Colon Cancer Clinical Trials
Colon cancer clinical trials provide patients with opportunities to access novel treatments before they are made available for use in other settings. Each trial is individualized based on a number of variables and overseen by a team of oncologists and research specialists. Generally speaking, these studies are performed to determine whether a new therapy is more effective than a standard one, what sort of side effects a treatment might produce, how well a therapy works with others or what type of patients are most likely to benefit from a new treatment.
The clinical trials program at Moffitt Cancer Center has provided countless patients with the ability to be among the first to benefit from new therapies as soon as they become available. It has also provided our oncologists with a better understanding of the condition in general, which we use to improve treatment for all patients.
Through past colon cancer clinical trials, researchers have determined:
- Which chemotherapy medications are most effective for the different types and stages of colon cancer
- How targeted therapies (medications that interfere with the growth of cancer cells while leaving healthy cells unaffected) can be used along with or in place of chemotherapy
- The most effective surgical techniques for removing a tumor from the delicate tissues of the colon
- The best ways to enhance long-term quality of life for colon cancer patients and survivors
- Ways to improve colon cancer screening and early detection processes
In recognition of our commitment to advancing colon cancer research and treatment strategies, Moffitt has been recognized as a Comprehensive Cancer Center by the National Cancer Institute. We are the only such center based in Florida.
If you are considering a clinical trial, our clinical trial navigators can help you find a study that meets your needs. For more information about the colon cancer clinical trials we are currently conducting, call 1-813-745-6100 or 1-800-679-0775 (toll-free) or submit a clinical trials inquiry form. No referral is required.
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Clinical Trials
CLINICAL TRIAL 16028
Transdisciplinary Research in Colorectal Cancer: The ColoCare Study
Condition: Gastrointestinal Tumor
Intervention:
CLINICAL TRIAL 21336
A Phase I/Ib Global, Multicenter, Open-Label Umbrella Study Evaluating the Safety and Efficacy of Targeted Therapies in Subpopulations of Patients with Metastatic Colorectal Cancer (Intrinsic)
Condition: Gastrointestinal Tumor
Intervention: 5-fluorouracil (); Atezolizumab (Tecentriq); Avastin (Bevacizumab); Bevacizumab (); Bevicizumab (); Cetuximab (); Divarasib (); Erbitux (Cetuximab); FOLFIRI (); FOLFOX (); GDC-6036 (); Inavolisib (); Oxaliplatin (); SY-5609 (); Tiragolumab (); eloxatin (Oxaliplatin); leucovorin ()
CLINICAL TRIAL 21459
Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease (CIRCULATE-US)
Condition: Gastrointestinal Tumor
Intervention: 5-fluorouracil (); CAPOX (); CPT-11 (irinotecan); Camptosar (irinotecan); FOLFIRINOX (); FOLFOX6 (); Oxaliplatin (); Xeloda (capecitabine); capecitabine (); eloxatin (Oxaliplatin); irinotecan (); leucovorin ()
CLINICAL TRIAL 21589
BASECAMP-1: An Observational Study Obtaining Solid Tumor Tissue from Subjects with Primary Surgical Resection and Leukapheresis for CAR T-Cell Therapy Manufacturing
Condition: Immunotherapy
Intervention:
CLINICAL TRIAL 21641
First-in-Human, Phase 1/1b, Open-label, Multicenter Study of Bifunctional EGFR/TGF_ Fusion Protein BCA101 Alone and in Combination with Pembrolizumab in Patients With EGFR-Driven Advanced Solid Tumors
Condition: Head & Neck
Intervention: BCA101 (); Pembrolizumab (Keytruda)
CLINICAL TRIAL 23132
A Phase 1 Study of SGN-EGFRd2 in Advanced Solid Tumors
Condition: Gastrointestinal Tumor
Intervention: SGN-EGFRd2 (PF-08046052)
CLINICAL TRIAL 23188
A Phase II Study of Enfortumab Vedotin in Patients with Advanced or Metastatic Colorectal Cancer or Hepatocellular Carcinoma
Condition: Gastrointestinal Tumor
Intervention: Enfortumab Vedotin (Padcev)
CLINICAL TRIAL 23309
A Platform Study of RAS(ON) Inhibitors to Treat Patients with Gastrointestinal Solid tumor - SUB-A: Study of RMC-6236 in Combination with 5-flourouracil-based regimens in Patients with Unresectable or Metastatic Colorectal Cancer or Metastatic Pancreatic Ductal Adenocarcinoma, - SUB: Study of RMC-6236 in Combination with Cetuximab with or without mFOLFOX6 in Patients with Unresectable or Metastatic Colorectal Cancer or Metastatic Pancreatic Ductal Adenocarcinoma, - SUB-C: Study of RMC-6236 in Combination with Gemcitabine and Nab-paclitaxel in Patients with Metastatic Pancreatic Ductal Adenocarcinoma - SUB-D: Study of RMC-9805 with or without RMC-6236 in Combination with 5-flourouracil-based Therapies in Patients with RAS G12D-Mutant Unresectable or Metastatic Colorectal Cancer or Metastatic Pancreatic Ductal Adenocarcinoma - SUB-E: Study of RMC-9805 with or without RMC-6236 in Combination with Cetuximab-based Therapies in Patients with RAS G12D-Mutant Unresectable or Metastatic Colorectal Cancer or Metastatic Pancreatic Ductal Adenocarcinoma - SUB-F: Study of RMC-9805 With or Without RMC-6236 in Combination with Gemcitabine and Nab-Paclitaxel in Patients with RAS G12D-Mutant Metastatic Pancreatic Ductal Adenocarcinoma
Condition: Gastrointestinal Tumor
Intervention: 5-fluorouracil (); Avastin (Bevacizumab); Bevacizumab (); CPT-11 (irinotecan); Camptosar (irinotecan); Cetuximab (); Daraxonrasib (); Erbitux (Cetuximab); Gemzar (gemcitabine); Nab-paclitaxel (Abraxane); Oxaliplatin (); RMC-6236 (); RMC-9805 (); Zoldonrasib (); eloxatin (Oxaliplatin); gemcitabine (); irinotecan (); leucovorin (); mFOLFIRINOX (); mFOLFOX6 ()
CLINICAL TRIAL 23448
A Phase 1 Trial Evaluating the Safety, Tolerability, PK, and Efficacy of QTX3034 in Patients with Solid Tumors with KRASG12D Mutation
Condition: Multiple
Intervention: Cemiplimab (); Cetuximab (); Erbitux (Cetuximab); Pembrolizumab (Keytruda); QTX3034 (); REGN2810 (Cemiplimab); mFOLFOX6 ()
CLINICAL TRIAL 23464
ColoCare GO
Condition: Gastrointestinal Tumor
Intervention:
CLINICAL TRIAL 23549
A Phase 1/1b Study of VET3-TGI Administered Alone and in Combination with Atezolizumab in Patients with Advanced Solid Tumors
Condition: Thoracic
Intervention: Atezolizumab (Tecentriq); VET3-TGI ()
CLINICAL TRIAL 23585
A Phase 1a/1b Open-Label Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of BBO-10203 in Subjects with Advanced Solid Tumors (The BREAKER-101 Trial)
Condition: Breast
Intervention: Avastin (Bevacizumab); BBO-10203 (); Bevacizumab (); FOLFOX (); Faslodex (fulvestrant); Herceptin (Trastuzumab); LEE011 (Ribociclib); Ribociclib (); Trastuzumab (); fulvestrant (); rhuMAb HER2 (Trastuzumab)
CLINICAL TRIAL 23599
Phase 1a/1b Open-Label Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Efficacy of BBO-11818 in Subjects with Advanced KRAS Mutant Cancers
Condition: Multiple
Intervention: Alimta (Pemetrexed); BBO-11818 (); Cetuximab (); Erbitux (Cetuximab); Paraplatin (carboplatin); Pembrolizumab (Keytruda); Pemetrexed (); carboplatin (); cisplatin ()
CLINICAL TRIAL 23553
DENALI-1: A Seamless Phase 1/2 Study to Evaluate the Safety and Efficacy of A2B395, an Allogeneic Logic-gated Tmod CAR T, in Heterozygous HLA A*02 Adults with Recurrent Unresectable, Locally Advanced, or Metastatic Solid Tumors That Express EGFR and Have Lost HLA A*02 Expression.
Condition: Immunotherapy
Intervention: A2B395 (); MESNA (); cyclophosphamide (); cytoxan (cyclophosphamide); fludarabine (Fludarabine phosphate)
CLINICAL TRIAL 23659
A Phase 1/2 Clinical Trial to Evaluate the Safety, Tolerability, and Pharmacokinetics of ARV-806 in Participants With KRAS G12D Mutated Advanced Solid Tumors
Condition: Multiple
Intervention: ARV-806 ()
CLINICAL TRIAL 23660
A Phase 1 Study of MOMA-341 as Monotherapy or Combination Therapy in Participants with Advanced or Metastatic Solid Tumors
Condition: Multiple
Intervention:
CLINICAL TRIAL 23766
A First-in-Human Phase 1 Dose Escalation Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of FID-022 as Monotherapy in Patients with Advanced Solid Tumors
Condition: Multiple
Intervention: FID-022 ()
CLINICAL TRIAL 23817
Assessing the Perspectives of Young Adult Colorectal Cancer Survivors on Colorectal Cancer Awareness, Access to Care, Screening and Early Detection
Condition: Gastrointestinal Tumor
Intervention: