Jie Xu, PhD

Dr. Jie Xu is Medical Director of Cytogenetics and Senior Member in the Department of Pathology at Moffitt Cancer Center & Research Institute. He is also Professor of Oncologic Sciences, Morsani College of Medicine, University of South Florida. He earned his PhD at University of Guelph and completed his training in clinical cytogenetics at Alberta Children’s Hospital and molecular genetics at Cleveland Clinic. He is certified by America Board of Medical Genetics and Genomics in Clinical Cytogenetics and Genomics and Laboratory Genetics and Genomics. Dr. Xu’s clinical focus is cytogenomics diagnosis of cancer. His research interests focus on the development and application of new cytogenomics diagnostics for hematologic and solid tumors.

• Cutz JC, Craddock KJ, Torlakovic E, Brandao G, Carter RF, Bigras G, Deschenes J, Izevbaye I, Xu Z, Greer W, Yatabe Y, Ionescu D, Karsan A, Jung S, Fraser RS, Blumenkrantz M, Lavoie J, Fortin F, Bojarski A, Côté GB, van den Berghe JA, Rashid-Kolvear F, Trotter M, Sekhon HS, Albadine R, Tran-Thanh D, Gorska I, Knoll JH, Xu J, Blencowe B, Iafrate AJ, Hwang DM, Pintilie M, Gaspo R, Couture C, Tsao MS. Canadian anaplastic lymphoma kinase study: a model for multicenter standardization and optimization of ALK testing in lung cancer. J Thorac Oncol. 2014 Sep.9(9):1255-1263. Pubmedid: 25122422.
• Cameron F, Xu J, Jung J, Prasad C. Array CGH Analysis and Developmental Delay: A Diagnostic Tool for Neurologists. Can J Neurol Sci. 2013 Nov.40(6):777-782. Pubmedid: 24257216.
• Lehmann KJ, Kovac JR, Xu J, Fischer MA. Isodicentric Yq mosaicism presenting as infertility and maturation arrest without altered SRY and AZF regions. J Assist Reprod Gen. 2012 Sep.29(9):939-942. Pubmedid: 22729464. Pmcid: PMC3463663.
• Lazo-Langner A, Xu J. Myelodyspastic syndrome with complex cytogenetics. Blood. 2012 Nov.120(23):4458. Pubmedid: 23326862.
• Dawson AJ, McGowan-Jordan J, Chernos J, Xu J, Lavoie J, Wang JC, Steinraths M, Shetty S. Canadian College of Medical Geneticists guidelines for the indications, analysis, and reporting of cancer specimens. Curr Oncol. 2011 Oct.18(5):e250-e255. Pubmedid: 21980257. Pmcid: PMC3185907.
• Dawson AJ, Chernos J, McGowan-Jordan J, Lavoie J, Shetty S, Steinraths M, Wang JC, Xu J. CCMG guidelines: prenatal and postnatal diagnostic testing for uniparental disomy. Clin Genet. 2011 Feb.79(2):118-124. Pubmedid: 21039433.
• Xu J, Siu VM. Is there a correlation between the proportion of cells with isodicentric Yp at amniocentesis and phenotypic sex?. Prenat Diagn. 2010 Sep.30(9):839-844. Pubmedid: 20658696.
• Xu J, Souter LH, Chambers AF, Rodenhiser DI, Tuck AB. Distinct karyotypes in three breast cancer cell lines --21PTCi, 21NTCi, and 21MT-1 --derived from the same patient and representing different stages of tumor progression. Cancer Genet Cytogen. 2008 Oct.186(1):33-40. Pubmedid: 18786440.
• Xu J, Fan YS, Siu VM. A child with features of Goldenhar syndrome and a novel 1.12 Mb deletion in 22q11.2 by cytogenetics and oligonucleotide array CGH: is this a candidate region for the syndrome?. Am J Med Genet A. 2008 Jul.146A(14):1886-1889. Pubmedid: 18553512.
• Nowaczyk MJ, Carter MT, Xu J, Huggins M, Raca G, Das S, Martin CL, Schwartz S, Rosenfield R, Waggoner DJ. Paternal deletion 6q24.3: a new congenital anomaly syndrome associated with intrauterine growth failure, early developmental delay and characteristic facial appearance. Am J Med Genet A. 2008 Feb.146A(3):354-360. Pubmedid: 18203180.
• Xu J, Chambers AF, Tuck AB, Rodenhiser DI. Molecular cytogenetic characterization of human breast cancer cell line MDA-MB-468 and its variant 468LN, which displays aggressive lymphatic metastasis. Cancer Genet Cytogen. 2008 Feb.181(1):1-7. Pubmedid: 18262045.
• Wei S, Siu VM, Decker A, Quigg MH, Roberson J, Xu J, Adeyinka A. False-positive prenatal diagnosis of trisomy 18 by interphase FISH: hybridization of chromosome 18 alpha-satellite DNA probe (D18Z1) to the heterochromatic region of chromosome 9. Prenat Diagn. 2007 Nov.27(11):1064-1066. Pubmedid: 17654752.
• Parfitt JR, Xu J, Kontozoglou T, Oluwafemi AR, Driman DK. Primary monophasic synovial sarcoma of the colon. Histopathology. 2007 Mar.50(4):521-523. Pubmedid: 17448034.
• Xu J, Mak L, Jung J. Amniotic fluid with an inconclusive result by interphase FISH and 45,X by routine G-banding turned out to have 46,X,+ mar.ish der(X)(DXZ1+). Prenat Diagn. 2007 Dec.27(13):1258-1259. Pubmedid: 17987598.
• Zwaigenbaum L, Sonnenberg LK, Heshka T, Eastwood S, Xu J. A girl with pervasive developmental disorder and complex chromosome rearrangement involving 8p and 10p. J Autism Dev Disord. 2005 Jun.35(3):393-399. Pubmedid: 16119480.
• Nowaczyk MJ, Bayani J, Freeman V, Watts J, Squire J, Xu J. De novo 1q32q44 duplication and distal 1q trisomy syndrome. Am J Med Genet A. 2003 Jul.120A(2):229-233. Pubmedid: 12833404.
• Xu J, Chen Z. Advances in molecular cytogenetics for the evaluation of mental retardation. Am J Med Genet C Semin Med Genet. 2003 Feb.117C(1):15-24. Pubmedid: 12561054.
• Xu J, Freeman V, Smith PA, Huggins M. Fluorescence in situ hybridization of uncultured lymphocytes from cystic hygroma fluid: a potential approach for rapid prenatal diagnosis. Prenat Diagn. 2002 Jan.22(1):81-82. Pubmedid: 11810661.
• Fan YS, Siu VM, Jung JH, Xu J. Sensitivity of multiple color spectral karyotyping in detecting small interchromosomal rearrangements. Genet Test. 2000 Jun.4(1):9-14. Pubmedid: 10794355.
• Xu J, Chernos JE, Bernier F, Lowry RB. Characterization of an interstitial deletion del(13)(q22q32) using microdissection and sequential FISH and G-banding. Genet Test. 2000 Dec.4(3):279-282. Pubmedid: 11142759.
• Xu J, Freeman V, Carter RF, Paes B, Heshka T, Nowaczyk JM. Wolf-Hirschorn syndrome resulting from partial monosomy 4p/trisomy 9p. Am J Med Genet. 2000 Aug.93(4):285-289. Pubmedid: 10946354.
• Xu J, Poon MC, Ruether BA, Roland B. Two new cases of myelodysplastic syndrome with 45,X,-X. Cancer Genet Cytogen. 1998 May.103(1):76-77. Pubmedid: 9595052.
• Xu J, Chernos J, Roland B. Trisomy 16pter to 16q12.1 and monosomy 22pter to 22q11.2 resulting from adjacent-2 segregation of a maternal complex chromosome rearrangement. Am J Med Genet. 1997 Dec.73(3):327-329. Pubmedid: 9415693.