David Joyce, MD

Cancer Focus:
Osteosarcoma, Sarcoma

Dr. David Joyce is an Assistant Member in the Sarcoma Department. Dr. Joyce earned his MD degree from Case Western Reserve University, Case School of Medicine in Cleveland, Ohio. He completed an Orthopaedic Residency at the Cleveland Clinic Foundation in Ohio and an Orthopaedic Trauma Fellowship at Vanderbilt University, Nashville, Tennessee. He most recently completed a Musculoskeletal Oncology Fellowship at Moffitt Cancer Center. Dr. Joyce’s clinical interests include bone and soft tissue sarcoma in the pelvis and extremities, limb salvage surgery, pelvic bone resection and reconstruction, metastatic bone disease and pathologic fracture, basic fracture care, primary and revision total hip and knee arthroplasty, and other adult reconstructive procedures unique in cancer patients. His research interests include endoprosthetic reconstruction after tumor resection, metastatic bone treatment, and technology and computer-assisted resection and reconstruction.

Education & Training

Fellowship:

• Vanderbilt University - Orthopaedic Trauma
• Moffitt Cancer Center - Orthopaedic Oncology

Residency:

• Cleveland Clinic Foundation - Orthopaedics

Medical School:

• Case Western Reserve University: Case School of Medicine - MD

• Huynh THN, Clampitt BA, Chose CM, Nester MD, Joyce DM, Binitie OT, Freeman CL, Lazarides AL. Influence of Chimeric Antigen Receptor T-Cell Therapy on Fracture Risk of Patients With Multiple Myeloma. J Am Acad Orthop Surg. 2025 Sep. Pubmedid: 40953403.
• Soupir A, Ospina OE, Hampton O, Churchman M, Radmacher M, Hedges D, McKean D, Agius P, Zeeshan S, Seligson ND, Pollock R, Liebner D, Chen JL, Tinoco G, Salhia B, McCarter M, Wilky BA, Miller BJ, Cavnar MJ, Groundland JS, Schneider BP, Riedlinger G, Edge SB, Moskaluk CA, Cardona K, Naqash AR, Gonzalez RJ, Mullinax JE, Joyce DM, Binitie O, Douglas Letson G, Naghavi AO, Druta M, Reed DR, Siegel EM, Teer JK, Fridley BL, Brohl AS. Genomic, transcriptomic, and immunogenomic landscape of over 1300 sarcomas of diverse histology subtypes. Nat Commun. 2025 May.16(1):4206. Pubmedid: 40328759. Pmcid: PMC12055966.
• Chose C, Zervoudakis G, Karadimas T, Huynh TH, Lapp S, Henning J, Lamba A, Joyce D, Binitie O, Kocharyan H, Gustainyte V, Al-Roubaie M, Lazarides A. Minimally Invasive Treatment Strategies for Metastatic Disease of the Skeleton: Current Concepts. Curr Oncol Rep. 2025 Aug.27(8):935-950. Pubmedid: 40498266.
• Kuruvilla D, Huynh T, Nester M, Chose C, Zervoudakis G, Letson GD, Joyce DM, Binitie OT, Figura NB, Costello JR, Freeman CL, Lazarides AL. Management of bone disease with concurrent chimeric antigen receptor T-cell therapy for multiple myeloma. Crit Rev Oncol Hematol. 2024 Sep.201:104429. Pubmedid: 38942219.
• West W, Moore A, Gerhardt C, Webb P, Binitie O, Lazarides A, Letson D, Joyce D. Dual plating in the metastatic distal humerus: Benefits may outweigh the risks. J Orthop. 2024 May.51:103-108. Pubmedid: 38361983. Pmcid: PMC10864758.
• Karadimas T, Huynh TH, Chose C, Zervoudakis G, Clampitt B, Lapp S, Joyce D, Letson GD, Metts J, Binitie O, Mullinax JE, Lazarides A. Oncolytic Viral Therapy in Osteosarcoma. Viruses. 2024 Jul.16(7). Pubmedid: 39066301. Pmcid: PMC11281467.
• Belzarena AC, Binitie O, Letson GD, Joyce DM. Unplanned Sarcoma Excisions: Understanding How They Happen. J Am Acad Orthop Surg Glob Res Rev. 2024 Jan.8(1). Pubmedid: 38252542. Pmcid: PMC10805420.
• Wright B, Moore A, Becker-Weidman D, Joyce D. Primary B cell lymphoma of the patella presenting as anterior knee pain: A case report. J Orthop. 2024 Feb.48:60-63. Pubmedid: 38077471. Pmcid: PMC10700799.
• Crimì A, Joyce DM, Binitie O, Ruggieri P, Letson GD. The history of resection prosthesis. Int Orthop. 2023 Mar.47(3):873-883. Pubmedid: 36651984.
• Huynh THN, Kuruvilla DR, Nester MD, Zervoudakis G, Letson GD, Joyce DM, Binitie OT, Lazarides AL. Limb Amputations in Cancer: Modern Perspectives, Outcomes, and Alternatives. Curr Oncol Rep. 2023 Dec.25(12):1457-1465. Pubmedid: 37999825.
• Ter-Zakarian AA, Joyce DM, Lyons S, Bernasek TL. Intractable Bleeding After Revision Hip Arthroplasty Because of Angiosarcoma: A Report of 2 Cases. JBJS Case Connect. 2023 Apr.13(2). Pubmedid: 37071738.
• Crimì A, Binitie OT, Crimì F, Letson GD, Joyce DM. Outcomes and Complications of Pelvic Chondrosarcomas Treated Using Navigation Guidance and Multidisciplinary Approach: Is the Tumor Volume a Prognostic Factor?. J Clin Med. 2022 Nov.11(23). Pubmedid: 36498687. Pmcid: PMC9740033.
• Alexander JH, Binitie OT, Letson GD, Joyce DM. Osteosarcoma: An Evolving Understanding of a Complex Disease. J Am Acad Orthop Surg. 2021 Oct.29(20):e993-e1004. Pubmedid: 34623342.
• Broman KK, Joyce D, Binitie O, Letson GD, Gonzalez RJ, Choi J, Mullinax JE. Intraoperative Localization Using an Implanted Radar Reflector Facilitates Resection of Non-Palpable Trunk and Extremity Sarcoma. Ann Surg Oncol. 2021 Jun.28(6):3366-3374. Pubmedid: 33073344.
• Belzarena AC, Binitie O, Letson D, Joyce DM. Intramedullary rod failure in metastatic breast cancer: Do triple negative cancer patients have more revision surgery?. J Bone Oncol. 2021 Jun.28:100358. Pubmedid: 33898214. Pmcid: PMC8056433.
• Zarate SD, Joyce DM, Belzarena AC. Tenosynovial giant cell tumor of the distal tibiofibular joint. Radiol Case Rep. 2021 Apr.16(4):950-955. Pubmedid: 33659035. Pmcid: PMC7896125.
• Piakong P, Kiatisevi P, Yau R, Trovarelli G, Lam YL, Joyce D, Ruggieri P, Temple HT, Letson D, Binitie O. What Is the 10-year Survivorship of Cemented Distal Femoral Endoprostheses for Tumor Reconstructions and What Radiographic Features Are Associated with Survival?. Clin Orthop Relat Res. 2020 Nov.478(11):2573-2581. Pubmedid: 32469487. Pmcid: PMC7594923.
• Gerhardt CA, Belzarena AC, Henderson-Jackson E, Mullinax JE, Joyce DM. Intrapelvic melanocytic schwannoma resection with computer-assisted navigation. Radiol Case Rep. 2020 Nov.15(11):2385-2390. Pubmedid: 32994847. Pmcid: PMC7516168.
• Belzarena AC, Paladino LP, Henderson-Jackson E, Joyce DM. Intraosseous lipoma of the clavicle with extraosseous extension. Radiol Case Rep. 2020 Jun.15(6):716-721. Pubmedid: 32280406. Pmcid: PMC7139142.
• Rizk VT, Naghavi AO, Brohl AS, Joyce DM, Binitie O, Kim Y, Hanna JP, Swank J, Gonzalez RJ, Reed DR, Druta M. Chemotherapy improves distant control in localized high-grade soft tissue sarcoma of the extremity/trunk. Clin Sarcoma Res. 2020 Jul.10:11. Pubmedid: 32670544. Pmcid: PMC7350709.
• Ackerman RS, Hirschi M, Trona N, Joyce DM, Evans T, Patel SY. Incidence of Thromboembolic Events in Oncology Patients Receiving Intraoperative Tranexamic Acid During Orthopedic Surgery: A Retrospective Review at a Comprehensive Cancer Center. A A Pract. 2020 Jan.14(2):63-66. Pubmedid: 31703004.
• Paladino LP, Belzarena AC, Henderson-Jackson E, Joyce DM. Metastatic vertebral lesion mimicking an atypical hemangioma with negative 18F-FDG positron emission tomography-computed tomography. Radiol Case Rep. 2019 Nov.14(11):1401-1406. Pubmedid: 31700555. Pmcid: PMC6823801.
• Belzarena AC, Wright M, Joyce DM. A case of a myxoma within the obturator externus muscle. Radiol Case Rep. 2019 May.14(7):872-875. Pubmedid: 31193120. Pmcid: PMC6517614.
• Belzarena AC, Makanji RJ, Joyce DM. Recurrent parachordoma of the lower back: A case report. Radiol Case Rep. 2019 Jan.14(1):94-96. Pubmedid: 30386446. Pmcid: PMC6205874.
• Avilucea FR, Joyce D, Mir HR. Dynamic Stress Fluoroscopy for Evaluation of the Femoral Neck After Intramedullary Nails: Improved Sensitivity for Identifying Occult Fractures. J Orthop Trauma. 2019 Feb.33(2):88-91. Pubmedid: 30489429.
• Hicks JK, Henderson-Jackson E, Duggan J, Joyce DM, Brohl AS. Identification of a novel MTAP-RAF1 fusion in a soft tissue sarcoma. Diagn Pathol. 2018 Oct.13(1):77. Pubmedid: 30314519. Pmcid: PMC6186031.
• Boddu S, Walko CM, Bienasz S, Bui MM, Henderson-Jackson E, Naghavi AO, Mullinax JE, Joyce DM, Binitie O, Letson GD, Gonzalez RJ, Reed DR, Druta M, Brohl AS. Clinical Utility of Genomic Profiling in the Treatment of Advanced Sarcomas: A Single-Center Experience. JCO Precis Oncol. 2018 Nov.2:1-8. Pubmedid: 35135155.
• Greenberg SE, Ihejirika RC, Sathiyakumar V, Lang MF, Estevez-Ordonez D, Prablek MA, Chern AY, Thakore RV, Obremskey WT, Joyce D, Sethi MK. Ankle Fractures and Modality of Hospital Transport at a Single Level 1 Trauma Center: Does Transport by Helicopter or Ground Ambulance Influence the Incidence of Complications?. J Foot Ankle Surg. 2016 May.54(5):826-829. Pubmedid: 25840759.
• Mesko NW, Joyce DM, Ilaslan H, Joyce MJ. Creating an Intraoperative MRI Suite for the Musculoskeletal Tumor Center. Clin Orthop Relat Res. 2016 Jun.474(6):1516-1522. Pubmedid: 26183844. Pmcid: PMC4868174.
• Sathiyakumar V, Shi H, Thakore RV, Lee YM, Joyce D, Ehrenfeld J, Obremskey WT, Sethi MK. Isolated sacral injuries: Postoperative length of stay, complications, and readmission. World J Orthop. 2015 Sep.6(8):629-635. Pubmedid: 26396939. Pmcid: PMC4573507.
• Thakore RV, Greenberg SE, Sathiyakumar V, Prablek MA, Elmashat D, Hinson JK, Joyce D, Obremskey WT, Sethi MK. Asking for the 22-modifier in isolated ankle fractures: does the operative note make the case?. J Foot Ankle Surg. 2015 Nov.54(2):192-197. Pubmedid: 25242207.
• Joyce DM, Klika AK, Mutnal A, Krebs V, Molloy R, Knothe U, Barsoum WK. Prospective randomised evaluation of a collagen/thrombin and autologous platelet haemostatic agent during cementless total hip arthroplasty. Blood Transfus. 2015 Jul.13(3):455-463. Pubmedid: 26057484. Pmcid: PMC4614299.
• Bloomfield MR, Klika AK, Lee HH, Joyce DM, Mehta P, Barsoum WK. Predictors of bone loss in revision total knee arthroplasty. J Knee Surg. 2010 Mar.23(1):51-55. Pubmedid: 20812582.

Voted top doctor in Orthopedic Surgery in Tampa Magazine's Top Doctors 2024.