Skip to nav Skip to content
David  Basanta Gutierrez

David Basanta Gutierrez, PhD

Program: Integrated Mathematical Oncology

Research Program: Cancer Biology & Evolution Program

View Lab Page

Google Scholar Profile


  • Overview

    To understand the evolutionary dynamics of cancer using integrative approaches so that one day we will be able to exert some control on cancer progression.


    • Integrated Mathematical Oncology
    • Genitourinary Oncology
    • Cancer Biology & Evolution Program
    • Center of Excellence for Evolutionary Therapy

    Education & Training


    • Universidad de Oviedo, School of Technical Engineers, MSc - Computer Science
    • Kings College, London, PhD - Computational Materials Science


    • H. Lee Moffitt Cancer Center & Research Institute - Integrated Mathematical Oncology
  • Research Interest

      Cancer is a disease in which genetic mutations play an important role but one in which evolution, in the Darwinian sense of the world, directs progression. Oftentimes this progression is towards increasingly malignant phenotypes. This evolutionary process is influenced by the interactions of the different tumour cells with each other but also by the interactions of these tumour populations with their environment. If we are going to understand and learn how to exert some control in cancer progression we need methods and approaches that can handle this evolutionary and ecological perspective of cancer. Given the complexity of this disease, mathematical and computational methods are not only useful but also necessary. For this reason my work will focus on mathematical and computational models of cancer evolution. I will be using tools already employed in theoretical ecology but will also develop new ones as needed and will make sure that they are part of an integrated research where the models are biologically inspired and validated and the results have a clinical impact.

  • Publications

    • Bishop RT, Miller AK, Froid M, Nerlakanti N, Li T, Frieling JS, Nasr MM, Nyman KJ, Sudalagunta PR, Canevarolo RR, Silva AS, Shain KH, Lynch CC, Basanta D. The bone ecosystem facilitates multiple myeloma relapse and the evolution of heterogeneous drug resistant disease. Nat Commun. 2024 Mar.15(1):2458. Pubmedid: 38503736. Pmcid: PMC10951361.
    • Miroshnychenko D, Miti T, Kumar P, Miller A, Laurie M, Giraldo N, Bui MM, Altrock PM, Basanta D, Marusyk A. Stroma-Mediated Breast Cancer Cell Proliferation Indirectly Drives Chemoresistance by Accelerating Tumor Recovery between Chemotherapy Cycles. Cancer Res. 2023 Nov.83(22):3681-3692. Pubmedid: 37791818. Pmcid: PMC10646478.
    • West J, Adler F, Gallaher J, Strobl M, Brady-Nicholls R, Brown J, Robertson-Tessi M, Kim E, Noble R, Viossat Y, Basanta D, Anderson ARA. A survey of open questions in adaptive therapy: Bridging mathematics and clinical translation. Elife. 2023 Mar.12. Pubmedid: 36952376. Pmcid: PMC10036119.
    • Miroshnychenko D, Miti T, Miller A, Kumar P, Laurie M, Bui MM, Altrock PM, Basanta D, Marusyk A. Paracrine enhancement of tumor cell proliferation provides indirect stroma-mediated chemoresistance via acceleration of tumor recovery between chemotherapy cycles. bioRxiv. 2023 Feb. Pubmedid: 36798328. Pmcid: PMC9934626.
    • Baratchart E, Lo CH, Lynch CC, Basanta D. Integrated computational and in vivo models reveal Key Insights into macrophage behavior during bone healing. PLoS Comput Biol. 2022 May.18(5):e1009839. Pubmedid: 35559958. Pmcid: PMC9106165.
    • Foo J, Basanta D, Rockne RC, Strelez C, Shah C, Ghaffarian K, Mumenthaler SM, Mitchell K, Lathia JD, Frankhouser D, Branciamore S, Kuo YH, Marcucci G, Vander Velde R, Marusyk A, Hang S, Hari K, Jolly MK, Hatzikirou H, Poels K, Spilker M, Shtylla B, Robertson-Tessi M, Anderson ARA. Roadmap on plasticity and epigenetics in cancer. Phys Biol. 2022 Apr.19(3). Pubmedid: 35078159. Pmcid: PMC9190291.
    • Miroshnychenko D, Baratchart E, Ferrall-Fairbanks MC, Velde RV, Laurie MA, Bui MM, Tan AC, Altrock PM, Basanta D, Marusyk A. Spontaneous cell fusions as a mechanism of parasexual recombination in tumour cell populations. Nat Ecol Evol. 2021 Mar.5(3):379-391. Pubmedid: 33462489.
    • Lo CH, Baratchart E, Basanta D, Lynch CC. Computational modeling reveals a key role for polarized myeloid cells in controlling osteoclast activity during bone injury repair. Sci Rep. 2021 Mar.11(1):6055. Pubmedid: 33723343. Pmcid: PMC7961065.
    • Tavakoli F, Sartakhti JS, Manshaei MH, Basanta D. Cancer immunoediting: A game theoretical approach. In Silico Biol. 2021 Jun.14(1-2):1-12. Pubmedid: 33216021. Pmcid: PMC8203245.
    • Edwards J, Marusyk A, Basanta D. Selection-driven tumor evolution with public goods leads to patterns of clonal expansion consistent with neutral growth. iScience. 2021 Jan.24(1):101901. Pubmedid: 33364589. Pmcid: PMC7753957.
    • Araujo A, Cook LM, Frieling JS, Tan W, Copland JA, Kohli M, Gupta S, Dhillon J, Pow-Sang J, Lynch CC, Basanta D. Quantification and Optimization of Standard-of-Care Therapy to Delay the Emergence of Resistant Bone Metastatic Prostate Cancer. Cancers (Basel). 2021 Feb.13(4). Pubmedid: 33567529. Pmcid: PMC7915310.
    • Grimes DR, Jansen M, Macauley RJ, Scott JG, Basanta D. Evidence for hypoxia increasing the tempo of evolution in glioblastoma. Brit J Cancer. 2020 Nov.123(10):1562-1569. Pubmedid: 32848201. Pmcid: PMC7653934.
    • Bravo RR, Baratchart E, West J, Schenck RO, Miller AK, Gallaher J, Gatenbee CD, Basanta D, Robertson-Tessi M, Anderson ARA. Hybrid Automata Library: A flexible platform for hybrid modeling with real-time visualization. PLoS Comput Biol. 2020 Mar.16(3):e1007635. Pubmedid: 32155140. Pmcid: PMC7105119.
    • Frankenstein Z, Basanta D, Franco OE, Gao Y, Javier RA, Strand DW, Lee M, Hayward SW, Ayala G, Anderson ARA. Stromal reactivity differentially drives tumour cell evolution and prostate cancer progression. Nat Ecol Evol. 2020 Jun.4(6):870-884. Pubmedid: 32393869.
    • Miller AK, Brown JS, Basanta D, Huntly N. What Is the Storage Effect, Why Should It Occur in Cancers, and How Can It Inform Cancer Therapy?. Cancer Control. 2020 Jul.27(3). Pubmedid: 32723185. Pmcid: PMC7658723.
    • Taylor-King JP, Buenzli PR, Chapman SJ, Lynch CC, Basanta D. Modeling Osteocyte Network Formation: Healthy and Cancerous Environments. Front Bioeng Biotechnol. 2020 Jul.8:757. Pubmedid: 32793566. Pmcid: PMC7387425.
    • Enderling H, Altrock PM, Andor N, Basanta D, Brown JS, Gatenby RA, Marusyk A, Rejniak KA, Silva A, Anderson ARA. High School Internship Program in Integrated Mathematical Oncology (HIP IMO): Five-Year Experience at Moffitt Cancer Center. Bull Math Biol. 2020 Jul.82(7):91. Pubmedid: 32648152.
    • Taylor-King JP, Baratchart E, Dhawan A, Coker EA, Rye IH, Russnes H, Chapman SJ, Basanta D, Marusyk A. Simulated ablation for detection of cells impacting paracrine signalling in histology analysis. Math Med Biol. 2019 Mar.36(1):93-112. Pubmedid: 29452382. Pmcid: PMC7197102.
    • Kaznatcheev A, Peacock J, Basanta D, Marusyk A, Scott JG. Fibroblasts and alectinib switch the evolutionary games played by non-small cell lung cancer. Nat Ecol Evol. 2019 Mar.3(3):450-456. Pubmedid: 30778184. Pmcid: PMC6467526.
    • Araujo A, Cook LM, Lynch CC, Basanta D. Size Matters: Metastatic Cluster Size and Stromal Recruitment in the Establishment of Successful Prostate Cancer to Bone Metastases. Bull Math Biol. 2018 May.80(5):1046-1058. Pubmedid: 29600344. Pmcid: PMC6482048.
    • Warman PI, Kaznatcheev A, Araujo A, Lynch CC, Basanta D. Fractionated follow-up chemotherapy delays the onset of resistance in bone metastatic prostate cancer. Games (Basel). 2018 Jun.9(2). Pubmedid: 33552562. Pmcid: PMC7864372.
    • Basanta D, Anderson AR. Homeostasis Back and Forth: An Ecoevolutionary Perspective of Cancer. Cold Spring Harb Perspect Med. 2017 Sep.7(9). Pubmedid: 28289244. Pmcid: PMC5580509.
    • Kaznatcheev A, Vander Velde R, Scott JG, Basanta D. Cancer treatment scheduling and dynamic heterogeneity in social dilemmas of tumour acidity and vasculature. Brit J Cancer. 2017 Mar.116(6):785-792. Pubmedid: 28183139. Pmcid: PMC5355932.
    • Taylor-King JP, Basanta D, Chapman SJ, Porter MA. Mean-field approach to evolving spatial networks, with an application to osteocyte network formation. Phys Rev E. 2017 Jul.96(1-1):012301. Pubmedid: 29347066.
    • Salimi Sartakhti J, Manshaei MH, Basanta D, Sadeghi M. Evolutionary emergence of angiogenesis in avascular tumors using a spatial public goods game. PLoS One. 2017 Apr.12(4):e0175063. Pubmedid: 28399181. Pmcid: PMC5388338.
    • Gerlee P, Basanta D, Anderson ARA. The Influence of Cellular Characteristics on the Evolution of Shape Homeostasis. Artif Life. 2017.23(3):424-448. Pubmedid: 28786729.
    • Cook LM, Araujo A, Pow-Sang JM, Budzevich MM, Basanta D, Lynch CC. Predictive computational modeling to define effective treatment strategies for bone metastatic prostate cancer. Sci Rep. 2016 Jul.6:29384. Pubmedid: 27411810. Pmcid: PMC4944130.
    • Kaznatcheev A, Scott JG, Basanta D. Edge effects in game-theoretic dynamics of spatially structured tumours. J R Soc Interface. 2015 Jul.12(108):20150154. Pubmedid: 26040596. Pmcid: PMC4528581.
    • Frieling JS, Basanta D, Lynch CC. Current and emerging therapies for bone metastatic castration-resistant prostate cancer. Cancer Control. 2015 Jan.22(1):109-120. Pubmedid: 25504285. Pmcid: PMC4673894.
    • Araujo A, Cook LM, Lynch CC, Basanta D. An integrated computational model of the bone microenvironment in bone-metastatic prostate cancer. Cancer Res. 2014 May.74(9):2391-2401. Pubmedid: 24788098. Pmcid: PMC4023121.
    • Scott JG, Hjelmeland AB, Chinnaiyan P, Anderson AR, Basanta D. Microenvironmental variables must influence intrinsic phenotypic parameters of cancer stem cells to affect tumourigenicity. PLoS Comput Biol. 2014 Jan.10(1):e1003433. Pubmedid: 24453958. Pmcid: PMC3894166.
    • Gallaher J, Cook LM, Gupta S, Araujo A, Dhillon J, Park JY, Scott JG, Pow-Sang J, Basanta D, Lynch CC. Improving treatment strategies for patients with metastatic castrate resistant prostate cancer through personalized computational modeling. Clin Exp Metastas. 2014 Dec.31(8):991-999. Pubmedid: 25173680. Pmcid: PMC5399888.
    • Scott JG, Basanta D, Anderson AR, Gerlee P. A mathematical model of tumour self-seeding reveals secondary metastatic deposits as drivers of primary tumour growth. J R Soc Interface. 2013 May.10(82):20130011. Pubmedid: 23427099. Pmcid: PMC3627086.
    • Kim E, Rebecca VW, Fedorenko IV, Messina JL, Mathew R, Maria-Engler SS, Basanta D, Smalley KS, Anderson AR. Senescent fibroblasts in melanoma initiation and progression: an integrated theoretical, experimental, and clinical approach. Cancer Res. 2013 Dec.73(23):6874-6885. Pubmedid: 24080279. Pmcid: PMC3926439.
    • Basanta D, Anderson AR. Exploiting ecological principles to better understand cancer progression and treatment. Interface Focus. 2013 Aug.3(4):20130020. Pubmedid: 24511383. Pmcid: PMC3915838.
    • Hatzikirou H, Basanta D, Simon M, Schaller K, Deutsch A. 'Go or Grow': the key to the emergence of invasion in tumour progression?. Math Med Biol. 2012 Mar.29(1):49-65. Pubmedid: 20610469.
    • Basanta D, Scott JG, Fishman MN, Ayala G, Hayward SW, Anderson AR. Investigating prostate cancer tumour-stroma interactions: clinical and biological insights from an evolutionary game. Brit J Cancer. 2012 Jan.106(1):174-181. Pubmedid: 22134510. Pmcid: PMC3251863.
    • Basanta D, Gatenby RA, Anderson AR. Exploiting evolution to treat drug resistance: combination therapy and the double bind. Mol Pharm. 2012 Apr.9(4):914-921. Pubmedid: 22369188. Pmcid: PMC3325107.
    • Basanta D, Ribba B, Watkin E, You B, Deutsch A. Computational analysis of the influence of the microenvironment on carcinogenesis. Math Biosci. 2011 Jan.229(1):22-29. Pubmedid: 21044636.
    • Basanta D, Scott JG, Rockne R, Swanson KR, Anderson AR. The role of IDH1 mutated tumour cells in secondary glioblastomas: an evolutionary game theoretical view. Phys Biol. 2011 Feb.8(1):015016. Pubmedid: 21301070. Pmcid: PMC3166886.
    • Scott JG, Basanta D, Chinnaiyan P, Canoll P, Swanson KR, Anderson AR. Production of 2-hydroxyglutarate by isocitrate dehydrogenase 1-mutated gliomas: an evolutionary alternative to the Warburg shift?. Neurooncol. 2011 Dec.13(12):1262-1264. Pubmedid: 21784755. Pmcid: PMC3223086.
    • Gerlee P, Basanta D, Anderson AR. Evolving homeostatic tissue using genetic algorithms. Prog Biophys Mol Biol. 2011 Aug.106(2):414-425. Pubmedid: 21419156. Pmcid: PMC3812677.
    • Strand DW, Franco OE, Basanta D, Anderson AR, Hayward SW. Perspectives on tissue interactions in development and disease. Curr Mol Med. 2010 Feb.10(1):95-112. Pubmedid: 20205682. Pmcid: PMC4195241.
    • Basanta D, Strand DW, Lukner RB, Franco OE, Cliffel DE, Ayala GE, Hayward SW, Anderson AR. The role of transforming growth factor-beta-mediated tumor-stroma interactions in prostate cancer progression: an integrative approach. Cancer Res. 2009 Sep.69(17):7111-7120. Pubmedid: 19706777. Pmcid: PMC2748342.
    • Anderson AR, Hassanein M, Branch KM, Lu J, Lobdell NA, Maier J, Basanta D, Weidow B, Narasanna A, Arteaga CL, Reynolds AB, Quaranta V, Estrada L, Weaver AM. Microenvironmental independence associated with tumor progression. Cancer Res. 2009 Nov.69(22):8797-8806. Pubmedid: 19887618. Pmcid: PMC2783510.
    • Basanta D, Miodownik M, Baum B. The evolution of robust development and homeostasis in artificial organisms. PLoS Comput Biol. 2008 Mar.4(3):e1000030. Pubmedid: 18369424. Pmcid: PMC2274883.
    • Basanta D, Simon M, Hatzikirou H, Deutsch A. Evolutionary game theory elucidates the role of glycolysis in glioma progression and invasion. Cell Prolif. 2008 Dec.41(6):980-987. Pubmedid: 19040573.
  • Grants

    • Title: Evolutionary Game Theory in Prostate Cancer Bone Metastasis: Elucidating the Dual Role of MSCs in Tumor Cell Dynamics
      Sponsor: Moffitt Cancer Center
      PI (Contact): Basanta Gutierrez, D.
    • Title: Defining bone ecosystem effects on metastatic prostate cancer evolution and treatment response using an integrated mathematical modeling approach
      Sponsor: Nat Institutes of Health
      PI (Contact): Lynch, C., PI (MPI): Basanta Gutierrez, D.

Find a Researcher Search