Non-Therapeutic Research Office Studies

The MIND-BC Study: MIND Diet for Breast Cancer Cognition (MCC 23571)

Principal Investigator: Crowder, Sylvia

Objective: Aim 1: To evaluate the efficacy of the MIND diet in reducing self-reported cancer-related cognitive impairment (primary outcome) in early-stage breast cancer survivors. Aim 2: To evaluate the efficacy of the MIND diet in improving objective cancer-related cognitive impairment (i.e., best objective performance and usual objective performance), fatigue, mood, and QOL (secondary outcomes) in early-stage breast cancer survivors. Exploratory Aim 3: To explore putative mechanisms of improvements in cognition secondary to the MIND diet (inflammatory biomarkers, body composition, nutrient biomarkers, etc.) versus controls.

Breast Cancer Survivors RESET (Reducing Weight and Elevated Stress Levels using Educational and Behavioral Tools): A pilot, feasibility study (MCC 22616)

Principal Investigator: Carson, Tiffany

The main objective of the Survivor’s RESET pilot study is to test the feasibility and acceptability of a cancer-relevant, stress management-enhanced behavioral weight loss intervention for Black breast cancer survivors with obesity and elevated stress.

Participants follow a lifestyle change plan, attend 16 group-based education sessions, complete surveys, and provide basic body measurements, blood fingerstick samples, and saliva samples at 2 time points during the 4-month duration of the study. Primary outcomes include feasibility of enrollment, retention, and adherence as determined by pre-defined benchmarks. Preliminary changes in weight, perceived stress, and other patient-reported outcomes are also assessed.

Remote Exercise and Nutritional Prehabilitation for Pancreatic Cancer: A Randomized Pilot Study (MCC 23088)

Principal Investigator: Parker, Nathan (Nate)

Summary: The purpose of the study is to examine the feasibility and acceptability of an exercise and nutrition prehabilitation program for patients preparing for pancreatic cancer resection (removal).

Objective: Aim 1: Evaluate the feasibility and acceptability of PA/N and RT/N programs among patients preparing for PC resection. Feasibility metrics will include rates of recruitment (≥70%), retention (≥70%), and adherence to PA/RT prescriptions and nutrition monitoring (≥75%). Acceptability evaluation will include participant ratings of satisfaction for specific intervention components and qualitative data from semi-structured interviews. Aim 2: Examine exploratory outcomes (e.g., weight and body composition, aerobic and muscular fitness, physical functioning, nutritional status, QOL) and clinical characteristics (e.g., postoperative length of stay, surgical complications, receipt of adjuvant therapy) among PA/N and RT/N participants. Aim 3: Compare clinical and treatment outcomes (e.g., weight and body composition, serum albumin, postoperative length of stay, surgical complications, receipt of adjuvant therapy) between study participants and a retrospectively-identified, usual care comparison group.

Augmented Reality as an Adjunct to Quitline Counseling for Smoking Cessation (MCC 23633)

Principal Investigator: Vinci Christine

Study Title: Beyond Smoking: Using Augmented Reality to Address Vaping and Dual Use in Emerging Adulthood

Objective: Aim 1. To develop and pilot test e-cigarette AR cues for dual and e-cigarette-only users aged 18-24. Interviews will be conducted with individuals aged 18-24 who are dual users (i.e., use combustible cigarettes and e-cigarettes) and e-cigarette only users to gather information on the types of e-cigarettes used and the context of use, and to obtain feedback on the existing AR app. Feedback will inform the development of the new set of AR e-cigarette cues to be integrated into the app, along with other app modifications relevant to this age group. The revised app will then be pilot tested among 5 individuals for additional feedback. Aim 2. To obtain feedback from key community college stakeholders about existing and future student programs for dual users and/or e-cigarette-only users. We will conduct interviews to collect information on existing student programs on e-cigarette use and to understand administrators' perspectives on facilitating future intervention engagement. Stakeholders will also provide insight into campus policies and culture that may affect the future implementation of the intervention.

Participating Trials

Click the plus sign for each section to view the clinical trials.

• Health Outcomes and Behavior (HOB)

  PI	Clinical Trial Number	Title
  Vidrine, Damon	Clinical Trial 23179	Creation of an Infrastructure to Support Delivery of mHealth Interventions for Cancer Patients Throughout Florida
  Alishahi Tabriz, Amir	Clinical Trial 22476	Support through remote observation and nutrition guidance program for individuals with pancreatic cancer undergoing surgery (STRONG-PCS)
  	Clinical Trial 23230	Support through remote observation and nutrition guidance program for individuals with gastroesophageal cancer (STRONG-GEC)
  Carson, Tiffany	Clinical Trial 21224	Determining the Structural- and Functional-Level Effects of Diet-specific Interventions on The Gut Microbiota of a Diverse Sample of Southern United States Adults
  Christy, Shannon	Clinical Trial 22345	Outreach Core Activities
  	Clinical Trial 23232	Multilevel Action Toward Colorectal Cancer and Hepatitis C Education and Screening (MATCHES)
  Crowder, Sylvia	Clinical Trial 23571	The MIND-BC Study: MIND Diet for Breast Cancer Cognition
  Gonzalez, Brian	Clinical Trial 23371	Ethnicity and Lung Cancer Survival: A Test of the Hispanic Sociocultural Hypothesis
  Green, B Lee	Clinical Trial 23286	Developing a Longitudinal Health Initiative to Positively Impact the Cardiovascular and Cancer Health of Black/African-American Men Nationally - The Kappa Alpha Psi Health Impact Initiative (KAPHII)
  Jim, Heather	Clinical Trial 16933	Older Breast Cancer Patients: Risk For Cognitive Decline
  	Clinical Trial 21752	Chimeric Antigen Receptor T-Cell Therapy: Neurocognitive Effects and Patient-Reported Outcomes
  	Clinical Trial 23489	Positive Psychology Intervention for Hematopoietic Stem Cell Transplantation Survivors
  	Clinical Trial 23502	BMT-CARE: Multimodal Psychosocial Intervention for Caregivers of Patients Undergoing Hematopoietic Stem Cell Transplantation
  	Clinical Trial 23570	Feasibility of Dietary Interventions for Optimizing CAR-T Cell Function in Cancer Patients and Adults without Cancer
  Kirtane, Kedar	Clinical Trial 21589	BASECAMP-1: An Observational Study Obtaining Solid Tumor Tissue from Subjects with Primary Surgical Resection and Leukapheresis for CAR T-Cell Therapy Manufacturing
  Oswald, Laura	Clinical Trial 23322	Survivorship in Patients with Multiple Myeloma Treated with Chimeric Antigen Receptor T-cell Therapy
  Parker, Nathan (Nate)	Clinical Trial 21742	Remote Resistance Exercise Powering Survivors- Gastrointestinal Oncology (Remote REPS-:GI)
  	Clinical Trial 23088	Remote Exercise and Nutritional Prehabilitation for Pancreatic Cancer: A Randomized Pilot Study
  	Clinical Trial 23121	Exercise Prehabilitation for Locoregional Esophageal Cancer: A Pilot Study
  Vadaparampil, Susan	Clinical Trial 22140	Working through Outreach, Navigation and Digital Enabled Referral and Recruitment Strategies (ACT WONDERS)
  	Clinical Trial 22140-AIM2	Working through Outreach, Navigation and Digital Enabled Referral and Recruitment Strategies (ACT WONDERS)
  Vinci, Christine	Clinical Trial 23499	Moffitt Community Registry (MCR)
  	Clinical Trial 23529	Development of a Mindfulness-Based Smartphone Application for BMT Caregivers
  	Clinical Trial 23633	Beyond Smoking: Using Augmented Reality to Address Vaping and Dual Use in Emerging Adulthood
  	Clinical Trial 23803	Development of a Mindfulness-Based Intervention for Caregivers of Head and Neck Cancer Patients

   

• Cancer Epidemiology (CE)

  Kanetsky, Peter	Clinical Trial 23436	A Hybrid Effectiveness-Implementation Trial to Integrate Precision Skin Cancer Risk Feedback in Federal Qualified Health Centers
  	Clinical Trial 23665	ProSalud: A Health Promotion Project to Reduce Cancer Risk in Latinos Living in Rural/Agricultural Communities within Moffitt's Catchment Area
  Byrd, Doratha (Armen)	Clinical Trial 16028	Transdisciplinary Research in Colorectal Cancer: The ColoCare Study
  	Clinical Trial 22709	A Randomized High-Fermented Food Intervention among Cancer Patients (The FEED Trial)
  	Clinical Trial 23464	ColoCare GO
  Coghill, Anna	Clinical Trial 23131	Impact of Behavior Modification Interventions and Lung Cancer Screening on Smoking Cessation in People Living with HIV: A Feasibility Study
  	Clinical Trial 23143	Trends and Outcomes in HIV-positive Patients Undergoing Treatment for Invasive or Preinvasive Cervical and Other Gynecologic Neoplasias
  Egan, Kathleen	Clinical Trial 21268	Biobanking for Breast Cancer Prevention and Disparity Research in Florida
  Giuliano, Anna	Clinical Trial 17716	A Biomarker-related Approach to Screening for HPV-related Oropharyngeal Cancer
  	Clinical Trial 23785	CASCADE: A Single-Arm, Open-Label Clinical Phase II Trial of the Safety and Immunogenicity of PDS0101 in People Living with HIV
  Heine, John	Clinical Trial 19209	Combined Imaging and Blood Biomarkers for Breast Cancer Diagnosis
  Islam, Jessica	Clinical Trial 22179	Determinants of Cancer Survivorship Among People Living with HIV (HIV/AIDS/AGING/CANCER)
  	Clinical Trial 23568	Inequities and Trends in Lung Cancer Screening Among People with HIV in the US
  	Clinical Trial 23910	Harnessing Big Data to Understand the Confluence of HIV and Cancer Stigma in the US Southeast
  Kresovich, Jacob	Clinical Trial 23559	Aging, DNA Methylation, and Incident Cardiovascular Disease in Breast Cancer Survivors
  Park, Jong	Clinical Trial 22726	miRNA-Related Polygenic Risk Score and miRNA Expression on Prostate Cancer Survival
  Permuth, Jennifer	Clinical Trial 20105	Using Radiogenomics to Noninvasively Predict the Malignant Potential of Intraductal Papillary Mucinous Neoplasms (IPMNs) of the Pancreas and Uncover Hidden Biology
  	Clinical Trial 23462	Physical Activity and Nutrition to Halt Elevated Risk in the Pancreas Interception Center (PANTHER-PIC)
  Schabath, Matthew	Clinical Trial 14690	Total Cancer Care Protocol: A Lifetime Partnership with Patients Who Have or May be at Risk of Having Cancer
  	Clinical Trial 17723	Radiomics and Non-Imaging Biomarkers in Lung Cancer Screening and Early Detection

   

• Clinical Sciences

  Radiation Oncology
  Yamoah, Kosj	Clinical Trial 19291	The Utility of PSMA-PET Imaging for Detecting Early Metastatic Prostate Cancer in Men with High GC Decipher® Test Scores: A Sub-aim of the VANDAAM Study (MCC #18523)
  Ahmed, Kamran	Clinical Trial 23433	Phase II Study of Systemic Screening in Pathologic Node Positive Breast Cancer following Neoadjuvant Chemotherapy and Surgery
  Gastrointestinal Oncology
  Anaya Saenz, Daniel	Clinical Trial 22363	Development and Implementation of a Standardized 3D-Printing Application to Optimize Routine Individualized Patient-Specific Surgical Care of Hepatobiliary Tumors
  Dineen, Sean	Clinical Trial 22722	Use of Synthetic Smart Polymers to Solubilize Mucin from Patients with Peritoneal Metastases of Mucinous Gastrointestinal Neoplasms
  Malignant Hematology
  Freeman, Ciara	Clinical Trial 23711	Artificial Intelligence-Integrated Clinical, Pathologic, Genomic, and Radiologic Model for Predicting Response to Complex Immunotherapies and Risk of Developing Extramedullary Disease in Multiple Myeloma
  Alsina, Melissa	Clinical Trial 23564	Phase II study of Elranatamab as maintenance therapy post ciltacabtagene-autoleucel(cilta-cel) in patients with clinical high risk relapsed myeloma
  Padron, Eric	Clinical Trial 22367	The Impact Of Inflammation On HSPC Composition And Disease Progression In Chronic Myelomonocytic Leukemia (CMML INTERCEPT STUDY) SUB-TITLE: Intercepting CMML Disease Progression Driven by Acute Inflammation
  Pidala, Joseph	Clinical Trial 23275	A Prospective, Observational Cohort Study of Participants at Risk for Chronic Graft-Versus-Host Disease in the United States (THRIVE)
  Cutaneous Oncology
  Karapetyan, Lilit	Clinical Trial 23082	Phase I/II Clinical Trial of CD40L-augmented Tumor Infiltrating Lymphocytes (TIL) for Patients with Advanced Melanoma
  Gynecologic Oncology
  Wenham, Robert	Clinical Trial 20187	Development of Intra-tumor Driver Mutation Prevalence as a Predictor of Efficacy of Targeted Agents