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A doctor explains chemotherapy for uterine cancer to a woman

Chemotherapy for uterine cancer is sometimes recommended after surgery to destroy cancer cells that were not visible or accessible to the surgeon, and also to reduce the risk of recurrence. This approach is often used for treating advanced-stage cancers that have spread beyond the uterine lining (endometrium) to other organs and tissues. Cancer-fighting chemo medications can be administered by mouth or injected into a vein so that the drugs can enter the bloodstream and travel throughout the body.

Some chemotherapy drugs that are commonly prescribed for treating uterine cancer include:

  • Paclitaxel
  • Carboplatin
  • Doxorubicin or liposomal doxorubicin
  • Cisplatin
  • A combination of drugs, such as carboplatin and paclitaxel or cisplatin and doxorubicin

How long is a course of chemotherapy for endometrial (uterine) cancer?

Chemotherapy is usually administered in cycles, with each treatment session followed by one or more off weeks to allow a patient’s body time to recuperate from any side effects. The recommended schedule can vary based on the medications prescribed and other factors. Generally, a course of chemotherapy is completed within three to six months and may be repeated if necessary.

In the Gynecologic Oncology Program at Moffitt Cancer Center, our multispecialty team of experts takes a highly individualized approach to uterine cancer treatment. We work closely with each patient to develop an appropriate treatment plan and, if chemotherapy is recommended, determine the most appropriate medications, dosages and delivery schedules.

As a National Cancer Institute-designated Comprehensive Cancer Center, Moffitt also offers patients unique opportunities to participate in promising clinical trials. Through these important research studies, participants can be among the first to benefit from groundbreaking new treatments as our researchers evaluate and compare the effectiveness of those treatments to the current standard of care. With an ultimate goal of benefiting all current and future patients, Moffitt is continually improving uterine cancer outcomes and enhancing quality of life for patients. 

check mark symbol Medically reviewed by Mian Shahzad, MD, PhD, gynecologic oncologist.

Chemotherapy for uterine cancer is available at all Moffitt locations. If you’d like to learn more, we provide consultations with or without referrals. Call 1-888-663-3488 or complete a new patient registration form online.


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