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Libin Ye, PhD

Research Program: Molecular Medicine Program

  • Overview


    • Molecular Medicine Program
  • Publications

    • Wang X, Neale C, Kim SK, Goddard WA, Ye L. Intermediate-state-trapped mutants pinpoint G protein-coupled receptor conformational allostery. Nat Commun. 2023 Mar.14(1):1325. Pubmedid: 36899002. Pmcid: PMC10006191.
    • Ye L, Wang X, McFarland A, Madsen JJ. 19F NMR: A promising tool for dynamic conformational studies of G protein-coupled receptors. Structure. 2022 Oct.30(10):1372-1384. Pubmedid: 36130592.
    • Madsen JJ, Ye L, Frimurer TM, Olsen OH. Mechanistic basis of GPCR activation explored by ensemble refinement of crystallographic structures. Protein Sci. 2022 Nov.31(11):e4456. Pubmedid: 36134696. Pmcid: PMC9601807.
    • Wang X, Bushra N, Muschol M, Madsen JJ, Ye L. An in-membrane NMR spectroscopic approach probing native ligand-GPCR interaction. Int J Biol Macromol. 2022 May.206:911-916. Pubmedid: 35318080.
    • K S Narayanan SS, Wang X, Paul J, Paley V, Weng Z, Ye L, Zhong Y. Disinfection and Electrostatic Recovery of N95 Respirators by Corona Discharge for Safe Reuse. Environ Sci Technol. 2021 Nov.55(22):15351-15360. Pubmedid: 34570480.
    • Fernandes DD, Neale C, Gomes GW, Li Y, Malik A, Pandey A, Orazietti AP, Wang X, Ye L, Scott Prosser R, Gradinaru CC. Ligand modulation of the conformational dynamics of the A2A adenosine receptor revealed by single-molecule fluorescence. Sci Rep. 2021 Mar.11(1):5910. Pubmedid: 33723285. Pmcid: PMC7960716.
    • Yin G, Kandapal S, Liu CH, Wang H, Huang J, Jiang ST, Ji T, Yan Y, Khalife S, Zhou R, Ye L, Xu B, Yang HB, Nieh MP, Li X. Metallo-Helicoid with Double Rims: Polymerization Followed by Folding by Intramolecular Coordination. Angew Chem Int Ed Engl. 2021 Jan.60(3):1281-1289. Pubmedid: 33009693.
    • Wang X, McFarland A, Madsen JJ, Aalo E, Ye L. The Potential of 19F NMR Application in GPCR Biased Drug Discovery. Trends Pharmacol Sci. 2021 Jan.42(1):19-30. Pubmedid: 33250272.
    • Wang X, Zhao W, Al-Abdul-Wahid S, Lu Y, Cheng T, Madsen JJ, Ye L. Trifluorinated Keto-Enol Tautomeric Switch in Probing Domain Rotation of a G Protein-Coupled Receptor. Bioconjug Chem. 2021 Jan.32(1):99-105. Pubmedid: 33377784.
    • Zhao W, Wang X, Ye L. Expression and Purification of Yeast-derived GPCR, Gα and Gβγ Subunits for Structural and Dynamic Studies. Bio Protoc. 2021 Feb.11(4):e3919. Pubmedid: 33732806. Pmcid: PMC7952927.

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