Clinical Trial 21351

• Overview

  Study Title:

  A Prospective Analysis of Biochemical Markers for Hematopoietic Cell Transplant-Associated Thrombotic Microangiopathy in Adults

  Summary:

  The purpose of this study is to collect and store samples obtained (blood samples) and data (clinical information about your blood disorder and transplant) from patients undergoing allogeneic hematopoietic stem cell transplants. These samples will be collected and stored only for research studies focused on transplant–related complications. This research could include genetic and noncancerous research to help prevent, diagnose and treat transplant–related thrombotic microangiopathy (TMA).

  Objective:

  The goal of this protocol is to establish a cohort of patients with clinical data and biologic samples collected prospectively from patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HCT) treated in 3 centers (OSU, RPCC, Moffitt) that will be a shared biospecimen resource to be stored and analyzed at Cincinnati Children s Hospital Medical center (CCHMC) for markers of endothelial activation

• Inclusion Criteria

  Inclusion criteria
  • Patients > 18.00 years undergoing a first allogeneic transplant
  • Patients with any malignant or non-malignant hematologic disorder
  • Patients who are on concomitant interventional trials are eligible.
  • Willing to provide informed consent

• Exclusion Criteria

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