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Non-Hodgkin lymphoma treatment depends primarily on the type and stage of the condition. Indolent (slow-growing) lymphomas may not require immediate treatment, but rather a “watch and wait” approach with routine monitoring. Aggressive (fast-growing) lymphomas, on the other hand, may need a combination of options such as chemotherapy, radiation therapy or stem cell transplantation.

Because non-Hodgkin lymphoma does not produce solid tumors the way that many other cancers do, surgery is not usually used to treat the condition. Instead, one or more of the following treatments may be recommended to destroy cancerous cells throughout the body:

  • Chemotherapy – Powerful medications are delivered to destroy cells that divide at an unusually rapid rate.
  • Radiation therapy – Radioactive materials are used to damage abnormal cells.
  • Immunotherapy (biologic therapy) – Man-made antibodies or genetically modified immune cells are used to trigger an immune response against cancerous cells. Moffitt has been a driving force in getting several immunotherapies FDA-approved like Zxicabtagene ciloleucel (Yescarta), which is used for the treatment of adult patients with large B-cell lymphoma that is refractory to first-line chemoimmunotherapy or that relapses within 12 months of first-line chemoimmunotherapy.
  • Radioimmunotherapy – Radiation therapy and immunotherapy are combined into one treatment, using biologic substances to deliver radiation directly to lymphoma cells.

Sometimes, stem cell transplantation is also used after one or more of these treatments. During such a transplant, healthy stem cells from a donor are infused into a patient’s body to replace the abnormal blood cells that were destroyed during radiation therapy or chemotherapy.

At Moffitt Cancer Center, we provide a comprehensive range of non-Hodgkin lymphoma treatment options in a single location. Our patients work with a multispecialty team of oncologists to determine which therapies are most appropriate for their unique needs. The therapies that are selected are then administered by highly experienced medical oncologists, hematologists and radiation oncologists. In some cases, patients work with our clinical trials team to access additional options that are not yet available in other settings.

To learn more about your options for non-Hodgkin lymphoma treatment, call 1-888-663-3488 or submit a new patient registration form online. We welcome patients with all types and stages of lymphoma, and we do not require physician referrals.