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Squamous cell liver cancer, or squamous cell liver carcinoma, is an extraordinarily uncommon cancer that develops in the thin, flat squamous cells of the liver. In 2015, a study by the National Center for Biotechnology Reporting claimed only 31 cases have been documented in English literatures since 1970.

Possible causes, symptoms & treatment options

There is still much to learn about squamous cell liver cancer. Its cause is not known, although the majority of patients with this cancer also had liver cysts, hepatolithiasis or hepatic teratomas. There may also be a link between anorexia and squamous cell liver cancer, although more research is needed. 

According to several studies, the most common symptoms associated with squamous cell liver cancer include:

  • Persistent abdominal pain or discomfort
  • Weight loss
  • Jaundice
  • Progressive dysphagia

There is no cure for squamous cell liver cancer. At this time, complete surgical removal of the tumor is viewed as the most effective treatment option, although chemotherapy may be useful in cases where surgery is not an option. Supportive care to reduce symptoms and improve quality of life is an important part of squamous cell liver treatment.

Our approach to squamous cell liver cancer

Uncommon cancers are an area of focus at Moffitt Cancer Center, where physician scientists, researchers, oncologists and other experts collaborate to discover breakthroughs in care. Moffitt spearheads trailblazing cancer research initiatives and clinical trials to improve treatment options for squamous cell liver cancer and other rare malignancies. In recognition of our steadfast commitment to cancer research, the National Cancer Institute designates Moffitt as a Comprehensive Cancer Center - and we are the only such cancer center based in Florida with this distinction. 

Individuals who would like to consult with a Moffitt oncologist about liver cancer clinical trials, treatment options or symptoms are invited to call us at 1-888-663-3488 or complete a new patient registration form online.