Brahm Segal, MD

Education & Training

Fellowship:

• National Institute of Allergy and Infectious Disease, National Institutes of Health -

Residency:

• New England Medical Center, Boston, MA -

Medical School:

• Albert Einstein College of Medicine, Bronx, New York - MD

• Giridharan T, Suzuki S, Khan ANH, Liu Q, Attwood K, Stokolosa A, Mahan S, Witkiewicz AK, Joseph J, Moysich K, Langermann S, Lovewell R, Flies D, Myint H, Odunsi K, Emmons TR, Yaffe MB, Zsiros E, Dey P, McGray AJR, Segal BH. NC410, a bivalent LAIR-2 construct, remodels collagen in the tumor microenvironment and abrogates neutrophil-driven T cell suppression. J Immunol. 2025 Sep.214(9):2464-2479. Pubmedid: 40560129. Pmcid: PMC12481037.
• Kajihara R, Long MD, Hoki T, Chen H, Yamauchi T, Kanemaru H, Segal BH, Dy GK, Ito F. Divergent transcriptional states and kinetics of circulating tumor-infiltrating lymphocyte repertoires with highly homologous T-cell receptor sequences in a patient during immunotherapy. J Immunother Cancer. 2025 Jan.13(1). Pubmedid: 39863301. Pmcid: PMC11784231.
• El-Atoum M, Gailor ME, Segal BH, Bonnewell JP, Almyroudis NG. Microbiology of Actinomyces Species Isolated From Patients With Invasive Disease and Contaminated Samples in a Comprehensive Cancer Center. Open Forum Infect Dis. 2024 Oct.11(10):ofae580. Pubmedid: 39450394. Pmcid: PMC11500449.
• Van Norden M, Falls Z, Mandloi S, Segal BH, Baysal BE, Samudrala R, Elkin PL. The implications of APOBEC3-mediated C-to-U RNA editing for human disease. Commun Biol. 2024 May.7(1):529. Pubmedid: 38704509. Pmcid: PMC11069577.
• Holling GA, Chavel CA, Sharda AP, Lieberman MM, James CM, Lightman SM, Tong JH, Qiao G, Emmons TR, Giridharan T, Hou S, Intlekofer AM, Higashi RM, Fan TWM, Lane AN, Eng KH, Segal BH, Repasky EA, Lee KP, Olejniczak SH. CD8+ T cell metabolic flexibility elicited by CD28-ARS2 axis-driven alternative splicing of PKM supports antitumor immunity. Cell Mol Immunol. 2024 Mar.21(3):260-274. Pubmedid: 38233562. Pmcid: PMC10902291.
• Rosario SR, Long MD, Chilakapati S, Gomez EC, Battaglia S, Singh PK, Wang J, Wang K, Attwood K, Hess SM, McGray AJR, Odunsi K, Segal BH, Paragh G, Liu S, Wargo JA, Zsiros E. Integrative multi-omics analysis uncovers tumor-immune-gut axis influencing immunotherapy outcomes in ovarian cancer. Nat Commun. 2024 Dec.15(1):10609. Pubmedid: 39638782. Pmcid: PMC11621351.
• Abdelfatah E, Long MD, Kajihara R, Oba T, Yamauchi T, Chen H, Sarkar J, Attwood K, Matsuzaki J, Segal BH, Dy GK, Ito F. Predictive and Prognostic Implications of Circulating CX3CR1+ CD8+ T Cells in Non-Small Cell Lung Cancer Patients Treated with Chemo-Immunotherapy. Cancer Res Commun. 2023 Mar.3(3):510-520. Pubmedid: 37009132. Pmcid: PMC10060186.
• Segal BH, Giridharan T, Suzuki S, Khan ANH, Zsiros E, Emmons TR, Yaffe MB, Gankema AAF, Hoogeboom M, Goetschalckx I, Matlung HL, Kuijpers TW. Neutrophil interactions with T cells, platelets, endothelial cells, and of course tumor cells. Immunol Rev. 2023 Mar.314(1):13-35. Pubmedid: 36527200. Pmcid: PMC10174640.
• Sarkar J, Cortes Gomez E, Oba T, Chen H, Dy GK, Segal BH, Ernstoff MS, Ito F. Fluctuations in Gut Microbiome Composition During Immune Checkpoint Inhibitor Therapy. World J Oncol. 2023 Jun.14(3):178-187. Pubmedid: 37350807. Pmcid: PMC10284636.
• Ascierto PA, Avallone A, Bifulco C, Bracarda S, Brody JD, Emens LA, Ferris RL, Formenti SC, Hamid O, Johnson DB, Kirchhoff T, Klebanoff CA, Lesinski GB, Monette A, Neyns B, Odunsi K, Paulos CM, Powell DJ, Rezvani K, Segal BH, Singh N, Sullivan RJ, Fox BA, Puzanov I. Perspectives in Immunotherapy: meeting report from Immunotherapy Bridge (Naples, November 30th-December 1st, 2022). J Transl Med. 2023 Jul.21(1):488. Pubmedid: 37475035. Pmcid: PMC10360352.
• Van Norden M, Falls Z, Mandloi S, Segal B, Baysal B, Samudrala R, Elkin PL. The Role of C-to-U RNA Editing in Human Biodiversity. bioRxiv. 2023 Jul. Pubmedid: 37577456. Pmcid: PMC10418052.
• Mehta N, Harrington JM, Wallace MA, Wasiura JM, Burnham CD, Mullin KM, Segal BH, Almyroudis NG. Molecular epidemiology of Clostridioides difficile isolates in a non-outbreak setting at a comprehensive cancer center. Antimicrob Steward Healthc Epidemiol. 2023 Jul.3(1):e131. Pubmedid: 37592971. Pmcid: PMC10428153.
• Mark J, Fisher DT, Kim M, Emmons T, Khan ANMN, Alqassim E, Singel K, Mistarz A, Lugade A, Zhan H, Yu H, Segal B, Lele S, Frederick P, Kozbor D, Skitzki J, Odunsi K. Carboplatin enhances lymphocyte-endothelial interactions to promote CD8+ T cell trafficking into the ovarian tumor microenvironment. Gynecol Oncol. 2023 Jan.168:92-99. Pubmedid: 36410228. Pmcid: PMC11236086.
• Zsiros E, Ricciuti J, Gallo S, Argentieri D, Attwood K, Ji W, Hutson A, Visco P, Coffey D, Riebandt G, Mark J, Varghese A, Hess SM, Furlani T, Fabiano A, Hennon M, Yendamuri S, Kauffman EC, Wooten KE, Hicks WL, Young J, Takabe K, Odunsi K, Case AA, Segal BH, Johnson CS, Kuvshinoff B, Nurkin S, Paragh G, de Leon-Casasola O. Postoperative Restrictive Opioid Protocols and Durable Changes in Opioid Prescribing and Chronic Opioid Use. JAMA Oncol. 2023 Feb.9(2):234-241. Pubmedid: 36602807. Pmcid: PMC9857779.
• Chen G, Herr M, Nowak J, Ho C, Almyroudis N, Attwood K, Bonnewell J, Walsh M, Segal B, Ross M, McCarthy P, Hahn T. Cytomegalovirus reactivation after CD19 CAR T-cell therapy is clinically significant. Haematologica. 2023 Feb.108(2):615-620. Pubmedid: 36263844. Pmcid: PMC9890024.
• Goretti Riça I, Joughin BA, Teke ME, Emmons TR, Griffith AM, Cahill LA, Banner-Goodspeed VM, Robson SC, Hernandez JM, Segal BH, Otterbein LE, Hauser CJ, Lederer JA, Yaffe MB. Neutrophil heterogeneity and emergence of a distinct population of CD11b/CD18-activated low-density neutrophils after trauma. J Trauma Acute Care Surg. 2023 Feb.94(2):187-196. Pubmedid: 36694330. Pmcid: PMC9881754.
• Khan ANH, Emmons TR, Magner WJ, Alqassim E, Singel KL, Ricciuti J, Eng KH, Odunsi K, Tomasi TB, Lee K, Abrams SI, Mesa C, Segal BH. VSSP abrogates murine ovarian tumor-associated myeloid cell-driven immune suppression and induces M1 polarization in tumor-associated macrophages from ovarian cancer patients. Cancer Immunol Immun. 2022 Oct.71(10):2355-2369. Pubmedid: 35166871. Pmcid: PMC10591410.
• Alam A, Levanduski E, Denz P, Villavicencio HS, Bhatta M, Alhorebi L, Zhang Y, Gomez EC, Morreale B, Senchanthisai S, Li J, Turowski SG, Sexton S, Sait SJ, Singh PK, Wang J, Maitra A, Kalinski P, DePinho RA, Wang H, Liao W, Abrams SI, Segal BH, Dey P. Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer. Cancer Cell. 2022 Feb.40(2):153-167.e11. Pubmedid: 35120601. Pmcid: PMC8847236.
• Segal BH, Fridlender Z. Editorial: Neutrophils in Cancer. Front Immunol. 2022 Feb.13:862257. Pubmedid: 35251054. Pmcid: PMC8894315.
• Ghione P, Gu JJ, Attwood K, Torka P, Goel S, Sundaram S, Mavis C, Johnson M, Thomas R, McWhite K, Darrall A, DeMarco J, Kostrewa J, Mohr A, Rivas L, Neiders M, Suresh L, Segal BH, Griffiths EA, Ramsperger V, Shen L, Hernandez-Ilizaliturri FJ. Impaired humoral responses to COVID-19 vaccination in patients with lymphoma receiving B-cell-directed therapies. Blood. 2021 Sep.138(9):811-814. Pubmedid: 34189565. Pmcid: PMC8245303.
• Yamauchi T, Hoki T, Oba T, Jain V, Chen H, Attwood K, Battaglia S, George S, Chatta G, Puzanov I, Morrison C, Odunsi K, Segal BH, Dy GK, Ernstoff MS, Ito F. T-cell CX3CR1 expression as a dynamic blood-based biomarker of response to immune checkpoint inhibitors. Nat Commun. 2021 Mar.12(1):1402. Pubmedid: 33658501. Pmcid: PMC7930182.
• Emmons TR, Giridharan T, Singel KL, Khan ANH, Ricciuti J, Howard K, Silva-Del Toro SL, Debreceni IL, Aarts CEM, Brouwer MC, Suzuki S, Kuijpers TW, Jongerius I, Allen LH, Ferreira VP, Schubart A, Sellner H, Eder J, Holland SM, Ram S, Lederer JA, Eng KH, Moysich KB, Odunsi K, Yaffe MB, Zsiros E, Segal BH. Mechanisms Driving Neutrophil-Induced T-cell Immunoparalysis in Ovarian Cancer. Cancer Immunol Res. 2021 Jul.9(7):790-810. Pubmedid: 33990375. Pmcid: PMC8287091.
• Alqassim EY, Sharma S, Khan ANMNH, Emmons TR, Cortes Gomez E, Alahmari A, Singel KL, Mark J, Davidson BA, Robert McGray AJ, Liu Q, Lichty BD, Moysich KB, Wang J, Odunsi K, Segal BH, Baysal BE. RNA editing enzyme APOBEC3A promotes pro-inflammatory M1 macrophage polarization. Commun Biol. 2021 Jan.4(1):102. Pubmedid: 33483601. Pmcid: PMC7822933.
• Aldhaam NA, Hussein AA, Elsayed AS, Jing Z, Osei J, Kurbiel Z, Babar T, Khan S, Nagra A, Segal B, Li Q, Guru KA. Detailed Analysis of Urinary Tract Infections After Robot-Assisted Radical Cystectomy. J Endourol. 2021 Jan.35(1):62-70. Pubmedid: 32664741.
• McGray AJR, Eppolito C, Miliotto A, Singel KL, Stephenson K, Lugade A, Segal BH, Keler T, Webster G, Lichty B, Kozbor D, Odunsi K. A prime/boost vaccine platform efficiently identifies CD27 agonism and depletion of myeloid-derived suppressor cells as therapies that rationally combine with checkpoint blockade in ovarian cancer. Cancer Immunol Immun. 2021 Dec.70(12):3451-3460. Pubmedid: 33880648. Pmcid: PMC8057655.
• Zhang N, Kim SH, Gainullina A, Erlich EC, Onufer EJ, Kim J, Czepielewski RS, Helmink BA, Dominguez JR, Saunders BT, Ding J, Williams JW, Jiang JX, Segal BH, Zinselmeyer BH, Randolph GJ, Kim KW. LYVE1+ macrophages of murine peritoneal mesothelium promote omentum-independent ovarian tumor growth. J Exp Med. 2021 Dec.218(12). Pubmedid: 34714329. Pmcid: PMC8575007.
• Griffiths EA, Segal BH. Immune responses to COVID-19 vaccines in patients with cancer: Promising results and a note of caution. Cancer Cell. 2021 Aug.39(8):1045-1047. Pubmedid: 34242573. Pmcid: PMC8253695.
• Chen GL, Wallace PK, Zhang Y, Tario JD, Przespolewski AC, Becker J, Almyroudis NG, Ross M, Riches M, Segal BH, Brix L, McCarthy PL, Hahn T. Low-Level Cytomegalovirus Antigenemia Promotes Protective Cytomegalovirus Antigen-Specific T Cells after Allogeneic Hematopoietic Cell Transplantation. Biol Blood Marrow Tr. 2020 Nov.26(11):2147-2154. Pubmedid: 32721522. Pmcid: PMC7609607.
• Lehman HK, Segal BH. The role of neutrophils in host defense and disease. J Allergy Clin Immun. 2020 Jun.145(6):1535-1544. Pubmedid: 32283205. Pmcid: PMC8912989.
• Khan ANH, Emmons TR, Wong JT, Alqassim E, Singel KL, Mark J, Smith BE, Tario JD, Eng KH, Moysich KB, Odunsi K, Abrams SI, Segal BH. Quantification of Early-Stage Myeloid-Derived Suppressor Cells in Cancer Requires Excluding Basophils. Cancer Immunol Res. 2020 Jun.8(6):819-828. Pubmedid: 32238380. Pmcid: PMC7269807.
• Santo BA, Segal BH, Tomaszewski JE, Mohammad I, Worral AM, Jain S, Visser MB, Sarder P. Neutrophil Extracellular Traps (NETs): An unexplored territory in renal pathobiology, a pilot computational study. Proc SPIE Int Soc Opt Eng. 2020 Feb.11320. Pubmedid: 32377029. Pmcid: PMC7202573.
• Singel KL, Emmons TR, Khan ANH, Mayor PC, Shen S, Wong JT, Morrell K, Eng KH, Mark J, Bankert RB, Matsuzaki J, Koya RC, Blom AM, McLeish KR, Qu J, Ram S, Moysich KB, Abrams SI, Odunsi K, Zsiros E, Segal BH. Mature neutrophils suppress T cell immunity in ovarian cancer microenvironment. JCI Insight. 2019 Mar.4(5). Pubmedid: 30730851. Pmcid: PMC6483507.
• Singel KL, Grzankowski KS, Khan ANMNH, Grimm MJ, D'Auria AC, Morrell K, Eng KH, Hylander B, Mayor PC, Emmons TR, Lénárt N, Fekete R, Környei Z, Muthukrishnan U, Gilthorpe JD, Urban CF, Itagaki K, Hauser CJ, Leifer C, Moysich KB, Odunsi K, Dénes Á, Segal BH. Mitochondrial DNA in the tumour microenvironment activates neutrophils and is associated with worse outcomes in patients with advanced epithelial ovarian cancer. Brit J Cancer. 2019 Jan.120(2):207-217. Pubmedid: 30518816. Pmcid: PMC6342981.
• Sharma S, Wang J, Alqassim E, Portwood S, Cortes Gomez E, Maguire O, Basse PH, Wang ES, Segal BH, Baysal BE. Mitochondrial hypoxic stress induces widespread RNA editing by APOBEC3G in natural killer cells. Genome Biol. 2019 Feb.20(1):37. Pubmedid: 30791937. Pmcid: PMC6383285.
• Wasiura J, Segal BH, Mullin KM. Cluster of Sphingomonas paucimobilis Bacteremias Linked to Diversion of Intravenous Hydromorphone. N Engl J Med. 2019 Aug.381(6):584-585. Pubmedid: 31390506.
• Mayor PC, Eng KH, Singel KL, Abrams SI, Odunsi K, Moysich KB, Fuleihan R, Garabedian E, Lugar P, Ochs HD, Bonilla FA, Buckley RH, Sullivan KE, Ballas ZK, Cunningham-Rundles C, Segal BH. Cancer in primary immunodeficiency diseases: Cancer incidence in the United States Immune Deficiency Network Registry. J Allergy Clin Immun. 2018 Mar.141(3):1028-1035. Pubmedid: 28606585. Pmcid: PMC5723251.
• Andermann TM, Peled JU, Ho C, Reddy P, Riches M, Storb R, Teshima T, van den Brink MRM, Alousi A, Balderman S, Chiusolo P, Clark WB, Holler E, Howard A, Kean LS, Koh AY, McCarthy PL, McCarty JM, Mohty M, Nakamura R, Rezvani K, Segal BH, Shaw BE, Shpall EJ, Sung AD, Weber D, Whangbo J, Wingard JR, Wood WA, Perales MA, Jenq RR, Bhatt AS. The Microbiome and Hematopoietic Cell Transplantation: Past, Present, and Future. Biol Blood Marrow Tr. 2018 Jul.24(7):1322-1340. Pubmedid: 29471034. Pmcid: PMC6045977.
• Minlikeeva AN, Moysich KB, Mayor PC, Etter JL, Cannioto RA, Ness RB, Starbuck K, Edwards RP, Segal BH, Lele S, Odunsi K, Diergaarde B, Modugno F. Anthropometric characteristics and ovarian cancer risk and survival. Cancer Causes Control. 2018 Feb.29(2):201-212. Pubmedid: 29327114. Pmcid: PMC5796836.
• Evans R, Reid M, Segal B, Abrams SI, Lee K. Case Study in International Cooperation: Cuba's Molecular Immunology Center and Roswell Park Cancer Institute. MEDICC Rev. 2018 Apr.20(2):35-39. Pubmedid: 29773775.
• Minlikeeva AN, Freudenheim JL, Eng KH, Cannioto RA, Friel G, Szender JB, Segal B, Odunsi K, Mayor P, Diergaarde B, Zsiros E, Kelemen LE, Köbel M, Steed H, deFazio A, Jordan SJ, Fasching PA, Beckmann MW, Risch HA, Rossing MA, Doherty JA, Chang-Claude J, Goodman MT, Dörk T, Edwards R, Modugno F, Ness RB, Matsuo K, Mizuno M, Karlan BY, Goode EL, Kjær SK, Høgdall E, Schildkraut JM, Terry KL, Cramer DW, Bandera EV, Paddock LE, Kiemeney LA, Massuger LFAG, Sutphen R, Anton-Culver H, Ziogas A, Menon U, Gayther SA, Ramus SJ, Gentry-Maharaj A, Pearce CL, Wu AH, Kupryjanczyk J, Jensen A, Webb PM, Moysich KB. History of Comorbidities and Survival of Ovarian Cancer Patients, Results from the Ovarian Cancer Association Consortium. Cancer Epidemiol Biomarkers Prev. 2017 Sep.26(9):1470-1473. Pubmedid: 28864456. Pmcid: PMC5649363.
• Szender JB, Emmons T, Belliotti S, Dickson D, Khan A, Morrell K, Khan ANMN, Singel KL, Mayor PC, Moysich KB, Odunsi K, Segal BH, Eng KH. Impact of ascites volume on clinical outcomes in ovarian cancer: A cohort study. Gynecol Oncol. 2017 Sep.146(3):491-497. Pubmedid: 28624153. Pmcid: PMC5568462.
• Minlikeeva AN, Freudenheim JL, Cannioto RA, Eng KH, Szender JB, Mayor P, Etter JL, Cramer DW, Diergaarde B, Doherty JA, Dörk T, Edwards R, deFazio A, Friel G, Goodman MT, Hillemanns P, Høgdall E, Jensen A, Jordan SJ, Karlan BY, Kjær SK, Klapdor R, Matsuo K, Mizuno M, Nagle CM, Odunsi K, Paddock L, Rossing MA, Schildkraut JM, Schmalfeldt B, Segal BH, Starbuck K, Terry KL, Webb PM, Zsiros E, Ness RB, Modugno F, Bandera EV, Chang-Claude J, Moysich KB. History of thyroid disease and survival of ovarian cancer patients: results from the Ovarian Cancer Association Consortium, a brief report. Brit J Cancer. 2017 Sep.117(7):1063-1069. Pubmedid: 28817835. Pmcid: PMC5625672.
• Minlikeeva AN, Freudenheim JL, Cannioto RA, Szender JB, Eng KH, Modugno F, Ness RB, LaMonte MJ, Friel G, Segal BH, Odunsi K, Mayor P, Zsiros E, Schmalfeldt B, Klapdor R, Dӧrk T, Hillemanns P, Kelemen LE, Kӧbel M, Steed H, de Fazio A, Jordan SJ, Nagle CM, Risch HA, Rossing MA, Doherty JA, Goodman MT, Edwards R, Matsuo K, Mizuno M, Karlan BY, Kjær SK, Høgdall E, Jensen A, Schildkraut JM, Terry KL, Cramer DW, Bandera EV, Paddock LE, Kiemeney LA, Massuger LF, Kupryjanczyk J, Berchuck A, Chang-Claude J, Diergaarde B, Webb PM, Moysich KB. History of hypertension, heart disease, and diabetes and ovarian cancer patient survival: evidence from the ovarian cancer association consortium. Cancer Causes Control. 2017 May.28(5):469-486. Pubmedid: 28293802. Pmcid: PMC5500209.
• Sucheston-Campbell LE, Cannioto R, Clay AI, Etter JL, Eng KH, Liu S, Battaglia S, Hu Q, Szender JB, Minlikeeva A, Joseph JM, Mayor P, Abrams SI, Segal BH, Wallace PK, Soh KT, Zsiros E, Anton-Culver H, Bandera EV, Beckmann MW, Berchuck A, Bjorge L, Bruegl A, Campbell IG, Campbell SP, Chenevix-Trench G, Cramer DW, Dansonka-Mieszkowska A, Dao F, Diergaarde B, Doerk T, Doherty JA, du Bois A, Eccles D, Engelholm SA, Fasching PA, Gayther SA, Gentry-Maharaj A, Glasspool RM, Goodman MT, Gronwald J, Harter P, Hein A, Heitz F, Hillemmanns P, Høgdall C, Høgdall EV, Huzarski T, Jensen A, Johnatty SE, Jung A, Karlan BY, Klapdor R, Kluz T, Konopka B, Kjær SK, Kupryjanczyk J, Lambrechts D, Lester J, Lubiński J, Levine DA, Lundvall L, McGuire V, McNeish IA, Menon U, Modugno F, Ness RB, Orsulic S, Paul J, Pearce CL, Pejovic T, Pharoah P, Ramus SJ, Rothstein J, Rossing MA, Rübner M, Schildkraut JM, Schmalfeldt B, Schwaab I, Siddiqui N, Sieh W, Sobiczewski P, Song H, Terry KL, Van Nieuwenhuysen E, Vanderstichele A, Vergote I, Walsh CS, Webb PM, Wentzensen N, Whittemore AS, Wu AH, Ziogas A, Odunsi K, Chang-Claude J, Goode EL, Moysich KB. No Evidence That Genetic Variation in the Myeloid-Derived Suppressor Cell Pathway Influences Ovarian Cancer Survival. Cancer Epidemiol Biomarkers Prev. 2017 Mar.26(3):420-424. Pubmedid: 27677730. Pmcid: PMC5500198.
• Ginley BG, Emmons T, Lutnick B, Urban CF, Segal BH, Sarder P. Computational detection and quantification of human and mouse neutrophil extracellular traps in flow cytometry and confocal microscopy. Sci Rep. 2017 Dec.7(1):17755. Pubmedid: 29259241. Pmcid: PMC5736696.
• Singel KL, Segal BH. Neutrophils in the tumor microenvironment: trying to heal the wound that cannot heal. Immunol Rev. 2016 Sep.273(1):329-343. Pubmedid: 27558344. Pmcid: PMC5477672.
• Hosseinzadeh A, Thompson PR, Segal BH, Urban CF. Nicotine induces neutrophil extracellular traps. J Leukoc Biol. 2016 Nov.100(5):1105-1112. Pubmedid: 27312847. Pmcid: PMC5069087.
• Cannioto RA, LaMonte MJ, Kelemen LE, Risch HA, Eng KH, Minlikeeva AN, Hong CC, Szender JB, Sucheston-Campbell L, Joseph JM, Berchuck A, Chang-Claude J, Cramer DW, DeFazio A, Diergaarde B, Dörk T, Doherty JA, Edwards RP, Fridley BL, Friel G, Goode EL, Goodman MT, Hillemanns P, Hogdall E, Hosono S, Kelley JL, Kjaer SK, Klapdor R, Matsuo K, Odunsi K, Nagle CM, Olsen CM, Paddock LE, Pearce CL, Pike MC, Rossing MA, Schmalfeldt B, Segal BH, Szamreta EA, Thompson PJ, Tseng CC, Vierkant R, Schildkraut JM, Wentzensen N, Wicklund KG, Winham SJ, Wu AH, Modugno F, Ness RB, Jensen A, Webb PM, Terry K, Bandera EV, Moysich KB. Recreational physical inactivity and mortality in women with invasive epithelial ovarian cancer: evidence from the Ovarian Cancer Association Consortium. Brit J Cancer. 2016 Jun.115(1):95-101. Pubmedid: 27299959. Pmcid: PMC4931371.
• Baden LR, Swaminathan S, Angarone M, Blouin G, Camins BC, Casper C, Cooper B, Dubberke ER, Engemann AM, Freifeld AG, Greene JN, Ito JI, Kaul DR, Lustberg ME, Montoya JG, Rolston K, Satyanarayana G, Segal B, Seo SK, Shoham S, Taplitz R, Topal J, Wilson JW, Hoffmann KG, Smith C. Prevention and Treatment of Cancer-Related Infections, Version 2.2016, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Ne. 2016 Jul.14(7):882-913. Pubmedid: 27407129.
• Patterson TF, Thompson GR, Denning DW, Fishman JA, Hadley S, Herbrecht R, Kontoyiannis DP, Marr KA, Morrison VA, Nguyen MH, Segal BH, Steinbach WJ, Stevens DA, Walsh TJ, Wingard JR, Young JA, Bennett JE. Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2016 Aug.63(4):e1-e60. Pubmedid: 27365388. Pmcid: PMC4967602.
• Patterson TF, Thompson GR, Denning DW, Fishman JA, Hadley S, Herbrecht R, Kontoyiannis DP, Marr KA, Morrison VA, Nguyen MH, Segal BH, Steinbach WJ, Stevens DA, Walsh TJ, Wingard JR, Young JA, Bennett JE. Executive Summary: Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2016 Aug.63(4):433-442. Pubmedid: 27481947. Pmcid: PMC4967611.
• Almyroudis NG, Osawa R, Samonis G, Wetzler M, Wang ES, McCarthy PL, Segal BH. Discontinuation of Systematic Surveillance and Contact Precautions for Vancomycin-Resistant Enterococcus (VRE) and Its Impact on the Incidence of VRE faecium Bacteremia in Patients with Hematologic Malignancies. Infect Cont Hosp Ep. 2016 Apr.37(4):398-403. Pubmedid: 26750087.
• Singel KL, Segal BH. NOX2-dependent regulation of inflammation. Clin Sci (Lond). 2016 Apr.130(7):479-490. Pubmedid: 26888560. Pmcid: PMC5513728.
• Mont S, Davies SS, Roberts Second LJ, Mernaugh RL, McDonald WH, Segal BH, Zackert W, Kropski JA, Blackwell TS, Sekhar KR, Galligan JJ, Massion PP, Marnett LJ, Travis EL, Freeman ML. Accumulation of isolevuglandin-modified protein in normal and fibrotic lung. Sci Rep. 2016 Apr.6:24919. Pubmedid: 27118599. Pmcid: PMC4847119.
• Khan AN, Kolomeyevskaya N, Singel KL, Grimm MJ, Moysich KB, Daudi S, Grzankowski KS, Lele S, Ylagan L, Webster GA, Abrams SI, Odunsi K, Segal BH. Targeting myeloid cells in the tumor microenvironment enhances vaccine efficacy in murine epithelial ovarian cancer. Oncotarget. 2015 May.6(13):11310-11326. Pubmedid: 25888637. Pmcid: PMC4484458.
• Itagaki K, Kaczmarek E, Lee YT, Tang IT, Isal B, Adibnia Y, Sandler N, Grimm MJ, Segal BH, Otterbein LE, Hauser CJ. Mitochondrial DNA released by trauma induces neutrophil extracellular traps. PLoS One. 2015 Mar.10(3):e0120549. Pubmedid: 25774524. Pmcid: PMC4361684.
• Kolomeyevskaya N, Eng KH, Khan AN, Grzankowski KS, Singel KL, Moysich K, Segal BH. Cytokine profiling of ascites at primary surgery identifies an interaction of tumor necrosis factor-α and interleukin-6 in predicting reduced progression-free survival in epithelial ovarian cancer. Gynecol Oncol. 2015 Aug.138(2):352-357. Pubmedid: 26001328. Pmcid: PMC4522366.
• Li H, Han W, Polosukhin V, Yull FE, Segal BH, Xie CM, Blackwell TS. NF-κB inhibition after cecal ligation and puncture reduces sepsis-associated lung injury without altering bacterial host defense. Mediators Inflamm. 2014 Oct.2013:503213. Pubmedid: 24347827. Pmcid: PMC3852536.
• Röhm M, Grimm MJ, D'Auria AC, Almyroudis NG, Segal BH, Urban CF. NADPH oxidase promotes neutrophil extracellular trap formation in pulmonary aspergillosis. Infect Immun. 2014 May.82(5):1766-1777. Pubmedid: 24549323. Pmcid: PMC3993456.
• Zucker SN, Fink EE, Bagati A, Mannava S, Bianchi-Smiraglia A, Bogner PN, Wawrzyniak JA, Foley C, Leonova KI, Grimm MJ, Moparthy K, Ionov Y, Wang J, Liu S, Sexton S, Kandel ES, Bakin AV, Zhang Y, Kaminski N, Segal BH, Nikiforov MA. Nrf2 amplifies oxidative stress via induction of Klf9. Mol Cell. 2014 Mar.53(6):916-928. Pubmedid: 24613345. Pmcid: PMC4049522.
• Kaloriti D, Jacobsen M, Yin Z, Patterson M, Tillmann A, Smith DA, Cook E, You T, Grimm MJ, Bohovych I, Grebogi C, Segal BH, Gow NA, Haynes K, Quinn J, Brown AJ. Mechanisms underlying the exquisite sensitivity of Candida albicans to combinatorial cationic and oxidative stress that enhances the potent fungicidal activity of phagocytes. MBio. 2014 Jul.5(4):e01334-e01314. Pubmedid: 25028425. Pmcid: PMC4161263.
• Grimm MJ, D'Auria AC, Segal BH. Assessing anti-fungal activity of isolated alveolar macrophages by confocal microscopy. J Vis Exp. 2014 Jul.(89). Pubmedid: 25045941. Pmcid: PMC4214184.
• Pomakova D, Segal BH. Prevention of infection in cancer patients. Cancer Treat Res. 2014 Jan.161:485-511. Pubmedid: 24706235.
• Tam JM, Mansour MK, Khan NS, Seward M, Puranam S, Tanne A, Sokolovska A, Becker CE, Acharya M, Baird MA, Choi AM, Davidson MW, Segal BH, Lacy-Hulbert A, Stuart LM, Xavier RJ, Vyas JM. Dectin-1-dependent LC3 recruitment to phagosomes enhances fungicidal activity in macrophages. J Infect Dis. 2014 Dec.210(11):1844-1854. Pubmedid: 24842831. Pmcid: PMC4271056.
• Godoy HE, Khan AN, Vethanayagam RR, Grimm MJ, Singel KL, Kolomeyevskaya N, Sexton KJ, Parameswaran A, Abrams SI, Odunsi K, Segal BH. Myeloid-derived suppressor cells modulate immune responses independently of NADPH oxidase in the ovarian tumor microenvironment in mice. PLoS One. 2014 Apr.8(7):e69631. Pubmedid: 23922763. Pmcid: PMC3724928.
• Han W, Li H, Cai J, Gleaves LA, Polosukhin VV, Segal BH, Yull FE, Blackwell TS. NADPH oxidase limits lipopolysaccharide-induced lung inflammation and injury in mice through reduction-oxidation regulation of NF-κB activity. J Immunol. 2013 May.190(9):4786-4794. Pubmedid: 23530143. Pmcid: PMC3633681.
• Almyroudis NG, Grimm MJ, Davidson BA, Röhm M, Urban CF, Segal BH. NETosis and NADPH oxidase: at the intersection of host defense, inflammation, and injury. Front Immunol. 2013 Mar.4:45. Pubmedid: 23459634. Pmcid: PMC3585429.
• Banik D, Khan AN, Walseng E, Segal BH, Abrams SI. Interferon regulatory factor-8 is important for histone deacetylase inhibitor-mediated antitumor activity. PLoS One. 2013 Feb.7(9):e45422. Pubmedid: 23028998. Pmcid: PMC3446900.
• Davidson BA, Vethanayagam RR, Grimm MJ, Mullan BA, Raghavendran K, Blackwell TS, Freeman ML, Ayyasamy V, Singh KK, Sporn MB, Itagaki K, Hauser CJ, Knight PR, Segal BH. NADPH oxidase and Nrf2 regulate gastric aspiration-induced inflammation and acute lung injury. J Immunol. 2013 Feb.190(4):1714-1724. Pubmedid: 23296708. Pmcid: PMC3563868.
• Zaynagetdinov R, Sherrill TP, Kendall PL, Segal BH, Weller KP, Tighe RM, Blackwell TS. Identification of myeloid cell subsets in murine lungs using flow cytometry. Am J Respir Cell Mol Biol. 2013 Aug.49(2):180-189. Pubmedid: 23492192. Pmcid: PMC3824033.
• Grimm MJ, Vethanayagam RR, Almyroudis NG, Dennis CG, Khan AN, D'Auria AC, Singel KL, Davidson BA, Knight PR, Blackwell TS, Hohl TM, Mansour MK, Vyas JM, Röhm M, Urban CF, Kelkka T, Holmdahl R, Segal BH. Monocyte- and macrophage-targeted NADPH oxidase mediates antifungal host defense and regulation of acute inflammation in mice. J Immunol. 2013 Apr.190(8):4175-4184. Pubmedid: 23509361. Pmcid: PMC3622122.
• Capitano ML, Nemeth MJ, Mace TA, Salisbury-Ruf C, Segal BH, McCarthy PL, Repasky EA. Elevating body temperature enhances hematopoiesis and neutrophil recovery after total body irradiation in an IL-1-, IL-17-, and G-CSF-dependent manner. Blood. 2012 Sep.120(13):2600-2609. Pubmedid: 22806894. Pmcid: PMC3460682.
• Han W, Li H, Segal BH, Blackwell TS. Bioluminescence imaging of NADPH oxidase activity in different animal models. J Vis Exp. 2012 Oct.(68). Pubmedid: 23117583. Pmcid: PMC3490291.
• Baden LR, Bensinger W, Angarone M, Casper C, Dubberke ER, Freifeld AG, Garzon R, Greene JN, Greer JP, Ito JI, Karp JE, Kaul DR, King E, Mackler E, Marr KA, Montoya JG, Morris-Engemann A, Pappas PG, Rolston K, Segal B, Seo SK, Swaminathan S, Naganuma M, Shead DA. Prevention and treatment of cancer-related infections. J Natl Compr Canc Ne. 2012 Nov.10(11):1412-1445. Pubmedid: 23138169.
• Pizzolla A, Hultqvist M, Nilson B, Grimm MJ, Eneljung T, Jonsson IM, Verdrengh M, Kelkka T, Gjertsson I, Segal BH, Holmdahl R. Reactive oxygen species produced by the NADPH oxidase 2 complex in monocytes protect mice from bacterial infections. J Immunol. 2012 May.188(10):5003-5011. Pubmedid: 22491245. Pmcid: PMC3566649.
• Jarkowski A, Forrest A, Sweeney RP, Tan W, Segal BH, Almyroudis N, Wang ES, Wetzler M. Characterization of vancomycin pharmacokinetics in the adult acute myeloid leukemia population. J Oncol Pharm Pract. 2012 Mar.18(1):91-96. Pubmedid: 21521799.
• Vethanayagam RR, Almyroudis NG, Grimm MJ, Lewandowski DC, Pham CT, Blackwell TS, Petraitiene R, Petraitis V, Walsh TJ, Urban CF, Segal BH. Role of NADPH oxidase versus neutrophil proteases in antimicrobial host defense. PLoS One. 2012 Jul.6(12):e28149. Pubmedid: 22163282. Pmcid: PMC3233573.
• Segal BH, Grimm MJ, Khan AN, Han W, Blackwell TS. Regulation of innate immunity by NADPH oxidase. Free Radical Bio Med. 2012 Jul.53(1):72-80. Pubmedid: 22583699. Pmcid: PMC3377837.
• Jhingran A, Mar KB, Kumasaka DK, Knoblaugh SE, Ngo LY, Segal BH, Iwakura Y, Lowell CA, Hamerman JA, Lin X, Hohl TM. Tracing conidial fate and measuring host cell antifungal activity using a reporter of microbial viability in the lung. Cell Rep. 2012 Dec.2(6):1762-1773. Pubmedid: 23200858. Pmcid: PMC3712646.
• Lugade AA, Vethanayagam RR, Nasirikenari M, Bogner PN, Segal BH, Thanavala Y. Nrf2 regulates chronic lung inflammation and B-cell responses to nontypeable Haemophilus influenzae. Am J Respir Cell Mol Biol. 2011 Sep.45(3):557-565. Pubmedid: 21216970. Pmcid: PMC3175582.
• Rahman M, Segal BH. Thematic issue: immunity, inflammation and fungal infections. Immunol Invest. 2011 Oct.40(7-8):670-675. Pubmedid: 21985300.
• Almyroudis NG, Lesse AJ, Hahn T, Samonis G, Hazamy PA, Wongkittiroch K, Wang ES, McCarthy PL, Wetzler M, Segal BH. Molecular epidemiology and risk factors for colonization by vancomycin-resistant Enterococcus in patients with hematologic malignancies. Infect Cont Hosp Ep. 2011 May.32(5):490-496. Pubmedid: 21515980.
• Segal BH, Veys P, Malech H, Cowan MJ. Chronic granulomatous disease: lessons from a rare disorder. Biol Blood Marrow Tr. 2011 Jan.17(1 Suppl):S123-S131. Pubmedid: 21195301. Pmcid: PMC3052948.
• Almyroudis NG, Segal BH. Transmission of resistant bacteria in intensive care. N Engl J Med. 2011 Aug.365(8):762-763. Pubmedid: 21864175.
• Grimm MJ, Vethanayagam RR, Almyroudis NG, Lewandowski D, Rall N, Blackwell TS, Segal BH. Role of NADPH oxidase in host defense against aspergillosis. Med Mycol. 2011 Apr.49 Suppl 1(Suppl 1):S144-S149. Pubmedid: 20560866. Pmcid: PMC5494985.
• Segal BH, Cornely O, Bromley M. Proceedings from the 4th Advances Against Aspergillosis Conference, February 4-6, 2010, Rome, Italy. Med Mycol. 2011 Apr.49 Suppl 1:S5-176. Pubmedid: 21108577.
• Sherif R, Segal BH. Pulmonary aspergillosis: clinical presentation, diagnostic tests, management and complications. Curr Opin Pulm Med. 2010 May.16(3):242-250. Pubmedid: 20375786. Pmcid: PMC3326383.
• Segal BH, Han W, Bushey JJ, Joo M, Bhatti Z, Feminella J, Dennis CG, Vethanayagam RR, Yull FE, Capitano M, Wallace PK, Minderman H, Christman JW, Sporn MB, Chan J, Vinh DC, Holland SM, Romani LR, Gaffen SL, Freeman ML, Blackwell TS. NADPH oxidase limits innate immune responses in the lungs in mice. PLoS One. 2010 Mar.5(3):e9631. Pubmedid: 20300512. Pmcid: PMC2838778.
• Nasirikenari M, Chandrasekaran EV, Matta KL, Segal BH, Bogner PN, Lugade AA, Thanavala Y, Lee JJ, Lau JT. Altered eosinophil profile in mice with ST6Gal-1 deficiency: an additional role for ST6Gal-1 generated by the P1 promoter in regulating allergic inflammation. J Leukoc Biol. 2010 Mar.87(3):457-466. Pubmedid: 20007243. Pmcid: PMC2830128.
• Almyroudis NG, Segal BH. Antifungal prophylaxis and therapy in patients with hematological malignancies and hematopoietic stem cell transplant recipients. Expert Rev Anti Infect Ther. 2010 Dec.8(12):1451-1466. Pubmedid: 21133669.
• Marr KA, Bow E, Chiller T, Maschmeyer G, Ribaud P, Segal B, Steinbach W, Wingard JR, Nucci M. Fungal infection prevention after hematopoietic cell transplantation. Bone Marrow Transplant. 2009 Oct.44(8):483-487. Pubmedid: 19861982.
• Almyroudis NG, Fabian J, Hahn T, Segal BH, Wetzler M, McCarthy PL. Late infectious complications after cord blood stem cell transplantation. Eur J Clin Microbiol Infect Dis. 2009 Nov.28(11):1405-1408. Pubmedid: 19672638.
• Segal BH, Romani LR. Invasive aspergillosis in chronic granulomatous disease. Med Mycol. 2009 Jul.47 Suppl 1:S282-S290. Pubmedid: 19296367.
• Segal BH, Romani L, Puccetti P. Chronic granulomatous disease. Cell Mol Life Sci. 2009 Feb.66(4):553-558. Pubmedid: 19189052. Pmcid: PMC11131496.
• Partridge-Hinckley K, Liddell GM, Almyroudis NG, Segal BH. Infection control measures to prevent invasive mould diseases in hematopoietic stem cell transplant recipients. Mycopathologia. 2009 Dec.168(6):329-337. Pubmedid: 19859825.
• Almyroudis NG, Segal BH. Editorial: Special issue, "invasive fungal diseases in allogeneic hematopoietic stem cell transplant recipients". Mycopathologia. 2009 Dec.168(6):269-270. Pubmedid: 19937130.
• Almyroudis NG, Segal BH. Prevention and treatment of invasive fungal diseases in neutropenic patients. Curr Opin Infect Dis. 2009 Aug.22(4):385-393. Pubmedid: 19506476.
• Segal BH. Aspergillosis. N Engl J Med. 2009 Apr.360(18):1870-1884. Pubmedid: 19403905.
• Segal BH, Herbrecht R, Stevens DA, Ostrosky-Zeichner L, Sobel J, Viscoli C, Walsh TJ, Maertens J, Patterson TF, Perfect JR, Dupont B, Wingard JR, Calandra T, Kauffman CA, Graybill JR, Baden LR, Pappas PG, Bennett JE, Kontoyiannis DP, Cordonnier C, Viviani MA, Bille J, Almyroudis NG, Wheat LJ, Graninger W, Bow EJ, Holland SM, Kullberg BJ, Dismukes WE, De Pauw BE. Defining responses to therapy and study outcomes in clinical trials of invasive fungal diseases: Mycoses Study Group and European Organization for Research and Treatment of Cancer consensus criteria. Clin Infect Dis. 2008 Sep.47(5):674-683. Pubmedid: 18637757. Pmcid: PMC2671230.
• De Pauw B, Walsh TJ, Donnelly JP, Stevens DA, Edwards JE, Calandra T, Pappas PG, Maertens J, Lortholary O, Kauffman CA, Denning DW, Patterson TF, Maschmeyer G, Bille J, Dismukes WE, Herbrecht R, Hope WW, Kibbler CC, Kullberg BJ, Marr KA, Muñoz P, Odds FC, Perfect JR, Restrepo A, Ruhnke M, Segal BH, Sobel JD, Sorrell TC, Viscoli C, Wingard JR, Zaoutis T, Bennett JE. Revised definitions of invasive fungal disease from the European Organization for Research and Treatment of Cancer/Invasive Fungal Infections Cooperative Group and the National Institute of Allergy and Infectious Diseases Mycoses Study Group (EORTC/MSG) C. Clin Infect Dis. 2008 Jun.46(12):1813-1821. Pubmedid: 18462102. Pmcid: PMC2671227.
• Parameswaran GI, Segal BH, Almyroudis NG. Antifungal agents in hematopoietic stem cell transplantation. Curr Pharm Des. 2008 Jan.14(20):2011-2021. Pubmedid: 18691111.
• Romani L, Fallarino F, De Luca A, Montagnoli C, D'Angelo C, Zelante T, Vacca C, Bistoni F, Fioretti MC, Grohmann U, Segal BH, Puccetti P. Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease. Nature. 2008 Jan.451(7175):211-215. Pubmedid: 18185592.
• Walsh TJ, Anaissie EJ, Denning DW, Herbrecht R, Kontoyiannis DP, Marr KA, Morrison VA, Segal BH, Steinbach WJ, Stevens DA, van Burik JA, Wingard JR, Patterson TF. Treatment of aspergillosis: clinical practice guidelines of the Infectious Diseases Society of America. Clin Infect Dis. 2008 Feb.46(3):327-360. Pubmedid: 18177225.
• Segal BH, Freifeld AG, Baden LR, Brown AE, Casper C, Dubberke E, Gelfand M, Greene JN, Ison MG, Ito JI, Karp JE, Kaul DR, King E, Mackler E, Marcucci G, Montoya JG, Engemann AM, Rolston K, The AS. Prevention and treatment of cancer-related infections. J Natl Compr Canc Ne. 2008 Feb.6(2):122-174. Pubmedid: 18319048.
• Gonzalez AV, Ullmann AJ, Almyroudis NG, Segal BH. Broad-spectrum antifungal prophylaxis in patients with cancer at high risk for invasive mold infections: point. J Natl Compr Canc Ne. 2008 Feb.6(2):175-182. Pubmedid: 18319049.
• Segal BH. Role of macrophages in host defense against aspergillosis and strategies for immune augmentation. Oncologist. 2007 Oct.12 Suppl 2:7-13. Pubmedid: 18039634.
• Segal BH, Steinbach WJ. Combination antifungals: an update. Expert Rev Anti Infect Ther. 2007 Oct.5(5):883-892. Pubmedid: 17914921.
• Brun YF, Dennis CG, Greco WR, Bernacki RJ, Pera PJ, Bushey JJ, Youn RC, White DB, Segal BH. Modeling the combination of amphotericin B, micafungin, and nikkomycin Z against Aspergillus fumigatus in vitro using a novel response surface paradigm. Antimicrob Agents Chemother. 2007 May.51(5):1804-1812. Pubmedid: 17325217. Pmcid: PMC1855564.
• Stergiopoulou T, Meletiadis J, Roilides E, Kleiner DE, Schaufele R, Roden M, Harrington S, Dad L, Segal B, Walsh TJ. Host-dependent patterns of tissue injury in invasive pulmonary aspergillosis. Am J Clin Pathol. 2007 Mar.127(3):349-355. Pubmedid: 17276936.
• Battiwalla M, Paplham P, Almyroudis NG, McCarthy A, Abdelhalim A, Elefante A, Smith P, Becker J, McCarthy PL, Segal BH. Leflunomide failure to control recurrent cytomegalovirus infection in the setting of renal failure after allogeneic stem cell transplantation. Transpl Infect Dis. 2007 Mar.9(1):28-32. Pubmedid: 17313468.
• Segal BH, Davidson BA, Hutson AD, Russo TA, Holm BA, Mullan B, Habitzruther M, Holland SM, Knight PR. Acid aspiration-induced lung inflammation and injury are exacerbated in NADPH oxidase-deficient mice. Am J Physiol Lung Cell Mol Physiol. 2007 Mar.292(3):L760-L768. Pubmedid: 17114280.
• Gupta S, Almyroudis NG, Battiwalla M, Bambach BJ, McCarthy PL, Proefrock AD, Ball D, Paplham P, Varma A, Kwon-Chung J, Segal BH. Successful treatment of disseminated fusariosis with posaconazole during neutropenia and subsequent allogeneic hematopoietic stem cell transplantation. Transpl Infect Dis. 2007 Jun.9(2):156-160. Pubmedid: 17462004.
• Padmanabhan S, Battiwalla M, Hahn T, Ball D, Paplham P, Brown K, Segal BH, McCarthy P, Almyroudis NG. Two cases of hepatic zygomycosis in allogeneic stem cell transplant recipients and review of literature. Transpl Infect Dis. 2007 Jun.9(2):148-152. Pubmedid: 17462002.
• Battiwalla M, Wu Y, Bajwa RP, Radovic M, Almyroudis NG, Segal BH, Wallace PK, Nakamura R, Padmanabhan S, Hahn T, McCarthy PL. Ganciclovir inhibits lymphocyte proliferation by impairing DNA synthesis. Biol Blood Marrow Tr. 2007 Jul.13(7):765-770. Pubmedid: 17580254.
• Parameswaran IG, Segal BH. Immunotherapy for fungal infections with special emphasis on central nervous system infections. Neurol India. 2007 Jul.55(3):260-266. Pubmedid: 17921655.
• Walsh TJ, Raad I, Patterson TF, Chandrasekar P, Donowitz GR, Graybill R, Greene RE, Hachem R, Hadley S, Herbrecht R, Langston A, Louie A, Ribaud P, Segal BH, Stevens DA, van Burik JA, White CS, Corcoran G, Gogate J, Krishna G, Pedicone L, Hardalo C, Perfect JR. Treatment of invasive aspergillosis with posaconazole in patients who are refractory to or intolerant of conventional therapy: an externally controlled trial. Clin Infect Dis. 2007 Jan.44(1):2-12. Pubmedid: 17143808.
• Segal BH, Almyroudis NG, Battiwalla M, Herbrecht R, Perfect JR, Walsh TJ, Wingard JR. Prevention and early treatment of invasive fungal infection in patients with cancer and neutropenia and in stem cell transplant recipients in the era of newer broad-spectrum antifungal agents and diagnostic adjuncts. Clin Infect Dis. 2007 Feb.44(3):402-409. Pubmedid: 17205448.
• Segal BH, Freifeld AG. Antibacterial prophylaxis in patients with neutropenia. J Natl Compr Canc Ne. 2007 Feb.5(2):235-242. Pubmedid: 17335692.
• Tao J, Segal BH, Eppolito C, Li Q, Dennis CG, Youn R, Shrikant PA. Aspergillus fumigatus extract differentially regulates antigen-specific CD4+ and CD8+ T cell responses to promote host immunity. J Leukoc Biol. 2006 Sep.80(3):529-537. Pubmedid: 16793916.
• Anaissie EJ, Segal BH, Graybill JR, Arndt C, Perfect JR, Kleinberg M, Pappas P, Benjamin D, Rubin R, Aberg JA, Adderson EE, Adler-Shohet FC, Akan H, Akova M, Almyroudis NG, Alexander BD, Andes D, Arrieta A, Baddley JW, Barron MA, Belzberg H, Boucher HW, Boyce TG, Casadevall A, Chandrasekar PH, Cleary JD, Cordonnier C, Cornely OA, Cuenca-Estrella M, Daly JS, Daoura N, Denning DW, dePauw B, de Repentigny L, Dignani MC, Dismukes WE, Donnelly JP, Donowitz GR, Dupont B, Drusano G, Ellis M, Espinel-Ingroff A, Fishman JA, Fleming R, Forrest G, Ghannoum M, Goldman M, Grazziutti M, Greene JN, Greenberg RN, Gubbins PO, Hadley S, Herbrecht R, Hiemenz JW, Hope W, Hospenthal DR, Husain S, Ito JI, Jacobson RM, Johnson M, Keating MR, Kett DH, Knapp K, Kontoyiannis DP, Krcmery VC, Larsen R, Laverdiere M, Ljungman P, Lortholary O, Maertens J, Marriott D, Mattiuzzi G, McGinnis MR, Morris M, Nucci M, Odds FC, Pankey GA, Patterson T, Pfaller M, Razonable RR, Reboli AC, Rinaldi MG, Roberts GD, Rodriguez Tudela JL, Rotstein C, Ruhnke M, Schuster M, Shoham S, Sia IG, Siebel N, Silviera F, Singh N, Sobel J, Solomkin JS, Sorrell TC, Steinbach WJ, Temesgen Z, Tortorano A, Vartivarian S, VerWeij P, Viscoli C, Viviani MA, Walker RC, Wheat JL, Wiley J, Williamson P, Wingard JR, Yu VL, Zaoutis T. Clinical research in the lay press: irresponsible journalism raises a huge dose of doubt. Clin Infect Dis. 2006 Oct.43(8):1031-1039. Pubmedid: 16983616.
• Nasirikenari M, Segal BH, Ostberg JR, Urbasic A, Lau JT. Altered granulopoietic profile and exaggerated acute neutrophilic inflammation in mice with targeted deficiency in the sialyltransferase ST6Gal I. Blood. 2006 Nov.108(10):3397-3405. Pubmedid: 16849643. Pmcid: PMC1895428.
• Segal BH, Wang XY, Dennis CG, Youn R, Repasky EA, Manjili MH, Subjeck JR. Heat shock proteins as vaccine adjuvants in infections and cancer. Drug Discov Today. 2006 Jun.11(11-12):534-540. Pubmedid: 16713905.
• Bhatti Z, Shaukat A, Almyroudis NG, Segal BH. Review of epidemiology, diagnosis, and treatment of invasive mould infections in allogeneic hematopoietic stem cell transplant recipients. Mycopathologia. 2006 Jul.162(1):1-15. Pubmedid: 16830186.
• Almyroudis NG, Segal BH. Antibacterial prophylaxis in patients with cancer and neutropenia. N Engl J Med. 2006 Jan.354(1):90-94. Pubmedid: 16395832.
• Segal BH, Kwon-Chung J, Walsh TJ, Klein BS, Battiwalla M, Almyroudis NG, Holland SM, Romani L. Immunotherapy for fungal infections. Clin Infect Dis. 2006 Feb.42(4):507-515. Pubmedid: 16421795.
• Dennis CG, Greco WR, Brun Y, Youn R, Slocum HK, Bernacki RJ, Lewis R, Wiederhold N, Holland SM, Petraitiene R, Walsh TJ, Segal BH. Effect of amphotericin B and micafungin combination on survival, histopathology, and fungal burden in experimental aspergillosis in the p47phox-/- mouse model of chronic granulomatous disease. Antimicrob Agents Chemother. 2006 Feb.50(2):422-427. Pubmedid: 16436692. Pmcid: PMC1366912.
• Dunford LM, Roy DM, Hahn TE, Padmanabhan S, Segal BH, Almyroudis N, McCarthy PL, Battiwalla M. Dapsone-induced methemoglobinemia after hematopoietic stem cell transplantation. Biol Blood Marrow Tr. 2006 Feb.12(2):241-242. Pubmedid: 16443522.
• Maertens J, Glasmacher A, Herbrecht R, Thiebaut A, Cordonnier C, Segal BH, Killar J, Taylor A, Kartsonis N, Patterson TF, Aoun M, Caillot D, Sable C. Multicenter, noncomparative study of caspofungin in combination with other antifungals as salvage therapy in adults with invasive aspergillosis. Cancer. 2006 Dec.107(12):2888-2897. Pubmedid: 17103444.
• Almyroudis NG, Kontoyiannis DP, Sepkowitz KA, DePauw BE, Walsh TJ, Segal BH. Issues related to the design and interpretation of clinical trials of salvage therapy for invasive mold infection. Clin Infect Dis. 2006 Dec.43(11):1449-1455. Pubmedid: 17083020.
• Bow EJ, Rotstein C, Noskin GA, Laverdiere M, Schwarer AP, Segal BH, Seymour JF, Szer J, Sanche S. A randomized, open-label, multicenter comparative study of the efficacy and safety of piperacillin-tazobactam and cefepime for the empirical treatment of febrile neutropenic episodes in patients with hematologic malignancies. Clin Infect Dis. 2006 Aug.43(4):447-459. Pubmedid: 16838234.
• Segal BH, Walsh TJ. Current approaches to diagnosis and treatment of invasive aspergillosis. Am J Respir Crit Care Med. 2006 Apr.173(7):707-717. Pubmedid: 16387806.
• Almyroudis NG, Holland SM, Segal BH. Invasive aspergillosis in primary immunodeficiencies. Med Mycol. 2005 May.43 Suppl 1:S247-S259. Pubmedid: 16110817.
• Segal BH, Barnhart LA, Anderson VL, Walsh TJ, Malech HL, Holland SM. Posaconazole as salvage therapy in patients with chronic granulomatous disease and invasive filamentous fungal infection. Clin Infect Dis. 2005 Jun.40(11):1684-1688. Pubmedid: 15889369.
• Shaukat A, Bakri F, Young P, Hahn T, Ball D, Baer MR, Wetzler M, Slack JL, Loud P, Czuczman M, McCarthy PL, Walsh TJ, Segal BH. Invasive filamentous fungal infections in allogeneic hematopoietic stem cell transplant recipients after recovery from neutropenia: clinical, radiologic, and pathologic characteristics. Mycopathologia. 2005 Feb.159(2):181-188. Pubmedid: 15770441.
• Iyer RV, Hahn T, Roy HN, Battiwalla M, Cooper M, Anderson B, Paplham P, Brown K, Bambach B, Segal BH, McCarthy PL. Long-term use of oral beclomethasone dipropionate for the treatment of gastrointestinal graft-versus-host disease. Biol Blood Marrow Tr. 2005 Aug.11(8):587-592. Pubmedid: 16041308.
• Cumbo TA, Segal BH. Prevention, diagnosis, and treatment of invasive fungal infections in patients with cancer and neutropenia. J Natl Compr Canc Ne. 2004 Sep.2(5):455-469. Pubmedid: 19780254.
• Freifeld AG, Baden LR, Brown AE, Elting LS, Gelfand M, Greene JN, Ito JI, King E, Marcucci G, Montoya JG, Morris A, Noskin G, Rolston K, Schott AF, Segal B. Fever and neutropenia clinical practice guidelines. J Natl Compr Canc Ne. 2004 Sep.2(5):390-432. Pubmedid: 19780251.
• Sadikot RT, Zeng H, Yull FE, Li B, Cheng DS, Kernodle DS, Jansen ED, Contag CH, Segal BH, Holland SM, Blackwell TS, Christman JW. p47phox deficiency impairs NF-kappa B activation and host defense in Pseudomonas pneumonia. J Immunol. 2004 Feb.172(3):1801-1808. Pubmedid: 14734763.
• Dibo I, Pillai SK, Gold HS, Baer MR, Wetzler M, Slack JL, Hazamy PA, Ball D, Hsiao CB, McCarthy PL, Segal BH. Linezolid-resistant Enterococcus faecalis isolated from a cord blood transplant recipient. J Clin Microbiol. 2004 Apr.42(4):1843-1845. Pubmedid: 15071066. Pmcid: PMC387622.
• van de Loo FA, Bennink MB, Arntz OJ, Smeets RL, Lubberts E, Joosten LA, van Lent PL, Coenen-de Roo CJ, Cuzzocrea S, Segal BH, Holland SM, van den Berg WB. Deficiency of NADPH oxidase components p47phox and gp91phox caused granulomatous synovitis and increased connective tissue destruction in experimental arthritis models. Am J Pathol. 2003 Oct.163(4):1525-1537. Pubmedid: 14507659. Pmcid: PMC1868292.
• Segal BH, Ding L, Holland SM. Phagocyte NADPH oxidase, but not inducible nitric oxide synthase, is essential for early control of Burkholderia cepacia and chromobacterium violaceum infection in mice. Infect Immun. 2003 Jan.71(1):205-210. Pubmedid: 12496167. Pmcid: PMC143145.
• Peter E, Bakri F, Ball DM, Cheney RT, Segal BH. Invasive pulmonary filamentous fungal infection in a patient receiving inhaled corticosteroid therapy. Clin Infect Dis. 2002 Sep.35(5):e54-e56. Pubmedid: 12173150.
• Hahn T, Cummings KM, Michalek AM, Lipman BJ, Segal BH, McCarthy PL. Efficacy of high-efficiency particulate air filtration in preventing aspergillosis in immunocompromised patients with hematologic malignancies. Infect Cont Hosp Ep. 2002 Sep.23(9):525-531. Pubmedid: 12269451.
• Segal BH, Kuhns DB, Ding L, Gallin JI, Holland SM. Thioglycollate peritonitis in mice lacking C5, 5-lipoxygenase, or p47(phox): complement, leukotrienes, and reactive oxidants in acute inflammation. J Leukoc Biol. 2002 Mar.71(3):410-416. Pubmedid: 11867678.
• Segal BH, Bow EJ, Menichetti F. Fungal infections in nontransplant patients with hematologic malignancies. Infect Dis Clin North Am. 2002 Dec.16(4):935-64, vii. Pubmedid: 12512188.
• Koay MA, Christman JW, Segal BH, Venkatakrishnan A, Blackwell TR, Holland SM, Blackwell TS. Impaired pulmonary NF-kappaB activation in response to lipopolysaccharide in NADPH oxidase-deficient mice. Infect Immun. 2001 Oct.69(10):5991-5996. Pubmedid: 11553535. Pmcid: PMC98726.
• Khushalani NI, Bakri FG, Wentling D, Brown K, Mohr A, Anderson B, Keesler C, Ball D, Bernstein ZP, Bernstein SH, Czuczman MS, Segal BH, McCarthy PL. Respiratory syncytial virus infection in the late bone marrow transplant period: report of three cases and review. Bone Marrow Transplant. 2001 May.27(10):1071-1073. Pubmedid: 11438823.
• Jackson SH, Miller GF, Segal BH, Mardiney M, Domachowske JB, Gallin JI, Holland SM. IFN-gamma is effective in reducing infections in the mouse model of chronic granulomatous disease (CGD). J Interferon Cytokine Res. 2001 Aug.21(8):567-573. Pubmedid: 11559434.
• Rusyn I, Kadiiska MB, Dikalova A, Kono H, Yin M, Tsuchiya K, Mason RP, Peters JM, Gonzalez FJ, Segal BH, Holland SM, Thurman RG. Phthalates rapidly increase production of reactive oxygen species in vivo: role of Kupffer cells. Mol Pharmacol. 2001 Apr.59(4):744-750. Pubmedid: 11259618.
• Rusyn I, Yamashina S, Segal BH, Schoonhoven R, Holland SM, Cattley RC, Swenberg JA, Thurman RG. Oxidants from nicotinamide adenine dinucleotide phosphate oxidase are involved in triggering cell proliferation in the liver due to peroxisome proliferators. Cancer Res. 2000 Sep.60(17):4798-4803. Pubmedid: 10987289.
• Kono H, Rusyn I, Yin M, Gäbele E, Yamashina S, Dikalova A, Kadiiska MB, Connor HD, Mason RP, Segal BH, Bradford BU, Holland SM, Thurman RG. NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease. J Clin Invest. 2000 Oct.106(7):867-872. Pubmedid: 11018074. Pmcid: PMC517812.
• Segal BH, Leto TL, Gallin JI, Malech HL, Holland SM. Genetic, biochemical, and clinical features of chronic granulomatous disease. Medicine. 2000 May.79(3):170-200. Pubmedid: 10844936.
• van der Veen RC, Dietlin TA, Hofman FM, Pen L, Segal BH, Holland SM. Superoxide prevents nitric oxide-mediated suppression of helper T lymphocytes: decreased autoimmune encephalomyelitis in nicotinamide adenine dinucleotide phosphate oxidase knockout mice. J Immunol. 2000 May.164(10):5177-5183. Pubmedid: 10799876.
• Cooper AM, Segal BH, Frank AA, Holland SM, Orme IM. Transient loss of resistance to pulmonary tuberculosis in p47(phox-/-) mice. Infect Immun. 2000 Mar.68(3):1231-1234. Pubmedid: 10678931. Pmcid: PMC97272.
• Hsich E, Segal BH, Pagano PJ, Rey FE, Paigen B, Deleonardis J, Hoyt RF, Holland SM, Finkel T. Vascular effects following homozygous disruption of p47(phox) : An essential component of NADPH oxidase. Circulation. 2000 Mar.101(11):1234-1236. Pubmedid: 10725280.
• Segal BH, Holland SM. Primary phagocytic disorders of childhood. Pediatr Clin North Am. 2000 Dec.47(6):1311-1338. Pubmedid: 11130998.
• Segal BH, Sakamoto N, Patel M, Maemura K, Klein AS, Holland SM, Bulkley GB. Xanthine oxidase contributes to host defense against Burkholderia cepacia in the p47(phox-/-) mouse model of chronic granulomatous disease. Infect Immun. 2000 Apr.68(4):2374-2378. Pubmedid: 10722648. Pmcid: PMC97432.
• Segal BH, Doherty TM, Wynn TA, Cheever AW, Sher A, Holland SM. The p47(phox-/-) mouse model of chronic granulomatous disease has normal granuloma formation and cytokine responses to Mycobacterium avium and Schistosoma mansoni eggs. Infect Immun. 1999 Apr.67(4):1659-1665. Pubmedid: 10085000. Pmcid: PMC96510.
• Segal BH, DeCarlo ES, Kwon-Chung KJ, Malech HL, Gallin JI, Holland SM. Aspergillus nidulans infection in chronic granulomatous disease. Medicine. 1998 Sep.77(5):345-354. Pubmedid: 9772923.
• Chang YC, Segal BH, Holland SM, Miller GF, Kwon-Chung KJ. Virulence of catalase-deficient aspergillus nidulans in p47(phox)-/- mice. Implications for fungal pathogenicity and host defense in chronic granulomatous disease. J Clin Invest. 1998 May.101(9):1843-1850. Pubmedid: 9576747. Pmcid: PMC508769.
• Segal BH, Walsh TJ, Liu JM, Wilson JD, Kwon-Chung KJ. Invasive infection with Fusarium chlamydosporum in a patient with aplastic anemia. J Clin Microbiol. 1998 Jun.36(6):1772-1776. Pubmedid: 9620419. Pmcid: PMC104919.
• Segal BH, Sneller MC. Infectious complications of immunosuppressive therapy in patients with rheumatic diseases. Rheum Dis Clin N Am. 1997 May.23(2):219-237. Pubmedid: 9156390.
• Segal BH, Engler HD, Little R, Wilson WH, Freifeld AG, Chanock SJ. Early foscarnet failure in herpes simplex virus infection in a patient with AIDS. Aids. 1997 Mar.11(4):552-553. Pubmedid: 9084815.
• Segal BH, Factor SM. Myocardial risk factors other than human immunodeficiency virus infection may contribute to histologic cardiomyopathic changes in acquired immune deficiency syndrome. Mod Pathol. 1993 Sep.6(5):560-564. Pubmedid: 8248112.
• van Hoeven KH, Segal B, Factor SM. AIDS cardiomyopathy: first rule out other myocardial risk factors. Int J Cardiol. 1990 Oct.29(1):35-37. Pubmedid: 2262214.

• Title: Neuritin-Mediated Reprogramming of Myeloid Cell Populations: Mechanisms of Immune Suppression and Roads to Improve Therapy in Ovarian Cancer
  Award Number: HT9425-23-1-0266
  Sponsor: Department of Defense (DOD)
  Segal, B. (PD/PI)
• Title: Targeting complement to enhance antitumor immunity and control malignant effusions in patients with recurrent epithelial ovarian cancer
  Award Number: 5R01CA267690-03
  Sponsor: National Cancer Institute (NCI)
  Segal, B. (PD/PI)