Immunology Research in the News

Moffitt Researchers Discover Regulatory Pathway That Blocks Immune Response Against Cancer- In an article published in the journal Immunity, Moffitt Cancer Center researchers show that TIM-3 inhibits the STING signaling pathway in dendritic cells, thereby blocking their ability to elicit an immune response.

S100A9-Induced Overexpression of Pd-1/Pd-L1 Contributes to Ineffective Hematopoiesis In Myelodysplastic Syndromes - D-1/PD-L1 blockade therapy, alone or in combination with other strategies, may have therapeutic potential to restore and promote effective hematopoiesis in MDS, according to new research from Moffitt Cancer Center that was published in Nature.com.

Moffitt Researchers Discover New Approach to Stimulate an Immune Response Against Tumor Cells - In an article published in the January issue of Cancer Cell, the researchers describe how a new type of immunotherapy drug targeting the protein TIM-3 works to stimulate the immune system. 

Bacteriotherapy Heals Cisplatin Damage - Bacteriotherapy with fecal pellets before chemotherapy reduces intestinal damage and systemic inflammation in response to cisplatin, according to new research from Moffitt Cancer Center that was published online by The Journal of Leukocyte Biology.

Moffitt Researchers Identify Novel Target to Improve Chemotherapeutic Response in Breast Cancer - In an article published in the January issue of Cancer Cell, members of the Department of Immunology at Moffitt report that TIM-3 is expressed by intratumoral CD103+ dendritic cells – the cells responsible for the initial activation of anti-tumor T cells – and alters their immunostimulatory function. 

ITUS Enters CAR-T Research Alliance with Moffitt Cancer Center - ITUS Corporation, a cancer-focused biotechnology company, has entered into a Cooperative Research and Development Agreement with Moffitt Cancer Center, to advance toward human clinical testing a Chimeric Receptor T-Cell technology aimed initially at ovarian cancer, and eventually additional solid tumors.

Fighting Cancer with Mathematics and Viruses - The laboratory of Daniel Abate-Daga, in collaboration with members of the Integrated Mathematical Oncology group, has published a review that made the cover of the journal "Viruses." 

Moffitt Cancer Center is one of the five institutions selected as a Cell Therapies Processing Facility by the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health (NIH).