Total Skin Electron Therapy (TSET)

Total skin electron therapy, or TSET, is an effective form of radiation-based treatment for mycosis fungoides, a type of cutaneous T-cell lymphoma. As the name suggests, the entire surface of the skin is treated with radiation; however, only low-energy electrons are used to destroy cancer cells. Because electrons do not travel deep below the surface of the skin, underlying tissues and organs are usually unaffected by TSET.

Most patients who receive total skin electron therapy have two sessions per week for a period of six to nine weeks. However, this schedule can be adjusted based on several patient-specific factors. Additionally, if signs of cancer are still present after the completion of an initial treatment cycle, additional “boost” treatments might be recommended to destroy any remaining cancer cells.  

To help improve a patient’s outcome, oncologists may recommend one or more treatments before or after TSET, such as:

• Immunotherapy
• Retinoid therapy
• Topical chemotherapy

At Moffitt Cancer Center, we offer an expansive range of treatments to improve not only patient outcomes, but also their quality of life. Because our radiation oncologists, radiation therapists and dosimetrists are highly specialized and experienced in their respective fields, they are able to make the most of our advanced technologies while helping to limit any treatment-related side effects.  

Medically reviewed by Dr. Michael Montejo.

For more information about total skin electron therapy or any of our other innovative radiation treatments, call 1-888-663-3488 or submit a new patient registration form online. You do not need a referral to request a consultation.