-FGFR1 Signaling. Methods Mol Biol. 2021 Oct.2303:637-644. Pubmedid: 34626412.
    • Mah D, Zhao J, Liu X, Zhang F, Liu J, Wang L, Linhardt R, Wang C. The Sulfation Code of Tauopathies: Heparan Sulfate Proteoglycans in the Prion Like Spread of Tau Pathology. Front Mol Biosci. 2021 May.8:671458. Pubmedid: 34095227. Pmcid: PMC8173255.
    • Yue J, Jin W, Yang H, Faulkner J, Song X, Qiu H, Teng M, Azadi P, Zhang F, Linhardt RJ, Wang L. Heparan Sulfate Facilitates Spike Protein-Mediated SARS-CoV-2 Host Cell Invasion and Contributes to Increased Infection of SARS-CoV-2 G614 Mutant and in Lung Cancer. Front Mol Biosci. 2021 Jun.8:649575. Pubmedid: 34179075. Pmcid: PMC8231436.
    • Mitra D, Hasan MH, Bates JT, Bierdeman MA, Ederer DR, Parmar RC, Fassero LA, Liang Q, Qiu H, Tiwari V, Zhang F, Linhardt RJ, Sharp JS, Wang L, Tandon R. The degree of polymerization and sulfation patterns in heparan sulfate are critical determinants of cytomegalovirus entry into host cells. PLoS Pathog. 2021 Aug.17(8):e1009803. Pubmedid: 34352038. Pmcid: PMC8384199.
    • Zhao J, Zhu Y, Song X, Xiao Y, Su G, Liu X, Wang Z, Xu Y, Liu J, Eliezer D, Ramlall TF, Lippens G, Gibson J, Zhang F, Linhardt RJ, Wang L, Wang C. 3-O-Sulfation of Heparan Sulfate Enhances Tau Interaction and Cellular Uptake. Angew Chem Int Ed Engl. 2020 Jan.59(5):1818-1827. Pubmedid: 31692167. Pmcid: PMC6982596.
    • Garbuzova-Davis S, Willing AE, Ehrhart J, Wang L, Sanberg PR, Borlongan CV. Cell-Free Extracellular Vesicles Derived from Human Bone Marrow Endothelial Progenitor Cells as Potential Therapeutics for Microvascular Endothelium Restoration in ALS. Neuromolecular Med. 2020 Dec.22(4):503-516. Pubmedid: 32820422. Pmcid: PMC7677172.

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