Clinical Trial 23188

• Overview

  Study Title:

  A Phase II Study of Enfortumab Vedotin in Patients with Advanced or Metastatic Colorectal Cancer or Hepatocellular Carcinoma

  Objective:

  Primary Objective: To determine the activity of enfortumab vedotin as measured by objective response rate (ORR) in patients with locally advanced or metastatic CRC or HCC who have previously received standard systemic therapy. Secondary Objective: To evaluate additional efficacy measures including duration of response (DOR), progression-free survival (PFS), and overall survival (OS); To assess the safety and tolerability of enfortumab vedotin in these patient population.

• Treatments

  Therapies:

  Antibody-Drug Conjugate

  Medications:

  Enfortumab Vedotin (Padcev)

• Inclusion Criteria

  Key Inclusion Criteria:
  • Participants must have histologically confirmed CRC or HCC that is metastatic or unresectable and have progressive disease or intolerance after standard front-line therapies as defined: Participants with CRC (cohort 1): Participants must have had progressive disease or intolerance after at least 2 but no more than 3 prior lines of systemic therapy in advanced or metastatic setting. Prior lines of therapy should include fluoropyrimidine (5-fluorouracil or capecitabine), oxaliplatin, and irinotecan with or without antiEGFR antibody for RAS/RAF wild-type CRC or bevacizumab unless contraindicated. For patients with microsatellite instability high (MSI-H) CRC, previous lines of therapy should include a PD-1/PD-L1 immune checkpoint inhibitor in additional to the chemotherapy agents mentioned above. Adjuvant chemotherapy with radiographic progression greater than 12 months after the last dose is not considered as a line of therapy. Participants with HCC (cohort 2): Participants must have had progressive disease or intolerance after at least 1 but no more than 2 prior lines of systemic therapy in advanced or metastatic setting. Prior lines of therapy should include a PD-1/PD-L1 immune checkpoint inhibitor or a multikinase inhibitor, which was administered either alone or in combination.
  • Participants must have measurable disease according to RECIST v1.1. Lesions in a prior radiation field must have progressed subsequent to radiotherapy to be considered measurable.
  • Participants must have had progression or recurrence of CRC or HCC during or following receipt of most recent therapy.
  • Legally an adult according to local regulation at the time of signing informed consent, and minimum age of 18 years.
  • ECOG performance status 1 or less.
  • Participants must have adequate organ and marrow function as defined in the protocol.
  • Tumor tissue samples must be available for submission prior to study treatment.
  • Participants must have an anticipated life expectancy of 3 or more months as assessed by the investigator.
  • The effects of enfortumab vedotin on the developing human fetus are unknown. For this reason, women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry, for the duration of study participation and for 4 months after the last dose. Should a woman become pregnant or suspect she is pregnant while she or her partner is participating in this study, she should inform her treating physician immediately.
  • Ability to understand and the willingness to sign a written informed consent document.
  • Other inclusion criteria may apply.

• Exclusion Criteria

  Key Exclusion Criteria:
  • Radiotherapy or major surgery or chemotherapy, biologics, investigational agents, and/or immunotherapy that is not completed 2 weeks prior to first dose of study drug.
  • Ongoing sensory or motor neuropathy Grade 2 or higher. Ongoing clinically significant toxicity (Grade 2 or higher) associated with prior treatment (including systemic therapy, radiotherapy or surgery).
  • Active central nervous system (CNS) metastases. Participants with treated CNS metastases are permitted on study if all the following are true: I) CNS metastases have been clinically stable for at least 6 weeks prior to screening and baseline scans show no evidence of new or enlarged metastasis. II) If requiring steroid treatment for CNS metastases, the patient is on a stable dose of 20 mg/day or less of prednisone or equivalent for at least 2 weeks. III) Participant does not have leptomeningeal disease.
  • Prior enrollment in an enfortumab vedotin study or prior treatment with other MMAE-based ADCs.
  • History of another malignancy within 3 years before the first dose of study drug, or any evidence of residual disease from a previously diagnosed malignancy. Participants with nonmelanoma skin cancer, localized prostate cancer treated with curative intent with no evidence of progression, low risk or very low risk (per standard guidelines) localized prostate cancer under active surveillance/watchful waiting without intent to treat, or carcinoma in situ of any type (if complete resection was performed) are allowed.
  • Currently receiving systemic antimicrobial treatment for active infection (viral, bacterial, or fungal) at the time of first dose of enfortumab vedotin. Routine antimicrobial prophylaxis is permitted.
  • Patients with a positive hepatitis B surface antigen and/or antihepatitis B core antibody. Patients with a negative polymerase chain reaction (PCR) assay (HBV DNA is less than 10 IU/ml) are permitted with appropriate antiviral prophylaxis.
  • Active hepatitis C infection or known human immunodeficiency virus (HIV) infection. Patients who have been treated for hepatitis C infection are permitted if they have negative HCV RNA test (less than 15 IU/ml) and have documented sustained virologic response of 12 weeks or greater.
  • Documented history of a cerebral vascular event (stroke or transient ischemic attack), unstable angina, myocardial infarction, or cardiac symptoms (including congestive heart failure) consistent with New York Heart Association Class III-IV within 6 months prior to the first dose of enfortumab vedotin.
  • Known hypersensitivity to enfortumab vedotin or to any excipient contained in the drug formulation of enfortumab vedotin (including histidine, trehalose dihydrate, and polysorbate 20).
  • Participants with active keratitis or corneal ulcerations. Patients with superficial punctate keratitis are allowed if the disorder is being adequately treated in the opinion of the investigator.
  • Participants with uncontrolled diabetes. Uncontrolled diabetes is defined as hemoglobin A1c (HbA1c) 8% or greater or HbA1c 7 to 8% with associated diabetes symptoms (polyuria or polydipsia) that are not otherwise explained.
  • Participants with uncontrolled tumor-related bone pain or impending spinal cord compression, uncontrolled intercurrent illness, psychiatric illness/social situations that would limit compliance with study requirements or other underlying medical condition that, in the opinion of the investigator, would impair the ability of the patient to receive or tolerate the planned treatment and follow-up.
  • Other exclusion criteria may apply.

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