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Alexander  Lazarides

Alexander Lazarides, MD

4.9 (214)

Specialty: Orthopaedic Surgery

Program: Sarcoma

Language(s): English

  • Overview

    Cancer Focus:
    Osteosarcoma, Sarcoma

    Dr. Lazarides received his MD degree from Duke University Medical School. He completed an Orthopaedic Surgery Residency at Duke University Medical Center, Department of Orthopaedic Surgery. Dr. Lazarides most recently completed an Orthopaedic Oncology Fellowship at Mount Sinai Hospital-University of Toronto, Division of Orthopaedic Surgery, in Toronto, Canada. Dr. Lazarides specializes in treating pediatric and adult patients with benign or malignant bone or soft tissue tumors of the musculoskeletal system. His focus is the treatment of sarcomas as well as benign tumors and metastatic bone disease. He is particularly interested in complex upper extremity tumors and reconstructions, limb salvage surgery and endoprosthetic/custom implant reconstruction. Dr. Lazarides’ research focus is on developing novel technologies and therapeutics for the treatment of sarcoma and improving clinical outcomes within Orthopaedic Oncology.  

    Education & Training


    • University of Toronto - Orthopaedic Oncology


    • Duke University Medical Center - Orthopaedic Surgery

    Medical School:

    • Duke University Medical School - MD
  • Publications

    • West W, Moore A, Gerhardt C, Webb P, Binitie O, Lazarides A, Letson D, Joyce D. Dual plating in the metastatic distal humerus: Benefits may outweigh the risks. J Orthop. 2024 May.51:103-108. Pubmedid: 38361983. Pmcid: PMC10864758.
    • Lazarides AL, Abar B, Leckey B, Martin JT, Kliassov EG, Brigman BE, Eward WC, Cardona DM, Visgauss JD. Tumor necrosis is an underappreciated histopathologic factor in the grading of chondrosarcoma. BMC Cancer. 2023 Jun.23(1):579. Pubmedid: 37353743. Pmcid: PMC10288799.
    • Floyd W, Pierpoint M, Su C, Patel R, Luo L, Deland K, Wisdom AJ, Zhu D, Ma Y, DeWitt SB, Williams NT, Lazarides AL, Somarelli JA, Corcoran DL, Eward WC, Cardona DM, Kirsch DG. Atrx deletion impairs CGAS/STING signaling and increases sarcoma response to radiation and oncolytic herpesvirus. J Clin Invest. 2023 Jul.133(13). Pubmedid: 37200088. Pmcid: PMC10313374.
    • Burke ZDC, Lazarides AL, Gundavda MK, Griffin AM, Tsoi KM, Ferguson PC, Wunder JS. Open Versus Core Needle Biopsy in Lower-Extremity Sarcoma: Current Practice Patterns and Patient Outcomes. J Bone Joint Surg Am. 2023 Jul.105(Suppl 1):57-64. Pubmedid: 37466581.
    • Huynh THN, Kuruvilla DR, Nester MD, Zervoudakis G, Letson GD, Joyce DM, Binitie OT, Lazarides AL. Limb Amputations in Cancer: Modern Perspectives, Outcomes, and Alternatives. Curr Oncol Rep. 2023 Dec.25(12):1457-1465. Pubmedid: 37999825.
    • Byers IS, Turner NA, Levine NL, Lazarides AL, Evans DR, Spasojevic I, Fan P, Jung SH, Gao J, Visgauss JD, Brigman BE, Eward WC. Antibiotic Prophylaxis for Megaprosthetic Reconstructions: Drug and Dosing May Matter More than Duration. Antimicrob Agents Chemother. 2022 Oct.66(10):e0014022. Pubmedid: 36165615. Pmcid: PMC9578431.
    • Lazarides AL, Saltzman EB, Visgauss JD, Mithani SK, Eward WC, Brigman BE. Intraoperative angiography imaging correlates with wound complications following soft tissue sarcoma resection. J Orthop Res. 2022 Oct.40(10):2382-2390. Pubmedid: 35005805.
    • Levin JM, Wickman J, Lazarides AL, Cunningham DJ, Goltz DE, Mather RC, Anakwenze O, Lassiter TE, Klifto CS. Is Advanced Imaging to Assess Rotator Cuff Integrity Before Shoulder Arthroplasty Cost-effective? A Decision Modeling Study. Clin Orthop Relat Res. 2022 Jun.480(6):1129-1139. Pubmedid: 35014977. Pmcid: PMC9263501.
    • Lazarides AL, Flamant EM, Cullen MM, Ferlauto HR, Goltz DE, Cochrane NH, Visgauss JD, Brigman BE, Eward WC. Corrigendum to 'Why Do Patients Undergoing Extremity Prosthetic Reconstruction for Metastatic Disease Get Readmitted?' [The Journal of Arthroplasty 37 (2022) 232-237]. J Arthroplasty. 2022 Jun.37(6):1212. Pubmedid: 35153117.
    • Meyer LE, Lazarides AL, Hendren S, Lassiter T, Klifto C, Anakwenze O. The Efficacy of Peroxide Solutions in Decreasing Cutibacterium acnes Burden Around the Shoulder. J Am Acad Orthop Surg. 2022 Jan.30(1):e91-e98. Pubmedid: 34437309.
    • Rao SR, Lazarides AL, Leckey BL, Lane WO, Visgauss JD, Somarelli JA, Kirsch DG, Larrier NA, Brigman BE, Blazer DG, Cardona DM, Eward WC. Extent of tumor fibrosis/hyalinization and infarction following neoadjuvant radiation therapy is associated with improved survival in patients with soft-tissue sarcoma. Cancer Med. 2022 Jan.11(1):194-206. Pubmedid: 34837341. Pmcid: PMC8704179.
    • Lazarides AL, Flamant EM, Cullen MC, Ferlauto HR, Goltz DE, Cochrane NH, Visgauss JD, Brigman BE, Eward WC. Why Do Patients Undergoing Extremity Prosthetic Reconstruction for Metastatic Disease Get Readmitted?. J Arthroplasty. 2022 Feb.37(2):232-237. Pubmedid: 34740789.
    • Evans DR, Lazarides AL, Cullen MM, Somarelli JA, Blazer DG, Visguass JD, Brigman BE, Eward WC. Identifying Modifiable and Non-modifiable Risk Factors of Readmission and Short-Term Mortality in Chondrosarcoma: A National Cancer Database Study. Ann Surg Oncol. 2022 Feb.29(2):1392-1408. Pubmedid: 34570333.
    • Lazarides AL, Somarelli JA, Brigman BE, Visgauss JD, Eward WC. ASO Author Reflections: Identifying Modifiable and Non-Modifiable Risk Factors of Readmission and Short-Term Mortality in Chondrosarcoma. Ann Surg Oncol. 2022 Feb.29(2):1409-1410. Pubmedid: 34635971.
    • Lazarides AL, Flamant EM, Cullen MM, Ferlauto HR, Cochrane N, Gao J, Jung SH, Visgauss JD, Brigman BE, Eward WC. Investigating readmission rates for patients undergoing oncologic resection and endoprosthetic reconstruction for primary sarcomas and tumors involving bone. J Surg Oncol. 2022 Aug.126(2):356-364. Pubmedid: 35319106.
    • Lazarides AL, Burke ZDC, Gundavda MK, Novak R, Ghert M, Wilson DA, Rose PS, Wong P, Griffin AM, Ferguson PC, Wunder JS, Houdek MT, Tsoi KM. How Do the Outcomes of Radiation-Associated Pelvic and Sacral Bone Sarcomas Compare to Primary Osteosarcomas following Surgical Resection?. Cancers (Basel). 2022 Apr.14(9). Pubmedid: 35565308. Pmcid: PMC9104334.
    • Lazarides AL, Ferlauto HR, Burke ZDC, Griffin AM, Leckey BD, Bernthal NM, Wunder JS, Ferguson PC, Visgauss JD, Brigman BE, Eward WC. The Utility of Chest Imaging for Surveillance of Atypical Lipomatous Tumors. Sarcoma. 2021 Oct.2021:4740924. Pubmedid: 34671190. Pmcid: PMC8523289.
    • Evans DR, Lazarides AL, Cullen MM, Visgauss JD, Somarelli JA, Blazer DG, Brigman BE, Eward WC. Identifying Modifiable and Non-modifiable Risk Factors of Readmission and Short-Term Mortality in Osteosarcoma: A National Cancer Database Study. Ann Surg Oncol. 2021 Nov.28(12):7961-7972. Pubmedid: 34018083.
    • Ferlauto HR, Wickman JR, Lazarides AL, Hendren S, Visgauss JD, Brigman BE, Anakwenze OA, Klifto CS, Eward WC. Reverse total shoulder arthroplasty for oncologic reconstruction of the proximal humerus: a systematic review. J Shoulder Elbow Surg. 2021 Nov.30(11):e647-e658. Pubmedid: 34273534.
    • Lazarides AL, Belay ES, Anastasio AT, Cook CE, Anakwenze OA. Physician burnout and professional satisfaction in orthopedic surgeons during the COVID-19 Pandemic. Work. 2021 Jun.69(1):15-22. Pubmedid: 33998571.
    • Kildow BJ, Ryan SP, Danilkowicz R, Lazarides AL, Penrose C, Bolognesi MP, Jiranek W, Seyler TM. Next-generation sequencing not superior to culture in periprosthetic joint infection diagnosis. Bone Joint J. 2021 Jan.103-B(1):26-31. Pubmedid: 33380207.
    • Ryan SP, Adams SB, Allen N, Lazarides AL, Wellman SS, Gage MJ. Intraoperative Fire Risk: Evaluating the 3-Minute Wait After Chlorhexidine-Alcohol Antiseptic Scrub. J Orthop Trauma. 2021 Jan.35(1):e31-e33. Pubmedid: 32618815.
    • Kavolus JJ, Lazarides AL, Moore C, Seyler TM, Wellman SS, Attarian DE, Bolognesi MP, Alman BA. The Calpain Gene is Correlated With Metal-on-Metal Hip Replacement Failures. J Arthroplasty. 2021 Jan.36(1):236-241.e3. Pubmedid: 32811707.
    • Evans DR, Lazarides AL, Visgauss JD, Somarelli JA, Blazer DG, Brigman BE, Eward WC. Limb salvage versus amputation in patients with osteosarcoma of the extremities: an update in the modern era using the National Cancer Database. BMC Cancer. 2020 Oct.20(1):995. Pubmedid: 33054722. Pmcid: PMC7557006.
    • Lazarides AL, Cerullo M, Moris D, Brigman BE, Blazer DG, Eward WC. Defining a textbook surgical outcome for patients undergoing surgical resection of intermediate and high-grade soft tissue sarcomas of the extremities. J Surg Oncol. 2020 Oct.122(5):884-896. Pubmedid: 32691847.
    • Somarelli JA, Rupprecht G, Altunel E, Flamant EM, Rao S, Sivaraj D, Lazarides AL, Hoskinson SM, Sheth MU, Cheng S, Kim SY, Ware KE, Agarwal A, Cullen MM, Selmic LE, Everitt JI, McCall SJ, Eward C, Eward WC, Hsu DS. A Comparative Oncology Drug Discovery Pipeline to Identify and Validate New Treatments for Osteosarcoma. Cancers (Basel). 2020 Nov.12(11). Pubmedid: 33187254. Pmcid: PMC7696249.
    • Kildow BJ, Ryan SP, Danilkowicz R, Lazarides AL, Vovos TJ, Bolognesi MP, Jiranek WA, Seyler TM. Commercially Available Polymerase Chain Reaction Has Minimal Utility in the Diagnosis of Periprosthetic Joint Infection. Orthopedics. 2020 Nov.43(6):333-338. Pubmedid: 33002175.
    • Dial BL, Kerr DL, Lazarides AL, Catanzano AA, Green CL, Risoli T, Blazer DG, Goodwin RC, Brigman BE, Eward WC, Larrier NA, Kirsch DG, Mendoza-Lattes SA. The Role of Radiotherapy for Chordoma Patients Managed With Surgery: Analysis of the National Cancer Database. Spine. 2020 Jun.45(12):E742-E751. Pubmedid: 32032324. Pmcid: PMC7649561.
    • Lazarides AL, Kerr DL, Dial BL, Steele JR, Lane WO, Blazer DG, Brigman BE, Mendoza-Lattes S, Erickson MM, Eward WC. Does facility volume influence survival in patients with primary malignant bone tumors of the vertebral column? A comparative cohort study. Spine J. 2020 Jul.20(7):1106-1113. Pubmedid: 32145357.
    • Steele JR, Lazarides AL, DeOrio JK. Tibiotalocalcaneal Arthrodesis Using a Novel Retrograde Intramedullary Nail. Foot Ankle Spec. 2020 Dec.13(6):463-469. Pubmedid: 31640417.
    • Alentorn-Geli E, Gotecha D, Steinbacher G, Álvarez-Díaz P, Barastegui D, Seijas R, Cuscó X, Samuelsson K, Lazarides AL, Cugat Bertomeu R. The presence of patellar tendinopathy in the bone-patellar tendon-bone autograft may increase the risk of anterior cruciate ligament graft failure. Knee Surg Sports Traumatol Arthrosc. 2019 Mar.27(3):766-772. Pubmedid: 30141146.
    • Lazarides AL, Vovos TJ, Reddy GB, DeOrio JK, Easley ME, Nunley JA, Adams SB. Algorithm for Management of Periprosthetic Ankle Fractures. Foot Ankle Int. 2019 Jun.40(6):615-621. Pubmedid: 30813821.
    • Jolly MK, Ware KE, Xu S, Gilja S, Shetler S, Yang Y, Wang X, Austin RG, Runyambo D, Hish AJ, Bartholf DeWitt S, George JT, Kreulen RT, Boss MK, Lazarides AL, Kerr DL, Gerber DG, Sivaraj D, Armstrong AJ, Dewhirst MW, Eward WC, Levine H, Somarelli JA. E-Cadherin Represses Anchorage-Independent Growth in Sarcomas through Both Signaling and Mechanical Mechanisms. Mol Cancer Res. 2019 Jun.17(6):1391-1402. Pubmedid: 30862685. Pmcid: PMC6548594.
    • Lazarides AL, Vovos TJ, Reddy GB, Kildow BJ, Wellman SS, Jiranek WA, Seyler TM. Traditional Laboratory Markers Hold Low Diagnostic Utility for Immunosuppressed Patients With Periprosthetic Joint Infections. J Arthroplasty. 2019 Jul.34(7):1441-1445. Pubmedid: 30930152.
    • Alentorn-Geli E, Lazarides AL, Utturkar GM, Myers HS, Samuelsson K, Choi JHJ, Stuart JJ, Moorman CT. Correction to: Factors associated with poorer outcomes in the surgical treatment of multiligament knee injuries. Knee Surg Sports Traumatol Arthrosc. 2019 Feb.27(2):460. Pubmedid: 30232542.
    • Alentorn-Geli E, Lazarides AL, Utturkar GM, Myers HS, Samuelsson K, Choi JHJ, Stuart JJ, Moorman CT. Factors predictive of poorer outcomes in the surgical repair of multiligament knee injuries. Knee Surg Sports Traumatol Arthrosc. 2019 Feb.27(2):445-459. Pubmedid: 30083969.
    • Lazarides AL, Duchman KR, Ledbetter L, Riboh JC, Garrigues GE. Arthroscopic Remplissage for Anterior Shoulder Instability: A Systematic Review of Clinical and Biomechanical Studies. Arthroscopy. 2019 Feb.35(2):617-628. Pubmedid: 30612762.
    • Kerr DL, Dial BL, Lazarides AL, Catanzano AA, Lane WO, Blazer DG, Brigman BE, Mendoza-Lattes S, Eward WC, Erickson ME. Epidemiologic and survival trends in adult primary bone tumors of the spine. Spine J. 2019 Dec.19(12):1941-1949. Pubmedid: 31306757.
    • Vovos TJ, Lazarides AL, Ryan SP, Kildow BJ, Wellman SS, Seyler TM. Prior Hip Arthroscopy Increases Risk for Perioperative Total Hip Arthroplasty Complications: A Matched-Controlled Study. J Arthroplasty. 2019 Aug.34(8):1707-1710. Pubmedid: 31005437.
    • Lazarides AL, Kerr DL, Nussbaum DP, Kreulen RT, Somarelli JA, Blazer DG, Brigman BE, Eward WC. Soft Tissue Sarcoma of the Extremities: What Is the Value of Treating at High-volume Centers?. Clin Orthop Relat Res. 2019 Apr.477(4):718-727. Pubmedid: 30485258. Pmcid: PMC6437385.
    • Catanzano AA, Kerr DL, Lazarides AL, Dial BL, Lane WO, Blazer DG, Larrier NA, Kirsch DG, Brigman BE, Eward WC. Revisiting the Role of Radiation Therapy in Chondrosarcoma: A National Cancer Database Study. Sarcoma. 2019.2019:4878512. Pubmedid: 31736653. Pmcid: PMC6815626.
    • Lazarides AL, Alentorn-Geli E, Vinson EN, Hash TW, Samuelsson K, Toth AP, Moorman CT, Garrett WE, Taylor DC. Advanced Patellar Tendinopathy Is Associated With Increased Rates of Bone-Patellar Tendon-Bone Autograft Failure at Early Follow-up After Anterior Cruciate Ligament Reconstruction. Orthop J Sports Med. 2018 Nov.6(11). Pubmedid: 30480020. Pmcid: PMC6243419.
    • Grimm NL, Lazarides AL, Amendola A. Tibial Tubercle Osteotomies: a Review of a Treatment for Recurrent Patellar Instability. Curr Rev Musculoskelet Med. 2018 Jun.11(2):266-271. Pubmedid: 29721692. Pmcid: PMC5970117.
    • Lazarides AL, Visgauss JD, Nussbaum DP, Green CL, Blazer DG, Brigman BE, Eward WC. Race is an independent predictor of survival in patients with soft tissue sarcoma of the extremities. BMC Cancer. 2018 Apr.18(1):488. Pubmedid: 29703171. Pmcid: PMC5923002.
    • Lazarides AL, Hamid KS, Kerzner MS. Novel Use of Active Leptospermum Honey for Ringed Fixator Pin Site Care in Diabetic Charcot Deformity Patients. Foot Ankle Spec. 2018 Apr.11(2):117-122. Pubmedid: 28506082.
    • Eward WC, Lazarides AL, Griffin AM, O'Donnell PW, Sternheim A, O'Neill A, Hofer SO, Ferguson PC, Wunder JS. Superficial Soft-Tissue Sarcomas Rarely Require Advanced Soft-Tissue Reconstruction following Resection. Plast Reconstr Surg Glob Open. 2017 Nov.5(11):e1553. Pubmedid: 29263959. Pmcid: PMC5732665.
    • Harston A, Lazarides AL, Adams SB, DeOrio JK, Easley ME, Nunley JA. Midterm Outcomes of a Fixed-Bearing Total Ankle Arthroplasty With Deformity Analysis. Foot Ankle Int. 2017 Dec.38(12):1295-1300. Pubmedid: 28948831.
    • Lazarides AL, Scott EJ, Cardona DM, Blazer DG, Brigman BE, Eward WC. Simultaneous Primary Presacral Myelolipomas: Case Report and Review of the Literature. J Gastrointest Cancer. 2016 Sep.47(3):331-335. Pubmedid: 26164122.
    • Lazarides AL, Whitley MJ, Strasfeld DB, Cardona DM, Ferrer JM, Mueller JL, Fu HL, Bartholf DeWitt S, Brigman BE, Ramanujam N, Kirsch DG, Eward WC. A Fluorescence-Guided Laser Ablation System for Removal of Residual Cancer in a Mouse Model of Soft Tissue Sarcoma. Theranostics. 2016 Jan.6(2):155-166. Pubmedid: 26877775. Pmcid: PMC4729765.
    • Bartholf DeWitt S, Eward WC, Eward CA, Lazarides AL, Whitley MJ, Ferrer JM, Brigman BE, Kirsch DG, Berg J. A Novel Imaging System Distinguishes Neoplastic from Normal Tissue During Resection of Soft Tissue Sarcomas and Mast Cell Tumors in Dogs. Vet Surg. 2016 Aug.45(6):715-722. Pubmedid: 27281113. Pmcid: PMC4970890.
    • Hou CH, Lazarides AL, Speicher PJ, Nussbaum DP, Blazer DG, Kirsch DG, Brigman BE, Eward WC. The use of radiation therapy in localized high-grade soft tissue sarcoma and potential impact on survival. Ann Surg Oncol. 2015 Sep.22(9):2831-2838. Pubmedid: 26040605.
    • Lazarides AL, Alentorn-Geli E, Choi JH, Stuart JJ, Lo IK, Garrigues GE, Taylor DC. Rotator cuff tears in young patients: a different disease than rotator cuff tears in elderly patients. J Shoulder Elbow Surg. 2015 Nov.24(11):1834-1843. Pubmedid: 26209913.
    • Lazarides AL, Eward WC, Speicher PJ, Hou CH, Nussbaum DP, Green C, Blazer DG, Kirsch DG, Brigman BE. The Use of Radiation Therapy in Well-Differentiated Soft Tissue Sarcoma of the Extremities: An NCDB Review. Sarcoma. 2015 Jun.2015:186581. Pubmedid: 26064077. Pmcid: PMC4439510.
    • Lazarides AL, Eward WC, Green K, Cardona DM, Brigman BE, Taylor DC. Histological Evaluation of Tendon-Bone Healing of an Anterior Cruciate Ligament Hamstring Graft in a 14-Year-Old Boy. Am J Sports Med. 2015 Aug.43(8):1935-1940. Pubmedid: 25968884.
  • Patient Comments

    Overall Satisfaction


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