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Clinical Trial Search

312 Clinical Trials Found

Clinical Trial 21778

An Open-Label Phase 1A/1B Dose Escalation and Expansion Cohort Study of SL-172154 (SIRPα-Fc-CD40L) in Combination With Azacitidine or With Azacitidine and Venetoclax for the Treatment of Subjects With Higher-Risk Myelodysplastic Syndrome (MDS) or Acute Myeloid Leukemia (AML)
Disease Site: Myeloid and Monocytic Leukemia
PI: Sallman, David

Clinical Trial 21712

A Phase 2 Open Label Study to Evaluate the Safety and Effectiveness of 212Pb-DOTAMTATE in PRRT Naïve Subjects with Somatostatin Receptor Expressing Neuroendocrine Tumors
Disease Site: Any Site, Liver, Lung, Other Digestive Organ, Other Endocrine System, Pancreas, Rectum, Small Intestine, Stomach
PI: Strosberg, Jonathan

Clinical Trial 22007

First in Human Phase 1/2 Trial of ELI-002 7P Immunotherapy as Treatment for Subjects with Kirsten Rat Sarcoma (KRAS)/Neuroblastoma RAS Viral Oncogene Homolog (NRAS) Mutated Pancreatic Ductal Adenocarcinoma (PDAC) and Other Solid Tumors
Disease Site: Other Digestive Organ
PI: Kim, Dae Won

Clinical Trial 21923

A Phase 1b/2 Multicenter, Open-label Study to Evaluate the Safety and Efficacy of TTI-101 as Monotherapy and in Combination in Participants with Locally Advanced or Metastatic, and Unresectable Hepatocellular Carcinoma
Disease Site: Liver
PI: Kim, Richard

Clinical Trial 21965

A Phase II, Multicenter, Single-Arm Clinical Trial of Definitive Radiotherapy And CeMiPlimAb-Rwlc ImmunoTherapy for Locally Advanced, Unresectable Cutaneous Squamous Cell Carcinoma: RAMPART
Disease Site: Other Skin
PI: Wuthrick, Evan

Clinical Trial 21971

Phase I Clinical Trial of CD40L-augmented Tumor Infiltrating Lymphocytes (CD40L TIL) for Patients with Oncogene-Driven Advanced Non-Small Cell Lung Cancer (NSCLC)
Disease Site: Lung
PI: Creelan, Benjamin

Clinical Trial 22190

A phase 1b, open label, multi-center, dose optimization and dose expansion study to assess the safety and efficacy of DFV890 in adult patients with myeloid diseases
Disease Site: Myeloid and Monocytic Leukemia
PI: Sallman, David

Clinical Trial 22199-A

TACTIVE-U: An Interventional Safety and Efficacy Phase 1b/2, Open-Label Umbrella Study To Investigate Tolerability, PK, and Antitumor Activity of Vepdegestrant (ARV-471/PF-07850327), An Oral Proteolysis Targeting Chimera, In Combination With Other Anticancer Treatments in Participants Aged 18 Years and Over With ER+ Advanced or Metastatic Breast Cancer, Sub-Study A (ARV-471 In Combination With Abemaciclib)
Disease Site: Breast
PI: Han, Heather

Clinical Trial 22263

A Phase 1b Study of Oral AS-1763 in Patients with Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma or B-cell Non-Hodgkin Lymphoma
Disease Site: Lymphoid Leukemia, Non-Hodgkin's Lymphoma, Soft Tissue
PI: Pinilla-Ibarz, Javier

Clinical Trial 22319

A Phase 1B/2 Open-Label Study to Investigate the Safety, Tolerance and Efficacy of Drug Resistant Immunotherapy with Activated, Gene Modified Allogeneic or Autologous gamma delta T Cells (DELTEX) in Combination with Maintenance Temozolomide in Subjects with Recurrent or Newly Diagnosed Glioblastoma
Disease Site: Brain and Nervous System
PI: Liu, James

Clinical Trial 22331

A Phase I trial to assess safety, tolerability, pharmacokinetics, radiation dosimetry, and positron emission tomography (PET) imaging properties of 89Zr-labelled hNd2 (NMK89) in patients with pancreatic cancer histologically positive for MUC5AC
Disease Site: Pancreas
PI: Gage, Kenneth

Clinical Trial 22349

Phase 1 Study of Erdafitinib Intravesical Delivery System (TAR-210) in Participants with Non-Muscle-Invasive or Muscle-Invasive Bladder Cancer and Selected FGFR Mutations or Fusions
Disease Site: Urinary Bladder
PI: Li, Roger