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Glen  Hortin

Glen Hortin, MD, PhD

Specialty: Pathology

Program: Pathology

Language(s): English

  • Publications

    • Hortin GL. Does Increased Regulation of Laboratory-Developed Tests (LDTs) Make Sense? The Harms of Over-Regulation. J Appl Lab Med. 2024 May.9(3):646-650. Pubmedid: 38332567.
    • Pakasticali N, Hortin GL, Li JY. Plasmablastic myeloma transformation of light-chain multiple myeloma. J Clin Exp Hematop. 2024 Apr. Pubmedid: 38684404.
    • Robinson MK, Caudill SP, Koch DD, Ritchie J, Hortin G, Eckfeldt JH, Sandberg S, Williams D, Myers G, Miller WG. Albumin adsorption onto surfaces of urine collection and analysis containers. Clin Chim Acta. 2014 Apr.431:40-45. Pubmedid: 24513540. Pmcid: PMC5708857.
    • Hortin GL. Identifying optimal sample types and decision thresholds for the urinary albumin-creatinine ratio. Clin Chem. 2013 Apr.59(4):598-600. Pubmedid: 23378567.
    • Bowen RA, Dowdell KC, Dale JK, Drake SK, Fleisher TA, Hortin GL, Remaley AT, Nexo E, Rao VK. Elevated vitamin B₁₂ levels in autoimmune lymphoproliferative syndrome attributable to elevated haptocorrin in lymphocytes. Clin Biochem. 2012 Apr.45(6):490-492. Pubmedid: 22306884. Pmcid: PMC3307947.
    • Drake SK, Hortin GL. Improved detection of intact tyrosine sulfate-containing peptides by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry in linear negative ion mode. Int J Biochem Cell B. 2010 Jan.42(1):174-179. Pubmedid: 19857600.
    • Bowen RA, Hortin GL, Csako G, Otañez OH, Remaley AT. Impact of blood collection devices on clinical chemistry assays. Clin Biochem. 2010 Jan.43(1-2):4-25. Pubmedid: 19822139.
    • Hortin GL, Sviridov D. The dynamic range problem in the analysis of the plasma proteome. J Proteomics. 2010 Jan.73(3):629-636. Pubmedid: 19619681.
    • Miller WG, Bruns DE, Hortin GL, Sandberg S, Aakre KM, McQueen MJ, Itoh Y, Lieske JC, Seccombe DW, Jones G, Bunk DM, Curhan GC, Narva AS. [Current issues in measurement and reporting of urinary albumin excretion]. Ann Biol Clin (Paris). 2010 Jan.68(1):9-25. Pubmedid: 20146974.
    • Hortin GL, Carr SA, Anderson NL. Introduction: Advances in protein analysis for the clinical laboratory. Clin Chem. 2010 Feb.56(2):149-151. Pubmedid: 19910505. Pmcid: PMC2865472.
    • Sturgeon C, Hill R, Hortin GL, Thompson D. Taking a new biomarker into routine use--a perspective from the routine clinical biochemistry laboratory. Proteom Clin Appl. 2010 Dec.4(12):892-903. Pubmedid: 21137030. Pmcid: PMC3060337.
    • Echeverry G, Hortin GL, Rai AJ. Introduction to urinalysis: historical perspectives and clinical application. Methods Mol Biol. 2010 Aug.641:1-12. Pubmedid: 20407938.
    • Hortin GL, Harris NS, Winter WE. Commentary. Clin Chem. 2009 Nov.55(11):1908-1909. Pubmedid: 19864514.
    • Seegmiller JC, Sviridov D, Larson TS, Borland TM, Hortin GL, Lieske JC. Comparison of urinary albumin quantification by immunoturbidimetry, competitive immunoassay, and protein-cleavage liquid chromatography-tandem mass spectrometry. Clin Chem. 2009 Nov.55(11):1991-1994. Pubmedid: 19745060.
    • Sviridov D, Owen WE, Roberts WL, Edelman LS, Drake SK, Hortin GL. Proteinuria without albuminuria: urinary protein excretion by a subset of patients with burn injuries. Clin Chim Acta. 2009 May.403(1-2):42-46. Pubmedid: 19361474. Pmcid: PMC5606198.
    • Sviridov D, Hortin GL. Urine albumin measurement: effects of urine matrix constituents. Clin Chim Acta. 2009 Jun.404(2):140-143. Pubmedid: 19332047.
    • Miller WG, Bruns DE, Hortin GL, Sandberg S, Aakre KM, McQueen MJ, Itoh Y, Lieske JC, Seccombe DW, Jones G, Bunk DM, Curhan GC, Narva AS. Current issues in measurement and reporting of urinary albumin excretion. Clin Chem. 2009 Jan.55(1):24-38. Pubmedid: 19028824.
    • Hortin GL, Sviridov D, Anderson NL. High-abundance polypeptides of the human plasma proteome comprising the top 4 logs of polypeptide abundance. Clin Chem. 2008 Oct.54(10):1608-1616. Pubmedid: 18687737.
    • Hortin GL, Sviridov D. Analysis of molecular forms of albumin in urine. Proteom Clin Appl. 2008 Jul.2(7-8):950-955. Pubmedid: 21136896.
    • Rehak NN, Cecco SA, Hortin GL. Photolysis of bilirubin in serum specimens exposed to room lighting. Clin Chim Acta. 2008 Jan.387(1-2):181-183. Pubmedid: 17967443. Pmcid: PMC2131702.
    • Lane JW, Rehak NN, Hortin GL, Zaoutis T, Krause PR, Walsh TJ. Pseudohyperphosphatemia associated with high-dose liposomal amphotericin B therapy. Clin Chim Acta. 2008 Jan.387(1-2):145-149. Pubmedid: 17936740. Pmcid: PMC2128727.
    • Sviridov D, Drake SK, Hortin GL. Reactivity of urinary albumin (microalbumin) assays with fragmented or modified albumin. Clin Chem. 2008 Jan.54(1):61-68. Pubmedid: 17981922.
    • Hortin GL. Of immunounreactive urinary albumin and unicorns. Am J Clin Pathol. 2008 Aug.130(2):314-315. Pubmedid: 18697291.
    • Seam N, Gonzales DA, Kern SJ, Hortin GL, Hoehn GT, Suffredini AF. Quality control of serum albumin depletion for proteomic analysis. Clin Chem. 2007 Nov.53(11):1915-1920. Pubmedid: 17890439.
    • Hortin GL, Sviridov D. Diagnostic potential for urinary proteomics. Pharmacogenomics. 2007 Mar.8(3):237-255. Pubmedid: 17324112.
    • Ressom HW, Varghese RS, Drake SK, Hortin GL, Abdel-Hamid M, Loffredo CA, Goldman R. Peak selection from MALDI-TOF mass spectra using ant colony optimization. Bioinformatics. 2007 Mar.23(5):619-626. Pubmedid: 17237065.
    • Bowen RA, Vu C, Remaley AT, Hortin GL, Csako G. Differential effect of blood collection tubes on total free fatty acids (FFA) and total triiodothyronine (TT3) concentration: a model for studying interference from tube constituents. Clin Chim Acta. 2007 Mar.378(1-2):181-193. Pubmedid: 17234171.
    • Hortin GL. A new era in protein quantification in clinical laboratories: application of liquid chromatography-tandem mass spectrometry. Clin Chem. 2007 Apr.53(4):543-544. Pubmedid: 17405946.
    • Muniyappa R, Karne RJ, Hall G, Crandon SK, Bronstein JA, Ver MR, Hortin GL, Quon MJ. Oral glucosamine for 6 weeks at standard doses does not cause or worsen insulin resistance or endothelial dysfunction in lean or obese subjects. Diabetes. 2006 Nov.55(11):3142-3150. Pubmedid: 17065354.
    • Orvisky E, Drake SK, Martin BM, Abdel-Hamid M, Ressom HW, Varghese RS, An Y, Saha D, Hortin GL, Loffredo CA, Goldman R. Enrichment of low molecular weight fraction of serum for MS analysis of peptides associated with hepatocellular carcinoma. Proteomics. 2006 May.6(9):2895-2902. Pubmedid: 16586431.
    • Sviridov D, Meilinger B, Drake SK, Hoehn GT, Hortin GL. Coelution of other proteins with albumin during size-exclusion HPLC: Implications for analysis of urinary albumin. Clin Chem. 2006 Mar.52(3):389-397. Pubmedid: 16397014.
    • Hortin GL, Jortani SA, Ritchie JC, Valdes R, Chan DW. Proteomics: a new diagnostic frontier. Clin Chem. 2006 Jul.52(7):1218-1222. Pubmedid: 16675505.
    • Hortin GL. The MALDI-TOF mass spectrometric view of the plasma proteome and peptidome. Clin Chem. 2006 Jul.52(7):1223-1237. Pubmedid: 16644871.
    • Rossi L, Martin BM, Hortin GL, White RL, Foster M, Moharram R, Stroncek D, Wang E, Marincola FM, Panelli MC. Inflammatory protein profile during systemic high dose interleukin-2 administration. Proteomics. 2006 Jan.6(2):709-720. Pubmedid: 16342236.
    • Hortin GL, Shen RF, Martin BM, Remaley AT. Diverse range of small peptides associated with high-density lipoprotein. Biochem Bioph Res Co. 2006 Feb.340(3):909-915. Pubmedid: 16386709. Pmcid: PMC1586118.
    • Ressom HW, Varghese RS, Orvisky E, Drake SK, Hortin GL, Abdel-Hamid M, Loffredo CA, Goldman R. Ant colony optimization for biomarker identification from MALDI-TOF mass spectra. Conf Proc IEEE Eng Med Biol Soc. 2006 Dec.2006:4560-4563. Pubmedid: 17946638.
    • Hortin GL, Seam N, Hoehn GT. Bound homocysteine, cysteine, and cysteinylglycine distribution between albumin and globulins. Clin Chem. 2006 Dec.52(12):2258-2264. Pubmedid: 17068168.
    • Bowen RA, Chan Y, Ruddel ME, Hortin GL, Csako G, Demosky SJ, Remaley AT. Immunoassay interference by a commonly used blood collection tube additive, the organosilicone surfactant silwet L-720. Clin Chem. 2005 Oct.51(10):1874-1882. Pubmedid: 16099932.
    • Hortin G. Overestimation of urinary peptide excretion. Am J Kidney Dis. 2005 May.45(5):961. Pubmedid: 15861366.
    • Hortin GL. Can mass spectrometric protein profiling meet desired standards of clinical laboratory practice?. Clin Chem. 2005 Jan.51(1):3-5. Pubmedid: 15613702.
    • Bowen RA, Chan Y, Cohen J, Rehak NN, Hortin GL, Csako G, Remaley AT. Effect of blood collection tubes on total triiodothyronine and other laboratory assays. Clin Chem. 2005 Feb.51(2):424-433. Pubmedid: 15576427.
    • Hortin GL, Meilinger B. Cross-reactivity of amino acids and other compounds in the biuret reaction: interference with urinary peptide measurements. Clin Chem. 2005 Aug.51(8):1411-1419. Pubmedid: 15951313.
    • Bowen RA, George DT, Hortin GL. False-negative result for cocaine metabolites on a lateral-flow drug test slide corrected by dilution. Clin Chem. 2005 Apr.51(4):790-791. Pubmedid: 15788788.
    • Hortin GL. Prolactinomas. N Engl J Med. 2004 Mar.350(10):1054-1057. Pubmedid: 15002120.
    • Hortin GL, Meilinger B, Drake SK. Size-selective extraction of peptides from urine for mass spectrometric analysis. Clin Chem. 2004 Jun.50(6):1092-1095. Pubmedid: 15161733.
    • Drake SK, Bowen RA, Remaley AT, Hortin GL. Potential interferences from blood collection tubes in mass spectrometric analyses of serum polypeptides. Clin Chem. 2004 Dec.50(12):2398-2401. Pubmedid: 15563493.
    • Gruszecki AC, Hortin G, Lam J, Kahler D, Smith D, Vines J, Lancaster L, Daly TM, Robinson CA, Hardy RW. Utilization, reliability, and clinical impact of point-of-care testing during critical care transport: six years of experience. Clin Chem. 2003 Jun.49(6 Pt 1):1017-1019. Pubmedid: 12766018.
    • Lawson ML, Macaluso M, Duerr A, Hortin G, Hammond KR, Blackwell R, Artz L, Bloom A. Partner characteristics, intensity of the intercourse, and semen exposure during use of the female condom. Am J Epidemiol. 2003 Feb.157(4):282-288. Pubmedid: 12578797.
    • Macaluso M, Lawson ML, Hortin G, Duerr A, Hammond KR, Blackwell R, Bloom A. Efficacy of the female condom as a barrier to semen during intercourse. Am J Epidemiol. 2003 Feb.157(4):289-297. Pubmedid: 12578798.
    • Chen ET, Nichols JH, Duh SH, Hortin G. Performance evaluation of blood glucose monitoring devices. Diabetes Technol Ther. 2003 Dec.5(5):749-768. Pubmedid: 14633341.
    • Horne MK, McCloskey DJ, Cullinane AM, Merryman PK, Rick ME, Hortin GL, Waclawiw MA, Cannon RO. Parameters of coagulant and fibrinolytic capacity and activity in postmenopausal women: within-subject variability. Thromb Res. 2002 Sep.107(5):229-233. Pubmedid: 12479883.
    • Star R, Hostetter T, Hortin GL. New markers for kidney disease. Clin Chem. 2002 Sep.48(9):1375-1376. Pubmedid: 12194910.
    • Hortin GL, Carter AB. Intraoperative parathyroid hormone testing: survey of testing program characteristics. Arch Pathol Lab Med. 2002 Sep.126(9):1045-1049. Pubmedid: 12204053.
    • Hortin GL, Murthy J. Substrate size selectivity of 20S proteasomes: analysis with variable-sized synthetic substrates. J Protein Chem. 2002 Jul.21(5):333-337. Pubmedid: 12206507.
    • Kopp JB, Falloon J, Filie A, Abati A, King C, Hortin GL, Mican JM, Vaughan E, Miller KD. Indinavir-associated interstitial nephritis and urothelial inflammation: clinical and cytologic findings. Clin Infect Dis. 2002 Apr.34(8):1122-1128. Pubmedid: 11915002.
    • Hortin GL, Sullivan P, Csako G. Relationships among plasma homocysteine, cysteine, and albumin concentrations: potential utility of assessing the cysteine/homocysteine ratio. Clin Chem. 2001 Jun.47(6):1121-1124. Pubmedid: 11375307.
    • Warshawsky I, Hortin GL. Effect of substrate size on immunoinhibition of amylase activity. J Clin Lab Anal. 2001 Jun.15(2):64-70. Pubmedid: 11291107. Pmcid: PMC6807950.
    • Hortin GL, Warshawsky I, Laude-Sharp M. Macromolecular chromogenic substrates for measuring proteinase activity. Clin Chem. 2001 Feb.47(2):215-222. Pubmedid: 11159769.
    • Hortin GL, King C, Miller KD, Kopp JB. Detection of indinavir crystals in urine: dependence on method of analysis. Arch Pathol Lab Med. 2000 Feb.124(2):246-250. Pubmedid: 10656734.
    • Hortin GL, Lok HT, Huang ST. Progress toward preparation of universal donor red cells. Artif Cells Blood Substit Immobil Biotechnol. 1997 Sep.25(5):487-491. Pubmedid: 9285051.
    • Hortin GL, Goolsby K. Lipemia interference with a rate-blanked creatinine method. Clin Chem. 1997 Feb.43(2):408-410. Pubmedid: 9023151.
    • Stott RA, Hortin GL, Wilhite TR, Miller SB, Smith CH, Landt M. Analytical artifacts in hematocrit measurements by whole-blood chemistry analyzers. Clin Chem. 1995 Feb.41(2):306-311. Pubmedid: 7874785.
    • Hortin GL, Landt M, Powderly WG. Changes in plasma amino acid concentrations in response to HIV-1 infection. Clin Chem. 1994 May.40(5):785-789. Pubmedid: 7909726.
    • Hortin GL, Summerfield AL, Wilhite TR, Smith CH, Branum EL, O'Brien JF, Landt M. Detection of autoantibodies to amylase by ELISA: comparison of detection of macroamylase and free autoantibody. Clin Chem. 1994 Dec.40(12):2254-2259. Pubmedid: 7527307.
    • Landt M, Hortin GL, Smith CH, McClellan A, Scott MG. Interference in ionized calcium measurements by heparin salts. Clin Chem. 1994 Apr.40(4):565-570. Pubmedid: 8149611.
    • Landt M, Hortin GL, Smith CH, Pashos G, Vaidya HC, Rosenblum JL. Rapid measurement of serum pancreatic amylase. J Clin Lab Anal. 1994.8(1):10-15. Pubmedid: 7513020.
    • Summerfield AL, Hortin GL, Smith CH, Wilhite TR, Landt M. Automated enzymatic analysis of inulin. Clin Chem. 1993 Nov.39(11 Pt 1):2333-2337. Pubmedid: 8222231.
    • Landt M, Smith CH, Hortin GL. Evaluation of evacuated blood-collection tubes: effects of three types of polymeric separators on therapeutic drug-monitoring specimens. Clin Chem. 1993 Aug.39(8):1712-1717. Pubmedid: 8353961.
    • Rosenblum JL, Hortin GL, Smith CH, Pashos GE, Landt M. Macroamylases: differences in activity against various-sized substrates. Clin Chem. 1992 Sep.38(9):1725-1729. Pubmedid: 1381999.
    • Hortin GL, Staatz WD, Santoro SA. Preparation of soluble peptide libraries: application to studies of platelet adhesion sequences. Biochem Int. 1992 Mar.26(4):731-738. Pubmedid: 1610377.
    • Lin WH, Larsen K, Hortin GL, Roth JA. Recognition of substrates by tyrosylprotein sulfotransferase. Determination of affinity by acidic amino acids near the target sites. J Biol Chem. 1992 Feb.267(5):2876-2879. Pubmedid: 1737745.
    • Rosenblum JL, Hortin GL, Smith CH, Pashos GE, Landt M. Macroamylases: differences in activity against various-size substrates. Clin Chem. 1992 Aug.38(8 Pt 1):1454-1458. Pubmedid: 1379525.
    • Hortin GL, Landt M, Wilhite T, Smith CH. Cross-reactivity of a vancomycin degradation product in three immunoassays of vancomycin. Clin Chem. 1991 Nov.37(11):2009. Pubmedid: 1934480.
    • Hortin GL, Trimpe BL. C1 inhibitor: different mechanisms of reaction with complement component C1 and C1s. Immunol Invest. 1991 Feb.20(1):75-82. Pubmedid: 2055603.
    • Hortin GL, Trimpe BL. Allosteric changes in thrombin's activity produced by peptides corresponding to segments of natural inhibitors and substrates. J Biol Chem. 1991 Apr.266(11):6866-6871. Pubmedid: 1849894.
    • Hortin GL. Sulfation of tyrosine residues in coagulation factor V. Blood. 1990 Sep.76(5):946-952. Pubmedid: 2168225.
    • Hortin GL, Benutto BM. Inhibition of thrombin's clotting activity by synthetic peptide segments of its inhibitors and substrates. Biochem Bioph Res Co. 1990 Jun.169(2):437-442. Pubmedid: 2357214.
    • Hortin GL. Isolation of glycopeptides containing O-linked oligosaccharides by lectin affinity chromatography on jacalin-agarose. Anal Biochem. 1990 Dec.191(2):262-267. Pubmedid: 2085172.
    • Hortin GL, Trimpe BL. Lectin affinity chromatography of proteins bearing O-linked oligosaccharides: application of jacalin-agarose. Anal Biochem. 1990 Aug.188(2):271-277. Pubmedid: 1699452.
    • Rens-Domiano S, Hortin GL, Roth JA. Sulfation of tert-butoxycarbonylcholecystokinin and other peptides by rat liver tyrosylprotein sulfotransferase. Mol Pharmacol. 1989 Oct.36(4):647-653. Pubmedid: 2811860.
    • Landt M, Hortin GL, Smith CH. Monoject Amber samplette free of bilirubin photolysis. Clin Chem. 1989 May.35(5):889-890. Pubmedid: 2720991.
    • Hortin GL, Trimpe BL, Fok KF. Plasmin's peptide-binding specificity: characterization of ligand sites in alpha 2-antiplasmin. Thromb Res. 1989 Jun.54(6):621-632. Pubmedid: 2551057.
    • Hortin GL, Farries TC, Graham JP, Atkinson JP. Sulfation of tyrosine residues increases activity of the fourth component of complement. Proc Natl Acad Sci U S A. 1989 Feb.86(4):1338-1342. Pubmedid: 2919182. Pmcid: PMC286685.
    • Hortin GL. Sulfation of a gamma-chain variant of human fibrinogen. Biochem Int. 1989 Dec.19(6):1355-1362. Pubmedid: 2561450.
    • Hortin GL, Tollefsen DM, Benutto BM. Antithrombin activity of a peptide corresponding to residues 54-75 of heparin cofactor II. J Biol Chem. 1989 Aug.264(24):13979-13982. Pubmedid: 2760054.
    • Hortin GL, Gibson BL. Purification of carboxypeptidase B by zinc chelate chromatography. Prep Biochem. 1989.19(1):49-59. Pubmedid: 2662173.
    • Hortin GL, Gibson BL, Fok KF. Alpha 2-antiplasmin's carboxy-terminal lysine residue is a major site of interaction with plasmin. Biochem Bioph Res Co. 1988 Sep.155(2):591-596. Pubmedid: 2458720.
    • Hortin GL, Cole TG, Gibson DW, Kessler G. Decreased stability of triglycerides and increased free glycerol in serum from heparin-treated patients. Clin Chem. 1988 Sep.34(9):1847-1849. Pubmedid: 3416432.
    • Hortin GL, Schilling M, Graham JP. Inhibitors of the sulfation of proteins, glycoproteins, and proteoglycans. Biochem Bioph Res Co. 1988 Jan.150(1):342-348. Pubmedid: 3422153.
    • Hortin GL, Graham JP. Sulfation of tyrosine residues does not influence secretion of alpha 2-antiplasmin or C4. Biochem Bioph Res Co. 1988 Feb.151(1):417-421. Pubmedid: 2450539.
    • Hortin GL, Tollefsen DM, Santoro SA. Assessment of interference by heparin cofactor II in the DuPont aca antithrombin-III assay. Am J Clin Pathol. 1988 Apr.89(4):515-517. Pubmedid: 3354504.
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