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  • Cancer Type: Gastrointestinal Tumor
  • Study Type: Supportive Care
  • NCT#: NCT05921552
  • Phase: N/A
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  • Overview

    Study Title:

    Feasibility of Exercise Prehabilitation Among Older Patients with Hepatobiliary Cancer Planning for Surgery


    The purpose of the study is to evaluate an exercise program for individuals with hepatobiliary cancer planning for surgery.


    Objectives: Specific Aim 1: Evaluate the feasibility, safety, and acceptability of a remote, multimodal exercise intervention as prehabilitation for older cancer patient having Hepatobiliary surgery. Hypothesis 1: The intervention will be feasible, safe, and acceptable based on published metrics. Specific Aim 2: Assess changes in objective and self-reported physical functioning, aerobic fitness, skeletal muscle mass and radiodensity, Geriatric outcomes (loss of functionality; loss of capacity to perform activities of daily living; non programmed hospitalization; discharge to nursing facility) and health-related quality of life among intervention participants. Hypothesis 2: Participants will show favorable changes in exploratory outcome measures over the course of the exercise intervention. Specific Aim 3: Compare changes in skeletal muscle mass and radiodensity, inflammatory Aging biomarkers (Neutrophil/lymphocyte ratio, modified Glasgow prognostic score), health-related quality of life, and clinical outcomes (Clavien-Dindo III-V events, length of hospital stay and ICU admissions,) between exercise participants and retrospectively identified, non-intervention patients who received standard care. Hypothesis 3: Exercise participants will show favorable changes in exploratory outcome measures compared to the retrospective, non-intervention patients.

  • Inclusion Criteria

    • Age >65 years
    • Resectable Hepatocellular carcinoma, Cholangiocarcinoma, or Liver metastasis with Liver resection planned >4 weeks
    • ECOG 0-2
    • Able to sign consent
  • Exclusion Criteria

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