Jing-Yi Chern, MD, ScM

Cancer Focus:
Cervical Cancer, Endometrial (Uterine) Cancer, Ovarian Cancer, Vaginal Cancer, Vulvar Cancer

Dr. Chern is a Gynecologic Oncologist at Moffitt Cancer Center.  After earning her Master’s Degree in Biochemistry and Molecular Biology at the Johns Hopkins University Bloomberg School of Public Health in Baltimore, Dr. Chern completed her Medical Degree at the University of South Florida College of Medicine. She subsequently completed her Residency in Obstetrics and Gynecology at the University of South Florida, where she served as Administrative Chief Resident and Scientific Review Committee Member.  Dr. Chern completed her Gynecologic Oncology Fellowship at New York University School of Medicine, where she earned a Certificate in Translational Research Methodologies under the Clinical and Translational Science Institute.  Her clinical focus is to provide personalized and comprehensive care for women with gynecologic cancers, with a special interest in the surgical management of advanced malignancies.  Dr. Chern also emphasizes the utilization of minimally invasive surgery, including the robotic platform. 

Dr. Chern’s research interest includes evaluating quality and safety measures to improve surgical outcomes in patients with malignancies.  Dr. Chern has worked as part of a multidisciplinary team to develop new protocols and safety measures with the goal of improving post-operative outcomes and patient satisfaction.  In addition, her research is involved in understanding genetic factors associated with gynecologic malignancies to improve and guide patient care.

Education & Training

Fellowship:

• New York University School of Medicine - Gynecologic Oncology
• Memorial Sloan Kettering - Galloway Fellowship

Residency:

• University of South Florida - Obstetrics & Gynecology

Medical School:

• University of South Florida - MD

Clinical Trial 20870
Pilot Study to Assess the Efficacy of Aspirin to Improve Immunological Features of Ovarian Tumors
Condition: Gynecological Tumor
Intervention: Aspirin/Placebo (); Avastin (Bevacizumab); Bevacizumab (); Paraplatin (carboplatin); Taxol (paclitaxel); carboplatin (); paclitaxel ()
Status: Open

Clinical Trial 23192
A Proof-of-Concept Study to Assess the Combination of SON-1010 (IL12-FHAB) and Atezolizumab in Patients with Platinum-resistant Ovarian Cancer
Condition: Gynecological Tumor
Intervention: Atezolizumab (Tecentriq); Doxil (doxorubicin liposome); SON-1010 (); Taxol (paclitaxel); Topotecan ()
Status: Open

If you believe you are eligible for one of these trials or studies, please call
813-745-6100 or toll-free 1-800-679-0775.

• Quian A, Mercier AM, Lam C, Wenham RM, Chon HS, Shahzad MM, Chern JY, Thompson Z, Hoffman MS. Specimen extraction techniques utilized in minimally invasive surgery for uterine cancer and an enlarged uterus: a quality assurance study. J Robot Surg. 2025 Sep.19(1):580. Pubmedid: 40926147.
• Quian A, Mercier AM, Akers A, Wenham RM, Chon HS, Shahzad MM, Chern JY, Mhaskar R, Hoffman M. Adnexal mass management by minimally invasive surgery at a comprehensive cancer center. J Robot Surg. 2025 Oct.19(1):699. Pubmedid: 41108488.
• Ahmed KA, Quick AM, Chon HS, Chern JY, Bixel K, Kim Y, Li J, Montejo ME, Dowell RA, Kim S, Fernandez DC, Lam CA, Hakam A, Rosa M, Shafique M, Shahzad MM, Wenham RM. Atezolizumab and Stereotactic Body Radiation in Metastatic, Recurrent, or Persistent Cervical Cancer: Results From a Phase 2 Multi-Institutional Study. Int J Radiat Oncol Biol Phys. 2025 May. Pubmedid: 40379142.
• Alqaisi HA, Cohn DE, Chern JY, Duska LR, Jewell A, Corr BR, Winer IS, Girda E, Crispens MA, Dhani NC, Madariaga A, Grant RC, Malaguti M, Lee C, Bowering V, Wong H, Poothullil A, Speers V, Wang L, Bedard PL, Brady JC, Nixon AB, Chen L, O'Connor C, Zamboni W, McKee T, Moscow JA, Oza AM, Lheureux S. Randomized Phase II Study of Bevacizumab with Weekly Anetumab Ravtansine or Weekly Paclitaxel in Platinum-Resistant/Refractory High-Grade Ovarian Cancer (NCI Trial). Clin Cancer Res. 2025 Mar.31(6):993-1001. Pubmedid: 39836408. Pmcid: PMC11911801.
• Colin-Leitzinger C, Lawson-Michod KA, Johnson CE, Vlasac IM, Yoder S, Mesa T, Roeber D, Huff C, Hildebrandt MAT, Haller K, Alberg AJ, Bandera EV, Bondy M, Cote ML, Hastert T, Peters ES, Terry PD, Lawson AB, Berchuck A, Fridley BL, Chern JY, Doherty JA, Marks JR, Schildkraut JM, Christensen BC, Salas LA, Peres LC. Retrotransposon methylation profiles and survival in Black women with high-grade serous ovarian carcinoma. Clin Epigenetics. 2025 Jul.17(1):134. Pubmedid: 40734190. Pmcid: PMC12309203.
• Martin AL, Colin-Leitzinger CM, Sinha SK, Chern JY, Peres LC. Impact of obesity on chemotherapy dosing of carboplatin and survival of women with ovarian cancer. Brit J Cancer. 2023 Jun.128(12):2236-2242. Pubmedid: 37024666. Pmcid: PMC10241930.
• Yang MJ, Martínez Ú, Fulton HJ, Maconi ML, Turner K, Powell ST, Chern JY, Brandon TH, Vidrine JI, Simmons VN. Qualitative evaluation of the implementation and future sustainability of an e-referral system for smoking cessation at a US NCI-designated comprehensive cancer center: lessons learned. Support Care Cancer. 2023 Jul.31(8):483. Pubmedid: 37480364.
• Fermin O, Delgado A, Sarkar P, Chern JY, Wenham R, Hoffman MS. Vaginal Evisceration Subsequent to Hysterectomy at a Major Cancer Center. J Gynecol Surg. 2023 Feb.39(1).
• Martin AL, Sinha S, Peres LC, Hakam A, Chon HS, Hoffman MS, Shahzad MM, Wenham RM, Chern JY. The impact of distance to closest negative margin on survival after pelvic exenteration. Gynecol Oncol. 2022 Jun.165(3):514-521. Pubmedid: 35487774.
• Karpel HC, Chern JY, Smith J M, Smith A J, Pothuri B. Utility of germline multi-gene panel testing in patients with endometrial cancer. Gynecol Oncol. 2022 Jun.165(3):546-551. Pubmedid: 35483985.
• Kuznicki ML, Mallen A, Ha K, McClung EC, Castaneda AV, Cao B, Fridley BL, Chon HS, Chern JY, Hoffman M, Wenham RM, Matsuo K, Shahzad MMK. Prognostic features of endometrial cancer metastasis to the central nervous system. PLoS One. 2022 Aug.17(8):e0268794. Pubmedid: 36018828. Pmcid: PMC9417007.
• Lee SS, Chern JY, Frey MK, Comfort A, Lee J, Roselli N, Boyd LR. Enhanced recovery Pathways in gynecologic surgery: Are they safe and effective in the elderly?. Gynecol Oncol Rep. 2021 Nov.38:100862. Pubmedid: 34621945. Pmcid: PMC8479239.
• Martin A, Wells A, Anderson ML, Chern JY, Rutherford TJ, Shahzad MM, Wenham RM, Hoffman MS. Trends in ureteral surgery on an academic gynecologic oncology service. Gynecol Oncol. 2021 Dec.163(3):552-556. Pubmedid: 34674890.
• Asamoah FA, Yarney J, Scott A, Vanderpuye V, Yuan Z, Fernandez DC, Montejo ME, Agyeman M, Boateng SN, Anarfi K, Aidoo C, Shahzad MM, Chern JY, Chon HS, Wenham RM, Yamoah K, Ahmed KA. Comparison of Definitive Cervical Cancer Management With Chemotherapy and Radiation Between Two Centers With Variable Resources and Opportunities for Improved Treatment. JCO Glob Oncol. 2020 Oct.6:1510-1518. Pubmedid: 33021855. Pmcid: PMC7605379.
• Rishi A, Rollins M, Ahmed KA, Hunt DC, Sarkar P, Fernandez DC, Hoffman MS, Apte SM, Shahzad MMK, Chon HS, Chern JY, Wenham RM, Montejo ME. High-dose intensity-modulated chemoradiotherapy in vulvar squamous cell carcinoma: Outcome and toxicity. Gynecol Oncol. 2020 Feb.156(2):349-356. Pubmedid: 31771865.
• Madden N, Frey MK, Joo L, Lee J, Musselman K, Chern JY, Blank SV, Pothuri B. Safety of robotic-assisted gynecologic surgery and early hospital discharge in elderly patients. Am J Obstet Gynecol. 2019 Mar.220(3):253.e1-253.e7. Pubmedid: 30557552.
• Chern JY, Lee SS, Frey MK, Lee J, Blank SV. The influence of BRCA variants of unknown significance on cancer risk management decision-making. J Gynecol Oncol. 2019 Jul.30(4):e60. Pubmedid: 31074248. Pmcid: PMC6543104.
• Chern JY, Boyd LR, Blank SV. Uterine Sarcomas: The Latest Approaches for These Rare but Potentially Deadly Tumors. Oncology (Williston Park). 2017 Mar.31(3):229-236. Pubmedid: 28299760.
• Frey MK, Ellis AE, Koontz LM, Shyne S, Klingenberg B, Fields JC, Chern JY, Blank SV. Ovarian cancer survivors' acceptance of treatment side effects evolves as goals of care change over the cancer continuum. Gynecol Oncol. 2017 Aug.146(2):386-391. Pubmedid: 28602549.
• Lee J, Aphinyanaphongs Y, Curtin JP, Chern JY, Frey MK, Boyd LR. The safety of same-day discharge after laparoscopic hysterectomy for endometrial cancer. Gynecol Oncol. 2016 Sep.142(3):508-513. Pubmedid: 27288543.
• Frey MK, Moss HA, Musa F, Rolnitzky L, David-West G, Chern JY, Boyd LR, Curtin JP. Preoperative experience for public hospital patients with gynecologic cancer: Do structural barriers widen the gap?. Cancer. 2016 Mar.122(6):859-867. Pubmedid: 26938270.
• Chern JY, Curtin JP. Appropriate Recommendations for Surgical Debulking in Stage IV Ovarian Cancer. CURR TREAT OPTION ON. 2016 Jan.17(1):1. Pubmedid: 26714493.
• Frey MK, Kim SH, Bassett RY, Martineau J, Dalton E, Chern JY, Blank SV. Rescreening for genetic mutations using multi-gene panel testing in patients who previously underwent non-informative genetic screening. Gynecol Oncol. 2015 Nov.139(2):211-215. Pubmedid: 26296696.
• McLoughlin J, Melis M, Siegel E, Dean E, Weber J, Chern J, Elliott M, Kelley S, Karl R. Are patients with esophageal cancer who become PET negative after neoadjuvant chemoradiation free of cancer?. J Am Coll Surg. 2008 May.206(5):879-886. Pubmedid: 18471715.
• Hohenstein KA, Pyle AD, Chern JY, Lock LF, Donovan PJ. Nucleofection mediates high-efficiency stable gene knockdown and transgene expression in human embryonic stem cells. Stem Cells. 2008 Jun.26(6):1436-1443. Pubmedid: 18323409. Pmcid: PMC3882114.
• Charron M, Chern JY, Wright WW. The cathepsin L first intron stimulates gene expression in rat sertoli cells. Biol Reprod. 2007 May.76(5):813-824. Pubmedid: 17229931.

• Title: A Presurgical Window of Opportunity Trial of the Effect of Aspirin on Immunological Features of Ovarian Tumors
  Award Number: W81XWH-20-1-0488 P00004
  Sponsor: Department of Defense (DOD)
  Chern, J. (PD/PI)

Voted top doctor in Gynecologic Oncology in Tampa Magazine’s Top Doctors 2025.

Voted top doctor in Gynecologic Oncology in Tampa Magazine's Top Doctors 2024.