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Steven Smith, MD

Research Program: Molecular Medicine Program

  • Overview


    • Molecular Medicine Program
  • Publications

    • Miller GM, Ellis JA, Sarangarajan R, Parikh A, Rodrigues LO, Bruce C, Mahaveer Chand N, Smith SR, Richardson K, Vazquez R, Kiebish MA, Haneesh C, Granger E, Holtz J, Hinkle J, Narain NR, Goodpaster B, Smith JC, Lupu DS. Hypothesis-Agnostic Network-Based Analysis of Real-World Data Suggests Ondansetron is Associated with Lower COVID-19 Any Cause Mortality. Drugs Real World Outcomes. 2022 Sep.9(3):359-375. Pubmedid: 35809196. Pmcid: PMC9281575.
    • Erdos E, Divoux A, Sandor K, Halasz L, Smith SR, Osborne TF. Unique role for lncRNA HOTAIR in defining depot-specific gene expression patterns in human adipose-derived stem cells. Gene Dev. 2022 May.36(9-10):566-581. Pubmedid: 35618313. Pmcid: PMC9186385.
    • Yeo RX, Dijkstra PJ, De Carvalho FG, Yi F, Pino MF, Smith SR, Sparks LM. Aerobic training increases mitochondrial respiratory capacity in human skeletal muscle stem cells from sedentary individuals. Am J Physiol Cell Physiol. 2022 Aug.323(2):C606-C616. Pubmedid: 35785986.
    • Whytock KL, Sun Y, Divoux A, Yu G, Smith SR, Walsh MJ, Sparks LM. Single cell full-length transcriptome of human subcutaneous adipose tissue reveals unique and heterogeneous cell populations. iScience. 2022 Aug.25(8):104772. Pubmedid: 35992069. Pmcid: PMC9385549.
    • Allerton TD, Carnero EA, Bock C, Corbin KD, Luyet PP, Smith SR, Ravussin E. Reliability of measurements of energy expenditure and substrate oxidation using whole-room indirect calorimetry. Obesity (Silver Spring). 2021 Sep.29(9):1508-1515. Pubmedid: 34355521. Pmcid: PMC9178907.
    • Marcus A, Davis TL, Rittmann BE, DiBaise JK, Carnero EA, Corbin K, Smith SR, Krajmalnik-Brown R. Developing a model for estimating the activity of colonic microbes after intestinal surgeries. PLoS One. 2021 Jul.16(7):e0253542. Pubmedid: 34319981. Pmcid: PMC8318292.
    • Davis TL, Dirks B, Carnero EA, Corbin KD, Krakoff J, Parrington S, Lee D, Smith SR, Rittmann BE, Krajmalnik-Brown R, Marcus AK. Chemical Oxygen Demand Can Be Converted to Gross Energy for Food Items Using a Linear Regression Model. J Nutr. 2021 Feb.151(2):445-453. Pubmedid: 33188419. Pmcid: PMC7850027.
    • Ravussin E, Smith SR, Ferrante AW. Physiology of Energy Expenditure in the Weight-Reduced State. Obesity (Silver Spring). 2021 Apr.29 Suppl 1:S31-S38. Pubmedid: 33759394. Pmcid: PMC8988211.
    • Corbin KD, Krajmalnik-Brown R, Carnero EA, Bock C, Emerson R, Rittmann BE, Marcus AK, Davis T, Dirks B, Ilhan ZE, Champagne C, Smith SR. Integrative and quantitative bioenergetics: Design of a study to assess the impact of the gut microbiome on host energy balance. Contemp Clin Trials Commun. 2020 Sep.19:100646. Pubmedid: 32875141. Pmcid: PMC7451766.
    • Divoux A, Sandor K, Bojcsuk D, Yi F, Hopf ME, Smith JS, Balint BL, Osborne TF, Smith SR. Fat Distribution in Women Is Associated With Depot-Specific Transcriptomic Signatures and Chromatin Structure. J Endocr Soc. 2020 Jun.4(6):bvaa042. Pubmedid: 32500109. Pmcid: PMC7261146.
    • Bray GA, Redman LM, de Jonge L, Rood J, Sutton EF, Smith SR. Plasma fatty acyl-carnitines during 8 weeks of overfeeding: relation to diet energy expenditure and body composition: the PROOF study. Metabolism. 2018 Jun.83:1-10. Pubmedid: 29374510. Pmcid: PMC9058975.
    • Bray GA, Redman LM, de Jonge L, Rood J, Sutton EF, Smith SR. Plasma Amino Acids During 8 Weeks of Overfeeding: Relation to Diet Body Composition and Fat Cell Size in the PROOF Study. Obesity (Silver Spring). 2018 Feb.26(2):324-331. Pubmedid: 29280309. Pmcid: PMC9048866.
    • Arterburn D, Wellman R, Emiliano A, Smith SR, Odegaard AO, Murali S, Williams N, Coleman KJ, Courcoulas A, Coley RY, Anau J, Pardee R, Toh S, Janning C, Cook A, Sturtevant J, Horgan C, McTigue KM. Comparative Effectiveness and Safety of Bariatric Procedures for Weight Loss: A PCORnet Cohort Study. Ann Intern Med. 2018 Dec.169(11):741-750. Pubmedid: 30383139. Pmcid: PMC6652193.
    • Smith SR, Garvey WT, Greenway FL, Zhou S, Fain R, Pilson R, Fujioka K, Aronne LJ. Coadministration of lorcaserin and phentermine for weight management: A 12-week, randomized, pilot safety study. Obesity (Silver Spring). 2017 May.25(5):857-865. Pubmedid: 28440045. Pmcid: PMC5518190.
    • Heianza Y, Ma W, Huang T, Wang T, Zheng Y, Smith SR, Bray GA, Sacks FM, Qi L. Macronutrient Intake-Associated FGF21 Genotype Modifies Effects of Weight-Loss Diets on 2-Year Changes of Central Adiposity and Body Composition: The POUNDS Lost Trial. Diabetes Care. 2016 Nov.39(11):1909-1914. Pubmedid: 27581055. Pmcid: PMC5079612.
    • Nissen SE, Wolski KE, Prcela L, Wadden T, Buse JB, Bakris G, Perez A, Smith SR. Effect of Naltrexone-Bupropion on Major Adverse Cardiovascular Events in Overweight and Obese Patients With Cardiovascular Risk Factors: A Randomized Clinical Trial. Jama. 2016 Mar.315(10):990-1004. Pubmedid: 26954408.
    • Bray GA, Redman LM, de Jonge L, Covington J, Rood J, Brock C, Mancuso S, Martin CK, Smith SR. Effect of protein overfeeding on energy expenditure measured in a metabolic chamber. Am J Clin Nutr. 2015 Mar.101(3):496-505. Pubmedid: 25733634.
    • Badin PM, Loubière C, Coonen M, Louche K, Tavernier G, Bourlier V, Mairal A, Rustan AC, Smith SR, Langin D, Moro C. Regulation of skeletal muscle lipolysis and oxidative metabolism by the co-lipase CGI-58. J Lipid Res. 2012 May.53(5):839-848. Pubmedid: 22383684. Pmcid: PMC3329383.
    • Sparks LM, Xie H, Koza RA, Mynatt R, Hulver MW, Bray GA, Smith SR. A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle. Diabetes. 2005 Jul.54(7):1926-1933. Pubmedid: 15983191.

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