Clinical Trial 23275

• Overview

  Study Title:

  A Prospective, Observational Cohort Study of Participants at Risk for Chronic Graft-Versus-Host Disease in the United States (THRIVE)

  Summary:

  The purpose of this prospective observational study is to collect data from participants who have recently had an allogenic Stem Cell Transplant(alloSCT) and are at risk of Chronic Graft Versus Host Disease(cGVHD)

  Objective:

  Primary: Describe the clinical course and burden of cGVHD after alloSCT. Secondary: Describe personal and healthcare resource utilization associated with the management of cGVHD. Describe practice patterns and therapy strategies in participants treated for cGVHD in both community and academic settings, including frequency, safety, and effectiveness of steroids. Assess the impact of SCT and cGVHD on organ specific symptoms as reported by participants. Assess the predictive, diagnostic, and prognostic associations of blood cytology with cGVHD.

• Inclusion Criteria

  Inclusion Criteria:
  • Age 18 years or older inclusive at the time of signing the ICF
  • Allogeneic SCT 90 to 180 days prior to enrollment
  • Able to comprehend and willing to provide informed consent
  • Willing and able to complete participant-assessment questionnaires either alone or with minimal assistance from a caregiver and/or trained site personnel

• Exclusion Criteria

  Exclusion Criteria:
  • Anyone not meeting all inclusion criteria will be considered ineligible

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