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  • Cancer Type: Cutaneous
  • Study Type: Basic Science
  • NCT#:
  • Phase: N/A
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  • Overview

    Study Title:

    MElanoma Research Lymph Node Prediction Implementation National_001 (MERLIN_001)


    1. The predictive capability of CP-GEP to identify primary cutaneous melanoma patients who can safely forgo sentinel lymph node biopsy 2. The prognostic value of CP-GEP regarding the outcome of cutaneous melanoma patients after a negative sentinel lymph node biopsy.

  • Inclusion Criteria

    • Newly diagnosed (biopsy within 120 days of study enrollment) invasive malignant melanoma of the skin; pT1b-pT3 (Breslow thickness ≥0.8 mm to 4.0 mm) cN0M0 OR pT1a (Breslow thickness > Male or female, age ≥18 years.
    • Elected to undergo sentinel lymph node biopsy per the treating physician’s recommendation.
  • Exclusion Criteria

    • Full primary melanoma pathology report unavailable.
    • Documented clinically apparent nodal metastases at diagnosis.
    • Distant metastatic disease (M1a,b,c,d) clinically present at primary diagnosis
    • Any prior or concurrent primary invasive melanoma mapping to the same draining lymph node basin(s).
    • Documented history of another (prior or concurrent) primary invasive melanoma of T1b or greater at any site within the last 5 years.
    • Previous surgery in or radiation therapy to the draining lymph node basin(s) of the current primary melanoma.
    • Ocular, vulvar, perianal or mucosal melanomas or melanocytic tumors of uncertain malignant potential (MELTUMP) or atypical Spitz tumors.

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