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Katarzyna  Rejniak

Katarzyna Rejniak, PhD

Program: Integrated Mathematical Oncology

Research Program: Cancer Biology & Evolution Program

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  • Overview

    Associations

    • Integrated Mathematical Oncology
    • Melanoma & Skin Cancer Center of Excellence
    • Molecular Oncology & Drug Discovery Program
    • Cancer Chemoprevention Research Interest Group
    • Cancer Biology & Evolution Program
    • Cancer Imaging & Technology Center of Excellence
    • Center of Excellence for Evolutionary Therapy
    • Center for Immunization & Infection Research in Cancer

    Education & Training

    Graduate:

    • University of Gdansk, Poland, MSc - Numerical methods and Computer Science
    • Tulane University, MSc - Mathematics
    • Tulane University, PhD - Applied Mathematics

    Fellowship:

    • Ohio State University, Mathematical Biosciences Institute -
  • Research Interest

    I have developed a general computational model (called IBCell model) that can represent accurately the structure of various soft tissues and mechanical transformations occurring during the tissue development and maintenance. This model has been applied to simulate the formation of abnormal folds in the human trophoblast bilayer, the development of epithelial cysts and ducts, and the growth of solid tumors, tumoral clones and various patterns of ductal carcinoma in situ. This model is ideally suited to represent small tissue portions, such as those taken from biopsy samples or those grown experimentally in the culture medium, and to simulate cell responses to various environmental factors and treatment protocols. My ultimate research goal is to integrate the IBCell model with the experimental and clinical data to provide a tool for simulating the growth of tumor cells in different tissues and under various external conditions. The model can be adjusted to represent distinct biomechanical properties of the tissue under consideration and can be extended to include distinct biochemical properties of the host cells, therefore it shows a promise in providing a supporting evaluation of the tumorigenic potential of the collected cell samples and in testing in silico various protocols for patient-specific treatment.

  • Publications

    • Ojwang' AME, Bazargan S, Johnson JO, Pilon-Thomas S, Rejniak KA. Histology-guided mathematical model of tumor oxygenation: sensitivity analysis of physical and computational parameters. bioRxiv. 2024 Mar. Pubmedid: 38496532. Pmcid: PMC10942376.
    • Hu A, Ojwang' AME, Olumoyin KD, Rejniak KA. Visualizing the Spatio-Temporal Dynamics of Clonal Evolution with LinG3D software. bioRxiv. 2024 Mar. Pubmedid: 38496472. Pmcid: PMC10942425.
    • Mathur S, Chen S, Rejniak KA. Exploring chronic and transient tumor hypoxia for predicting the efficacy of hypoxia-activated pro-drugs. NPJ Syst Biol Appl. 2024 Jan.10(1):1. Pubmedid: 38182612. Pmcid: PMC10770176.
    • Bazargan S, Bunch B, Ojwang' AME, Blauvelt J, Landin A, Ali J, Abrahams D, Cox C, Hall AM, Beatty MS, Poch M, Rejniak KA, Pilon-Thomas S. Targeting myeloid-derived suppressor cells with gemcitabine to enhance efficacy of adoptive cell therapy in bladder cancer. Front Immunol. 2023 Oct.14:1275375. Pubmedid: 37901214. Pmcid: PMC10602731.
    • Poonja S, Forero Pinto A, Lloyd MC, Damaghi M, Rejniak KA. Dynamics of Fibril Collagen Remodeling by Tumor Cells: A Model of Tumor-Associated Collagen Signatures. Cells. 2023 Nov.12(23). Pubmedid: 38067116. Pmcid: PMC10705683.
    • Gardner A, de Mingo Pulido Á, Hänggi K, Bazargan S, Onimus A, Kasprzak A, Conejo-Garcia JR, Rejniak KA, Ruffell B. TIM-3 blockade enhances IL-12-dependent antitumor immunity by promoting CD8+ T cell and XCR1+ dendritic cell spatial co-localization. J Immunother Cancer. 2022 Jan.10(1). Pubmedid: 34987021. Pmcid: PMC8734033.
    • Suveges S, Chamseddine I, Rejniak KA, Eftimie R, Trucu D. Collective Cell Migration in a Fibrous Environment: A Hybrid Multiscale Modelling Approach. Front Appl Math Stat. 2021 Jun.7. Pubmedid: 34322539. Pmcid: PMC8315487.
    • Kingsley JL, Costello JR, Raghunand N, Rejniak KA. Bridging cell-scale simulations and radiologic images to explain short-time intratumoral oxygen fluctuations. PLoS Comput Biol. 2021 Jul.17(7):e1009206. Pubmedid: 34310608. Pmcid: PMC8341701.
    • Berrouet C, Dorilas N, Rejniak KA, Tuncer N. Comparison of Drug Inhibitory Effects ([Formula: see text]) in Monolayer and Spheroid Cultures. Bull Math Biol. 2020 Jun.82(6):68. Pubmedid: 32495209. Pmcid: PMC9773863.
    • Enderling H, Altrock PM, Andor N, Basanta D, Brown JS, Gatenby RA, Marusyk A, Rejniak KA, Silva A, Anderson ARA. High School Internship Program in Integrated Mathematical Oncology (HIP IMO): Five-Year Experience at Moffitt Cancer Center. Bull Math Biol. 2020 Jul.82(7):91. Pubmedid: 32648152.
    • Chamseddine IM, Rejniak KA. Hybrid modeling frameworks of tumor development and treatment. Wiley Interdiscip Rev Syst Biol Med. 2020 Jan.12(1):e1461. Pubmedid: 31313504. Pmcid: PMC6898741.
    • Pérez-Velázquez J, Rejniak KA. Drug-Induced Resistance in Micrometastases: Analysis of Spatio-Temporal Cell Lineages. Front Physiol. 2020 Apr.11:319. Pubmedid: 32362836. Pmcid: PMC7180185.
    • Karolak A, Rejniak KA. Micropharmacology: An In Silico Approach for Assessing Drug Efficacy Within a Tumor Tissue. Bull Math Biol. 2019 Sep.81(9):3623-3641. Pubmedid: 29423880. Pmcid: PMC6082744.
    • Karolak A, Huffstutler B, Khan Z, Rejniak KA. Assessment of patient-specific efficacy of chemo- and targeted-therapies: a micropharmacology approach. bioRxiv. 2019 May.
    • Karolak A, Poonja S, Rejniak KA. Morphophenotypic classification of tumor organoids as an indicator of drug exposure and penetration potential. PLoS Comput Biol. 2019 Jul.15(7):e1007214. Pubmedid: 31310602. Pmcid: PMC6660094.
    • Karolak A, Markov DA, McCawley LJ, Rejniak KA. Towards personalized computational oncology: from spatial models of tumour spheroids, to organoids, to tissues. J R Soc Interface. 2018 Jan.15(138). Pubmedid: 29367239. Pmcid: PMC5805971.
    • Karolak A, Estrella VC, Huynh AS, Chen T, Vagner J, Morse DL, Rejniak KA. Targeting Ligand Specificity Linked to Tumor Tissue Topological Heterogeneity via Single-Cell Micro-Pharmacological Modeling. Sci Rep. 2018 Feb.8(1):3638. Pubmedid: 29483578. Pmcid: PMC5827036.
    • Rejniak KA. Circulating Tumor Cells: When a Solid Tumor Meets a Fluid Microenvironment. Adv Exp Med Biol. 2016 Oct.936:93-106. Pubmedid: 27739044. Pmcid: PMC5113997.
    • Pérez-Velázquez J, Gevertz JL, Karolak A, Rejniak KA. Microenvironmental Niches and Sanctuaries: A Route to Acquired Resistance. Adv Exp Med Biol. 2016 Dec.936:149-164. Pubmedid: 27739047. Pmcid: PMC5113820.
    • Shah AB, Rejniak KA, Gevertz JL. Limiting the development of anti-cancer drug resistance in a spatial model of micrometastases. Math Biosci Eng. 2016 Dec.13(6):1185-1206. Pubmedid: 27775375. Pmcid: PMC5113823.
    • Rejniak KA, Lloyd MC, Reed DR, Bui MM. Diagnostic assessment of osteosarcoma chemoresistance based on Virtual Clinical Trials. Med Hypotheses. 2015 Sep.85(3):348-354. Pubmedid: 26130106. Pmcid: PMC4549200.
    • Lloyd MC, Rejniak KA, Brown JS, Gatenby RA, Minor ES, Bui MM. Pathology to enhance precision medicine in oncology: lessons from landscape ecology. Adv Anat Pathol. 2015 Jul.22(4):267-272. Pubmedid: 26050264. Pmcid: PMC4729443.
    • Wojtkowiak JW, Cornnell HC, Matsumoto S, Saito K, Takakusagi Y, Dutta P, Kim M, Zhang X, Leos R, Bailey KM, Martinez G, Lloyd MC, Weber C, Mitchell JB, Lynch RM, Baker AF, Gatenby RA, Rejniak KA, Hart C, Krishna MC, Gillies RJ. Pyruvate sensitizes pancreatic tumors to hypoxia-activated prodrug TH-302. Cancer Metab. 2015 Jan.3(1):2. Pubmedid: 25635223. Pmcid: PMC4310189.
    • Kim M, Rejniak KA. Mechanical aspects of microtubule bundling in taxane-treated circulating tumor cells. Biophys J. 2014 Sep.107(5):1236-1246. Pubmedid: 25185559. Pmcid: PMC4156678.
    • Kim M, Reed D, Rejniak KA. The formation of tight tumor clusters affects the efficacy of cell cycle inhibitors: a hybrid model study. J Theor Biol. 2014 Jul.352:31-50. Pubmedid: 24607745. Pmcid: PMC5483857.
    • Rejniak KA. Homeostatic imbalance in epithelial ducts and its role in carcinogenesis. Scientifica (Cairo). 2013 Nov.2012:132978. Pubmedid: 24278670. Pmcid: PMC3820568.
    • Kim M, Gillies RJ, Rejniak KA. Current advances in mathematical modeling of anti-cancer drug penetration into tumor tissues. Front Oncol. 2013 Nov.3:278. Pubmedid: 24303366. Pmcid: PMC3831268.
    • Enderling H, Rejniak KA. Simulating cancer: computational models in oncology. Front Oncol. 2013.3:233. Pubmedid: 24062986. Pmcid: PMC3772565.
    • Rejniak KA, Estrella V, Chen T, Cohen AS, Lloyd MC, Morse DL. The role of tumor tissue architecture in treatment penetration and efficacy: an integrative study. Front Oncol. 2013.3:111. Pubmedid: 23717812. Pmcid: PMC3650652.
    • Rejniak KA, Anderson AR. State of the art in computational modelling of cancer. Math Med Biol. 2012 Mar.29(1):1-2. Pubmedid: 22200587.
    • Rejniak KA, Quaranta V, Anderson AR. Computational investigation of intrinsic and extrinsic mechanisms underlying the formation of carcinoma. Math Med Biol. 2012 Mar.29(1):67-84. Pubmedid: 21106672. Pmcid: PMC3499074.
    • Kam Y, Rejniak KA, Anderson AR. Cellular modeling of cancer invasion: integration of in silico and in vitro approaches. J Cell Physiol. 2012 Feb.227(2):431-438. Pubmedid: 21465465. Pmcid: PMC3687536.
    • Rejniak KA. Investigating dynamical deformations of tumor cells in circulation: predictions from a theoretical model. Front Oncol. 2012.2:111. Pubmedid: 23024961. Pmcid: PMC3444760.
    • Rejniak KA, Anderson AR. Hybrid models of tumor growth. Wiley Interdiscip Rev Syst Biol Med. 2011 Jan.3(1):115-125. Pubmedid: 21064037. Pmcid: PMC3057876.
    • Rejniak KA, Wang SE, Bryce NS, Chang H, Parvin B, Jourquin J, Estrada L, Gray JW, Arteaga CL, Weaver AM, Quaranta V, Anderson AR. Linking changes in epithelial morphogenesis to cancer mutations using computational modeling. PLoS Comput Biol. 2010 Aug.6(8). Pubmedid: 20865159. Pmcid: PMC2928778.
    • Rejniak KA, McCawley LJ. Current trends in mathematical modeling of tumor-microenvironment interactions: a survey of tools and applications. Exp Biol Med (Maywood). 2010 Apr.235(4):411-423. Pubmedid: 20407073.
    • Anderson AR, Rejniak KA, Gerlee P, Quaranta V. Microenvironment driven invasion: a multiscale multimodel investigation. J Math Biol. 2009 Apr.58(4-5):579-624. Pubmedid: 18839176. Pmcid: PMC5563464.
    • Quaranta V, Rejniak KA, Gerlee P, Anderson AR. Invasion emerges from cancer cell adaptation to competitive microenvironments: quantitative predictions from multiscale mathematical models. Semin Cancer Biol. 2008 Oct.18(5):338-348. Pubmedid: 18524624. Pmcid: PMC3789515.
    • Rejniak KA, Anderson AR. A computational study of the development of epithelial acini: II. Necessary conditions for structure and lumen stability. Bull Math Biol. 2008 Jul.70(5):1450-1479. Pubmedid: 18401665. Pmcid: PMC3812684.
    • Rejniak K, Anderson A. A computational study of the development of epithelial acini: I. Sufficient conditions for the formation of a hollow structure. Bull Math Biol. 2008 Apr.70(3):677-712. Pubmedid: 18188652. Pmcid: PMC3812693.
    • Rejniak K. An immersed boundary framework for modelling the growth of individual cells: an application to the early tumour development. J Theor Biol. 2007 Jul.247(1):186-204. Pubmedid: 17416390.
    • Rejniak K, Dillon R. A single cell based model of the ductal tumour microarchitecture. Computational & Mathematical Methods In Medicine. 2007.8(1):51-69.
    • Anderson A, Rejniak K, Gerlee P, Quaranta V. Modelling of cancer growth, evolution and invasion: bridging scales and models. Math Mod Nat Phenom. 2007.2:1-29.
    • Rejniak KA. A single-cell approach in modeling the dynamics of tumor microregions. Math Biosci Eng. 2005 Jul.2(3):643-655. Pubmedid: 20369945.
    • Rejniak K, Kliman H, Fauci L. A computational model of the mechanics of growth of the villous trophoblast bilayer. Bull Math Biol. 2004 Mar.66(2):199-232. Pubmedid: 14871565.
    • Popesco M, Frostholm A, Rejniak K, Rotter A. Digital transcriptome analysis in the aging cerebellum. Ann N Y Acad Sci. 2004 Jun.1019:58-63. Pubmedid: 15246995.
  • Grants

    • Title: Development of Adoptive T-Cell Therapy in Bladder Cancer Incorporating Patient-Specific Tumor Microenvironment
      Sponsor: US Army
      PI: Rejniak, K.
    • Title: Modeling the Role and Regulation of Reactive Stroma in Breast Ductal Carcinoma Microinvasions
      Sponsor: Nat Institutes of Health
      PI: Rejniak, K.
    • Title: Mathematical Model-Guided Adoptive Immunotherapy in Bladder Cancer
      Sponsor: Nat Institutes of Health
      PI (Contact): Rejniak, K., PI (MPI): Pilon-Thomas, S.

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