Clinical Trial 23121

• Overview

  Study Title:

  Exercise Prehabilitation for Locoregional Esophageal Cancer: A Pilot Study

  Objective:

  Aim 1: Evaluate the feasibility and acceptability of PA and RT exercise prehabilitation components among patients preparing for LEC resection. Feasibility metrics will include rates of enrollment, retention, and adherence to PA and RT prescriptions. Hypothesis: PA and RT components will meet established feasibility and acceptability standards. Aim 2 (exploratory): Examine changes in exploratory outcomes (e.g., bodyweight and body composition, aerobic and muscular fitness, physical functioning, readiness for surgery, frailty, biomarkers, QOL) over the course of exercise prehabilitation and recovery in these measures following therapy. Aim 3 (exploratory): Compare clinical and treatment outcomes (e.g., weight and body composition, readiness for surgery, frailty, biomarkers, postoperative length of stay, surgical complications, adjuvant therapy) to those of a retrospectively identified comparison group that received no formal exercise prehabilitation programming.

• Inclusion Criteria

  Inclusion Criteria:
  • Aged 18 years or older
  • Biopsy-proven locoregional esophageal cancer
  • Eastern Cooperative Oncology Group (ECOG) performance status 0-2
  • Treatment plan including neoadjuvant chemoradiation therapy and surgical resection
  • Ability to read and speak English
  • Other criteria may apply

• Exclusion Criteria

  Exclusion Criteria:
  • Regular engagement in resistance training (2x/week targeting all muscle groups)
  • Screen failure for exercise safety based on PAR-Q
  • Underlying unstable cardiac or pulmonary disease or symptomatic cardiac disease
  • Recent fracture or acute musculoskeletal injury that preludes ability to participate in resistance training safely
  • Numeric pain rating scale of 7 or more out of 10
  • Myopathic or rheumatologic disease that impacts physical function
  • Other criteria may apply

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