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Medically reviewed by Sarah Tepper, MD, Orthopaedic Oncology, Orthopaedic Surgery

The timing of your osteosarcoma treatment plan will depend on a number of unique factors, such as the type and stage of your cancer. Generally speaking, however, treatment is usually recommended shortly after diagnosis. The sooner that the cancer is treated, the more options that you are likely to have, and the better your outcome and quality of life may be as a result.

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Treatment for low-grade vs. high-grade osteosarcoma

Some osteosarcomas are classified as low-grade, meaning they tend to grow more slowly and are less likely to spread. Others are high-grade, meaning they grow more aggressively and have a higher risk of metastasis.

Low-grade osteosarcomas are often treated successfully with surgery alone if the tumor can be completely removed. In contrast, most patients with localized high-grade osteosarcoma receive chemotherapy before and after surgery. Chemotherapy is a standard part of treatment because it helps eliminate microscopic cancer cells that may have spread beyond the main tumor.

Depending on the individual situation, additional treatment options may include:

  • Radiation therapy: Not routinely used for osteosarcoma but may be recommended when surgery is not possible, when the tumor cannot be completely removed, or to relieve symptoms.
  • Targeted therapy: May be considered for some patients with recurrent or advanced osteosarcoma, often as part of a clinical trial or for specific tumor characteristics.
  • Immunotherapy: Currently being studied in clinical trials and is not a standard treatment for most osteosarcoma patients.

A “watch and wait” approach is generally not appropriate for osteosarcoma because prompt treatment is important. You may want a second opinion before starting osteosarcoma treatment, but it’s best to decide on a plan as soon as you feel comfortable moving forward.

Comprehensive osteosarcoma treatment at Moffitt Cancer Center

Moffitt Cancer Center offers the newest and most effective osteosarcoma therapies in a single location, with each patient’s treatment plan fully individualized to his or her needs. To schedule an appointment with an osteosarcoma specialist, call 1-888-663-3488 or submit a new patient registration form online. No referral is required.