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Xuefeng  Wang

Xuefeng Wang, PhD

Vice Chair, Biostatistics and Bioinformatics

Program: Biostatistics and Bioinformatics

Research Program: Immuno-Oncology Program

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  • Overview

    Associations

    • Biostatistics and Bioinformatics
    • Immuno-Oncology Program
    • Melanoma & Skin Cancer Center of Excellence

    Education & Training

    Graduate:

    • Case Western Reserve University, PhD - Biostatistics & Epidemiology

    Fellowship:

    • Harvard School of Public Health - Biostatistics
    • Merck Foundation -
  • Research Interest

    Dr. Wang’s research interests include Biostatistics, statistical genomics, and computational biology.His group develops efficient machine learning methods, such as kernel learning and probabilistic learning, for analyzing data in genomics, drug development and personalized medicine. Dr. Wang is currently involved in multiple collaborative research projects in cancer immunology and cancer epidemiology at Moffitt Cancer Center. Dr. Wang also holds adjunct faculty positions at Stony Brook University and Yale University. He was a Merck Quantitative Science Fellow (with Robert Elston) at Case Western Reserve University and a postdoctoral fellow at Harvard University. 

  • Publications

    • Huelster HL, Gould B, Schiftan EA, Camperlengo L, Davaro F, Rose KM, Soupir AC, Jia S, Zheng T, Sexton WJ, Pow-Sang J, Spiess PE, Daniel Grass G, Wang L, Wang X, Vosoughi A, Necchi A, Meeks JJ, Faltas BM, Du P, Li R. Novel Use of Circulating Tumor DNA to Identify Muscle-invasive and Non-organ-confined Upper Tract Urothelial Carcinoma. Eur Urol. 2024 Mar.85(3):283-292. Pubmedid: 37802683.
    • Faramand RG, Lee SB, Jain MD, Cao B, Wang X, Rejeski K, Subklewe M, Fahrmann JF, Saini NY, Hanash SM, Kang YP, Chang D, Rodriguez PC, Dean EA, Nishihori T, Shah BD, Lazaryan A, Chavez J, Khimani F, Pinilla-Ibarz JA, Dam M, Reid KM, Corallo SA, Menges M, Hidalgo Vargas M, Mandula JK, Holliday BA, Bachmeier CA, Speth K, Song Q, Mattie M, Locke FL, Davila ML. Baseline Serum Inflammatory Proteins Predict Poor CAR T Outcomes in Diffuse Large B-cell Lymphoma. Blood Cancer Discov. 2024 Mar.5(2):106-113. Pubmedid: 38194367. Pmcid: PMC10905320.
    • Wang H, Reid BM, Richmond RC, Lane JM, Saxena R, Gonzalez BD, Fridley BL, Redline S, Tworoger SS, Wang X. Impact of insomnia on ovarian cancer risk and survival: a Mendelian randomization study. EBioMedicine. 2024 Jun.104:105175. Pubmedid: 38823087. Pmcid: PMC11169961.
    • Linscott JA, Miyagi H, Murthy PB, Yao S, Grass GD, Vosoughi A, Xu H, Wang X, Yu X, Yu A, Zemp L, Gilbert SM, Poch MA, Sexton WJ, Spiess PE, Li R. From Detection to Cure - Emerging Roles for Urinary Tumor DNA (utDNA) in Bladder Cancer. Curr Oncol Rep. 2024 Jun. Pubmedid: 38837106.
    • Li R, Sexton WJ, Dhillon J, Berglund A, Naidu S, Borjas G, Rose K, Kim Y, Wang X, Conejo-Garcia JR, Jain RK, Poch MA, Spiess PE, Pow-Sang J, Gilbert SM, Zhang J. A Phase II Study of Durvalumab for Bacillus Calmette-Guerin (BCG) Unresponsive Urothelial Carcinoma In Situ of the Bladder. Clin Cancer Res. 2023 Oct.29(19):3875-3881. Pubmedid: 37505486.
    • Yaghjyan L, Mai V, Darville LNF, Cline J, Wang X, Ukhanova M, Tagliamonte MS, Martinez YC, Rich SN, Koomen JM, Egan KM. Associations of gut microbiome with endogenous estrogen levels in healthy postmenopausal women. Cancer Causes Control. 2023 Oct.34(10):873-881. Pubmedid: 37286847.
    • Akhtar OS, Cao B, Wang X, Torka P, Al-Jumayli M, Locke FL, Freeman CL. CAR T-cell therapy has comparable efficacy with autologous transplantation in older adults with DLBCL in partial response. Blood Adv. 2023 Oct.7(19):5937-5940. Pubmedid: 37236167. Pmcid: PMC10562759.
    • Chaudhary R, Slebos RJC, Noel LC, Song F, Poole MI, Hoening DS, Hernandez-Prera JC, Conejo-Garcia JR, Guevara-Patino JA, Wang X, Xie M, Tan AC, Chung CH. EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma. Cancer Res Commun. 2023 May.3(5):896-907. Pubmedid: 37377902. Pmcid: PMC10202124.
    • Frieling JS, Tordesillas L, Bustos XE, Ramello MC, Bishop RT, Cianne JE, Snedal SA, Li T, Lo CH, de la Iglesia J, Roselli E, Benzaïd I, Wang X, Kim Y, Lynch CC, Abate-Daga D. γδ-Enriched CAR-T cell therapy for bone metastatic castrate-resistant prostate cancer. Sci Adv. 2023 May.9(18):eadf0108. Pubmedid: 37134157. Pmcid: PMC10156127.
    • Patel KB, Alishahi Tabriz A, Turner K, Gonzalez BD, Oswald LB, Jim HSL, Nguyen OT, Hong YR, Aldawoodi N, Cao B, Wang X, Rollison DE, Robinson EJ, Naso C, Spiess PE. Telemedicine Adoption in an NCI-Designated Cancer Center During the COVID-19 Pandemic: A Report on Patient Experience of Care. J Natl Compr Canc Ne. 2023 May.21(5):496-502.e6. Pubmedid: 37156477.
    • Wang X, Fridley BL. Multi-omics Data Deconvolution and Integration: New Methods, Insights, and Translational Implications. Methods Mol Biol. 2023 Mar.2629:1-9. Pubmedid: 36929070.
    • Jain RK, Singh AM, Wang X, Guevara-Patiño JA, Sonpavde G. Emerging monoclonal antibody therapies in the treatment of metastatic urothelial carcinoma. Expert Opin Emerg Drugs. 2023 Mar.28(1):17-26. Pubmedid: 36882977.
    • Obermayer A, Chang D, Nobles G, Teng M, Tan AC, Wang X, Eschrich S, Rodriguez P, Grass GD, Meshinchi S, Tarhini A, Chen DT, Shaw T. DRPPM-PATH-SURVEIOR: Plug-and-Play Survival Analysis of Pathway-level Signatures and Immune Components. Res Sq. 2023 Mar. Pubmedid: 36993526. Pmcid: PMC10055629.
    • Obermayer AN, Chang D, Nobles G, Teng M, Tan AC, Wang X, Chen YA, Eschrich S, Rodriguez PC, Grass GD, Meshinchi S, Tarhini A, Chen DT, Shaw TI. PATH-SURVEYOR: pathway level survival enquiry for immuno-oncology and drug repurposing. BMC Bioinformatics. 2023 Jun.24(1):266. Pubmedid: 37380943. Pmcid: PMC10303868.
    • Yao S, Cao B, Li T, Kalos D, Yuan Y, Wang X. Prediction-oriented prognostic biomarker discovery with survival machine learning methods. NAR Genom Bioinform. 2023 Jun.5(2):lqad055. Pubmedid: 37332657. Pmcid: PMC10273194.
    • Li T, Patel KB, Yu X, Yao S, Wang L, Chung CH, Wang X. Unveiling targeted cell-free DNA methylation regions through paired methylome analysis of tumor and normal tissues. bioRxiv. 2023 Jun. Pubmedid: 37425680. Pmcid: PMC10327111.
    • Meng L, Thapa R, Delgado MG, Gomez MF, Ji R, Knepper TC, Hubbard JM, Wang X, Permuth JB, Kim RD, Laber DA, Xie H. Association of Age With Treatment-Related Adverse Events and Survival in Patients With Metastatic Colorectal Cancer. JAMA Netw Open. 2023 Jun.6(6):e2320035. Pubmedid: 37358854. Pmcid: PMC10293914.
    • Rose KM, Huelster HL, Meeks JJ, Faltas BM, Sonpavde GP, Lerner SP, Ross JS, Spiess PE, Grass GD, Jain RK, Kamat AM, Vosoughi A, Wang L, Wang X, Li R. Author Correction: Circulating and urinary tumour DNA in urothelial carcinoma - upper tract, lower tract and metastatic disease. Nat Rev Urol. 2023 Jul.20(7):452. Pubmedid: 37217696.
    • Rose KM, Huelster HL, Meeks JJ, Faltas BM, Sonpavde GP, Lerner SP, Ross JS, Spiess PE, Grass GD, Jain RK, Kamat AM, Vosoughi A, Wang L, Wang X, Li R. Circulating and urinary tumour DNA in urothelial carcinoma - upper tract, lower tract and metastatic disease. Nat Rev Urol. 2023 Jul.20(7):406-419. Pubmedid: 36977797.
    • Singh AM, Guevara-Patino JA, Wang X, Li R, Sonpavde G, Jain RK. Antibody-Drug Conjugates in the Treatment of Urothelial Cancer. BioDrugs. 2023 Jul.37(4):505-520. Pubmedid: 37256534.
    • Patel KB, Gonzalez BD, Turner K, Alishahi Tabriz A, Rollison DE, Robinson E, Naso C, Wang X, Spiess PE. Estimated Carbon Emissions Savings With Shifts From In-Person Visits to Telemedicine for Patients With Cancer. JAMA Netw Open. 2023 Jan.6(1):e2253788. Pubmedid: 36719682. Pmcid: PMC9890284.
    • Patel KB, Turner K, Alishahi Tabriz A, Gonzalez BD, Oswald LB, Nguyen OT, Hong YR, Jim HSL, Nichols AC, Wang X, Robinson E, Naso C, Spiess PE. Estimated Indirect Cost Savings of Using Telehealth Among Nonelderly Patients With Cancer. JAMA Netw Open. 2023 Jan.6(1):e2250211. Pubmedid: 36626174. Pmcid: PMC9856804.
    • Lester DK, Burton C, Gardner A, Innamarato P, Kodumudi K, Liu Q, Adhikari E, Ming Q, Williamson DB, Frederick DT, Sharova T, White MG, Markowitz J, Cao B, Nguyen J, Johnson J, Beatty M, Mockabee-Macias A, Mercurio M, Watson G, Chen PL, McCarthy S, MoranSegura C, Messina J, Thomas KL, Darville L, Izumi V, Koomen JM, Pilon-Thomas SA, Ruffell B, Luca VC, Haltiwanger RS, Wang X, Wargo JA, Boland GM, Lau EK. Fucosylation of HLA-DRB1 regulates CD4+ T cell-mediated anti-melanoma immunity and enhances immunotherapy efficacy. Nat Cancer. 2023 Feb.4(2):222-239. Pubmedid: 36690875. Pmcid: PMC9970875.
    • Cao B, Patel KB, Li T, Yao S, Chung CH, Wang X. A subnetwork-based framework for prioritizing and evaluating prognostic gene modules from cancer transcriptome data. iScience. 2023 Feb.26(2):105915. Pubmedid: 36685033. Pmcid: PMC9845797.
    • Liu J, Wang X, Sahin IH, Imanirad I, Felder SI, Kim RD, Xie H. Tumor Response-speed Heterogeneity as a Novel Prognostic Factor in Patients With Metastatic Colorectal Cancer. Am J Clin Oncol. 2023 Feb.46(2):50-57. Pubmedid: 36606664.
    • Byrd DA, Fan W, Greathouse KL, Wu MC, Xie H, Wang X. The intratumor microbiome is associated with microsatellite instability. J Natl Cancer Inst. 2023 Aug.115(8):989-993. Pubmedid: 37192013. Pmcid: PMC10407713.
    • Patel KB, Padhya TA, Huang J, Hernandez-Prera JC, Li T, Chung CH, Wang L, Wang X. Plasma cell-free DNA methylome profiling in pre- and post-surgery oral cavity squamous cell carcinoma. Mol Carcinogen. 2023 Apr.62(4):493-502. Pubmedid: 36636912. Pmcid: PMC10023468.
    • Anadon CM, Zhang C, Wang X, Cen L, Conejo-Garcia JR, Yu X. Protocol for the isolation of CD8+ tumor-infiltrating lymphocytes from human tumors and their characterization by single-cell immune profiling and multiome. STAR Protoc. 2022 Sep.3(3):101649. Pubmedid: 36065294. Pmcid: PMC9440482.
    • Yu X, Cen L, Chen YA, Markowitz J, Shaw TI, Tsai KY, Conejo-Garcia JR, Wang X. Tumor Expression Quantitative Trait Methylation Screening Reveals Distinct CpG Panels for Deconvolving Cancer Immune Signatures. Cancer Res. 2022 May.82(9):1724-1735. Pubmedid: 35176128. Pmcid: PMC9064917.
    • Mandal G, Biswas S, Anadon CM, Yu X, Gatenbee CD, Prabhakaran S, Payne KK, Chaurio RA, Martin A, Innamarato P, Moran C, Powers JJ, Harro CM, Mine JA, Sprenger KB, Rigolizzo KE, Wang X, Curiel TJ, Rodriguez PC, Anderson ARA, Saglam O, Conejo-Garcia JR. IgA-Dominated Humoral Immune Responses Govern Patients' Outcome in Endometrial Cancer. Cancer Res. 2022 Mar.82(5):859-871. Pubmedid: 34949671. Pmcid: PMC8898267.
    • Wang X, Muzaffar J, Kirtane K, Song F, Johnson M, Schell MJ, Li J, Yoder SJ, Conejo-Garcia JR, Guevara-Patino JA, Bonomi M, Bhateja P, Rocco JW, Steuer CE, Saba NF, Chung CH. T cell repertoire in peripheral blood as a potential biomarker for predicting response to concurrent cetuximab and nivolumab in head and neck squamous cell carcinoma. J Immunother Cancer. 2022 Jun.10(6). Pubmedid: 35676062. Pmcid: PMC9185557.
    • Li K, Yao S, Zhang Z, Cao B, Wilson CM, Kalos D, Kuan PF, Zhu R, Wang X. Efficient gradient boosting for prognostic biomarker discovery. Bioinformatics. 2022 Jan. Pubmedid: 34978570.
    • Shabani S, Turner K, Nichols AC, Wang X, Patel KB. A Review of Health Care Disparities in Head and Neck Squamous Cell Carcinomas. J Health Care Poor Underserved. 2022 Feb.33(1):478-491. Pubmedid: 35153235.
    • Saglam O, Cao B, Wang X, Toruner GA, Conejo-Garcia JR. Expression of epigenetic pathway related genes in association with PD-L1, ER/PgR and MLH1 in endometrial carcinoma. PLoS One. 2022 Feb.17(2):e0264014. Pubmedid: 35226658. Pmcid: PMC8884513.
    • Patel KB, Shabani S, Padhya T, Cao B, Wang X, Turner K, Nichols AC, Kang SY, Rocco JW, Old M. The Impact of the Affordable Care Act on Insurance Coverage and Stage Among Head and Neck Squamous Cell Carcinoma Patients. J Health Care Poor Underserved. 2022 Aug.33(3):1322-1336. Pubmedid: 36245166.
    • Jain MD, Ziccheddu B, Coughlin CA, Faramand RG, Griswold AJ, Reid KM, Menges M, Zhang Y, Cen L, Wang X, Hussaini MO, Landgren O, Davila ML, Schatz JH, Locke FL, Maura F. Whole-genome sequencing reveals complex genomic features underlying anti-CD19 CAR T-cell treatment failures in lymphoma. Blood. 2022 Aug.140(5):491-503. Pubmedid: 35476848. Pmcid: PMC9353150.
    • Tan ES, Knepper TC, Wang X, Permuth JB, Wang L, Fleming JB, Xie H. Copy Number Alterations as Novel Biomarkers and Therapeutic Targets in Colorectal Cancer. Cancers (Basel). 2022 Apr.14(9). Pubmedid: 35565354. Pmcid: PMC9101426.
    • de la Iglesia JV, Slebos RJC, Martin-Gomez L, Wang X, Teer JK, Tan AC, Gerke TA, Aden-Buie G, van Veen T, Masannat J, Chaudhary R, Song F, Fournier M, Siegel EM, Schabath MB, Wadsworth JT, Caudell J, Harrison L, Wenig BM, Conejo-Garcia J, Hernandez-Prera JC, Chung CH. Correction: Effects of Tobacco Smoking On the Tumor Immune Microenvironment in Head and Neck Squamous Cell Carcinoma. Clin Cancer Res. 2021 Sep.27(17):4941. Pubmedid: 34470812.
    • Reid S, Haddad D, Tezak A, Weidner A, Wang X, Mautz B, Moore J, Cadiz S, Zhu Y, Zheng W, Mayer IA, Shu XO, Pal T. Impact of molecular subtype and race on HR+, HER2- breast cancer survival. Breast Cancer Res Treat. 2021 Oct.189(3):845-852. Pubmedid: 34331630. Pmcid: PMC8511072.
    • Jain MD, Zhao H, Wang X, Atkins R, Menges M, Reid K, Spitler K, Faramand R, Bachmeier CA, Dean EA, Cao B, Chavez JC, Shah BD, Lazaryan A, Nishihori T, Hussaini MO, Gonzalez RJ, Mullinax JE, Rodriguez P, Conejo-Garcia J, Anasetti C, Davila ML, Locke FL. Tumor interferon signaling and suppressive myeloid cells are associated with CAR T-cell failure in large B-cell lymphoma. Blood. 2021 May.137(19):2621-2633. Pubmedid: 33512407. Pmcid: PMC8120145.
    • Bejanyan N, Pidala JA, Wang X, Thapa R, Nishihori T, Elmariah H, Lazaryan A, Khimani F, Davila ML, Mishra A, Faramand R, Jain MD, Ochoa L, Perez LE, Liu H, Alsina M, Kharfan-Dabaja MA, Fernandez H, Nieder ML, Locke FL, Anasetti C, Ayala E. A phase 2 trial of GVHD prophylaxis with PTCy, sirolimus, and MMF after peripheral blood haploidentical transplantation. Blood Adv. 2021 Mar.5(5):1154-1163. Pubmedid: 33635333. Pmcid: PMC7948297.
    • Zhao X, Wang MY, Jiang H, Lwin T, Park PM, Gao J, Meads MB, Ren Y, Li T, Sun J, Fahmi NA, Singh S, Sehgal L, Wang X, Silva AS, Sotomayor EM, Shain KH, Cleveland JL, Wang M, Zhang W, Qi J, Shah BD, Tao J. Transcriptional programming drives Ibrutinib-resistance evolution in mantle cell lymphoma. Cell Rep. 2021 Mar.34(11):108870. Pubmedid: 33730585. Pmcid: PMC8057695.
    • Wilson CM, Li K, Sun Q, Kuan PF, Wang X. Fenchel duality of Cox partial likelihood with an application in survival kernel learning. Artif Intell Med. 2021 Jun.116:102077. Pubmedid: 34020756. Pmcid: PMC8159024.
    • Yaghjyan L, Mai V, Wang X, Ukhanova M, Tagliamonte M, Martinez YC, Rich SN, Egan KM. Gut microbiome, body weight, and mammographic breast density in healthy postmenopausal women. Cancer Causes Control. 2021 Jul.32(7):681-692. Pubmedid: 33772705.
    • Perez L, Fernandez H, Kharfan-Dabaja M, Khimani F, Betts B, Mishra A, Ayala E, Locke FL, Ochoa-Bayona L, Nieder M, Pidala J, Achille A, Powers J, Sahakian E, Thapa R, Wang X, Anasetti C. A phase 2 trial of the histone deacetylase inhibitor panobinostat for graft-versus-host disease prevention. Blood Adv. 2021 Jul.5(13):2740-2750. Pubmedid: 34242388. Pmcid: PMC8288668.
    • Boucher JC, Li G, Kotani H, Cabral ML, Morrissey D, Lee SB, Spitler K, Beatty NJ, Cervantes EV, Shrestha B, Yu B, Kazi A, Wang X, Sebti SM, Davila ML. CD28 Costimulatory Domain-Targeted Mutations Enhance Chimeric Antigen Receptor T-cell Function. Cancer Immunol Res. 2021 Jan.9(1):62-74. Pubmedid: 33188139. Pmcid: PMC7864379.
    • Wilson CM, Fridley BL, Conejo-Garcia JR, Wang X, Yu X. Wide and deep learning for automatic cell type identification. Comput Struct Biotechnol J. 2021 Jan.19:1052-1062. Pubmedid: 33613870. Pmcid: PMC7878986.
    • Chaudhary R, Slebos RJC, Song F, McCleary-Sharpe KP, Masannat J, Tan AC, Wang X, Amaladas N, Wu W, Hall GE, Conejo-Garcia JR, Hernandez-Prera JC, Chung CH. Effects of checkpoint kinase 1 inhibition by prexasertib on the tumor immune microenvironment of head and neck squamous cell carcinoma. Mol Carcinogen. 2021 Feb.60(2):138-150. Pubmedid: 33378592. Pmcid: PMC7856233.
    • Mishra A, Pidala J, Thapa R, Betts BC, Fernandez H, Locke FL, Nishihori T, Perez L, Wang X, Anasetti C, Jim H. Objective and subjective physical function in allogeneic hematopoietic stem cell transplant recipients. Bone Marrow Transplant. 2021 Dec.56(12):2897-2903. Pubmedid: 34381169.
    • Shi LL, McMullen C, Vorwald K, Nichols AC, MacNeil SD, Wadsworth JT, Chung CH, Wang X, Patel KB. Survival outcomes of patients with subglottic squamous cell carcinoma : a study of the National Cancer Database. Eur Arch Otorhinolaryngol. 2021 Dec.278(12):4923-4932. Pubmedid: 33646344.
    • Figura NB, Robinson TJ, Sim AJ, Wang X, Cao B, Chavez JC, Shah BD, Khimani F, Lazaryan A, Davila M, Bachmeier C, Nishihori T, Liu HD, Kim S, Locke FL, Jain MD. Patterns and Predictors of Failure in Recurrent or Refractory Large B-Cell Lymphomas After Chimeric Antigen Receptor T-Cell Therapy. Int J Radiat Oncol Biol Phys. 2021 Dec.111(5):1145-1154. Pubmedid: 34242714. Pmcid: PMC9791939.
    • Li Q, Wang X. Differential Expression Analysis of Long Noncoding RNAs. Methods Mol Biol. 2021 Apr.2284:193-205. Pubmedid: 33835444.
    • Faramand R, Jain M, Staedtke V, Kotani H, Bai R, Reid K, Lee SB, Spitler K, Wang X, Cao B, Pinilla J, Lazaryan A, Khimani F, Shah B, Chavez JC, Nishihori T, Mishra A, Mullinax J, Gonzalez R, Hussaini M, Dam M, Brandjes BD, Bachmeier CA, Anasetti C, Locke FL, Davila ML. Tumor Microenvironment Composition and Severe Cytokine Release Syndrome (CRS) Influence Toxicity in Patients with Large B-Cell Lymphoma Treated with Axicabtagene Ciloleucel. Clin Cancer Res. 2020 Sep.26(18):4823-4831. Pubmedid: 32669372. Pmcid: PMC7501265.
    • Wang X, Yu X, Krauthammer M, Hugo W, Duan C, Kanetsky PA, Teer JK, Thompson ZJ, Kalos D, Tsai KY, Smalley KSM, Sondak VK, Chen YA, Conejo-Garcia JR. The Association of MUC16 Mutation with Tumor Mutation Burden and Its Prognostic Implications in Cutaneous Melanoma. Cancer Epidemiol Biomarkers Prev. 2020 Sep.29(9):1792-1799. Pubmedid: 32611582. Pmcid: PMC7483810.
    • Saglam O, Zhou J, Wang X, Conejo-Garcia JR. PD-L1 Expression Correlates With Young Age and CD8+ TIL Density in Poorly Differentiated Cervical Squamous Cell Carcinoma. Int J Gynecol Pathol. 2020 Sep.39(5):428-435. Pubmedid: 31274701. Pmcid: PMC7010346.
    • Paredes J, Zabaleta J, Garai J, Ji P, Imtiaz S, Spagnardi M, Alvarado J, Li L, Akadri M, Barrera K, Munoz-Sagastibelza M, Gupta R, Alshal M, Agaronov M, Talus H, Wang X, Carethers JM, Williams JL, Martello LA. Immune-Related Gene Expression and Cytokine Secretion Is Reduced Among African American Colon Cancer Patients. Front Oncol. 2020 Sep.10:1498. Pubmedid: 32983990. Pmcid: PMC7492388.
    • de la Iglesia JV, Slebos RJ, Martin-Gomez L, Wang X, Teer JK, Tan AC, Gerke TA, Aden-Buie G, Van Veen T, Masannat J, Chaudhary R, Song F, Fournier M, Siegel EM, Schabath MB, Wadsworth JT, Caudell JJ, Harrison LB, Wenig B, Conejo-Garcia JR, Hernandez-Prera JC, Chung CH. Effects of Tobacco Smoking on the Tumor Immune Microenvironment in Head and Neck Squamous Cell Carcinoma. Clin Cancer Res. 2020 Mar.26(6):1474-1485. Pubmedid: 31848186. Pmcid: PMC7073297.
    • Valderrabano P, Wang X, McIver B. Concerns About Methodology in Study of Thyroid Nodule Gene Expression Classifier-Reply. JAMA Otolaryngol Head Neck Surg. 2020 Mar.146(3):313-314. Pubmedid: 31917407.
    • Chaudhary R, Wang X, Cao B, De La Iglesia J, Masannat J, Song F, Hernandez-Prera JC, Gimbrone NT, Slebos RJ, Chung CH. Long noncoding RNA, LINC00460, as a prognostic biomarker in head and neck squamous cell carcinoma (HNSCC). Am J Transl Res. 2020 Feb.12(2):684-696. Pubmedid: 32194915. Pmcid: PMC7061833.
    • Shrestha B, Zhang Y, Yu B, Li G, Boucher JC, Beatty NJ, Tsai HC, Wang X, Mishra A, Sweet K, Lancet JE, Kelley L, Davila ML. Generation of Antitumor T Cells For Adoptive Cell Therapy With Artificial Antigen Presenting Cells. J Immunother. 2020 Apr.43(3):79-88. Pubmedid: 31834208. Pmcid: PMC7077957.
    • Valderrabano P, Hallanger-Johnson JE, Thapa R, Wang X, McIver B. Comparison of Postmarketing Findings vs the Initial Clinical Validation Findings of a Thyroid Nodule Gene Expression Classifier: A Systematic Review and Meta-analysis. JAMA Otolaryngol Head Neck Surg. 2019 Sep.145(9):783-792. Pubmedid: 31318389. Pmcid: PMC6647006.
    • Zhao X, Ren Y, Lawlor M, Shah BD, Park PMC, Lwin T, Wang X, Liu K, Wang M, Gao J, Li T, Xu M, Silva AS, Lee K, Zhang T, Koomen JM, Jiang H, Sudalagunta PR, Meads MB, Cheng F, Bi C, Fu K, Fan H, Dalton WS, Moscinski LC, Shain KH, Sotomayor EM, Wang GG, Gray NS, Cleveland JL, Qi J, Tao J. BCL2 Amplicon Loss and Transcriptional Remodeling Drives ABT-199 Resistance in B Cell Lymphoma Models. Cancer Cell. 2019 May.35(5):752-766.e9. Pubmedid: 31085176. Pmcid: PMC6945775.
    • Yu X, Chen YA, Conejo-Garcia JR, Chung CH, Wang X. Estimation of immune cell content in tumor using single-cell RNA-seq reference data. BMC Cancer. 2019 Jul.19(1):715. Pubmedid: 31324168. Pmcid: PMC6642583.
    • Li Q, Yu X, Chaudhary R, Slebos RJC, Chung CH, Wang X. lncDIFF: a novel quasi-likelihood method for differential expression analysis of non-coding RNA. BMC Genomics. 2019 Jul.20(1):539. Pubmedid: 31266446. Pmcid: PMC6604377.
    • Li E, Zhang Y, Tian X, Wang X, Gathungu G, Wolber A, Shiekh SS, Sartor RB, Davidson NO, Ciorba MA, Zhu W, Nelson LM, Robertson CE, Frank DN. Influence of Crohn's disease related polymorphisms in innate immune function on ileal microbiome. PLoS One. 2019 Feb.14(2):e0213108. Pubmedid: 30818349. Pmcid: PMC6395037.
    • Wilson CM, Li K, Yu X, Kuan PF, Wang X. Multiple-kernel learning for genomic data mining and prediction. BMC Bioinformatics. 2019 Aug.20(1):426. Pubmedid: 31416413. Pmcid: PMC6694479.
    • Li G, Boucher JC, Kotani H, Park K, Zhang Y, Shrestha B, Wang X, Guan L, Beatty N, Abate-Daga D, Davila ML. 4-1BB enhancement of CAR T function requires NF-κB and TRAFs. JCI Insight. 2018 Sep.3(18). Pubmedid: 30232281. Pmcid: PMC6237232.
    • Wang X, Chen H, Zhang NR. DNA copy number profiling using single-cell sequencing. Brief Bioinform. 2018 Sep.19(5):731-736. Pubmedid: 28159966. Pmcid: PMC6171490.
    • Yu X, Wang X. Tumor immunity landscape in non-small cell lung cancer. PeerJ. 2018 Mar.6:e4546. Pubmedid: 29593943. Pmcid: PMC5868477.
    • Ren Y, Bi C, Zhao X, Lwin T, Wang C, Yuan J, Silva AS, Shah BD, Fang B, Li T, Koomen JM, Jiang H, Chavez JC, Pham L, Sudalagunta PR, Wan L, Wang X, Dalton WS, Moscinski LC, Shain KH, Vose J, Cleveland JL, Sotomayor EM, Fu K, Tao J. PLK1 stabilizes a MYC-dependent kinase network in aggressive B cell lymphomas. J Clin Invest. 2018 Dec.128(12):5517-5530. Pubmedid: 30260324. Pmcid: PMC6264635.
    • Chen L, Reeve J, Zhang L, Huang S, Wang X, Chen J. GMPR: A robust normalization method for zero-inflated count data with application to microbiome sequencing data. PeerJ. 2018 Apr.6:e4600. Pubmedid: 29629248. Pmcid: PMC5885979.
    • Wang X, Zhang Z, Morris N, Cai T, Lee S, Wang C, Yu TW, Walsh CA, Lin X. Rare variant association test in family-based sequencing studies. Brief Bioinform. 2017 Nov.18(6):954-961. Pubmedid: 27677958. Pmcid: PMC5862290.
    • Wang H, Choi Y, Tayo B, Wang X, Morris N, Zhang X, Broeckel U, Hanis C, Kardia S, Redline S, Cooper RS, Tang H, Zhu X. Genome-wide survey in African Americans demonstrates potential epistasis of fitness in the human genome. Genet Epidemiol. 2017 Feb.41(2):122-135. Pubmedid: 27917522. Pmcid: PMC5226866.
    • Yue L, Bartenstein M, Zhao W, Ho WT, Han Y, Murdun C, Mailloux AW, Zhang L, Wang X, Budhathoki A, Pradhan K, Rapaport F, Wang H, Shao Z, Ren X, Steidl U, Levine RL, Zhao ZJ, Verma A, Epling-Burnette PK. Efficacy of ALK5 inhibition in myelofibrosis. JCI Insight. 2017 Apr.2(7):e90932. Pubmedid: 28405618. Pmcid: PMC5374075.
    • Canli T, Wen R, Wang X, Mikhailik A, Yu L, Fleischman D, Wilson RS, Bennett DA. Differential transcriptome expression in human nucleus accumbens as a function of loneliness. Mol Psychiatry. 2016 Nov. Pubmedid: 27801889. Pmcid: PMC5411331.
    • Wang X, Chen M, Yu X, Pornputtapong N, Chen H, Zhang NR, Powers RS, Krauthammer M. Global copy number profiling of cancer genomes. Bioinformatics. 2016 Mar.32(6):926-928. Pubmedid: 26576652. Pmcid: PMC4907391.
    • Wang X, Ji P, Zhang Y, LaComb JF, Tian X, Li E, Williams JL. Correction: Aberrant DNA Methylation: Implications in Racial Health Disparity. PLoS One. 2016 Jun.11(6):e0158251. Pubmedid: 27326861. Pmcid: PMC4915714.
    • Wang X, Ji P, Zhang Y, LaComb JF, Tian X, Li E, Williams JL. Aberrant DNA Methylation: Implications in Racial Health Disparity. PLoS One. 2016 Apr.11(4):e0153125. Pubmedid: 27111221. Pmcid: PMC4844165.
    • Wang X, Xing EP, Schaid DJ. Kernel methods for large-scale genomic data analysis. Brief Bioinform. 2015 Mar.16(2):183-192. Pubmedid: 25053743. Pmcid: PMC4375394.
    • Wang X, Yu X, Zhu W, McCombie WR, Antoniou E, Powers RS, Davidson NO, Li E, Williams J. A trimming-and-retrieving alignment scheme for reduced representation bisulfite sequencing. Bioinformatics. 2015 Jun.31(12):2040-2042. Pubmedid: 25681254. Pmcid: PMC4481698.
    • Tian X, Wang X, Chen J. Network-constrained group lasso for high-dimensional multinomial classification with application to cancer subtype prediction. Cancer Inform. 2015 Jan.13(Suppl 6):25-33. Pubmedid: 25635165. Pmcid: PMC4295837.
    • Wang X, Biernacka JM. Assessing the effects of multiple markers in genetic association studies. Front Genet. 2015 Feb.6:66. Pubmedid: 25759719. Pmcid: PMC4338793.
    • Wang X. Firth logistic regression for rare variant association tests. Front Genet. 2014 Jun.5:187. Pubmedid: 24995013. Pmcid: PMC4063169.
    • Wang X, Morris NJ, Zhu X, Elston RC. A variance component based multi-marker association test using family and unrelated data. BMC Genet. 2013 Mar.14:17. Pubmedid: 23497289. Pmcid: PMC3614458.
    • Wang X, Lee S, Zhu X, Redline S, Lin X. GEE-based SNP set association test for continuous and discrete traits in family-based association studies. Genet Epidemiol. 2013 Dec.37(8):778-786. Pubmedid: 24166731. Pmcid: PMC4007511.
    • Tang ZX, Wang XF, Zhang MZ, Zhang YH, Deng DX, Xu CW. The maternal cytoplasmic environment may be involved in the viability selection of gametes and zygotes. Heredity (Edinb). 2013 Apr.110(4):331-337. Pubmedid: 23169560. Pmcid: PMC3607179.
    • Wang X, Morris NJ, Schaid DJ, Elston RC. Power of single- vs. multi-marker tests of association. Genet Epidemiol. 2012 Jul.36(5):480-487. Pubmedid: 22648939. Pmcid: PMC3708310.
    • Wang X, Elston RC, Zhu X. The meaning of interaction. Hum Hered. 2012 Feb.70(4):269-277. Pubmedid: 21150212. Pmcid: PMC3025890.
    • Wang X, Qin H, Morris NJ, Zhu X, Elston RC. Testing gene-environment interactions in gene-based association studies. BMC Proc. 2011 Nov.5 Suppl 9:S26. Pubmedid: 22373316. Pmcid: PMC3287861.
    • Bickeböller H, Houwing-Duistermaat JJ, Wang X, Yan X. Dealing with high dimensionality for the identification of common and rare variants as main effects and for gene-environment interaction. Genet Epidemiol. 2011 Nov.35 Suppl 1:S35-S40. Pubmedid: 22128056.
    • Wang X, Elston RC, Zhu X. Statistical interaction in human genetics: how should we model it if we are looking for biological interaction?. Nat Rev Genet. 2011 Jan.12(1):74. Pubmedid: 21102529. Pmcid: PMC5189671.
    • Wang X, Song W, Yang Z, Wang Y, Tang Z, Xu C. Improved genetic mapping of endosperm traits using NCIII and TTC designs. J Hered. 2009 Jul.100(4):496-500. Pubmedid: 19332617.
    • Wang X, Xu C, Wu R, Larkins BA. Genetic dissection of complex endosperm traits. Trends Plant Sci. 2009 Jul.14(7):391-398. Pubmedid: 19546022.
    • Xu C, Wang X, Li Z, Xu S. Mapping QTL for multiple traits using Bayesian statistics. Genet Res (Camb). 2009 Feb.91(1):23-37. Pubmedid: 19220929.
    • Lu Q, Song Y, Wang X, Won S, Cui Y, Elston RC. The effect of multiple genetic variants in predicting the risk of type 2 diabetes. BMC Proc. 2009 Dec.3 Suppl 7:S49. Pubmedid: 20018041. Pmcid: PMC2795948.
    • Nock NL, Wang X, Thompson CL, Song Y, Baechle D, Raska P, Stein CM, Gray-McGuire C. Defining genetic determinants of the Metabolic Syndrome in the Framingham Heart Study using association and structural equation modeling methods. BMC Proc. 2009 Dec.3 Suppl 7:S50. Pubmedid: 20018043. Pmcid: PMC2795950.
    • Yang Z, Gu S, Wang X, Li W, Tang Z, Xu C. Molecular evolution of the CPP-like gene family in plants: insights from comparative genomics of Arabidopsis and rice. J Mol Evol. 2008 Sep.67(3):266-277. Pubmedid: 18696028.
    • Yang Z, Zhou Y, Wang X, Gu S, Yu J, Liang G, Yan C, Xu C. Genomewide comparative phylogenetic and molecular evolutionary analysis of tubby-like protein family in Arabidopsis, rice, and poplar. Genomics. 2008 Oct.92(4):246-253. Pubmedid: 18620041.
    • Wang X, Hu Z, Wang W, Li Y, Zhang YM, Xu C. A mixture model approach to the mapping of QTL controlling endosperm traits with bulked samples. Genetica. 2008 Jan.132(1):59-70. Pubmedid: 17427035.
    • Yang Z, Wang X, Gu S, Hu Z, Xu H, Xu C. Comparative study of SBP-box gene family in Arabidopsis and rice. Gene. 2008 Jan.407(1-2):1-11. Pubmedid: 17629421.
    • Tang Z, Wang X, Hu Z, Yang Z, Xu C. Genetic dissection of cytonuclear epistasis in line crosses. Genetics. 2007 Sep.177(1):669-672. Pubmedid: 17720901. Pmcid: PMC2013686.
    • Xiao J, Wang X, Hu Z, Tang Z, Xu C. Multivariate segregation analysis for quantitative traits in line crosses. Heredity (Edinb). 2007 Jun.98(6):427-435. Pubmedid: 17392707.
    • Hu Z, Wang X, Xu C. A method for identification of the expression mode and mapping of QTL underlying embryo-specific characters. J Hered. 2006 Sep.97(5):473-482. Pubmedid: 16982669.
  • Grants

    • Title: Next-Generation Biomedical Big Data Platform for Cancer Research and Collaboration Across Florida
      Sponsor: Florida Biomedical Research Program (FBRP)
      PI: Wang, X.

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