John Arrington, MD

Cancer Focus:
Head and Neck Cancer

Clinical interests include imaging and response to therapy of primary and metastatic brain tumors with focus on GBMs

Education & Training

Fellowship:

• Johns Hopkins Hospital - Neuroradiology

Residency:

• University of South Florida - Diagnostic Radiology

Medical School:

• University of South Florida - MD

• Ahmed KA, Kim Y, Armaghani AJ, Arrington JA, Costa RL, Czerniecki BJ, Diaz R, Dowell RA, Extermann M, Forsyth PA, Lee KT, Loftus L, Mills MN, Phuoc VH, Rosa M, Soliman HH, Sam CS, Washington IR, Soyano AE, Han HS. Phase II trial of brain MRI surveillance in stage IV breast cancer. Neurooncol. 2025 Jul.27(6):1550-1558. Pubmedid: 39851040. Pmcid: PMC12309701.
• Sahebjam S, Raval RR, Forsyth PA, Enderling H, Tran ND, Arrington JA, Macaulay R, Perlow HK, Palmer JD, Ghose J, Rajappa P, Giglio P, Li Z, Etame AB, Mokhtari S, Cruz-Chamorro RJ, Bhandari M, Thapa R, Robinson TJ, Chen DT, Yu HM. Phase 1 trial of hypofractionated stereotactic re-irradiation in combination with nivolumab, ipilimumab, and bevacizumab for recurrent high-grade gliomas. Neurooncol Adv. 2025 Feb.7(1):vdaf033. Pubmedid: 40134851. Pmcid: PMC11934552.
• Piña Y, Law V, Sahebjam S, Tran N, Siddarajappa N, Li J, Mo Q, Phadke MS, Arrington J, Macaulay R, Mokhtari S, Evernden B, Ahmed KA, Smalley I, Yu M, Smalley KSM, Forsyth PA. Phase IB Study of Avelumab and Whole Brain Radiotherapy (WBRT) in Patients with Leptomeningeal Disease (LMD) from Solid Tumors: Results and Molecular Analyses. Neurooncol. 2025 Aug. Pubmedid: 40888040.
• Ahmed KA, Kim Y, Kim S, Wang MH, DeJesus M, Arrington JA, Soyano AE, Armaghani AJ, Costa RLB, Loftus LS, Rosa M, Caudell JJ, Diaz R, Etame AB, Tran ND, Soliman H, Czerniecki BJ, Forsyth PA, Yu HM, Han HS. Nivolumab and stereotactic radiosurgery for patients with breast cancer brain metastases: long-term results and biomarker analysis from a non-randomized, open-label, phase Ib study. J Immunother Cancer. 2025 Apr.13(4). Pubmedid: 40295143. Pmcid: PMC12039042.
• Ravi H, Hawkins SH, Stringfield O, Pereira M, Chen DT, Enderling H, Michael Yu HH, Arrington JA, Sahebjam S, Raghunand N. Rules-based Volumetric Segmentation of Multiparametric MRI for Response Assessment in Recurrent High-Grade Glioma. Res Sq. 2023 Sep. Pubmedid: 37790451. Pmcid: PMC10543497.
• Schoenfeld D, Lee D, Arrington JA, Greene J, Klinkova O. Bacillus Cereus bacteremia complicated by brain abscess in a severely immunocompromised patient: Addressing importance of early recognition and challenges in diagnosis. IDCases. 2022 Jun.29:e01525. Pubmedid: 35712054. Pmcid: PMC9194585.
• Mills MN, Potluri TK, Kawahara Y, Fahey M, Figura NB, Soyano AE, Washington IR, Diaz R, Oliver DE, Yu HM, Etame AB, Vogelbaum MA, Czerniecki BJ, Arrington JA, Sahebjam S, Forsyth PA, Soliman HH, Han HS, Ahmed KA. The presentation of brain metastases in melanoma, non-small cell lung cancer, and breast cancer and potential implications for screening brain MRIs. Breast Cancer Res Treat. 2022 Jan.191(1):209-217. Pubmedid: 34669082.
• Lynes J, Rubino S, Rogers A, Gaballa S, Liu HD, Arrington JA, Peguero E, Liu JKC. Spontaneous Spinal Subdural Hematoma Secondary to Hemophilia A and Zanubrutinib. J Neurol Surg Rep. 2022 Jan.83(1):e19-e22. Pubmedid: 35273899. Pmcid: PMC8920709.
• Lowe SR, Wang CP, Brisco A, Whiting J, Arrington J, Ahmed K, Yu M, Robinson T, Oliver D, Etame A, Tran N, Beer Furlan A, Sahebjam S, Mokhtari S, Piña Y, Macaulay R, Forsyth P, Vogelbaum MA, Liu JKC. Surgical and anatomic factors predict development of leptomeningeal disease in patients with melanoma brain metastases. Neurooncol. 2022 Aug.24(8):1307-1317. Pubmedid: 35092434. Pmcid: PMC9340645.
• Lynes J, Flores-Milan G, Rubino S, Arrington J, Macaulay R, Liu JKC, Beer-Furlan A, Tran ND, Vogelbaum MA, Etame AB. Molecular determinants of outcomes in meningiomas. Front Oncol. 2022 Aug.12:962702. Pubmedid: 36033542. Pmcid: PMC9413043.
• Ahmed KA, Kim Y, Arrington JA, Kim S, DeJesus M, Soyano AE, Armaghani AJ, Costa RLB, Khong HT, Loftus LS, Rosa M, Caudell JJ, Diaz R, Robinson TJ, Etame AB, Tran ND, Sahebjam S, Soliman HH, Czerniecki BJ, Forsyth PA, Yu HM, Han HS. Nivolumab and Stereotactic Radiosurgery for Patients With Breast Cancer Brain Metastases: A Nonrandomized, Open-Label Phase 1b Study. Adv Radiat Oncol. 2021 Sep.6(6):100798. Pubmedid: 34934864. Pmcid: PMC8655428.
• Sahebjam S, Forsyth PA, Tran ND, Arrington JA, Macaulay R, Etame AB, Walko CM, Boyle T, Peguero EN, Jaglal M, Mokhtari S, Enderling H, Raghunand N, Gatewood T, Long W, Dzierzeski JL, Evernden B, Robinson T, Wicklund MC, Kim S, Thompson ZJ, Chen DT, Chinnaiyan P, Yu HM. Hypofractionated stereotactic re-irradiation with pembrolizumab and bevacizumab in patients with recurrent high-grade gliomas: results from a phase I study. Neurooncol. 2021 Apr.23(4):677-686. Pubmedid: 33173935. Pmcid: PMC8041351.
• Mitchell JR, Kamnitsas K, Singleton KW, Whitmire SA, Clark-Swanson KR, Ranjbar S, Rickertsen CR, Johnston SK, Egan KM, Rollison DE, Arrington J, Krecke KN, Passe TJ, Verdoorn JT, Nagelschneider AA, Carr CM, Port JD, Patton A, Campeau NG, Liebo GB, Eckel LJ, Wood CP, Hunt CH, Vibhute P, Nelson KD, Hoxworth JM, Patel AC, Chong BW, Ross JS, Boxerman JL, Vogelbaum MA, Hu LS, Glocker B, Swanson KR. Deep neural network to locate and segment brain tumors outperformed the expert technicians who created the training data. J Med Imaging (Bellingham). 2020 Sep.7(5):055501. Pubmedid: 33102623. Pmcid: PMC7567400.
• Glazar DJ, Grass GD, Arrington JA, Forsyth PA, Raghunand N, Yu HM, Sahebjam S, Enderling H. Tumor Volume Dynamics as an Early Biomarker for Patient-Specific Evolution of Resistance and Progression in Recurrent High-Grade Glioma. J Clin Med. 2020 Jun.9(7). Pubmedid: 32605050. Pmcid: PMC7409184.
• Glitza IC, Smalley KSM, Brastianos PK, Davies MA, McCutcheon I, Liu JKC, Ahmed KA, Arrington JA, Evernden BR, Smalley I, Eroglu Z, Khushalani N, Margolin K, Kluger H, Atkins MB, Tawbi H, Boire A, Forsyth P. Leptomeningeal disease in melanoma patients: An update to treatment, challenges, and future directions. Pigment Cell Melanoma Res. 2020 Jul.33(4):527-541. Pubmedid: 31916400.
• Mills MN, Figura NB, Arrington JA, Yu HM, Etame AB, Vogelbaum MA, Soliman H, Czerniecki BJ, Forsyth PA, Han HS, Ahmed KA. Management of brain metastases in breast cancer: a review of current practices and emerging treatments. Breast Cancer Res Treat. 2020 Apr.180(2):279-300. Pubmedid: 32030570.
• Figura NB, Rizk VT, Armaghani AJ, Arrington JA, Etame AB, Han HS, Czerniecki BJ, Forsyth PA, Ahmed KA. Breast leptomeningeal disease: a review of current practices and updates on management. Breast Cancer Res Treat. 2019 Sep.177(2):277-294. Pubmedid: 31209686.
• Arendash G, Cao C, Abulaban H, Baranowski R, Wisniewski G, Becerra L, Andel R, Lin X, Zhang X, Wittwer D, Moulton J, Arrington J, Smith A. A Clinical Trial of Transcranial Electromagnetic Treatment in Alzheimer's Disease: Cognitive Enhancement and Associated Changes in Cerebrospinal Fluid, Blood, and Brain Imaging. J Alzheimers Dis. 2019 Sep.71(1):57-82. Pubmedid: 31403948. Pmcid: PMC6839500.
• Kushchayev SV, Wiener PC, Teytelboym OM, Arrington JA, Khan M, Preul MC. Percutaneous Vertebroplasty: A History of Procedure, Technology, Culture, Specialty, and Economics. Neuroimaging Clin N Am. 2019 Nov.29(4):481-494. Pubmedid: 31677725.
• Stringfield O, Arrington JA, Johnston SK, Rognin NG, Peeri NC, Balagurunathan Y, Jackson PR, Clark-Swanson KR, Swanson KR, Egan KM, Gatenby RA, Raghunand N. Multiparameter MRI Predictors of Long-Term Survival in Glioblastoma Multiforme. Tomography. 2019 Mar.5(1):135-144. Pubmedid: 30854451. Pmcid: PMC6403044.
• Figura NB, Potluri TK, Mohammadi H, Oliver DE, Arrington JA, Robinson TJ, Etame AB, Tran ND, Liu JK, Soliman H, Forsyth PA, Sahebjam S, Yu HM, Han HS, Ahmed KA. CDK 4/6 inhibitors and stereotactic radiation in the management of hormone receptor positive breast cancer brain metastases. J Neurooncol. 2019 Aug.144(3):583-589. Pubmedid: 31399935.
• Ahmed KA, Scott JG, Arrington JA, Naghavi AO, Grass GD, Perez BA, Caudell JJ, Berglund AE, Welsh EA, Eschrich SA, Dilling TJ, Torres-Roca JF. Radiosensitivity of Lung Metastases by Primary Histology and Implications for Stereotactic Body Radiation Therapy Using the Genomically Adjusted Radiation Dose. J Thorac Oncol. 2018 Aug.13(8):1121-1127. Pubmedid: 29733909. Pmcid: PMC7810135.
• Ahmed KA, Kim S, Arrington J, Naghavi AO, Dilling TJ, Creelan BC, Antonia SJ, Caudell JJ, Harrison LB, Sahebjam S, Gray JE, Etame AB, Johnstone PA, Yu M, Perez BA. Outcomes targeting the PD-1/PD-L1 axis in conjunction with stereotactic radiation for patients with non-small cell lung cancer brain metastases. J Neurooncol. 2017 Jun.133(2):331-338. Pubmedid: 28466250.
• Sahebjam S, Stallworth DG, Mokhtari S, Tran ND, Arrington JA. Assessing Response of High-Grade Gliomas to Immune Checkpoint Inhibitors. Cancer Control. 2017 Apr.24(2):180-186. Pubmedid: 28441372.
• Arrington JA, Klippenstein DL, Gatenby RA. Innovations in Diagnostic Imaging and the Transformation of the Clinical Practice of Radiology in Collaborative, Multidisciplinary Cancer Care. Cancer Control. 2017 Apr.24(2):115-117. Pubmedid: 28441378.
• Gage KL, Thomas K, Jeong D, Stallworth DG, Arrington JA. Multimodal Imaging of Head and Neck Squamous Cell Carcinoma. Cancer Control. 2017 Apr.24(2):172-179. Pubmedid: 28441371.
• Ahmed KA, Abuodeh YA, Echevarria MI, Arrington JA, Stallworth DG, Hogue C, Naghavi AO, Kim S, Kim Y, Patel BG, Sarangkasiri S, Johnstone PA, Sahebjam S, Khushalani NI, Forsyth PA, Harrison LB, Yu M, Etame AB, Caudell JJ. Clinical outcomes of melanoma brain metastases treated with stereotactic radiosurgery and anti-PD-1 therapy, anti-CTLA-4 therapy, BRAF/MEK inhibitors, BRAF inhibitor, or conventional chemotherapy. Ann Oncol. 2016 Dec.27(12):2288-2294. Pubmedid: 27637745. Pmcid: PMC8890451.
• Wagner A, Murtagh F, Arrington J, Stallworth D. Relationship of Schmorl's nodes to vertebral body endplate fractures and acute endplate disk extrusions. Ajnr Am J Neuroradiol. 2000 Feb.21(2):276-281. Pubmedid: 10696008. Pmcid: PMC7975332.
• Gosche K, Velthuizen R, Murtagh F, Arrington J, Gross W, Mortimer J, Clarke L. Automated quantification of brain resonance image hyperintensitites using hybrid clustering and knowledge-based methods. Int J Imag Sci. 1999 May.10(3):287-293.
• Arrington J, Smith R. Managed care clinical corner: a closer look at lower back pain. Am J Man Care. 1998.4(6):875-879. Pubmedid: noPMID.
• Gal T, Ridley M, Arrington J, Muro-Cacho C. Renal cell carcinoma presenting as a masseteric space mass. Am J Otolaryngol. 1997 Jul.18(4):280-282. Pubmedid: 9242882.
• Esposito MB, Arrington JA, Murtagh FR, Ridley MB, Endicott JN, Silbiger ML. Anterior approach for CT-guided biopsy of skull base and parapharyngeal space lesions. J Comput Assist Tomo. 1996 Sep.20(5):739-741. Pubmedid: 8797904.
• Velthuizen R, Clarke L, Phuphanich S, Hall L, Bensaid A, Arrington J, Greenberg H, Silbiger M. Unsupervised measurement of brain tumor volume on MR images. J Magn Reson Imaging. 1995 Sep.5(5):594-605. Pubmedid: 8574047.
• Murtagh F, Phuphanich S, Iman N, Clarke L, Greenberg H, Arrington J. Novel Methods of Evaluating the Growth Response Patterns of Treated Brain Tumors. Cancer Control. 1995 Jul.2(4):293-299. Pubmedid: 10862168.
• Greenfield GB, Arrington JA. Magnetic Resonance Imaging of Soft Tissue Tumors. Cancer Control. 1994 Nov.1(6):581-585. Pubmedid: 10887010.
• Greenfield G, Arrington J. Magnetic resonance imaging of soft tissue tumors. Cancer Control. 1994.1:581-585.
• Esposito MB, Arrington JA, Murtaugh FR, Coleman JM, Sergay SM. MR of the spinal cord in a patient with herpes zoster. Ajnr Am J Neuroradiol. 1993 Jan.14(1):203-204. Pubmedid: 8427090. Pmcid: PMC8334430.
• Greenfield G, Arrington J, Kudryk B. MRI of soft tissue tumors. Skeletal Radiol. 1993.22:77-84.
• Clarke L, Velthuizen R, Phuphanich S, Schellenberg J, Arrington J, Silbiger M. MRI: stability of three supervised segmentation techniques. Magn Reson Imaging. 1993.11(1):95-106.
• Murtagh FR, Arrington JA. Computer tomographically guided discography as a determinant of normal disc level before fusion. Spine. 1992 Jul.17(7):826-830. Pubmedid: 1502648.
• Murtagh F, Arrington J. Computer tomographically guided discography as a determinant of normal disc level before fusion. Spine. 1992.17(7):826-830.
• Merandi SF, Kudryk BT, Murtagh FR, Arrington JA. Contrast-enhanced MR imaging of optic nerve lesions in patients with acute optic neuritis. Ajnr Am J Neuroradiol. 1991 Sep.12(5):923-926. Pubmedid: 1950922. Pmcid: PMC8333530.
• Kudryk BT, Coleman JM, Murtagh FR, Arrington JA, Silbiger ML. MR imaging of an extreme case of cerebellar ectopia in a patient with Chiari II malformation. Ajnr Am J Neuroradiol. 1991 Jul.12(4):705-706. Pubmedid: 1882748. Pmcid: PMC8331585.
• Zinreich SJ, Kennedy DW, Kumar AJ, Rosenbaum AE, Arrington JA, Johns ME. MR imaging of normal nasal cycle: comparison with sinus pathology. J Comput Assist Tomo. 1988 Nov.12(6):1014-1019. Pubmedid: 3183103.
• Nokes SR, Dauito R, Murtagh FR, Love LC, Arrington JA. Intracranial mesenchymal chondrosarcoma. Ajnr Am J Neuroradiol. 1987 Nov.8(6):1137-1138. Pubmedid: 3120541. Pmcid: PMC8332360.
• Nokes SR, Martinez CR, Arrington JA, Dauito R. Significance of vaginal air on computed tomography. J Comput Assist Tomo. 1986 Nov.10(6):997-999. Pubmedid: 3782571.
• Arrington JA, Murtagh FR, Silbiger ML, Rechtine GR, Nokes SR. Magnetic resonance imaging of postdiscogram discitis and osteomyelitis in the lumbar spine: case report. J Fla Med Assoc. 1986 Mar.73(3):192-194. Pubmedid: 3701296.
• Arrington JA, Murtagh FR, Martinez CR, Schnitzlein HN. CT of multiple intracranial cryptococcoma. Ajnr Am J Neuroradiol. 1984 Jul.5(4):472-473. Pubmedid: 6431782. Pmcid: PMC8332050.
• Harris E, Lafond G, Arrington J, Berman C, Brodsky N. The head and neck. In: Oncologic Imaging: a clinical perspective. The McGraw Hill Companies; 1998;79-118.
• Arrington J. Imaging of the upper airways and sinuses. In: Diagnostic testing of allergic disease. New York, NY: Marcel Dekker, Inc.; 2000;263-286.
• Arrington J, Linden C, Murtagh F. The central nervous system. In: Oncologic imaging: a clinical perspective. The Mcgraw Hill Companies; 1998;7-78.
• Arrington J, Greenfield G. Greenfield G, Arrington J, eds. Imaging of Bone Tumors - A Multimodality Approach. Philadelphia, PA: J.B. Lippincott Company; 1995;1-492.
• Ruckdeschel J, Patterson S, Cuthbertson D, Murtagh F, Arrington J. 1997.

Voted top doctor in Radiology in Tampa Magazine's Top Doctors 2025.

Voted top doctor in Radiation in Tampa Magazine's Top Doctors 2024.