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Uterine cancer most often develops in the cells that form the endometrium, or lining of the uterus, which is a hollow, pear-shaped organ where fetal development takes place in a woman’s pelvis. Sometimes, due to abnormal changes in the cellular structure of the endometrium, new cells form when the body doesn’t need them, and old or damaged cells don’t die when they should. The resulting accumulation of excess cells can form a malignant, or cancerous, tumor, which can be serious if not treated properly. Endometrial cancer cells can also break away and travel to other parts of the body.

Signs and symptoms of uterine cancer

The most common sign of uterine cancer is abnormal vaginal bleeding—that is, bleeding that occurs between menstrual cycles or after menopause for older women. If you’re experiencing this type of bleeding, it’s important to speak with your gynecologist or physician right away to get to the bottom of this abnormality. Other symptoms of uterine cancer include irregular vaginal discharge, pain while urinating, unexplained weight loss, pelvic discomfort and anemia.

Risk factors of uterine cancer

Woman standing on scaleWhile the exact cause of uterine cancer has yet to be discovered, researchers have identified several risk factors that increase a woman’s chance of being diagnosed with this condition. They include:

  • Being overweight or obese
  • Being older than 50
  • Having trouble getting pregnant
  • Having fewer than five periods a year before going through menopause
  • Taking estrogen-only hormone replacement therapy after menopause
  • Having excess estrogen exposure due to early-onset menstruation, never giving birth and/or late-onset menopause
  • Taking tamoxifen, a hormonal therapy used to treat or reduce the risk of breast cancer
  • Having a first-degree relative (mother, sister or daughter) with endometrial cancer

How uterine cancer is diagnosed

Uterine cancer is not typically detected through a routine Pap smear, as it develops in a woman’s uterus. (Pap smears generally only detect cervical cancers.) That’s why it’s important to talk to your physician if you’re experiencing abnormal vaginal symptoms, so that he or she can conduct additional testing of your endometrial tissue. Some of the different ways to test for uterine cancer include:

  • Endometrial biopsy – A small amount of endometrial tissue is removed using a thin, flexible tube that is inserted through the cervix and into the uterus.
  • Dilation and curettage – The uterus is dilated and a small, spoon-shaped instrument is inserted into the uterus to remove tissue.
  • Hysteroscopy – The uterus is filled with saline solution and a tiny telescope is inserted through the cervix so that a physician can closely look at the uterus and gather samples.

Stages of uterine cancer

Staging describes the extent to which the cancer has spread in the body and helps oncologists determine the optimal treatment plan for their patients. Uterine cancer has five stages, which include:

  • Stage 0 – Pre-invasive cancer cells are found on the surface of uterine cells but have not spread.
  • Stage 1 – Cancer is limited to the uterus.
  • Stage 2 – Cancer has spread to the cervix.
  • Stage 3 – Cancer has spread beyond the uterus to various structures of the pelvic region, most likely the ovaries, fallopian tubes, vagina or nearby lymph nodes.
  • Stage 4 – Cancer has spread to the bladder and/or rectum or to distant lymph nodes or organs.

Treating uterine cancer

Uterine cancer patient talking to doctorUterine cancer is most commonly treated with surgery followed by chemotherapy, radiation therapy and/or hormone therapy. These additional cancer therapies are completed even if the surgeon was able to remove the entire tumor to help ensure that any residual cancer cells are destroyed. Surgical options typically include:

  • Hysterectomy, which removes the uterus and cervix
  • Bilateral salpingo-oophorectomy, which removes the ovaries and fallopian tubes
  • Radical hysterectomy, which removes the uterus and cervix as well as part of the vagina and, possibly, the ovaries, fallopian tubes and nearby lymph nodes
  • Pelvic exenteration, which removes the uterus, cervix, vagina, ovaries, bladder, rectum and surrounding lymph nodes

Another treatment option for uterine cancer is immunotherapy, which harnesses the body’s immune system to fight cancer. Uterine cancer immunotherapy most commonly uses checkpoint inhibitors that stop cancer proteins from interacting with the immune system, effectively strengthening the immune system to fight cancer.

Moffitt Cancer Center’s approach to uterine cancer treatment

If you have concerns about or are facing uterine cancer, the gynecological clinic at Moffitt Cancer Center offers a complete range of diagnosis and treatment options to provide the care you need. Our team takes a unique, multispecialty approach to patient care that is guided by evidence-based clinical pathways.

In a single location, our patients have full access to a cohesive team of experts, including fellowship-trained surgeons, medical oncologists, pathologists, radiologists, radiation oncologists, fertility preservation specialists, social workers and supportive care providers—all of whom work together to create individualized treatment plans. These experts meet regularly for tumor board reviews to evaluate each patient’s treatment options in order to ensure the best possible care.

As a leader in cancer research, Moffitt has a robust clinical trials program that provides participants with unique opportunities to improve their quality of life and contribute to our research. With a firm commitment to developing and translating scientific knowledge from promising laboratory discoveries into new treatments for cancer patients, Moffitt is proud to be the only National Cancer Institute-designated Comprehensive Cancer Center based in Florida.

Moffitt Cancer Center is redefining how uterine cancer and other gynecologic cancers are diagnosed and treated. Through our ambitious research efforts, we are learning more about  the unique needs of cancer patients and their families by combining clinical data with genetic information. To request an appointment, please call 1-888-663-3488 or fill out our new patient registration form.


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