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  • Cancer Type: Gastrointestinal Tumor
  • Study Type: Supportive Care
  • NCT#: NCT05664178
  • Phase: N/A
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  • Overview

    Study Title:

    Remote Resistance Exercise Powering Survivors- Gastrointestinal Oncology (Remote REPS-:GI)


    The purpose of the study is to evaluate a tele-resistance training exercise program for individuals undergoing chemotherapy for advanced upper gastrointestinal cancer.


    Specific Aim #1 Evaluate the feasibility (enrollment, retention, and adherence to exercise sessions and prescribed exercise volumes), safety, and acceptability of a 12-week tele-RT intervention during first-line chemotherapy for advanced upper GI cancer. Specific Aim #2 Compare 12-week changes in muscular strength and muscular endurance, skeletal muscle index (SMI) and skeletal muscle density (SMD), quality of life, fatigue, and physical functioning between patients randomized to tele-RT vs. usual care (UC) during first-line chemotherapy for advanced upper GI cancer.

  • Inclusion Criteria

    • Age >18 years
    • Biopsy-proven upper GI cancer, stage III-IV
    • ECOG performance status 0-1
    • Treatment plan of chemotherapy with planned return to Moffitt Cancer Center for restaging
    • Able to read and speak English fluently
    • Capable of providing informed consent
  • Exclusion Criteria

    • Regular engagement in RT (2x/week targeting all major muscle groups)
    • Screen failure for exercise safety based on Physical Activity Readiness Questionnaire (PAR-Q) and Patient-Reported Measurement Information System (PROMIS) screening questions
    • Underlying unstable cardiac or pulmonary disease or symptomatic cardiac disease (New York Heart Association functional class III or IV).
    • Recent fracture or acute musculoskeletal injury that precludes ability to participate in RT
    • Numeric pain rating scale of >7 out of 10
    • Myopathic or rheumatologic disease that impacts physical function

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