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Two researchers work in one of Moffitt's labs

Moffitt's size, its singular focus on cancer, and its close interaction and outreach with academic partners and caregivers throughout the state, nation, and world all contribute to the rich, collegial, and collaborative environment required to perform outstanding cancer research and educate the next generation. Moffitt's five research programs, supported in part by the Cancer Center Support Grant (CCSG), consist of integrative teams of more than 140 faculty members working together to tackle the complexity of cancer. The five programs are:

Cancer Biology and Evolution

The Cancer Biology and Evolution (CBE) Program is focused on understanding tumor development, progression and resistance from a basic and evolutionary perspective. Research within CBE is conducted at the interface of molecular cancer biology, translational research and mathematical modeling with a focus on priority cancers in Moffitt’s catchment area.

Cancer Epidemiology

The overarching goal of the Cancer Epidemiology (CE) Program is to reduce the cancer burden through identification and confirmation of biological factors affecting carcinogenesis across the cancer continuum that contribute to disease development, progression, and outcomes, and to exploit learned knowledge to inform advances in clinical and public health practice.

Health Outcomes and Behavior

The Health Outcomes and Behavior (HOB) Program contributes to the prevention, detection, and control of cancer through the study of health-related behaviors, health care practices, and health-related quality of life. Work toward this goal involves research across the disease spectrum – from prevention and detection through to survivorship or advanced disease.  


The Immuno-Oncology Program defines the mechanisms by which tumors evade rejection by the immune system and develops strategies to thwart them. Key to the Program's success is the close integration of immuno-oncology clinical, translational, and basic scientists that facilitates rapid progression of novel immunotherapies from the bench to bedside. 

Molecular Medicine

The Molecular Medicine (MM) Program integrates chemical biology and systems biology technologies to develop new therapeutic approaches for the treatment of cancer. Along with research in chemistry, drug discovery and clinical trials, the MM Program includes members interrogating signaling pathways that regulate cell proliferation and survival to identify new targets for cancer therapeutics.