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Alexander  Anderson

Alexander Anderson, PhD

Research Department Chair, Integrated Mathematical Oncology
Chair, Integrated Mathematical Oncology

Program: Integrated Mathematical Oncology

Research Program: Cancer Biology & Evolution Program

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  • Overview

    Our goal is to develop truly integrated models of specific cancers that can have both predictive and therapeutic potential.


    • Integrated Mathematical Oncology
    • Diagnostic Imaging and Interventional Radiology
    • Radiation Oncology
    • Melanoma & Skin Cancer Center of Excellence
    • Cancer Biology & Evolution Program
    • Center of Excellence for Evolutionary Therapy

    Education & Training


    • University of Dundee, MSc - Mathematical Biology
    • University of Dundee, PhD - Mathematical Biology

    Continuing Education:

    • Scottish Crop Research Institute - Scientific Officer


    • University of Dundee - Mathematics
  • Research Interest

    Mathematical models, in general, have suffered greatly due to a lack of true experimental parameterization and derivation with the new Integrated Mathematical Oncology division at Moffitt we hope to address this issue and develop truly integrated models of specific cancers that can have both predictive and therapeutic application. Cancer is a complex, multiscale process, in which genetic mutations occurring at a subcellular level manifest themselves as functional changes at the cellular and tissue scale. The multiscale nature of cancer requires mathematical modelling approaches of a similar nature. The Hybrid-Discrete Continuum (HDC) model developed initially in application to nematode movement (1996), and subsequently applied to tumor angiogenes (1998), invasion (2000, 2005, 2006) and Dictyostelium dynamics (2002) is one such multiscale approach. The HDC technique is both simple and powerful, allowing discrete individuals and continuous variables to interact at the scales they naturally occur. However, we are open to utilising any tool or technique be it individual, hybrid, or purely continuum based in order to better capture the complexity of cancer and address the specific aspect under consideration. One aspect of Cancer that is currently of great interest is that of tumor cell/microenvironment interactions since both the immediate microenvironment (cell-cell or cell-matrix interactions) and the extended microenvironment (e.g. vascular bed, stroma) are thought to play crucial roles in both tumor progression and suppression. Much of my current work on tumor invasion examines the key role of the microenvironment as a selective force in the growth and evolution of cancer. The evolutionary dynamics of the tumor population have almost solely been considered at the genetic scale and very little work has considered the phenotype scale. My work focuses in part on the link between between these scales, the so called genotype to phenotype mapping and in part on how tumor cell phenotypes behave under different microenvironmental conditions and the impact this has on tumor morphology. An important aspect of this work is to understand how best to link, using mathematical models, the wealth of gene expression data that currently exist with the phenotypes that create the tumor. Thus creating a cell centered bridge between genetic change and clinical outcome.

  • Publications

    • Marzban S, Srivastava S, Kartika S, Bravo R, Safriel R, Zarski A, Anderson A, Chung CH, Amelio AL, West J. Spatial interactions modulate tumor growth and immune infiltration. bioRxiv. 2024 Mar. Pubmedid: 38370722. Pmcid: PMC10871273.
    • Pierik L, McDonald P, Anderson ARA, West J. Second-Order Effects of Chemotherapy Pharmacodynamics and Pharmacokinetics on Tumor Regression and Cachexia. Bull Math Biol. 2024 Mar.86(5):47. Pubmedid: 38546759.
    • Seyedi S, Teo R, Foster L, Saha D, Mina L, Northfelt D, Anderson KS, Shibata D, Gatenby R, Cisneros LH, Troan B, Anderson ARA, Maley CC. Testing Adaptive Therapy Protocols Using Gemcitabine and Capecitabine in a Preclinical Model of Endocrine-Resistant Breast Cancer. Cancers (Basel). 2024 Jan.16(2). Pubmedid: 38254748. Pmcid: PMC10813385.
    • West J, Rentzeperis F, Adam C, Bravo R, Luddy KA, Robertson-Tessi M, Anderson ARA. Tumor-immune metaphenotypes orchestrate an evolutionary bottleneck that promotes metabolic transformation. Front Immunol. 2024 Feb.15:1323319. Pubmedid: 38426105. Pmcid: PMC10902449.
    • Aguadé-Gorgorió G, Anderson ARA, Solé R. Modeling tumors as species-rich ecological communities. bioRxiv. 2024 Apr. Pubmedid: 38712062. Pmcid: PMC11071393.
    • Gallagher K, Strobl MA, Park DS, Spoendlin FC, Gatenby RA, Maini PK, Anderson AR. Mathematical Model-Driven Deep Learning Enables Personalized Adaptive Therapy. Cancer Res. 2024 Apr. Pubmedid: 38569183.
    • Seyedi S, Teo R, Foster L, Saha D, Mina L, Northfelt D, Anderson KS, Shibata D, Gatenby R, Cisneros L, Troan B, Anderson ARA, Maley CC. Testing Adaptive Therapy Protocols using Gemcitabine and Capecitabine on a Mouse Model of Endocrine-Resistant Breast Cancer. bioRxiv. 2023 Sep. Pubmedid: 37781632. Pmcid: PMC10541126.
    • Strobl MAR, Gallaher J, Robertson-Tessi M, West J, Anderson ARA. Treatment of evolving cancers will require dynamic decision support. Ann Oncol. 2023 Oct.34(10):867-884. Pubmedid: 37777307.
    • Chahoud J, Anderson ARA, Zhang J, Brown J, Gatenby RA. Evolutionary Dynamics and Intermittent Therapy for Metastatic Cancers. J Clin Oncol. 2023 Oct.41(28):4469-4471. Pubmedid: 37418680. Pmcid: PMC10553063.
    • West J, Adler F, Gallaher J, Strobl M, Brady-Nicholls R, Brown J, Robertson-Tessi M, Kim E, Noble R, Viossat Y, Basanta D, Anderson ARA. A survey of open questions in adaptive therapy: Bridging mathematics and clinical translation. Elife. 2023 Mar.12. Pubmedid: 36952376. Pmcid: PMC10036119.
    • Strobl M, Martin AL, West J, Gallaher J, Robertson-Tessi M, Gatenby R, Wenham R, Maini P, Damaghi M, Anderson A. Adaptive therapy for ovarian cancer: An integrated approach to PARP inhibitor scheduling. bioRxiv. 2023 Mar. Pubmedid: 36993591. Pmcid: PMC10055330.
    • Kulkarni P, Wiley HS, Levine H, Sauro H, Anderson A, Wong STC, Meyer AS, Iyengar P, Corlette K, Swanson K, Mohanty A, Bhattacharya S, Patel A, Jain V, Salgia R. Addressing the genetic/nongenetic duality in cancer with systems biology. Trends Cancer. 2023 Mar.9(3):185-187. Pubmedid: 36635119.
    • Gatenbee CD, Baker AM, Prabhakaran S, Swinyard O, Slebos RJC, Mandal G, Mulholland E, Andor N, Marusyk A, Leedham S, Conejo-Garcia JR, Chung CH, Robertson-Tessi M, Graham TA, Anderson ARA. Virtual alignment of pathology image series for multi-gigapixel whole slide images. Nat Commun. 2023 Jul.14(1):4502. Pubmedid: 37495577. Pmcid: PMC10372014.
    • Gallaher J, Strobl M, West J, Gatenby R, Zhang J, Robertson-Tessi M, Anderson ARA. Intermetastatic and Intrametastatic Heterogeneity Shapes Adaptive Therapy Cycling Dynamics. Cancer Res. 2023 Aug.83(16):2775-2789. Pubmedid: 37205789. Pmcid: PMC10425736.
    • West J, Robertson-Tessi M, Anderson ARA. Agent-based methods facilitate integrative science in cancer. Trends Cell Biol. 2023 Apr.33(4):300-311. Pubmedid: 36404257.
    • Adler FR, Anderson ARA, Bhushan A, Bogdan P, Bravo-Cordero JJ, Brock A, Chen Y, Cukierman E, DelGiorno KE, Denis GV, Ferrall-Fairbanks MC, Gartner ZJ, Germain RN, Gordon DM, Hunter G, Jolly MK, Karacosta LG, Mythreye K, Katira P, Kulkarni RP, Kutys ML, Lander AD, Laughney AM, Levine H, Lou E, Lowenstein PR, Masters KS, Pe'er D, Peyton SR, Platt MO, Purvis JE, Quon G, Richer JK, Riddle NC, Rodriguez A, Snyder JC, Lee Szeto G, Tomlin CJ, Yanai I, Zervantonakis IK, Dueck H. Modeling collective cell behavior in cancer: Perspectives from an interdisciplinary conversation. Cell Syst. 2023 Apr.14(4):252-257. Pubmedid: 37080161.
    • Zhang J, Gallaher J, Cunningham JJ, Choi JW, Ionescu F, Chatwal MS, Jain R, Kim Y, Wang L, Brown JS, Anderson AR, Gatenby RA. A Phase 1b Adaptive Androgen Deprivation Therapy Trial in Metastatic Castration Sensitive Prostate Cancer. Cancers (Basel). 2022 Oct.14(21). Pubmedid: 36358643. Pmcid: PMC9656891.
    • Anadon CM, Yu X, Hänggi K, Biswas S, Chaurio RA, Martin A, Payne KK, Mandal G, Innamarato P, Harro CM, Mine JA, Sprenger KB, Cortina C, Powers JJ, Costich TL, Perez BA, Gatenbee CD, Prabhakaran S, Marchion D, Heemskerk MHM, Curiel TJ, Anderson AR, Wenham RM, Rodriguez PC, Conejo-Garcia JR. Ovarian cancer immunogenicity is governed by a narrow subset of progenitor tissue-resident memory T cells. Cancer Cell. 2022 May.40(5):545-557.e13. Pubmedid: 35427494. Pmcid: PMC9096229.
    • Gabbutt C, Schenck RO, Weisenberger DJ, Kimberley C, Berner A, Househam J, Lakatos E, Robertson-Tessi M, Martin I, Patel R, Clark SK, Latchford A, Barnes CP, Leedham SJ, Anderson ARA, Graham TA, Shibata D. Fluctuating methylation clocks for cell lineage tracing at high temporal resolution in human tissues. Nat Biotechnol. 2022 May.40(5):720-730. Pubmedid: 34980912. Pmcid: PMC9110299.
    • Thomas DS, Cisneros LH, Anderson ARA, Maley CC. In Silico Investigations of Multi-Drug Adaptive Therapy Protocols. Cancers (Basel). 2022 May.14(11). Pubmedid: 35681680. Pmcid: PMC9179496.
    • Mandal G, Biswas S, Anadon CM, Yu X, Gatenbee CD, Prabhakaran S, Payne KK, Chaurio RA, Martin A, Innamarato P, Moran C, Powers JJ, Harro CM, Mine JA, Sprenger KB, Rigolizzo KE, Wang X, Curiel TJ, Rodriguez PC, Anderson ARA, Saglam O, Conejo-Garcia JR. IgA-Dominated Humoral Immune Responses Govern Patients' Outcome in Endometrial Cancer. Cancer Res. 2022 Mar.82(5):859-871. Pubmedid: 34949671. Pmcid: PMC8898267.
    • Prabhakaran S, Gatenbee C, Robertson-Tessi M, West J, Beg AA, Gray J, Antonia S, Gatenby RA, Anderson ARA. Mistic: An open-source multiplexed image t-SNE viewer. Patterns (N Y). 2022 Jul.3(7):100523. Pubmedid: 35845830. Pmcid: PMC9278502.
    • Prabhakaran S, Gatenbee C, Anderson ARA. Developing tools for analyzing and viewing multiplexed images. Patterns (N Y). 2022 Jul.3(7):100549. Pubmedid: 35845839. Pmcid: PMC9278522.
    • Schenck RO, Kim E, Bravo RR, West J, Leedham S, Shibata D, Anderson ARA. Homeostasis limits keratinocyte evolution. Proc Natl Acad Sci U S A. 2022 Aug.119(35). Pubmedid: 35998218. Pmcid: PMC9436311.
    • Schenck RO, Brosula G, West J, Leedham S, Shibata D, Anderson AR. Gattaca: Base-Pair Resolution Mutation Tracking for Somatic Evolution Studies using Agent-based Models. Mol Biol Evol. 2022 Apr.39(4). Pubmedid: 35298641. Pmcid: PMC9034688.
    • Strobl MAR, Gallaher J, West J, Robertson-Tessi M, Maini PK, Anderson ARA. Spatial structure impacts adaptive therapy by shaping intra-tumoral competition. Commun Med (Lond). 2022 Apr.2:46. Pubmedid: 35603284. Pmcid: PMC9053239.
    • Gatenbee CD, Baker AM, Schenck RO, Strobl M, West J, Neves MP, Hasan SY, Lakatos E, Martinez P, Cross WCH, Jansen M, Rodriguez-Justo M, Whelan CJ, Sottoriva A, Leedham S, Robertson-Tessi M, Graham TA, Anderson ARA. Immunosuppressive niche engineering at the onset of human colorectal cancer. Nat Commun. 2022 Apr.13(1):1798. Pubmedid: 35379804. Pmcid: PMC8979971.
    • Foo J, Basanta D, Rockne RC, Strelez C, Shah C, Ghaffarian K, Mumenthaler SM, Mitchell K, Lathia JD, Frankhouser D, Branciamore S, Kuo YH, Marcucci G, Vander Velde R, Marusyk A, Hang S, Hari K, Jolly MK, Hatzikirou H, Poels K, Spilker M, Shtylla B, Robertson-Tessi M, Anderson ARA. Roadmap on plasticity and epigenetics in cancer. Phys Biol. 2022 Apr.19(3). Pubmedid: 35078159. Pmcid: PMC9190291.
    • Biswas S, Mandal G, Payne KK, Anadon CM, Gatenbee CD, Chaurio RA, Costich TL, Moran C, Harro CM, Rigolizzo KE, Mine JA, Trillo-Tinoco J, Sasamoto N, Terry KL, Marchion D, Buras A, Wenham RM, Yu X, Townsend MK, Tworoger SS, Rodriguez PC, Anderson AR, Conejo-Garcia JR. IgA transcytosis and antigen recognition govern ovarian cancer immunity. Nature. 2021 Mar.591(7850):464-470. Pubmedid: 33536615. Pmcid: PMC7969354.
    • Hernandez-Prera J, Valderrabano P, Creed J, de la Iglesia JV, Slebos R, Centeno BA, Tarasova V, Hallanger-Johnson J, Veloski C, Otto KJ, Wenig BM, Yoder S, Lam C, Park DS, Anderson AR, Raghunand N, Berglund A, Caudell J, Gerke TA, Chung CH. Molecular Determinants of Thyroid Nodules with Indeterminate Cytology and RAS Mutations. Thyroid. 2021 Jan.31(1):36-49. Pubmedid: 32689909. Pmcid: PMC7864115.
    • Walker SA, Pham A, Nizzero S, Kim M, Riter B, Bletz J, Judge S, Phillips B, Noble D, Murray D, Wetzel E, Samson S, McMahon M, Flink C, Couch J, Tomlin C, Swanson K, Anderson ARA, Odde D, Shen H, Hughes S, Zahir N, Enderling H, Wolfram J. Education and Outreach in Physical Sciences in Oncology. Trends Cancer. 2021 Jan.7(1):3-9. Pubmedid: 33168416. Pmcid: PMC7895467.
    • Damaghi M, West J, Robertson-Tessi M, Xu L, Ferrall-Fairbanks MC, Stewart PA, Persi E, Fridley BL, Altrock PM, Gatenby RA, Sims PA, Anderson ARA, Gillies RJ. The harsh microenvironment in early breast cancer selects for a Warburg phenotype. Proc Natl Acad Sci U S A. 2021 Jan.118(3). Pubmedid: 33452133. Pmcid: PMC7826394.
    • Strobl MAR, West J, Viossat Y, Damaghi M, Robertson-Tessi M, Brown JS, Gatenby RA, Maini PK, Anderson ARA. Turnover Modulates the Need for a Cost of Resistance in Adaptive Therapy. Cancer Res. 2021 Feb.81(4):1135-1147. Pubmedid: 33172930. Pmcid: PMC8455086.
    • Kim E, Brown JS, Eroglu Z, Anderson ARA. Adaptive Therapy for Metastatic Melanoma: Predictions from Patient Calibrated Mathematical Models. Cancers (Basel). 2021 Feb.13(4). Pubmedid: 33669315. Pmcid: PMC7920057.
    • Massey SC, Whitmire P, Doyle TE, Ippolito JE, Mrugala MM, Hu LS, Canoll P, Anderson ARA, Wilson MA, Fitzpatrick SM, McCarthy MM, Rubin JB, Swanson KR. Sex differences in health and disease: A review of biological sex differences relevant to cancer with a spotlight on glioma. Cancer Lett. 2021 Feb.498:178-187. Pubmedid: 33130315. Pmcid: PMC8409250.
    • Cassidy T, Nichol D, Robertson-Tessi M, Craig M, Anderson ARA. The role of memory in non-genetic inheritance and its impact on cancer treatment resistance. PLoS Comput Biol. 2021 Aug.17(8):e1009348. Pubmedid: 34460809. Pmcid: PMC8432806.
    • West J, Schenck RO, Gatenbee C, Robertson-Tessi M, Anderson ARA. Normal tissue architecture determines the evolutionary course of cancer. Nat Commun. 2021 Apr.12(1):2060. Pubmedid: 33824323. Pmcid: PMC8024392.
    • Ardaševa A, Anderson ARA, Gatenby RA, Byrne HM, Maini PK, Lorenzi T. Comparative study between discrete and continuum models for the evolution of competing phenotype-structured cell populations in dynamical environments. Phys Rev E. 2020 Oct.102(4-1):042404. Pubmedid: 33212726.
    • Lakatos E, Williams MJ, Schenck RO, Cross WCH, Househam J, Zapata L, Werner B, Gatenbee C, Robertson-Tessi M, Barnes CP, Anderson ARA, Sottoriva A, Graham TA. Evolutionary dynamics of neoantigens in growing tumors. Nat Genetics. 2020 Oct.52(10):1057-1066. Pubmedid: 32929288. Pmcid: PMC7610467.
    • Bravo RR, Baratchart E, West J, Schenck RO, Miller AK, Gallaher J, Gatenbee CD, Basanta D, Robertson-Tessi M, Anderson ARA. Hybrid Automata Library: A flexible platform for hybrid modeling with real-time visualization. PLoS Comput Biol. 2020 Mar.16(3):e1007635. Pubmedid: 32155140. Pmcid: PMC7105119.
    • El-Kenawi A, Gatenbee C, Robertson-Tessi M, Bravo R, Dhillon J, Balagurunathan Y, Berglund A, Vishvakarma N, Ibrahim-Hashim A, Choi J, Luddy K, Gatenby R, Pilon-Thomas S, Anderson A, Ruffell B, Gillies R. Correction: Acidity promotes tumour progression by altering macrophage phenotype in prostate cancer. Brit J Cancer. 2020 Mar.122(7):1118. Pubmedid: 31937927. Pmcid: PMC7109119.
    • Ardaševa A, Gatenby RA, Anderson ARA, Byrne HM, Maini PK, Lorenzi T. A Mathematical Dissection of the Adaptation of Cell Populations to Fluctuating Oxygen Levels. Bull Math Biol. 2020 Jun.82(6):81. Pubmedid: 32556703.
    • Frankenstein Z, Basanta D, Franco OE, Gao Y, Javier RA, Strand DW, Lee M, Hayward SW, Ayala G, Anderson ARA. Stromal reactivity differentially drives tumour cell evolution and prostate cancer progression. Nat Ecol Evol. 2020 Jun.4(6):870-884. Pubmedid: 32393869.
    • Scott JG, Maini PK, Anderson ARA, Fletcher AG. Inferring Tumor Proliferative Organization from Phylogenetic Tree Measures in a Computational Model. Syst Biol. 2020 Jul.69(4):623-637. Pubmedid: 31665523. Pmcid: PMC7302056.
    • Gatenbee CD, Minor ES, Slebos RJC, Chung CH, Anderson ARA. Histoecology: Applying Ecological Principles and Approaches to Describe and Predict Tumor Ecosystem Dynamics Across Space and Time. Cancer Control. 2020 Jul.27(3). Pubmedid: 32869651. Pmcid: PMC7710396.
    • Enderling H, Altrock PM, Andor N, Basanta D, Brown JS, Gatenby RA, Marusyk A, Rejniak KA, Silva A, Anderson ARA. High School Internship Program in Integrated Mathematical Oncology (HIP IMO): Five-Year Experience at Moffitt Cancer Center. Bull Math Biol. 2020 Jul.82(7):91. Pubmedid: 32648152.
    • Strobl MAR, Krause AL, Damaghi M, Gillies R, Anderson ARA, Maini PK. Mix and Match: Phenotypic Coexistence as a Key Facilitator of Cancer Invasion. Bull Math Biol. 2020 Jan.82(1):15. Pubmedid: 31953602. Pmcid: PMC6968991.
    • Ardaševa A, Gatenby RA, Anderson ARA, Byrne HM, Maini PK, Lorenzi T. Evolutionary dynamics of competing phenotype-structured populations in periodically fluctuating environments. J Math Biol. 2020 Feb.80(3):775-807. Pubmedid: 31641842. Pmcid: PMC7028828.
    • Gallaher JA, Massey SC, Hawkins-Daarud A, Noticewala SS, Rockne RC, Johnston SK, Gonzalez-Cuyar L, Juliano J, Gil O, Swanson KR, Canoll P, Anderson ARA. From cells to tissue: How cell scale heterogeneity impacts glioblastoma growth and treatment response. PLoS Comput Biol. 2020 Feb.16(2):e1007672. Pubmedid: 32101537. Pmcid: PMC7062288.
    • Park DS, Luddy KA, Robertson-Tessi M, O'Farrelly C, Gatenby RA, Anderson ARA. Searching for Goldilocks: How Evolution and Ecology Can Help Uncover More Effective Patient-Specific Chemotherapies. Cancer Res. 2020 Dec.80(23):5147-5154. Pubmedid: 32934022.
    • West J, Ma Y, Kaznatcheev A, Anderson ARA. IsoMaTrix: a framework to visualize the isoclines of matrix games and quantify uncertainty in structured populations. Bioinformatics. 2020 Dec. Pubmedid: 33325501. Pmcid: PMC8016459.
    • West J, You L, Zhang J, Gatenby RA, Brown JS, Newton PK, Anderson ARA. Towards Multidrug Adaptive Therapy. Cancer Res. 2020 Apr.80(7):1578-1589. Pubmedid: 31948939. Pmcid: PMC7307613.
    • Smalley I, Kim E, Li J, Spence P, Wyatt CJ, Eroglu Z, Sondak VK, Messina JL, Babacan NA, Maria-Engler SS, De Armas L, Williams SL, Gatenby RA, Chen YA, Anderson ARA, Smalley KSM. Leveraging transcriptional dynamics to improve BRAF inhibitor responses in melanoma. EBioMedicine. 2019 Oct.48:178-190. Pubmedid: 31594749. Pmcid: PMC6838387.
    • Park DS, Robertson-Tessi M, Luddy KA, Maini PK, Bonsall MB, Gatenby RA, Anderson ARA. The Goldilocks Window of Personalized Chemotherapy: Getting the Immune Response Just Right. Cancer Res. 2019 Oct.79(20):5302-5315. Pubmedid: 31387920. Pmcid: PMC6801094.
    • El-Kenawi A, Gatenbee C, Robertson-Tessi M, Bravo R, Dhillon J, Balagurunathan Y, Berglund A, Visvakarma N, Ibrahim-Hashim A, Choi J, Luddy K, Gatenby R, Pilon-Thomas S, Anderson A, Ruffell B, Gillies R. Acidity promotes tumour progression by altering macrophage phenotype in prostate cancer. Brit J Cancer. 2019 Oct.121(7):556-566. Pubmedid: 31417189. Pmcid: PMC6889319.
    • Nichol D, Robertson-Tessi M, Anderson ARA, Jeavons P. Model genotype-phenotype mappings and the algorithmic structure of evolution. J R Soc Interface. 2019 Nov.16(160):20190332. Pubmedid: 31690233. Pmcid: PMC6893500.
    • Schenck RO, Lakatos E, Gatenbee C, Graham TA, Anderson ARA. NeoPredPipe: high-throughput neoantigen prediction and recognition potential pipeline. BMC Bioinformatics. 2019 May.20(1):264. Pubmedid: 31117948. Pmcid: PMC6532147.
    • Rockne RC, Hawkins-Daarud A, Swanson KR, Sluka JP, Glazier JA, Macklin P, Hormuth D, Jarrett AM, Lima EABDF, Oden J, Biros G, Yankeelov TE, Curtius K, Bakir IA, Wodarz D, Komarova N, Aparicio L, Bordyuh M, Rabadan R, Finley S, Enderling H, Caudell JJ, Moros EG, Anderson ARA, Gatenby R, Kaznatcheev A, Jeavons P, Krishnan N, Pelesko J, Wadhwa RR, Yoon N, Nichol D, Marusyk A, Hinczewski M, Scott JG. The 2019 mathematical oncology roadmap. Phys Biol. 2019 Jun.16(4):041005. Pubmedid: 30991381. Pmcid: PMC6655440.
    • Massey SC, Hawkins-Daarud A, Gallaher J, Anderson ARA, Canoll P, Swanson KR. Lesion Dynamics Under Varying Paracrine PDGF Signaling in Brain Tissue. Bull Math Biol. 2019 Jun.81(6):1645-1664. Pubmedid: 30796683. Pmcid: PMC6494675.
    • West JB, Dinh MN, Brown JS, Zhang J, Anderson AR, Gatenby RA. Multidrug Cancer Therapy in Metastatic Castrate-Resistant Prostate Cancer: An Evolution-Based Strategy. Clin Cancer Res. 2019 Jul.25(14):4413-4421. Pubmedid: 30992299. Pmcid: PMC6665681.
    • Nichol D, Rutter J, Bryant C, Hujer AM, Lek S, Adams MD, Jeavons P, Anderson ARA, Bonomo RA, Scott JG. Antibiotic collateral sensitivity is contingent on the repeatability of evolution. Nat Commun. 2019 Jan.10(1):334. Pubmedid: 30659188. Pmcid: PMC6338734.
    • Gallaher JA, Brown JS, Anderson ARA. The impact of proliferation-migration tradeoffs on phenotypic evolution in cancer. Sci Rep. 2019 Feb.9(1):2425. Pubmedid: 30787363. Pmcid: PMC6382810.
    • West J, Robertson-Tessi M, Luddy K, Park DS, Williamson DFK, Harmon C, Khong HT, Brown J, Anderson ARA. The Immune Checkpoint Kick Start: Optimization of Neoadjuvant Combination Therapy Using Game Theory. JCO Clin Cancer Inform. 2019 Feb.3:1-12. Pubmedid: 30742484. Pmcid: PMC6873943.
    • Gatenbee CD, Schenck RO, Bravo RR, Anderson ARA. EvoFreq: visualization of the Evolutionary Frequencies of sequence and model data. BMC Bioinformatics. 2019 Dec.20(1):710. Pubmedid: 31842729. Pmcid: PMC6916070.
    • Park DS, Akuffo AA, Muench DE, Grimes HL, Epling-Burnette PK, Maini PK, Anderson ARA, Bonsall MB. Clonal hematopoiesis of indeterminate potential and its impact on patient trajectories after stem cell transplantation. PLoS Comput Biol. 2019 Apr.15(4):e1006913. Pubmedid: 31026273. Pmcid: PMC6505959.
    • Gillies RJ, Brown JS, Anderson ARA, Gatenby RA. Eco-evolutionary causes and consequences of temporal changes in intratumoural blood flow. Nat Rev Cancer. 2018 Sep.18(9):576-585. Pubmedid: 29891961. Pmcid: PMC6441333.
    • Cross W, Kovac M, Mustonen V, Temko D, Davis H, Baker AM, Biswas S, Arnold R, Chegwidden L, Gatenbee C, Anderson AR, Koelzer VH, Martinez P, Jiang X, Domingo E, Woodcock DJ, Feng Y, Kovacova M, Maughan T, Jansen M, Rodriguez-Justo M, Ashraf S, Guy R, Cunningham C, East JE, Wedge DC, Wang LM, Palles C, Heinimann K, Sottoriva A, Leedham SJ, Graham TA, Tomlinson IPM. The evolutionary landscape of colorectal tumorigenesis. Nat Ecol Evol. 2018 Oct.2(10):1661-1672. Pubmedid: 30177804. Pmcid: PMC6152905.
    • Massey SC, Rockne RC, Hawkins-Daarud A, Gallaher J, Anderson ARA, Canoll P, Swanson KR. Simulating PDGF-Driven Glioma Growth and Invasion in an Anatomically Accurate Brain Domain. Bull Math Biol. 2018 May.80(5):1292-1309. Pubmedid: 28842831.
    • Kim E, Kim JY, Smith MA, Haura EB, Anderson ARA. Cell signaling heterogeneity is modulated by both cell-intrinsic and -extrinsic mechanisms: An integrated approach to understanding targeted therapy. PLoS Biol. 2018 Mar.16(3):e2002930. Pubmedid: 29522507. Pmcid: PMC5844524.
    • Walker R, Poleszczuk J, Pilon-Thomas S, Kim S, Anderson AARA, Czerniecki BJ, Harrison LB, Moros EG, Enderling H. Immune interconnectivity of anatomically distant tumors as a potential mediator of systemic responses to local therapy. Sci Rep. 2018 Jun.8(1):9474. Pubmedid: 29930290. Pmcid: PMC6013469.
    • Juliano J, Gil O, Hawkins-Daarud A, Noticewala S, Rockne RC, Gallaher J, Massey SC, Sims PA, Anderson ARA, Swanson KR, Canoll P. Comparative dynamics of microglial and glioma cell motility at the infiltrative margin of brain tumours. J R Soc Interface. 2018 Feb.15(139). Pubmedid: 29445035. Pmcid: PMC5832721.
    • Gallaher J, Enriquez-Navas PM, Luddy KA, Gatenby RA, Anderson AR. Spatial Heterogeneity and Evolutionary Dynamics Modulate Time to Recurrence in Continuous and Adaptive Cancer Therapies. Cancer Res. 2018 Apr.78(8):2127-2139. Pubmedid: 29382708. Pmcid: PMC5899666.
    • Anderson ARA, Maini PK. Mathematical Oncology. Bull Math Biol. 2018 05.80(5):945-953. Pubmedid: 29679280.
    • Basanta D, Anderson AR. Homeostasis Back and Forth: An Ecoevolutionary Perspective of Cancer. Cold Spring Harb Perspect Med. 2017 Sep.7(9). Pubmedid: 28289244. Pmcid: PMC5580509.
    • Maley CC, Aktipis A, Graham TA, Sottoriva A, Boddy AM, Janiszewska M, Silva AS, Gerlinger M, Yuan Y, Pienta KJ, Anderson KS, Gatenby R, Swanton C, Posada D, Wu CI, Schiffman JD, Hwang ES, Polyak K, Anderson ARA, Brown JS, Greaves M, Shibata D. Classifying the evolutionary and ecological features of neoplasms. Nat Rev Cancer. 2017 Oct.17(10):605-619. Pubmedid: 28912577. Pmcid: PMC5811185.
    • Picco N, Sahai E, Maini PK, Anderson AR. Integrating Models to Quantify Environment-Mediated Drug Resistance. Cancer Res. 2017 Oct.77(19):5409-5418. Pubmedid: 28754669. Pmcid: PMC8455089.
    • Yagawa Y, Robertson-Tessi M, Zhou SL, Anderson ARA, Mulé JJ, Mailloux AW. Systematic Screening of Chemokines to Identify Candidates to Model and Create Ectopic Lymph Node Structures for Cancer Immunotherapy. Sci Rep. 2017 Nov.7(1):15996. Pubmedid: 29167448. Pmcid: PMC5700067.
    • Ibrahim-Hashim A, Robertson-Tessi M, Enrizues-Navas P, Damaghi M, Balagurunathan Y, Wojtkowiak JW, Russell S, Yoonseok K, Lloyd MC, Bui MM, Brown JS, Anderson AR, Gillies RJ, Gatenby RA. Defining Cancer Subpopulations by Adaptive Strategies Rather Than Molecular Properties Provides Novel Insights into Intratumoral Evolution. Cancer Res. 2017 May.77(9):2242-2254. Pubmedid: 28249898. Pmcid: PMC6005351.
    • Picco N, Gatenby RA, Anderson AR. Stem Cell Plasticity and Niche Dynamics in Cancer Progression. IEEE Trans Biomed Eng. 2017 Mar.64(3):528-537. Pubmedid: 28113244. Pmcid: PMC5634531.
    • Gerlee P, Basanta D, Anderson ARA. The Influence of Cellular Characteristics on the Evolution of Shape Homeostasis. Artif Life. 2017.23(3):424-448. Pubmedid: 28786729.
    • Picco N, Gatenby RA, Anderson AR. Stem Cell Plasticity And Niche Dynamics in Cancer Progression. IEEE Trans Biomed Eng. 2016 Sep. Pubmedid: 27623570.
    • Kim E, Rebecca VW, Smalley KS, Anderson AR. Phase i trials in melanoma: A framework to translate preclinical findings to the clinic. Eur J Cancer. 2016 Nov.67:213-222. Pubmedid: 27689717. Pmcid: PMC5658204.
    • Scott JG, Fletcher AG, Anderson AR, Maini PK. Spatial Metrics of Tumour Vascular Organisation Predict Radiation Efficacy in a Computational Model. PLoS Comput Biol. 2016 Jan.12(1):e1004712. Pubmedid: 26800503. Pmcid: PMC4723304.
    • Nichol D, Robertson-Tessi M, Jeavons P, Anderson AR. Stochasticity in the Genotype-Phenotype Map: Implications for the Robustness and Persistence of Bet-Hedging. Genetics. 2016 Dec.204(4):1523-1539. Pubmedid: 27770034. Pmcid: PMC5161283.
    • Werner B, Scott JG, Sottoriva A, Anderson AR, Traulsen A, Altrock PM. The Cancer Stem Cell Fraction in Hierarchically Organized Tumors Can Be Estimated Using Mathematical Modeling and Patient-Specific Treatment Trajectories. Cancer Res. 2016 Apr.76(7):1705-1713. Pubmedid: 26833122. Pmcid: PMC4900896.
    • Nichol D, Jeavons P, Fletcher AG, Bonomo RA, Maini PK, Paul JL, Gatenby RA, Anderson AR, Scott JG. Steering Evolution with Sequential Therapy to Prevent the Emergence of Bacterial Antibiotic Resistance. PLoS Comput Biol. 2015 Sep.11(9):e1004493. Pubmedid: 26360300. Pmcid: PMC4567305.
    • Robertson-Tessi M, Anderson AR. Big Bang and context-driven collapse. Nat Genetics. 2015 Mar.47(3):196-197. Pubmedid: 25711865.
    • Gerlee P, Kim E, Anderson AR. Bridging scales in cancer progression: mapping genotype to phenotype using neural networks. Semin Cancer Biol. 2015 Feb.30:30-41. Pubmedid: 24830623. Pmcid: PMC4533881.
    • Gerlee P, Anderson AR. The evolution of carrying capacity in constrained and expanding tumour cell populations. Phys Biol. 2015 Aug.12(5):056001. Pubmedid: 26266550.
    • Hawkins-Daarud A, Rockne R, Corwin D, Anderson AR, Kinahan P, Swanson KR. In silico analysis suggests differential response to bevacizumab and radiation combination therapy in newly diagnosed glioblastoma. J R Soc Interface. 2015 Aug.12(109):20150388. Pubmedid: 26202682. Pmcid: PMC4535409.
    • Robertson-Tessi M, Gillies RJ, Gatenby RA, Anderson AR. Impact of metabolic heterogeneity on tumor growth, invasion, and treatment outcomes. Cancer Res. 2015 Apr.75(8):1567-1579. Pubmedid: 25878146. Pmcid: PMC4421891.
    • Scott JG, Fletcher AG, Maini PK, Anderson AR, Gerlee P. A filter-flow perspective of haematogenous metastasis offers a non-genetic paradigm for personalised cancer therapy. Eur J Cancer. 2014 Nov.50(17):3068-3075. Pubmedid: 25306188. Pmcid: PMC4258103.
    • Rebecca VW, Massaro RR, Fedorenko IV, Sondak VK, Anderson AR, Kim E, Amavaradi RK, Maria-Engler SS, Messina JL, Gibney GT, Kudchadkar RR, Smalley KS. Inhibition of autophagy enhances the effects of the AKT inhibitor MK-2206 when combined with paclitaxel and carboplatin in BRAF wild-type melanoma. Pigment Cell Melanoma Res. 2014 May.27(3):465-478. Pubmedid: 24490764. Pmcid: PMC3988257.
    • Scott JG, Hjelmeland AB, Chinnaiyan P, Anderson AR, Basanta D. Microenvironmental variables must influence intrinsic phenotypic parameters of cancer stem cells to affect tumourigenicity. PLoS Comput Biol. 2014 Jan.10(1):e1003433. Pubmedid: 24453958. Pmcid: PMC3894166.
    • Gallaher J, Babu A, Plevritis S, Anderson AR. Bridging population and tissue scale tumor dynamics: a new paradigm for understanding differences in tumor growth and metastatic disease. Cancer Res. 2014 Jan.74(2):426-435. Pubmedid: 24408919. Pmcid: PMC3913019.
    • Scott JG, Basanta D, Anderson AR, Gerlee P. A mathematical model of tumour self-seeding reveals secondary metastatic deposits as drivers of primary tumour growth. J R Soc Interface. 2013 May.10(82):20130011. Pubmedid: 23427099. Pmcid: PMC3627086.
    • Kim E, Rebecca VW, Fedorenko IV, Messina JL, Mathew R, Maria-Engler SS, Basanta D, Smalley KS, Anderson AR. Senescent fibroblasts in melanoma initiation and progression: an integrated theoretical, experimental, and clinical approach. Cancer Res. 2013 Dec.73(23):6874-6885. Pubmedid: 24080279. Pmcid: PMC3926439.
    • Gallaher J, Anderson AR. Evolution of intratumoral phenotypic heterogeneity: the role of trait inheritance. Interface Focus. 2013 Aug.3(4):20130016. Pubmedid: 24511380. Pmcid: PMC3915835.
    • Basanta D, Anderson AR. Exploiting ecological principles to better understand cancer progression and treatment. Interface Focus. 2013 Aug.3(4):20130020. Pubmedid: 24511383. Pmcid: PMC3915838.
    • Hawkins-Daarud A, Rockne RC, Anderson AR, Swanson KR. Modeling Tumor-Associated Edema in Gliomas during Anti-Angiogenic Therapy and Its Impact on Imageable Tumor. Front Oncol. 2013.3:66. Pubmedid: 23577324. Pmcid: PMC3616256.
    • Rejniak KA, Anderson AR. State of the art in computational modelling of cancer. Math Med Biol. 2012 Mar.29(1):1-2. Pubmedid: 22200587.
    • Rejniak KA, Quaranta V, Anderson AR. Computational investigation of intrinsic and extrinsic mechanisms underlying the formation of carcinoma. Math Med Biol. 2012 Mar.29(1):67-84. Pubmedid: 21106672. Pmcid: PMC3499074.
    • Gu S, Chakraborty G, Champley K, Alessio AM, Claridge J, Rockne R, Muzi M, Krohn KA, Spence AM, Alvord EC, Anderson AR, Kinahan PE, Swanson KR. Applying a patient-specific bio-mathematical model of glioma growth to develop virtual [18F]-FMISO-PET images. Math Med Biol. 2012 Mar.29(1):31-48. Pubmedid: 21562060. Pmcid: PMC4104689.
    • Basanta D, Scott JG, Fishman MN, Ayala G, Hayward SW, Anderson AR. Investigating prostate cancer tumour-stroma interactions: clinical and biological insights from an evolutionary game. Brit J Cancer. 2012 Jan.106(1):174-181. Pubmedid: 22134510. Pmcid: PMC3251863.
    • Kam Y, Rejniak KA, Anderson AR. Cellular modeling of cancer invasion: integration of in silico and in vitro approaches. J Cell Physiol. 2012 Feb.227(2):431-438. Pubmedid: 21465465. Pmcid: PMC3687536.
    • Basanta D, Gatenby RA, Anderson AR. Exploiting evolution to treat drug resistance: combination therapy and the double bind. Mol Pharm. 2012 Apr.9(4):914-921. Pubmedid: 22369188. Pmcid: PMC3325107.
    • Scott J, Kuhn P, Anderson AR. Unifying metastasis--integrating intravasation, circulation and end-organ colonization. Nat Rev Cancer. 2012 07.12(7):445-446. Pubmedid: 22912952. Pmcid: PMC4533867.
    • Rejniak KA, Anderson AR. Hybrid models of tumor growth. Wiley Interdiscip Rev Syst Biol Med. 2011 Jan.3(1):115-125. Pubmedid: 21064037. Pmcid: PMC3057876.
    • Basanta D, Scott JG, Rockne R, Swanson KR, Anderson AR. The role of IDH1 mutated tumour cells in secondary glioblastomas: an evolutionary game theoretical view. Phys Biol. 2011 Feb.8(1):015016. Pubmedid: 21301070. Pmcid: PMC3166886.
    • Scott JG, Basanta D, Chinnaiyan P, Canoll P, Swanson KR, Anderson AR. Production of 2-hydroxyglutarate by isocitrate dehydrogenase 1-mutated gliomas: an evolutionary alternative to the Warburg shift?. Neurooncol. 2011 Dec.13(12):1262-1264. Pubmedid: 21784755. Pmcid: PMC3223086.
    • Flach EH, Rebecca VW, Herlyn M, Smalley KS, Anderson AR. Fibroblasts contribute to melanoma tumor growth and drug resistance. Mol Pharm. 2011 Dec.8(6):2039-2049. Pubmedid: 22067046. Pmcid: PMC3235959.
    • Swanson KR, Rockne RC, Claridge J, Chaplain MA, Alvord EC, Anderson AR. Quantifying the role of angiogenesis in malignant progression of gliomas: in silico modeling integrates imaging and histology. Cancer Res. 2011 Dec.71(24):7366-7375. Pubmedid: 21900399. Pmcid: PMC3398690.
    • Gerlee P, Basanta D, Anderson AR. Evolving homeostatic tissue using genetic algorithms. Prog Biophys Mol Biol. 2011 Aug.106(2):414-425. Pubmedid: 21419156. Pmcid: PMC3812677.
    • Paraiso KH, Xiang Y, Rebecca VW, Abel EV, Chen YA, Munko AC, Wood E, Fedorenko IV, Sondak VK, Anderson AR, Ribas A, Palma MD, Nathanson KL, Koomen JM, Messina JL, Smalley KS. PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression. Cancer Res. 2011 Apr.71(7):2750-2760. Pubmedid: 21317224. Pmcid: PMC3070772.
    • Silva A, Anderson AR, Gatenby R. A multiscale model of the bone marrow and hematopoiesis. Math Biosci Eng. 2011 Apr.8(2):643-658. Pubmedid: 21631151. Pmcid: PMC3754791.
    • Gillies RJ, Anderson AR, Gatenby RA, Morse DL. The biology underlying molecular imaging in oncology: from genome to anatome and back again. Clin Radiol. 2010 Jul.65(7):517-521. Pubmedid: 20541651. Pmcid: PMC4009364.
    • Strand DW, Franco OE, Basanta D, Anderson AR, Hayward SW. Perspectives on tissue interactions in development and disease. Curr Mol Med. 2010 Feb.10(1):95-112. Pubmedid: 20205682. Pmcid: PMC4195241.
    • Rejniak KA, Wang SE, Bryce NS, Chang H, Parvin B, Jourquin J, Estrada L, Gray JW, Arteaga CL, Weaver AM, Quaranta V, Anderson AR. Linking changes in epithelial morphogenesis to cancer mutations using computational modeling. PLoS Comput Biol. 2010 Aug.6(8). Pubmedid: 20865159. Pmcid: PMC2928778.
    • Gerlee P, Anderson AR. Diffusion-limited tumour growth: simulations and analysis. Math Biosci Eng. 2010 Apr.7(2):385-400. Pubmedid: 20462295. Pmcid: PMC3812687.
    • Basanta D, Strand DW, Lukner RB, Franco OE, Cliffel DE, Ayala GE, Hayward SW, Anderson AR. The role of transforming growth factor-beta-mediated tumor-stroma interactions in prostate cancer progression: an integrative approach. Cancer Res. 2009 Sep.69(17):7111-7120. Pubmedid: 19706777. Pmcid: PMC2748342.
    • Anderson AR, Hassanein M, Branch KM, Lu J, Lobdell NA, Maier J, Basanta D, Weidow B, Narasanna A, Arteaga CL, Reynolds AB, Quaranta V, Estrada L, Weaver AM. Microenvironmental independence associated with tumor progression. Cancer Res. 2009 Nov.69(22):8797-8806. Pubmedid: 19887618. Pmcid: PMC2783510.
    • Enderling H, Anderson AR, Chaplain MA, Beheshti A, Hlatky L, Hahnfeldt P. Paradoxical dependencies of tumor dormancy and progression on basic cell kinetics. Cancer Res. 2009 Nov.69(22):8814-8821. Pubmedid: 19887613.
    • Ramis-Conde I, Chaplain MA, Anderson AR, Drasdo D. Multi-scale modelling of cancer cell intravasation: the role of cadherins in metastasis. Phys Biol. 2009 Mar.6(1):016008. Pubmedid: 19321920.
    • Gerlee P, Anderson AR. Evolution of cell motility in an individual-based model of tumour growth. J Theor Biol. 2009 Jul.259(1):67-83. Pubmedid: 19285513. Pmcid: PMC2706369.
    • Hinow P, Gerlee P, McCawley LJ, Quaranta V, Ciobanu M, Wang S, Graham JM, Ayati BP, Claridge J, Swanson KR, Loveless M, Anderson AR. A spatial model of tumor-host interaction: application of chemotherapy. Math Biosci Eng. 2009 Jul.6(3):521-546. Pubmedid: 19566124. Pmcid: PMC2981353.
    • Kam Y, Karperien A, Weidow B, Estrada L, Anderson AR, Quaranta V. Nest expansion assay: a cancer systems biology approach to in vitro invasion measurements. BMC Res Notes. 2009 Jul.2:130. Pubmedid: 19594934. Pmcid: PMC2716356.
    • Poplawski NJ, Agero U, Gens JS, Swat M, Glazier JA, Anderson AR. Front instabilities and invasiveness of simulated avascular tumors. Bull Math Biol. 2009 Jul.71(5):1189-1227. Pubmedid: 19234746. Pmcid: PMC2739624.
    • Gerlee P, Anderson AR. Modelling evolutionary cell behaviour using neural networks: application to tumour growth. Biosystems. 2009 Feb.95(2):166-174. Pubmedid: 19026711. Pmcid: PMC2668102.
    • Gerlee P, Lundh T, Zhang B, Anderson AR. Gene divergence and pathway duplication in the metabolic network of yeast and digital organisms. J R Soc Interface. 2009 Dec.6(41):1233-1245. Pubmedid: 19324678. Pmcid: PMC2817152.
    • Anderson AR, Rejniak KA, Gerlee P, Quaranta V. Microenvironment driven invasion: a multiscale multimodel investigation. J Math Biol. 2009 Apr.58(4-5):579-624. Pubmedid: 18839176. Pmcid: PMC5563464.
    • Macklin P, McDougall S, Anderson AR, Chaplain MA, Cristini V, Lowengrub J. Multiscale modelling and nonlinear simulation of vascular tumour growth. J Math Biol. 2009 Apr.58(4-5):765-798. Pubmedid: 18781303. Pmcid: PMC3037282.
    • Enderling H, Alexander NR, Clark ES, Branch KM, Estrada L, Crooke C, JourquinJ, Lobdell N, Zaman MH, Guelcher SA, Anderson AR, Weaver AM. Dependence of invadopodia function on collagen fiber spacing and cross-linking: computational modeling and experimental evidence. Biophys J. 2008 Sep.95(5):2203-2218. Pubmedid: 18515372. Pmcid: PMC2517013.
    • Collinge JE, Anderson AR, Weeks AR, Johnson TK, McKechnie SW. Latitudinal and cold-tolerance variation associate with DNA repeat-number variation in the hsr-omega RNA gene of Drosophila melanogaster. Heredity (Edinb). 2008 Sep.101(3):260-270. Pubmedid: 18560441.
    • Quaranta V, Rejniak KA, Gerlee P, Anderson AR. Invasion emerges from cancer cell adaptation to competitive microenvironments: quantitative predictions from multiscale mathematical models. Semin Cancer Biol. 2008 Oct.18(5):338-348. Pubmedid: 18524624. Pmcid: PMC3789515.
    • Anderson A, Quaranta V. Integrative mathematical oncology. Nat Rev Cancer. 2008 Mar.8(3):227-234. Pubmedid: 18273038.
    • Rejniak KA, Anderson AR. A computational study of the development of epithelial acini: II. Necessary conditions for structure and lumen stability. Bull Math Biol. 2008 Jul.70(5):1450-1479. Pubmedid: 18401665. Pmcid: PMC3812684.
    • Ramis-Conde I, Drasdo D, Anderson AR, Chaplain MA. Modeling the influence of the E-cadherin-beta-catenin pathway in cancer cell invasion: a multiscale approach. Biophys J. 2008 Jul.95(1):155-165. Pubmedid: 18339758. Pmcid: PMC2426623.
    • Gerlee P, Anderson AR. A hybrid cellular automaton model of clonal evolution in cancer: the emergence of the glycolytic phenotype. J Theor Biol. 2008 Feb.250(4):705-722. Pubmedid: 18068192. Pmcid: PMC2846650.
    • Georgescu W, Jourquin J, Estrada L, Anderson AR, Quaranta V, Wikswo JP. Model-controlled hydrodynamic focusing to generate multiple overlapping gradients of surface-immobilized proteins in microfluidic devices. Lab Chip. 2008 Feb.8(2):238-244. Pubmedid: 18231661. Pmcid: PMC4357342.
    • Rejniak K, Anderson A. A computational study of the development of epithelial acini: I. Sufficient conditions for the formation of a hollow structure. Bull Math Biol. 2008 Apr.70(3):677-712. Pubmedid: 18188652. Pmcid: PMC3812693.
    • Pearce I, Chaplain M, Schofield P, Anderson A, Hubbard S. Chemotaxis-induced spatio-temporal heterogeneity in multi-species host-parasitoid systems. J Math Biol. 2007 Sep.55(3):365-388. Pubmedid: 17435998.
    • Enderling H, Chaplain M, Anderson A, Vaidya J. A mathematical model of breast cancer development, local treatment and recurrence. J Theor Biol. 2007 May.246(2):245-259. Pubmedid: 17289081.
    • Gerlee P, Anderson A. Stability analysis of a hybrid cellular automaton model of cell colony growth. Phys Rev E Stat Nonlin Soft Matter Phys. 2007 May.75(5 Pt 1):051911. Pubmedid: 17677102.
    • Gerlee P, Anderson AR. An evolutionary hybrid cellular automaton model of solid tumour growth. J Theor Biol. 2007 Jun.246(4):583-603. Pubmedid: 17374383. Pmcid: PMC2652069.
    • Anderson A, Rejniak K, Gerlee P, Quaranta V. Modelling of cancer growth, evolution and invasion: bridging scales and models. Math Mod Nat Phenom. 2007.2:1-29.
    • Rako L, Anderson A, Sgro C, Stocker A, Hoffmann A. The association between inversion In(3R)Payne and clinally varying traits in Drosophila melanogaster. Genetica. 2006 Sep.128(1-3):373-384. Pubmedid: 17028965.
    • Enderling H, Anderson AR, Chaplain MA, Rowe GW. Visualisation of the numerical solution of partial differential equation systems in three space dimensions and its importance for mathematical models in biology. Math Biosci Eng. 2006 Oct.3(4):571-582. Pubmedid: 20361833.
    • Schor S, Ellis I, Harada K, Motegi K, Anderson A, Chaplain M, Keatch R, Schor A. A novel 'sandwich' assay for quantifying chemo-regulated cell migration within 3-dimensional matrices: wound healing cytokines exhibit distinct motogenic activities compared to the transmembrane assay. Cell Motil Cytoskel. 2006 May.63(5):287-300. Pubmedid: 16528704.
    • Enderling H, Anderson A, Chaplain M, Munro A, Vaidya J. Mathematical modelling of radiotherapy strategies for early breast cancer. J Theor Biol. 2006 Jul.241(1):158-171. Pubmedid: 16386275.
    • Anderson AR, Weaver AM, Cummings PT, Quaranta V. Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment. Cell. 2006 Dec.127(5):905-915. Pubmedid: 17129778.
    • Pearce I, Chaplain M, Schofield P, Anderson A, Hubbard S. Modelling the spatio-temporal dynamics of multi-species host-parasitoid interactions: heterogeneous patterns and ecological implications. J Theor Biol. 2006 Aug.241(4):876-886. Pubmedid: 16546216.
    • McDougall S, Anderson A, Chaplain M. Mathematical modelling of dynamic adaptive tumour-induced angiogenesis: clinical implications and therapeutic targeting strategies. J Theor Biol. 2006 Aug.241(3):564-589. Pubmedid: 16487543.
    • Chaplain M, McDougall S, Anderson A. Mathematical modeling of tumor-induced angiogenesis. Annu Rev Biomed Eng. 2006.8:233-257. Pubmedid: 16834556.
    • Enderling H, Anderson A, Chaplain M, Rowe G. Visualisation of the numerical solution of partial differential equation systems in three space dimensions and its importance for mathematical models in biology. Math Biosci Eng. 2006.3:571-582.
    • Stepahnou A, McDougall S, Anderson A, Chaplain M. Mathematical modelling of dynamic adaptive tumour-induced angiogenesis: clinical implications and therapeutic targeting strategies. Math Comput Modell. 2006.44:96123-96123.
    • Anderson A, Vasiev B. An individual based model of rippling movement in a myxobacteria population. J Theor Biol. 2005 Jun.234(3):341-349. Pubmedid: 15784269.
    • Anderson A. A hybrid mathematical model of solid tumour invasion: the importance of cell adhesion. Math Med Biol. 2005 Jun.22(2):163-186. Pubmedid: 15781426.
    • Quaranta V, Weaver A, Cummings P, Anderson A. Mathematical modeling of cancer: the future of prognosis and treatment. Clin Chim Acta. 2005 Jul.357(2):173-179. Pubmedid: 15907826.
    • Ayati B, Webb G, Anderson A. Computational methods and results for structured multiscale models of tumor invasion. Multiscale Mod Sim. 2005.5:1-20.
    • Stephanou A, McDougall S, Anderson A, Chaplain M. Mathematical modelling of flow through in 2D and 3D vascular networks: applications to anti-angiogenic and chemotherapeutic drug strategies. Math Comp Mod. 2004.41:1137-1156.
    • Anderson AR, Collinge JE, Hoffmann AA, Kellett M, McKechnie SW. Thermal tolerance trade-offs associated with the right arm of chromosome 3 and marked by the hsr-omega gene in Drosophila melanogaster. Heredity (Edinb). 2003 Feb.90(2):195-202. Pubmedid: 12634827.
    • McDougall S, Anderson A, Chaplain M, Sherratt J. Mathematical modelling of flow through vascular networks: implications for tumour-induced angiogenesis and chemotherapy strategies. Bull Math Biol. 2002 Jul.64(4):673-702. Pubmedid: 12216417.
    • Farnwsorth K, Anderson A. How simple grazing rules lead to reaction diffusion systems and their consequence for vegetation community dynamics. Oikos. 2001.95:15-24.
    • Davidson F, Anderson A, Chaplain M. Steady state solutions of a generic model for the formation of capillary networks. Appl Math Letters. 2000 Jul.13(5):127-132.
    • Anderson A, Chaplain M, Newman E, Steele R, Thompson A. Methematical modelling of tumour invasion and metastasis. J Theor Med. 2000.2:129-154.
    • Pitcairn W, Chaplain M, Weijer C, Anderson A. A discrete-continuum mathematical model of Dictyostelium aggregation. Ecmtb. 2000.2:6-11.
    • Anderson A, Chaplain M, Garcia-Reimbert C, Vargas C. A gradient-driven model of anti-angiogensis. Math Comp Mod. 2000.32:1141-1152.
    • Sleeman B, Anderson A, Chaplain M. A mathematical analysis of a model for capillary network formation in the absence of endothelial cell proliferation. Appl Math Letters. 1999 Nov.12(8):121-127.
    • Baum M, Chaplain M, Anderson A, Douek M, Vaidya J. Does breast cancer exist in a state of chaos?. Eur J Cancer. 1999 Jun.35(6):886-891. Pubmedid: 10533467.
    • Anderson A, Chaplain M. Continuous and discrete mathematical models of tumor-induced angiogenesis. Bull Math Biol. 1998 Sep.60(5):857-899. Pubmedid: 9739618 .
    • Anderson A, Chaplain M. A mathematical model for capillary network formation in the absence of endothelial cell proliferations. Appl Math Letters. 1998.11:109-114.
    • Chaplain M, Anderson A. Dynamic chemotactic-haptotactic pattern formation associated with tumour-induced angiogenesis. Ecole De Biologie Theorique. 1998.3:213-235.
    • Anderson A, Sleeman B, Young I, Griffiths B. Sensing of chemical gradients in a structurally heterogeneous environment by nematodes: II. Theory. Fundam App Nematol. 1997.20:165-172.
    • Anderson AR, Young IM, Sleeman B, Griffiths B, Robertson W. Sensing of chemical gradients in a structurally heterogeneous environment by nematodes: I. experiments. Fundam App Nematol. 1997.20:157-164.
    • Hobbs GD, Anderson AR, Greene TJ, Yealy DM. Comparison of hyperbaric oxygen and dapsone therapy for loxosceles envenomation. Acad Emerg Med. 1996 Aug.3(8):758-761. Pubmedid: 8853670.
    • Chaplain M, Anderson A. Mathematical modelling, simulation and prediction of tumour-induced angiogenesis. Invasion Metastasis. 1996.16(4-5):222-234. Pubmedid: 9311387 .
    • Anderson AR, Sleeman B. Wave front propagation and its failure in coupled systems of discrete excitable cells modelled by FitzHugh-Nagumo dynamics. Int J Bif Chaos. 1995.5:63-74.
    • Chaplain M, Anderson A. Mathematical modelling of tissue invasion. In: Bellomo N, Preziosi L, eds. Cancer Modelling and Simulation. London, UK: CRC Press; 2003;269-297.
    • Anderson A. A hybrid discrete-continuum technique for individual based migration models. In: Alt W, Chaplain M, Griebel M, Lenz J, et al, eds. Polymer and Cell Dynamics. Basel, Switzerland: Birkhauser; 2003;251-259.
    • Anderson A. The effects of cell adhesion on solid tumour geometry. In: Noji S, Ueno N, Sekimura T, Maini P, et al, eds. Morphogenesis and Pattern Formation in Biological Systems. Tokyo, Japan: Springer-Verlag; 2003;315-325.
    • Chaplain M, Anderson A. Modelling the growth and form of capillary networks. In: Chaplain M, Singh G, McLachlan J, et al, eds. On Growth and Form (Spatio-Temporal Patterning in Biology. Chichester, UK: Wiley; 1999;225-250.
    • Chaplain M, Anderson A. Mathematical modelling of tumour-induced angiogenesis: network growth and structure. In: Kirsch M, Black P, eds. Angiogensis in Brain Tumours. Boston, MA: Kluwer; 2004;51-75.
    • Anderson A, Pitcairn A. Application of Hybrid Discrete-Continuum Technique. In: Alt W, Chaplain M, Griebel M, Lenz J, et al, eds. Polymer and Cell Dynamics. Basel, Switzerland: Birkhauser; 2003;267-279.
    • Anderson A. Solid tumour growth: the importance of adhesion. In: Deutsch A, Falcke M, Howard J, Zimmermann W, et al, eds. Function and regulation of cellular systems: experiments and models. Basel, Switzerland: Birkhauser; 2004;379-389.
  • Grants

    • Title: The Delta Ecology of NSCLC Treatment
      Sponsor: Nat Institutes of Health
      PI (Contact): Anderson, A., PI (MPI): Gatenby, R., Project PI: Marusyk, A., Core PI/Director: Brown, J.
    • Title: Feasibility of Generating Novel Translational and Therapeutic Strategies based on a Multicenter, Pediatric and AYA Evolutionary Tumor Board; pedsETB
      Sponsor: Florida Biomedical Research Program (FBRP)
      PI: Metts, J., CO-PI: Robertson-Tessi, M., CO-PI: Anderson, A., CO-PI: Brown, J., CO-PI: Marusyk, A.
    • Title: St of FL Appropriation-CET Developmental Funds-12
      Sponsor: State of Florida
      PI (Contact): Cleveland, J., PI: Anderson, A.

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